Gene

KWMTBOMO05092  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012515

Annotation

S-adenosylmethionine_synthetase_[Bombyx_mori]

Location

Bomo_Chr9(-):7766088-7773873      View in EpiBrowser

Full name

S-adenosylmethionine synthase      

Alternative Name

Methionine adenosyltransferase
MAT

Location in the cell

Cytoplasmic   Reliability : 4.057

CDS

ATGCCGGAGACTTCAAAAATGAATGGATACGCGAAAACCAACGGACACAGTTATGATATGGAAGATGGATCAGTATTTTTGTTCACATCGGAATCTGTTGGCGAGGGTCATCCAGACAAAATGTGCGACCAAATAAGCGACGCTATTCTAGACGCGCACCTGAATCAGGATCCGGACGCAAAAGTTGCATGTGAAACCATAACTAAAACCGGTATGGTGCTTTTGTGTGGCGAAATCACATCCAAAGCTAACGTGGATTATCAAAAAGTTGTGCGCGAAACGGTCAAACATATTGGTTATGATGATTCGTCCAAAGGCTTTGATTACAAGACATGCAGTGTGATGCTCGCACTAGACCAACAATCACCAAACATTGCTGCTGGGGTGCATGAGAACAGAAATGACGAGGAAGTTGGGGCAGGAGACCAGGGCTTGATGTTCGGTTATGCAACAGATGAGACAGAAGAATGCATGCCGTTGACTGTAGTGCTTGCACACAAACTCAATCAGAAAATTGCAGAGCTCAGGCGAAATGGAGAATTTTGGTGGGCAAGACCAGATTCAAAAACACAGGTTACTTGCGAATATGTATTTGCTGGTGGTGCAACAGTCCCACAGAGAGTTCATACTGTAGTCGTGTCACTGCAACACTCTGAAAAGATTACCCTAGAGACCTTGCGAGATGAGATCAGAGAAAAGGTCATCAAAGAGGTTATCCCTGCACAATATCTTGATGAGAGAACTGTAATTCACATTAATCCATGTGGACTCTTTATAATTGGAGGACCTCAGTCAGACGCGGGCCTGACGGGACGCAAAATCATCGTGGACACGTATGGCGGGTGGGGGGCGCACGGCGGGGGCGCTTTCTCTGGCAAGGACTTCACCAAGGTCGACCGCTCCGCAGCATACGCCGCCCGATGGGTCGCCAAGTCGCTCGTCAAGGCGGGCTTGTGCCGGCGCTGCATGGTGCAGGTTGCTTATGCTATTGGTGTAGCTGAGCCATTATCGATTACAGTCTTTGATTATGGCACTTCACATAAGACTCAGCAACAACTGCTCTCCATCGTACAAAAGAATTTCGATTTACGACCGGGCAAAATCGTCAAAGAGTTGAACCTCAGAGCACCAATTTATCAGAGAACAAGTACCTATGGACACTTTGGAAGGGCAGGATTCCCCTGGGAGAGTCCCAAGCCGCTGATTGTAGAATGA

Protein

MPETSKMNGYAKTNGHSYDMEDGSVFLFTSESVGEGHPDKMCDQISDAILDAHLNQDPDAKVACETITKTGMVLLCGEITSKANVDYQKVVRETVKHIGYDDSSKGFDYKTCSVMLALDQQSPNIAAGVHENRNDEEVGAGDQGLMFGYATDETEECMPLTVVLAHKLNQKIAELRRNGEFWWARPDSKTQVTCEYVFAGGATVPQRVHTVVVSLQHSEKITLETLRDEIREKVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGRAGFPWESPKPLIVE

Description

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.

Catalytic Activity

ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine

Cofactor

K(+)
Mg(2+)

Subunit

Homotetramer; dimer of dimers.

Similarity

Belongs to the AdoMet synthase family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Magnesium   Metal-binding   Nucleotide-binding   One-carbon metabolism   Potassium   Reference proteome   Transferase  

Feature

chain  S-adenosylmethionine synthase
splice variant  In isoform 4.

