Gene

KWMTBOMO05100

Pre Gene Modal

BGIBMGA012456

Annotation

aquaporin_[Bombyx_mori]

Location

Bomo_Chr9(+):7902354-7903480      View in EpiBrowser

Full name

Adenylosuccinate synthetase      

Alternative Name

IMP--aspartate ligase

Location in the cell

PlasmaMembrane   Reliability : 4.964

CDS

ATGACGGTTTCGGCGACTAACCCCCAATCGGTCATCGAAGTAATCGAAAATAAAGTACGGTCAGACGTCTCGCAAGCATCAGGATGCAGAGCGATGTACGCGTGGTGCTATGAGTGGAGACAAATCGTATCGGAGTTTATTTCCACGTTGCTGCTTCTCGTGTTTGGGTGCATGGCATGTATACCGCACGCTGGATATTTACCTCAACCACCAATATACGGAGCACTAGGGTTCGGTTTGGTAGTCTCGTTTAATGTCCAAATATTTGGACATATATCTGGAGCGCACATGAATCCGTCCGTCACACTGGCCTCGCTGATATGGGGCGCGATATCGTTTCCGCTGGCTATTGCGTTTATAGTAGCACAATGCGCAGGAGCGATTTTAGGATACGGATTGTTAATAGCTGTTTCGCACATAGACATGGATGGGGTCTGTATGACGTTACCACGTACGGAAATTACATTGTTTCAAGCTTTAATCGTCGAAGCAGTTTTGACTGCGGCTCTTTCATTTTTGAACTGCGCCTGCTGGGATCCCGTCAACAAGAACAAACAGGACTCCGTTCCGGTTAAGTTTGGTTTGGCTATTGCGGGATTATCGATAGCTGGAGGGCCACTAACCGGCGCCAGTATGAATCCCGCGAGGTCCTTGGGCCCGGCATTGTGGACGGGTATTTGGACAGGTCACTGGGTTTACTGGGTTGGACCACTAGTGGGGTCTGCAATCGCCGCTGTATTTTATCTTTTCGTTTGGTTGAAAAAAGAAGACACTCCCTGA

Protein

MTVSATNPQSVIEVIENKVRSDVSQASGCRAMYAWCYEWRQIVSEFISTLLLLVFGCMACIPHAGYLPQPPIYGALGFGLVVSFNVQIFGHISGAHMNPSVTLASLIWGAISFPLAIAFIVAQCAGAILGYGLLIAVSHIDMDGVCMTLPRTEITLFQALIVEAVLTAALSFLNCACWDPVNKNKQDSVPVKFGLAIAGLSIAGGPLTGASMNPARSLGPALWTGIWTGHWVYWVGPLVGSAIAAVFYLFVWLKKEDTP

Description

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic Activity

GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate

Cofactor

Mg(2+)

Subunit

Homodimer.

Similarity

Belongs to the MIP/aquaporin (TC 1.A.8) family.
Belongs to the adenylosuccinate synthetase family.

Uniprot

Q14UC7   A0A0L7KME2   A0A194RPZ7   A0A194PDL8   A0A1L4AID9   A0A194PF74   + More
A0A194PDD3   A0A194RQ82   A0A212FKG4   A0A212EN57   A0A2A4ITK6   A0A2A4ITP2   A0A1W4ULP2   A0A1W4U9S9   A0A0N8P075   B5E1J3   B3MFH9   B3NPP7   B4GHV1   B4P9Q4   A0A0R3NVJ4   A0A0R1DYX4   A0A1B6JK86   A0A0C9Q2R0   A0A1I8P8W1   B4NMM7   A0A0C4DHF9   H8F4Q9   A0A1B6HZY3   B4QAW5   Q9W1M3   B4I8Q6   A0A0L0BY40   Q8T0N8   A0A3B0JHY1   A0A1B6EVC9   A0A087ZYA3   A0A0J9RKT5   A0A2A3EGJ9   A0A346A6B6   A0A1L8EAI5   B4KS07   T1PJL7   A0A1I8MXP2   D6WL09   A0A1L8EA86   A0A1Q3FS97   A0A1L8EA73   B4LMB0   A0A336LPE3   B0WQA3   H5V8H0   A0A2M4AFT1   B4J7D0   B4J7D1   A0A1W4ULV4   A0A182J224   A0A0M3QV32   W8B2D9   W8AQS3   A0A1I8M4V4   W8AYH9   A0A0K8TPP6   A0A1I8M4V5   A0A0L7QSR9   A0A1I8MXM4   T1PC32   A0A2M3Z6Y2   A0A3B0JP92   A0A0M4EGW3   A0A087YZX4   A0A023EL60   A0A182FLF4   A0A0K8TQ22   N6U2L0   A0A139W8G1   A0A2M4CZJ1   A0A034VCZ6   B4KS06   A0A0Q9X8G0   A0A182WQU4   A0A2M4CQA9   A0A0Q9W5S5   A0A182JZ56   A0A084W6R2   A0A154PBE5   A0A0Q9XID1   A0A336LNC8   A0A182PTA4   A0A182GE62   A0A182NDR1   Q9W1M2   A0A0A9XV76   W6CR90   A0A034VA81   W6CIU3   A0A182S554   B4P9Q5   A0A336K939   F4X1V4  

