Silkworm Genome Informatics Database

Gene

KWMTBOMO05084

Annotation

acetylcholinesterase_[Bombyx_mori]

Location

Bomo_Chr9(-):7402326-7429259 View in EpiBrowser

Full name

Carboxylic ester hydrolase + More
Acetylcholinesterase

Location in the cell

Lysosomal Reliability : 2.292

CDS

ATGGGACGCGAGGTACACATTTTTACGGGTATCCCGTTTGCGAAACCTCCATTAGGACCCCTGAGATTCCGTAAACCGGTACCAATCGAGCCATGGCATGGCGTGCTTGAAGCAAACTTAATGCCAAACAGTTGCTATCAAGAACGCTACGAATATTTCCCAGGTTTCGAAGGAGAAGAAATGTGGAATCCAAATACTAATATATCAGAAGATTGCCTTTATTTGAATATTTGGGTACCACAGCACTTACGAGTTCGTCACCATCAAGATAAACCACTCGCCGAAAGACCTAAAGTGCCGATTCTTGTGTGGATTTACGGCGGTGGCTACATGAGTGGCACGGCTACACTTGACCTATATAAAGCAGATATAATGGCATCTACAAGCGACGTAATAGTGGCTTCTATGCAATACAGGGTTGGTGCATTTGGATTTTTATATTTGAATAAATATTTTTCTCCGGGTAGTGAAGAAGCTCCTGGAAATATGGGTTTATGGGATCAACAACTCGCTATTCGTTGGATAAAAGAGAACGCTCGTGCTTTTGGAGGAGACCCTGAACTCATTACGCTGTTCGGGGAATCTGCCGGTGGCGGTAGTGTAAGCCTTCATATGCTATCACCTGAAATGAAAGGATTGTTTAAAAGAGGTATATTGCAATCAGGAACGTTGAATGCACCTTGGAGTTGGATGACTGGAGAAAGAGCTCAAGATATTGGAAAAGTATTAATTGATGACTGTAACTGCAACAGTAGTCTTTTAGCCAAGGATCCTAGTCTCGTAATGGATTGCATGCGTGGAGTTGACGCTAAAACGATTTCTGTCCAGCAATGGAATTCTTATACTGGAATTTTGGGTTTTCCGTCCGCACCTACGGTTGATGGTATTTTTTTGCCAAAAGATCCTGATACCATGATGAAGGAAGGAAATTTCCATAATAGTGAAGTGCTACTTGGCAGTAACCAAGACGAAGGGACATATTTTTTGCTGTACGACTTCCTGGATTATTTCGAAAAGGATGGGCCTAGTTTTCTTCAGAGGGAGAAATTTCTCGAAATCGTTGACACTATTTTCAAGGACTTTTCTAAAATTAAAAGAGAAGCCATTGTGTTCCAGTATACAGATTGGGAAGAGATCACCGACGGATATTTGAACCAGAAGATGATAGCTGATGTCGTAGGAGACTACTTCTTCGTATGCCCCACTAACTACTTCGCCGAAATACTTGCCGACGCTGGTGTCGATGTTTACTATTACTATTTTACTCATCGTACCAGCACAAGTCTCTGGGGAGAATGGATGGGCGTGATGCATGGTGACGAAATGGAATATGTTTTTGGACATCCCTTGAACATGTCCCTTCAGTACCATTCCCGGGAGCGTGATTTAGCAGCACACATTATGCAGTCTTTCACACAGTTTGCTCTTACCGGAAAACCTCACAAGCCTGACGAGAAGTGGCCTCTGTACTCCCGGTCTTCGCCTCATTACTACACATACACGGCGGTGGGTCCAAGCGGTCCAGCTGGACCCCGCGGCCCGCGTGCCTCCGCTTGCGCTTTCTGGAACGATTTCTTGAACAAACTTAACGAGTTGGAGCGTGTACCGTGTGACGGCGCCGTGACCGGTCCTTACAGCAGTGTCGCCGGCACTGCCCTCCCTGTAACCCTTCTCACCACTTTGGCAATCACTATTGCTTTGTAA