Uniprot

Q1HQB5   A0A2H1WQI2   H9JSK4   A0A3S2L3K0   A0A0T6AV40   N6T4Q1   + More
Q0IFM6   A0A2M3YX87   A0A2M4BPV6   W5J5M5   Q7PTN3   A0A2M4A0J8   A0A084VPR9   T1DI67   T1E8C0   A0A1W4X5D8   A0A1Q3F3Q3   A0A158NRC9   A0A2M3ZZ46   B0W244   A0A182RGA4   A0A1Q3F3T2   A0A1Q3F3Q7   K7J547   A0A0K8TNX2   V9ICM2   A0A0C9QJ66   T1PCY3   A0A034VY08   A0A1Y1MTA1   V5GQX9   A0A1S3D847   A0A1Q3FWJ2   A0A2J7RI80   A0A1W4X411   A0A1I8PNE2   A0A023ESR9   A0A0J9QTU8   A0A0Q5W8R3   P40320   A0A1W4V3Z4   B4P1V0   A0A2H8TWK6   A0A1S4H166   A0A0A1WZ25   J9JXG1   A0A1I8NA59   A0A1L8DZP2   B3MLT7   A0A1J1HV82   B4N0M1   A0A0P6IPP1   E0VI81   A0A3B0JUP6   A0A0J9QSU3   B3N770   P40320-3   A4UZW2   B4GQT3   A0A0R3NRQ1   A0A0R1DIG4   A0A1S3D9I4   J9JWP7   A0A1B6H484   A0A0A9VPX0   A0A1W4UQK6   B4ICR7   A0A1Y1MT92   A0A0L0BLR5   A0A0N8NZ13   A0A1I8PNH7   A0A069DYW6   T1I729   A0A1J1HV75   A0A023F8X8   A0A1B6L7Z3   W8BP23   A0A1A9ZJ02   B4MDB4   R4WRS0   A0A3B0K2G9   A0A0Q9WR93   Q29NR2   A0A1A9V8X4   D3TPX3   A0A1L8DZK7   A0A1A9W0H9   A0A2R7W5M8   A0A0A9VWE3   A0A0Q9WV10   R4FQA5   A0A0H4IRI4   A0A336MJF9   A0A1B6I9T0   A0A067R1V0   A0A1B6J7T8   A0A0P4WB30   A0A226EU99   A0A323TLE5   A0A3R7MAV7  

EC Number

2.5.1.6

Pubmed

19121390    23537049    17510324    20920257    23761445    12364791    + More
14747013    17210077    24438588    24330624    21347285    20075255    26369729    25315136    25348373    28004739    24945155    26483478    22936249    17994087    18057021    8150093    10731132    12537572    12537569    17550304    25830018    20566863    12537568    12537573    12537574    16110336    17569856    17569867    15632085    23185243    25401762    26823975    26108605    26334808    25474469    24495485    23691247    20353571    24845553   

EMBL

DQ443137    ABF51226.1    ODYU01010301    SOQ55313.1    BABH01028031    RSAL01000185    + More
RVE44816.1    LJIG01022734    KRT78988.1    APGK01052480    KB741213    KB631625    ENN72583.1    ERL84820.1    CH477306    EAT44117.1    GGFM01000138    MBW20889.1    GGFJ01005974    MBW55115.1    ADMH02002093    ETN59291.1    AAAB01008797    EAA03629.2    GGFK01000950    MBW34271.1    ATLV01015034    KE524999    KFB39963.1    GALA01001111    JAA93741.1    GAMD01002903    JAA98687.1    GFDL01012872    JAV22173.1    ADTU01023878    ADTU01023879    GGFK01000409    MBW33730.1    DS231825    DS232411    EDS28172.1    EDS41283.1    GFDL01012866    JAV22179.1    GFDL01012849    JAV22196.1    AAZX01000337    GDAI01001772    JAI15831.1    JR038775    AEY58407.1    GBYB01014768    JAG84535.1    KA646524    AFP61153.1    GAKP01012223    GAKP01012222    JAC46730.1    GEZM01021619    JAV88902.1    GALX01004479    JAB63987.1    GFDL01003120    JAV31925.1    NEVH01003505    PNF40533.1    JXUM01092894    JXUM01104861    JXUM01104862    GAPW01001762    KQ564921    KQ564018    JAC11836.1    KXJ71573.1    KXJ72925.1    CM002910    KMY87234.1    CH954177    KQS69900.1    X77392    AE014134    AY051918    CM000157    EDW87086.2    GFXV01006870    MBW18675.1    GBXI01010185    JAD04107.1    ABLF02028542    GFDF01002187    JAV11897.1    CH902620    EDV30808.2    KPU73042.1    CVRI01000021    CRK91984.1    CH963920    EDW77634.2    GDIQ01002231    JAN92506.1    DS235184    EEB13087.1    OUUW01000004    SPP79200.1    KMY87232.1    EDV57177.1    AAN10504.1    CH479187    EDW39955.1    CH379059    KRT03689.1    KRJ97015.1    ABLF02027607    GECZ01000264    JAS69505.1    GBHO01045083    GBHO01045082    GBHO01045079    GBRD01002445    GDHC01000816    JAF98520.1    JAF98521.1    JAF98524.1    JAG63376.1    JAQ17813.1    CH480829    EDW45343.1    GEZM01021618    JAV88903.1    JRES01001684    KNC20967.1    KPU73044.1    GBGD01001675    JAC87214.1    ACPB03024900    ACPB03024901    CRK91983.1    GBBI01000820    JAC17892.1    GEBQ01020159    JAT19818.1    GAMC01015102    GAMC01015101    JAB91454.1    CH940661    EDW71175.1    KRF85501.1    AK417397    BAN20612.1    SPP79201.1    KRF98714.1    EAL34156.2    KRT03690.1    EZ423475    ADD19751.1    GFDF01002174    JAV11910.1    KK854356    PTY15036.1    GBHO01045081    GBHO01045080    GBHO01045078    GBRD01002447    JAF98522.1    JAF98523.1    JAF98525.1    JAG63374.1    KRF85505.1    GAHY01000514    JAA76996.1    KP689344    AKO63326.1    UFQT01001434    SSX30542.1    GECU01024039    JAS83667.1    KK852809    KDR15976.1    GECU01012460    JAS95246.1    GDRN01057346    JAI65702.1    LNIX01000002    OXA60196.1    MDVM02000056    PYZ99334.1    QCYY01001486    ROT77738.1   