EC Number

6.3.4.4

Pubmed

19121390    26227816    26354079    27914170    22118469    17994087    + More
15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    26109357    26109356    26108605    25315136    18362917    19820115    24495485    26369729    20920257    24945155    23537049    25348373    18057021    24438588    26483478    25401762    24333473    21719571   

EMBL

BABH01028012    AB245966    BAE97427.1    JTDY01008629    KOB64472.1    KQ459896    + More
KPJ19479.1    KQ459606    KPI91347.1    KX808646    API68430.1    KPI91349.1    KPI91346.1    KPJ19480.1    AGBW02008039    OWR54234.1    AGBW02013713    OWR42935.1    NWSH01008553    PCG62502.1    PCG62503.1    CH902619    KPU76340.1    CM000071    EDY69116.1    EDV36664.1    CH954179    EDV56838.2    CH479183    EDW36071.1    CM000158    EDW92362.1    KRT02438.1    KRK00474.1    GECU01008194    JAS99512.1    GBYB01008263    JAG78030.1    CH964282    EDW85616.1    AE013599    AAO41346.2    BT133299    AFC97495.1    GECU01033896    GECU01027445    GECU01006341    JAS73810.1    JAS80261.1    JAT01366.1    CM000362    CM002911    EDX08402.1    KMY96068.1    BT044510    AAF47034.2    ACH95284.1    CH480824    EDW56981.1    JRES01001162    KNC24942.1    AY069151    AAL39296.1    OUUW01000001    SPP72999.1    GECZ01027901    JAS41868.1    KMY96069.1    KZ288266    PBC30131.1    MF467208    AXK92485.1    GFDG01003160    JAV15639.1    CH933808    EDW09448.1    KA648138    AFP62767.1    KQ971343    EFA04046.1    GFDG01003161    JAV15638.1    GFDL01004742    JAV30303.1    GFDG01003162    JAV15637.1    CH940648    EDW62005.2    UFQS01000094    UFQT01000094    SSW99285.1    SSX19665.1    DS232037    EDS32766.1    BT133271    AFC35456.1    GGFK01006319    MBW39640.1    CH916367    EDW01054.1    EDW01055.1    CP012524    ALC41709.1    GAMC01015359    GAMC01015357    JAB91198.1    GAMC01015360    GAMC01015356    JAB91195.1    GAMC01015358    JAB91197.1    GDAI01001512    JAI16091.1    KQ414756    KOC61675.1    KA646326    AFP60955.1    GGFM01003499    MBW24250.1    SPP72998.1    ALC41710.1    GAPW01003645    JAC09953.1    GDAI01001370    JAI16233.1    APGK01044994    APGK01044995    APGK01044996    APGK01044997    APGK01044998    APGK01044999    APGK01045000    KB741028    ENN74861.1    KQ973384    KXZ75551.1    GGFL01006574    MBW70752.1    GAKP01019525    GAKP01019524    JAC39428.1    EDW09447.2    KRG04671.1    KRG04672.1    GGFL01003193    MBW67371.1    KRF80380.1    ATLV01020915    KE525310    KFB45906.1    KQ434868    KZC09226.1    KRG04670.1    SSW99284.1    SSX19664.1    JXUM01057256    JXUM01057257    JXUM01057258    KQ561947    KXJ77077.1    BT124824    AAF47035.2    ADF87919.1    GBHO01020826    GBRD01012356    JAG22778.1    JAG53468.1    KF048097    AHI85748.1    GAKP01019523    JAC39429.1    KF048093    AHI85744.1    EDW92363.1    SSW99283.1    SSX19663.1    GL888553    EGI59563.1    EGI59564.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000007151    UP000218220    + More
UP000192221    UP000007801    UP000001819    UP000008711    UP000008744    UP000002282    UP000095300    UP000007798    UP000000803    UP000000304    UP000001292    UP000037069    UP000268350    UP000005203    UP000242457    UP000009192    UP000095301    UP000007266    UP000008792    UP000002320    UP000001070    UP000075880    UP000092553    UP000053825    UP000069272    UP000019118    UP000075920    UP000075881    UP000030765    UP000076502    UP000075885    UP000069940    UP000249989    UP000075884    UP000075900    UP000007755   