Protein

MGREVHIFTGIPFAKPPLGPLRFRKPVPIEPWHGVLEANLMPNSCYQERYEYFPGFEGEEMWNPNTNISEDCLYLNIWVPQHLRVRHHQDKPLAERPKVPILVWIYGGGYMSGTATLDLYKADIMASTSDVIVASMQYRVGAFGFLYLNKYFSPGSEEAPGNMGLWDQQLAIRWIKENARAFGGDPELITLFGESAGGGSVSLHMLSPEMKGLFKRGILQSGTLNAPWSWMTGERAQDIGKVLIDDCNCNSSLLAKDPSLVMDCMRGVDAKTISVQQWNSYTGILGFPSAPTVDGIFLPKDPDTMMKEGNFHNSEVLLGSNQDEGTYFLLYDFLDYFEKDGPSFLQREKFLEIVDTIFKDFSKIKREAIVFQYTDWEEITDGYLNQKMIADVVGDYFFVCPTNYFAEILADAGVDVYYYYFTHRTSTSLWGEWMGVMHGDEMEYVFGHPLNMSLQYHSRERDLAAHIMQSFTQFALTGKPHKPDEKWPLYSRSSPHYYTYTAVGPSGPAGPRGPRASACAFWNDFLNKLNELERVPCDGAVTGPYSSVAGTALPVTLLTTLAITIAL

Catalytic Activity

acetylcholine + H2O = acetate + choline + H(+)

Subunit

Homodimer; disulfide-linked.

Similarity

Belongs to the type-B carboxylesterase/lipase family.
Belongs to the CRISP family.

Keywords

Cell junction Cell membrane Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Neurotransmitter degradation Serine esterase Signal Synapse Complete proteome Reference proteome

Feature

chain Carboxylic ester hydrolase
propeptide Removed in mature form

Uniprot

B0FGT2 B8YJN7 Q2QDG2 Q08M18 A1Z267 A5A2M5 + More
Q5RLH9 Q86QW5 G1CRK3 Q8MX85 A0A2H1VS32 A0A1S5YCX9 B2BD82 A0A076VJ71 J7EKA1 Q8MZL2 A0A1D8QQG3 C7C6F4 A0A1U9X1Z7 Q2XQ04 A0A194RTQ3 A0A0L7LHP2 Q8MZM0 A0A1Y1N3L2 D6W9E2 E0W5T7 Q27677 F8TTP3 A0A1W4WUW0 E7DN62 Q5W1L0 D2KTM8 D2KTL8 D2KTR6 D2KTR1 D2KTT7 D2KTU1 D2KTP0 D2KTQ7 D2KTP1 H9N1D1 Q9NJH6 D2KTQ9 D2KTM9 D2KTM4 A0A212FFY1 D2KTQ3 D2KTS5 B6VQ29 W6FSH5 D2KTT5 A4GNM1 T1HG41 Q2PZB3 A0A166AIA1 B6D7G9 C0KYN0 G1K820 Q4LEZ2 A0A087ZSR6 A2PZ98 B3SST5 V9IBM9 A2PZ96 A0A248SM46 F6M7Z4 A0A154PD75 A0A026WK96 K7ITU0 A0A151I5M4 A0A1P8LIA9 A0A0A9YXX9 X5BXV0 A0A0K8SFJ9 A0A1I7PJ30 E2FZ90 A0A182PFX9 D2U6X6 U5ESU7 J9K9C0 A0A1B0CMR9 Q7QFG0 A0A182VBV1 A0A182IAP7 A0A2H8THX6 A0A195DQQ3 A0A0X9E4F6 A0A182ITI2 A0A182XXS2 Q8T7U9 A0A2S2PQ23 P56161 Q66S79 Q7YZQ0 Q65YU0 A0A182QN65 A0A182RHI2 A0A2J7QIR5 A0A084VLT1

EC Number

3.1.1.-
3.1.1.7

Pubmed

16352398 12386838 28111266 19028456 26470257 16876707 + More
26354079 26227816 28004739 18362917 19820115 8580913 21689750 10727899 22118469 16907838 22136067 17294923 18721883 24508170 20075255 25401762 26823975 27521910 25074274 12396499 12364791 14747013 17210077 25244985 1901515 16604106 15373811 24438588