Proteomes

UP000005204    UP000283053    UP000019118    UP000030742    UP000008820    UP000000673    + More
UP000007062    UP000030765    UP000192223    UP000005205    UP000002320    UP000075900    UP000002358    UP000095301    UP000079169    UP000235965    UP000095300    UP000069940    UP000249989    UP000008711    UP000000803    UP000192221    UP000002282    UP000007819    UP000007801    UP000183832    UP000007798    UP000009046    UP000268350    UP000008744    UP000001819    UP000001292    UP000037069    UP000015103    UP000092445    UP000008792    UP000078200    UP000091820    UP000027135    UP000198287    UP000247427    UP000283509   

PRIDE

Q1HQB5    H9JSK4    P40320    A4UZW2   

Pfam

PF00438   S-AdoMet_synt_N        + More
PF02772   S-AdoMet_synt_M
PF02773   S-AdoMet_synt_C

Interpro

IPR022636   S-AdoMet_synthetase_sfam        + More
IPR022629   S-AdoMet_synt_central       
IPR002133   S-AdoMet_synthetase       
IPR022631   ADOMET_SYNTHASE_CS       
IPR022628   S-AdoMet_synt_N       
IPR022630   S-AdoMet_synt_C       

SUPFAM

SSF55973   SSF55973       

ProteinModelPortal

Q1HQB5   A0A2H1WQI2   H9JSK4   A0A3S2L3K0   A0A0T6AV40   N6T4Q1   + More
Q0IFM6   A0A2M3YX87   A0A2M4BPV6   W5J5M5   Q7PTN3   A0A2M4A0J8   A0A084VPR9   T1DI67   T1E8C0   A0A1W4X5D8   A0A1Q3F3Q3   A0A158NRC9   A0A2M3ZZ46   B0W244   A0A182RGA4   A0A1Q3F3T2   A0A1Q3F3Q7   K7J547   A0A0K8TNX2   V9ICM2   A0A0C9QJ66   T1PCY3   A0A034VY08   A0A1Y1MTA1   V5GQX9   A0A1S3D847   A0A1Q3FWJ2   A0A2J7RI80   A0A1W4X411   A0A1I8PNE2   A0A023ESR9   A0A0J9QTU8   A0A0Q5W8R3   P40320   A0A1W4V3Z4   B4P1V0   A0A2H8TWK6   A0A1S4H166   A0A0A1WZ25   J9JXG1   A0A1I8NA59   A0A1L8DZP2   B3MLT7   A0A1J1HV82   B4N0M1   A0A0P6IPP1   E0VI81   A0A3B0JUP6   A0A0J9QSU3   B3N770   P40320-3   A4UZW2   B4GQT3   A0A0R3NRQ1   A0A0R1DIG4   A0A1S3D9I4   J9JWP7   A0A1B6H484   A0A0A9VPX0   A0A1W4UQK6   B4ICR7   A0A1Y1MT92   A0A0L0BLR5   A0A0N8NZ13   A0A1I8PNH7   A0A069DYW6   T1I729   A0A1J1HV75   A0A023F8X8   A0A1B6L7Z3   W8BP23   A0A1A9ZJ02   B4MDB4   R4WRS0   A0A3B0K2G9   A0A0Q9WR93   Q29NR2   A0A1A9V8X4   D3TPX3   A0A1L8DZK7   A0A1A9W0H9   A0A2R7W5M8   A0A0A9VWE3   A0A0Q9WV10   R4FQA5   A0A0H4IRI4   A0A336MJF9   A0A1B6I9T0   A0A067R1V0   A0A1B6J7T8   A0A0P4WB30   A0A226EU99   A0A323TLE5   A0A3R7MAV7  

PDB

6FWB     E-value=1.4778e-169,     Score=1530

KEGG

733097    K00789 S-adenosylmethionine synthetase [EC:2.5.1.6] | (RefSeq) S-adenosylmethionine synthetase

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0006730   GO:0046872   GO:0004478   GO:0006556   GO:0005524   GO:0005829   GO:0008340   GO:0000287   GO:0005737   GO:0004252   GO:0006508   GO:0046034   GO:0016616   GO:0046168   GO:0016491   GO:0003824  

PANTHER

PTHR11964  

Subcellular location

Cytoplasm  

Length:

404

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11316

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01111

outside

1  -  404

 

 

Pi

268.608058

Theta

214.257659

Tajima's D

1.034085

CLR

0.225878

CSRT

0.665366731663417

Interpretation

Uncertain