Gene

KWMTBOMO05078  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012550

Annotation

signal_peptidase_18_kDa_subunit_[Bombyx_mori]

Location

Bomo_Chr9(+):7100798-7102808      View in EpiBrowser

Full name

Signal peptidase complex catalytic subunit SEC11      

Location in the cell

Cytoplasmic   Reliability : 1.102 PlasmaMembrane   Reliability : 1.396

CDS

ATGTTGGAAAGTCTATTTGATGATGTGCGGCGAATGAACAAGCGGCAGTTCATGTACCAAGTGTTAAGCTTTGGTATGATAGTGTCTTCTGCCTTGATGATATGGAAAGGTTTGATGGTAGTAACAGGAAGTGAAAGCCCAATAGTAGTAGTACTGTCAGGCAGTATGGAGCCAGCTTTTCACAGAGGAGACTTGCTGTTTTTAACCAATTACCCTGAGGAGCCTGTCCGCGTTGGAGAAATTGTTGTCTTCAAAGTAGAGGGCCGGGATATCCCGATTGTTCACAGAGTATTGAAACTACATGAAAAGAACAATGGCACAGTAAAGTTCTTAACCAAAGGTGACAATAATAGCGTTGATGACAGAGGCTTGTATGCCCAGGGCCAACTGTGGCTCACTAAAAAAGATGTGGTTGGCCGTGCAAGAGGATTTTTGCCATATGTTGGAATGGTCACCATATATATGAATGAATATCCTAAGTTTAAGTTTGCTGTGCTGGCTTGTCTTGCAATTTATGTATTAGTACACAGGGAGTGA

Protein

MLESLFDDVRRMNKRQFMYQVLSFGMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNYPEEPVRVGEIVVFKVEGRDIPIVHRVLKLHEKNNGTVKFLTKGDNNSVDDRGLYAQGQLWLTKKDVVGRARGFLPYVGMVTIYMNEYPKFKFAVLACLAIYVLVHRE

Catalytic Activity

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Subunit

Component of the signal peptidase complex.

Similarity

Belongs to the peptidase S26B family.

Uniprot

Q2F5L1   A0A1E1WSK5   A0A194RNT8   A0A212EH79   I4DKG1   S4PI45   + More
A0A2P8ZF68   A0A1Y1NFT5   A0A067RKB9   J3JW13   D6WCL9   N6T7X5   V5IA04   E2A6R7   A0A026WQ02   E9IZM2   E2BXM5   A0A0T6AYL7   F4WDI9   A0A195FRW3   A0A158NIP3   A0A151WI65   A0A151J5T1   R9UE57   A0A1B6DH21   A0A0P4VW34   R4G542   A0A224XLW5   E2J7E8   A0A069DPF7   A0A0A9Y9J6   A0A1W4WW12   A0A0N0BHK2   A0A1B6GV79   A0A1B6KQV8   A0A1J1J634   A0A2H1WNW7   A0A2H8TF19   A0A154P703   C4WT12   A0A2S2PGI3   A0A1L8DUQ9   A0A023FB37   H9JSN9   A0A1D2ND94   A0A2A3E975   V9IJF5   A0A088A934   A0A212EJR7   A0A1B6H5H5   E0VAM4   U5EVP6   A0A0L7RHP6   A0A0K8TQ36   D3PJ83   C1C2A4   A0A023EI51   E9GGE4   A0A0P5RRX4   A0A210QEZ9   C1BS39   A0A182N6K6   A0A2T7PSJ2   C1BVD8   V3ZR90   A0A182TNY9   C3ZJI0   B4NA20   B4KBK0   B4LZ46   A0A182P2Y4   A0A182UUD7   A0A182LC10   A0A182X8B3   A0T4G0   Q06DK2   A0A182HIW8   A0A084VXC7   A0A170YFH8   A0A0L0BUU5   A0A1S3D8K9   A0A182Q9Q2   A0A182XVR1   A0A0P5FIB0   A0A2L2XV54   B4JGV9   A0A1L8EFB7   A7S5L9   A0A1I8P0I9   B3M0S1   A0A182W0B6   A0A087UYK2   A0A1A9XSD1   A0A1A9UNU2   A0A1B0BLX8   D3TNE7   T1ISQ2   A0A1A9WHT6   Q3YMT3   Q3YMT4  