PRIDE

Q14UC7    H8F4Q9    Q9W1M3    Q8T0N8    H5V8H0    Q9W1M2    + More

Pfam

PF00230   MIP        + More
PF00709   Adenylsucc_synt

Interpro

IPR023271   Aquaporin-like        + More
IPR022357   MIP_CS       
IPR000425   MIP       
IPR034294   Aquaporin_transptr       
IPR042110   Adenylosuccinate_synth_dom2       
IPR001114   Adenylosuccinate_synthetase       
IPR042109   Adenylosuccinate_synth_dom1       
IPR027417   P-loop_NTPase       
IPR018220   Adenylosuccin_syn_GTP-bd       
IPR033128   Adenylosuccin_syn_Lys_AS       

SUPFAM

SSF81338   SSF81338        + More
SSF52540   SSF52540       

Gene 3D

1.20.1080.10     1.10.300.10     3.40.440.10    

CDD

cd00333  MIP

ProteinModelPortal

Q14UC7   A0A0L7KME2   A0A194RPZ7   A0A194PDL8   A0A1L4AID9   A0A194PF74   + More
A0A194PDD3   A0A194RQ82   A0A212FKG4   A0A212EN57   A0A2A4ITK6   A0A2A4ITP2   A0A1W4ULP2   A0A1W4U9S9   A0A0N8P075   B5E1J3   B3MFH9   B3NPP7   B4GHV1   B4P9Q4   A0A0R3NVJ4   A0A0R1DYX4   A0A1B6JK86   A0A0C9Q2R0   A0A1I8P8W1   B4NMM7   A0A0C4DHF9   H8F4Q9   A0A1B6HZY3   B4QAW5   Q9W1M3   B4I8Q6   A0A0L0BY40   Q8T0N8   A0A3B0JHY1   A0A1B6EVC9   A0A087ZYA3   A0A0J9RKT5   A0A2A3EGJ9   A0A346A6B6   A0A1L8EAI5   B4KS07   T1PJL7   A0A1I8MXP2   D6WL09   A0A1L8EA86   A0A1Q3FS97   A0A1L8EA73   B4LMB0   A0A336LPE3   B0WQA3   H5V8H0   A0A2M4AFT1   B4J7D0   B4J7D1   A0A1W4ULV4   A0A182J224   A0A0M3QV32   W8B2D9   W8AQS3   A0A1I8M4V4   W8AYH9   A0A0K8TPP6   A0A1I8M4V5   A0A0L7QSR9   A0A1I8MXM4   T1PC32   A0A2M3Z6Y2   A0A3B0JP92   A0A0M4EGW3   A0A087YZX4   A0A023EL60   A0A182FLF4   A0A0K8TQ22   N6U2L0   A0A139W8G1   A0A2M4CZJ1   A0A034VCZ6   B4KS06   A0A0Q9X8G0   A0A182WQU4   A0A2M4CQA9   A0A0Q9W5S5   A0A182JZ56   A0A084W6R2   A0A154PBE5   A0A0Q9XID1   A0A336LNC8   A0A182PTA4   A0A182GE62   A0A182NDR1   Q9W1M2   A0A0A9XV76   W6CR90   A0A034VA81   W6CIU3   A0A182S554   B4P9Q5   A0A336K939   F4X1V4  

PDB

3IYZ     E-value=2.88373e-31,     Score=335

KEGG

100127126    K09884 aquaporin rerated protein, invertebrate | (RefSeq) aqp; aquaporin

GO

GO:0016021   GO:0015267   GO:0003014   GO:0005886   GO:0055085   GO:0015250   GO:0005737   GO:0000287   GO:0004019   GO:0005525   GO:0044208   GO:0005215   GO:0006810   GO:0016020   GO:0004888   GO:0007166   GO:0016616   GO:0046168   GO:0016491   GO:0003824  

PANTHER

PTHR19139  

Subcellular location

Cytoplasm  

Length:

259

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

140.41629

Exp number, first 60 AAs:

16.49745

Total prob of N-in:

0.98237

POSSIBLE N-term signal

sequence

inside

1  -  45

TMhelix

46  -  68

outside

69  -  71

TMhelix

72  -  94

inside

95  -  105

TMhelix

106  -  139

outside

140  -  153

TMhelix

154  -  176

inside

177  -  188

TMhelix

189  -  211

outside

212  -  230

TMhelix

231  -  253

inside

254  -  259

 

 

Pi

177.650334

Theta

229.308344

Tajima's D

-0.715784

CLR

327.701487

CSRT

0.189290535473226

Interpretation

Uncertain