EMBL

EU328262 ABY50089.1 FJ542316 ACL80034.1 DQ115793 DQ115792 + More
AAZ20311.1 AAZ91685.1 AB161180 BAF33337.1 EF166089 EU262632 ABM46999.1 ABW96132.1 EF521819 ABP96887.1 AY817736 AAV65638.1 AY142325 AAN37403.1 JF894119 AEK27380.1 AF369793 AAM90333.1 ODYU01004122 SOQ43663.1 KY130419 AQQ79919.1 EF470245 KP657635 ABR24230.1 AKL78860.1 KF574431 AIK27531.1 GQ489251 ADM83589.1 AY061975 JX404027 GEYN01000062 AAL33820.1 AFS33092.1 JAV02067.1 KT893314 AOW44164.1 KU845253 FN538987 AOT83641.1 CBA18234.1 KY021892 AQY62781.1 DQ267976 ABB76665.1 KQ459896 KPJ19496.1 JTDY01001082 KOB74930.1 AY032625 AAK39639.1 GEZM01014758 JAV92008.1 KQ971312 EEZ99262.2 EU086056 ABX44667.2 L41180 JF343437 AEI70752.1 HQ260969 ADU33190.1 AJ852420 CAH65679.2 AB264460 BAI63733.1 AB264450 AB264451 AB264452 AB264453 AB264458 AB264459 AB264462 AB264463 AB264464 AB264465 AB264466 AB264467 AB264468 AB264469 AB264474 AB264475 AB264476 AB264477 AB264479 AB264480 AB264481 AB264483 AB264484 AB264486 AB264492 AB264495 AB264497 AB264499 AB264500 AB264501 AB264502 AB264503 AB264504 AB264505 AB264508 AB264509 AB264510 AB264511 AB264514 AB264516 AB264518 AB264520 AB264521 AB264522 AB264524 BAI63723.1 BAI63732.1 BAI63752.1 BAI63753.1 BAI63754.1 BAI63756.1 BAI63757.1 BAI63759.1 BAI63765.1 BAI63768.1 BAI63770.1 BAI63772.1 BAI63773.1 BAI63774.1 BAI63775.1 BAI63776.1 BAI63777.1 BAI63778.1 BAI63781.1 BAI63782.1 BAI63783.1 BAI63784.1 BAI63787.1 BAI63789.1 BAI63791.1 BAI63793.1 BAI63794.1 BAI63795.1 BAI63797.1 AB264498 BAI63771.1 AB264493 BAI63766.1 AB264519 BAI63792.1 AB264523 BAI63796.1 AB264472 BAI63745.1 AB264489 BAI63762.1 AB264473 BAI63746.1 JN688930 AFC61184.1 AF145235 AB264449 AB264454 AB264455 AB264457 AB264470 AB264471 AB264478 AB264482 AB264488 AB264490 AB264506 AB264512 AB264515 AAF65202.1 BAI63722.1 BAI63751.1 BAI63755.1 BAI63761.1 BAI63763.1 BAI63779.1 BAI63785.1 BAI63788.1 AB264491 BAI63764.1 AB264461 AB264494 AB264496 AB264513 BAI63734.1 BAI63767.1 BAI63769.1 BAI63786.1 AB264456 BAI63729.1 AGBW02008750 OWR52638.1 AB264485 AB264487 BAI63758.1 BAI63760.1 AB264507 BAI63780.1 FM866396 CAS01766.2 KF895367 AHJ25667.1 AB264517 BAI63790.1 EF362950 ABO31937.1 ACPB03014365 DQ288847 ABB89947.1 KU060812 AMZ80114.1 EU854150 ACI16652.1 FJ647187 ACN43353.1 GU597839 ADE08464.1 AB181702 BAE06051.1 KU532289 ANT80564.1 AB266614 BAF46106.1 EF675189 EF675190 ABV45414.1 ABV45415.1 JR037618 AEY57876.1 AB266605 BAF46104.1 MF523539 ASV46143.1 JF742990 AEF13373.1 KQ434868 KZC09208.1 KK107167 EZA56450.1 KQ976413 KYM90380.1 KX259125 APW85181.1 GBHO01007651 GBRD01013759 GDHC01008645 JAG35953.1 JAG52067.1 JAQ09984.1 KJ174464 AHW29554.1 GBRD01013760 JAG52066.1 KT805421 AOS89451.1 HM212643 ADK39309.1 FN645951 CBI83254.1 GANO01003085 JAB56786.1 ABLF02029895 ABLF02029896 AJWK01019130 BN000067 AAAB01008846 CAD29866.1 EAA06531.3 APCN01001298 APCN01001299 GFXV01001901 MBW13706.1 KQ980612 KYN15142.1 KP723527 ALS35349.1 AF287291 AAL99585.1 GGMR01018962 MBY31581.1 AY707318 AAU11285.1 AJ576070 CAE11220.1 AB180401 AB180402 AB180403 BAD51410.1 BAD51411.1 BAD51412.1 AXCN02002156 NEVH01013579 PNF28466.1 ATLV01014550 KE524974 KFB38925.1