EC Number

3.4.21.89

Pubmed

26354079    22118469    22651552    23622113    29403074    28004739    + More
24845553    22516182    18362917    19820115    23537049    20798317    24508170    30249741    21282665    21719571    21347285    24467622    27129103    26334808    25401762    26823975    25474469    19121390    27289101    20566863    26369729    24945155    26483478    21292972    28812685    23254933    18563158    17994087    20966253    12364791    14747013    17210077    17244545    24438588    26108605    25244985    26561354    17615350    20353571    15917496   

EMBL

DQ311412    ABD36356.1    GDQN01001025    JAT90029.1    KQ459896    KPJ19503.1    + More
AGBW02014953    OWR40832.1    AK401779    KQ459606    BAM18401.1    KPI91321.1    GAIX01005545    JAA87015.1    PYGN01000075    PSN55146.1    GEZM01003462    JAV96794.1    KK852630    KDR19862.1    BT127431    AEE62393.1    KQ971317    EEZ97812.1    APGK01048489    KB741112    KB632184    ENN73808.1    ERL89640.1    GALX01002030    JAB66436.1    GL437197    EFN70861.1    KK107152    QOIP01000007    EZA57174.1    RLU20654.1    GL767232    EFZ13940.1    GL451281    EFN79543.1    LJIG01022561    KRT79918.1    GL888087    EGI67769.1    KQ981285    KYN43171.1    ADTU01017036    KQ983089    KYQ47527.1    KQ979945    KYN18569.1    KC576515    AGN53399.1    GEDC01012297    JAS25001.1    GDKW01001705    JAI54890.1    ACPB03018001    GAHY01000815    JAA76695.1    GFTR01002961    JAW13465.1    HP429366    ADN29866.1    GBGD01003169    JAC85720.1    GBHO01015841    GBRD01003562    GDHC01005585    JAG27763.1    JAG62259.1    JAQ13044.1    KQ435753    KOX76114.1    GECZ01003440    JAS66329.1    GEBQ01026151    JAT13826.1    CVRI01000073    CRL07867.1    ODYU01009595    SOQ54134.1    GFXV01000869    MBW12674.1    KQ434829    KZC07715.1    ABLF02035666    AK340416    BAH71032.1    GGMR01015920    MBY28539.1    GFDF01003914    JAV10170.1    GBBI01000020    JAC18692.1    BABH01032096    LJIJ01000082    ODN03212.1    KZ288318    PBC28278.1    JR050379    AEY61258.1    AGBW02014409    OWR41710.1    GECU01037747    JAS69959.1    DS235012    EEB10430.1    GANO01001782    JAB58089.1    KQ414590    KOC70318.1    GDAI01001350    JAI16253.1    BT121689    HACA01007091    ADD38619.1    CDW24452.1    BT080983    ACO15407.1    JXUM01101939    GAPW01004831    KQ564686    JAC08767.1    KXJ71898.1    GL732543    EFX81390.1    GDIQ01103913    GDIP01116465    LRGB01000725    JAL47813.1    JAL87249.1    KZS16330.1    NEDP02003952    OWF47322.1    BT077418    ACO11842.1    PZQS01000002    PVD36388.1    BT078567    ACO12991.1    KB203331    ESO85075.1    GG666632    EEN47322.1    CH964232    EDW81775.1    CH933806    EDW13667.1    CH940650    EDW67053.1    AAAB01008879    EAA08439.2    DQ910323    ABI83745.1    APCN01002097    ATLV01017955    KE525202    KFB42621.1    GEMB01003348    JAR99866.1    JRES01001300    KNC23807.1    AXCN02000288    GDIQ01256785    JAJ94939.1    IAAA01008391    IAAA01008392    IAAA01008393    IAAA01008394    IAAA01008395    LAA00026.1    CH916369    EDV93737.1    GFDG01001377    JAV17422.1    DS469583    EDO41033.1    CH902617    EDV42086.1    KK122296    KFM82441.1    JXJN01016598    CCAG010011328    EZ422949    ADD19225.1    JH431446    DQ062793    AAY56666.1    DQ062792    AAY56665.1   

Proteomes

UP000053240    UP000007151    UP000053268    UP000245037    UP000027135    UP000007266    + More
UP000019118    UP000030742    UP000000311    UP000053097    UP000279307    UP000008237    UP000007755    UP000078541    UP000005205    UP000075809    UP000078492    UP000015103    UP000192223    UP000053105    UP000183832    UP000076502    UP000007819    UP000005204    UP000094527    UP000242457    UP000005203    UP000009046    UP000053825    UP000069940    UP000249989    UP000000305    UP000076858    UP000242188    UP000075884    UP000245119    UP000030746    UP000075902    UP000001554    UP000007798    UP000009192    UP000008792    UP000075885    UP000075903    UP000075882    UP000076407    UP000007062    UP000075900    UP000075840    UP000030765    UP000037069    UP000079169    UP000075886    UP000076408    UP000001070    UP000001593    UP000095300    UP000007801    UP000075920    UP000054359    UP000092443    UP000078200    UP000092460    UP000092444    UP000091820   

PRIDE

Q2F5L1    H9JSN9    Q3YMT4   

Pfam

PF00717   Peptidase_S24        + More
PF00899   ThiF
PF08825   E2_bind

Interpro

IPR019756   Pept_S26A_signal_pept_1_Ser-AS        + More
IPR037710   SEC11C       
IPR015927   Peptidase_S24_S26A/B/C       
IPR019758   Pept_S26A_signal_pept_1_CS       
IPR036286   LexA/Signal_pep-like_sf       
IPR001733   Peptidase_S26B       
IPR037712   SEC11A       
IPR023318   Ub_act_enz_dom_a_sf       
IPR035985   Ubiquitin-activating_enz       
IPR000594   ThiF_NAD_FAD-bd       
IPR030468   Uba3       
IPR014929   E2_binding       
IPR033127   UBQ-activ_enz_E1_Cys_AS       

SUPFAM

SSF51306   SSF51306        + More
SSF69572   SSF69572       

Gene 3D

1.10.10.520    

ProteinModelPortal

Q2F5L1   A0A1E1WSK5   A0A194RNT8   A0A212EH79   I4DKG1   S4PI45   + More
A0A2P8ZF68   A0A1Y1NFT5   A0A067RKB9   J3JW13   D6WCL9   N6T7X5   V5IA04   E2A6R7   A0A026WQ02   E9IZM2   E2BXM5   A0A0T6AYL7   F4WDI9   A0A195FRW3   A0A158NIP3   A0A151WI65   A0A151J5T1   R9UE57   A0A1B6DH21   A0A0P4VW34   R4G542   A0A224XLW5   E2J7E8   A0A069DPF7   A0A0A9Y9J6   A0A1W4WW12   A0A0N0BHK2   A0A1B6GV79   A0A1B6KQV8   A0A1J1J634   A0A2H1WNW7   A0A2H8TF19   A0A154P703   C4WT12   A0A2S2PGI3   A0A1L8DUQ9   A0A023FB37   H9JSN9   A0A1D2ND94   A0A2A3E975   V9IJF5   A0A088A934   A0A212EJR7   A0A1B6H5H5   E0VAM4   U5EVP6   A0A0L7RHP6   A0A0K8TQ36   D3PJ83   C1C2A4   A0A023EI51   E9GGE4   A0A0P5RRX4   A0A210QEZ9   C1BS39   A0A182N6K6   A0A2T7PSJ2   C1BVD8   V3ZR90   A0A182TNY9   C3ZJI0   B4NA20   B4KBK0   B4LZ46   A0A182P2Y4   A0A182UUD7   A0A182LC10   A0A182X8B3   A0T4G0   Q06DK2   A0A182HIW8   A0A084VXC7   A0A170YFH8   A0A0L0BUU5   A0A1S3D8K9   A0A182Q9Q2   A0A182XVR1   A0A0P5FIB0   A0A2L2XV54   B4JGV9   A0A1L8EFB7   A7S5L9   A0A1I8P0I9   B3M0S1   A0A182W0B6   A0A087UYK2   A0A1A9XSD1   A0A1A9UNU2   A0A1B0BLX8   D3TNE7   T1ISQ2   A0A1A9WHT6   Q3YMT3   Q3YMT4  

KEGG

692977    K13280 signal peptidase I [EC:3.4.21.89] | (RefSeq) signal peptidase 18 kDa subunit

PATHWAY

03060    Protein export - Bombyx mori (domestic silkworm)

GO

GO:0008236   GO:0016021   GO:0006465   GO:0005787   GO:0008233   GO:0019781   GO:0005789   GO:0045116   GO:0012505   GO:0005783   GO:0016020   GO:0046034   GO:0016616   GO:0046168   GO:0016491   GO:0003824  

PANTHER

PTHR10806   PTHR10806:SF12   PTHR10806:SF18   PTHR10953:SF6  

Subcellular location

Endoplasmic reticulum membrane  

Length:

178

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

33.60669

Exp number, first 60 AAs:

22.48245

Total prob of N-in:

0.99018

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  178

 

 

Pi

263.180191

Theta

185.773245

Tajima's D

1.22337

CLR

0

CSRT

0.722413879306035

Interpretation

Uncertain