Proteomes

UP000053240 UP000037510 UP000007266 UP000192223 UP000007151 UP000015103 + More
UP000005203 UP000076502 UP000053097 UP000002358 UP000078540 UP000075885 UP000007819 UP000092461 UP000007062 UP000075903 UP000075840 UP000078492 UP000075880 UP000076408 UP000075886 UP000075900 UP000235965 UP000030765

PRIDE

B0FGT2 Q2QDG2 Q08M18 A5A2M5 P56161

Pfam

PF00135 COesterase + More
PF00188 CAP

Interpro

IPR029058   AB_hydrolase        + More
IPR002018   CarbesteraseB
IPR001445   Acylcholinesterase_insect
IPR019826   Carboxylesterase_B_AS
IPR000997   Cholinesterase
IPR019819   Carboxylesterase_B_CS
IPR035940   CAP_sf
IPR014044   CAP_domain
IPR018244   Allrgn_V5/Tpx1_CS

SUPFAM

SSF53474 SSF53474 + More
SSF55797 SSF55797

Gene 3D

3.40.50.1820 3.40.33.10

ProteinModelPortal

B0FGT2 B8YJN7 Q2QDG2 Q08M18 A1Z267 A5A2M5 + More
Q5RLH9 Q86QW5 G1CRK3 Q8MX85 A0A2H1VS32 A0A1S5YCX9 B2BD82 A0A076VJ71 J7EKA1 Q8MZL2 A0A1D8QQG3 C7C6F4 A0A1U9X1Z7 Q2XQ04 A0A194RTQ3 A0A0L7LHP2 Q8MZM0 A0A1Y1N3L2 D6W9E2 E0W5T7 Q27677 F8TTP3 A0A1W4WUW0 E7DN62 Q5W1L0 D2KTM8 D2KTL8 D2KTR6 D2KTR1 D2KTT7 D2KTU1 D2KTP0 D2KTQ7 D2KTP1 H9N1D1 Q9NJH6 D2KTQ9 D2KTM9 D2KTM4 A0A212FFY1 D2KTQ3 D2KTS5 B6VQ29 W6FSH5 D2KTT5 A4GNM1 T1HG41 Q2PZB3 A0A166AIA1 B6D7G9 C0KYN0 G1K820 Q4LEZ2 A0A087ZSR6 A2PZ98 B3SST5 V9IBM9 A2PZ96 A0A248SM46 F6M7Z4 A0A154PD75 A0A026WK96 K7ITU0 A0A151I5M4 A0A1P8LIA9 A0A0A9YXX9 X5BXV0 A0A0K8SFJ9 A0A1I7PJ30 E2FZ90 A0A182PFX9 D2U6X6 U5ESU7 J9K9C0 A0A1B0CMR9 Q7QFG0 A0A182VBV1 A0A182IAP7 A0A2H8THX6 A0A195DQQ3 A0A0X9E4F6 A0A182ITI2 A0A182XXS2 Q8T7U9 A0A2S2PQ23 P56161 Q66S79 Q7YZQ0 Q65YU0 A0A182QN65 A0A182RHI2 A0A2J7QIR5 A0A084VLT1

PDB

1QON E-value=0, Score=1769

KEGG

692776 K01049 acetylcholinesterase [EC:3.1.1.7] | (RefSeq) ace2, AChE, Ace, Bmace2, ace1; acetylcholinester

PATHWAY

00564 Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0043083 GO:0001507 GO:0003990 GO:0016021 GO:0005886 GO:0031225 GO:0030054 GO:0004104 GO:0004252 GO:0006508 GO:0046034 GO:0016616 GO:0046168 GO:0016491 GO:0003824

Subcellular location

Cell junction   Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.   With evidence from 1 publications.
Synapse   Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.   With evidence from 1 publications.
Cell membrane   Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.   With evidence from 1 publications.

Length:

567

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.3652

Exp number, first 60 AAs:

0.00087

Total prob of N-in:

0.01340

outside

1 - 567

Pi

199.2251

Theta

165.306888

Tajima's D

0.413592

CLR

0.675983

CSRT

0.490425478726064

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics