Gene
KWMTBOMO05077  
Validated by peptides from experiments
Pre Gene Modal
BGIBMGA012550
Annotation
PREDICTED:_NEDD8-activating_enzyme_E1_catalytic_subunit_[Amyelois_transitella]
Full name
Signal peptidase complex catalytic subunit SEC11
+ More
NEDD8-activating enzyme E1 catalytic subunit
Alternative Name
NEDD8-activating enzyme E1C
Ubiquitin-activating enzyme E1C
Ubiquitin-like modifier-activating enzyme 3
Location in the cell
Cytoplasmic   Reliability : 1.656
Sequence
CDS
ATGACTTCAGAATCTCAAACGGCTGATTATCAAAATAGGAGATGGCAACATATAAGGAAGCTGCTGGAAAGATCTGGTCCTTTCTGCCATCCAGATTTTGAAGCTTCAGCAGAAATTCTAAATTTCATCATGAACTGTTGTAAAGTTCTCATTGTTGGGGCAGGTGGTCTTGGTTGTGAATTATTGAAAGATTTAGCCTTAATGGGCTTCAAAAAGTTACATATTGTAGATATGGATACAATAGAACTATCAAATTTAAACCGGCAATTTTTGTTCAGAAGAAATGATATTGGCCTACCTAAAGCTAAATGTGCTGTGGAATTTGTCAATAAAAGAGTTCCTGGGTGTGAAGCTGTAGCTCACCACTGTGCCATTCAGGACCTTGATGAAGATTTTTATAGACAATTTCACATTGTTGTTTGTGGGCTTGACTCAATTATTGCTCGGAGATGGCTTAATGGAATGCTGGTATCCTTGTTGCAGTACAATGATGACAGAAGTTTGGACCAGAGTAGTGTAATTCCAATGGTGGATGGAGGTACTGAGGGATTTAAAGGCAATGCTAGAGTTATATTACCTGGCATGAGTGCATGTATTGAGTGTACTTTAGATCTATATCCCCCACAAAAAACTTTCCCTTTGTGCACCATTGCTAACACTCCAAGATTACCAGAACATTGTATCGAATATGTTAAAGTAATTCAATGGGCAAAGGAGAATCCATGGGGTAGTTCAACAACTTTAGATGGTGATGATCCACAGCATGTCGTGTGGGTGTATGAAAAGGCCCAAGAAAGGGCAATGAAGCATGGGATTGCTAATGTTACATACAGGTTGACCCAAGGAGTTTTAAAGAACATTATACCTGCTGTTGCCAGTACTAATGCTGCTATAGCTGCTGCTTGTGCTACAGAGGTATTTAAACTAGCTTCATCTTGTTGTGTGAATATGAACAACTACATGGTACTGAATATGGCTGATGGTGTGTATACATATACATTTAGTGCAGAGAAAAGGCCTGATTGCGTTGCTTGTTGCAATTCTACTAGGGTTATGAAAATCGATCCTGATGCTACATTACAATATATTTATACAAAACTTTGCGAAGATCAAGCTTATTTGATGAAGAGTCCAGGCATAACCACTGTAATTAATGGATGCAATAAAACATTATACATGTCATCTATTAAGAGCATTGAAGAAAGGACAAAAGATAATTTAAAGAAGAAATTAACAGATTTGGGTTTGTTTAATGGTGCTGATATATTAGTAGCAGATGTGACTACTCCTAACACCATAACCATAAAATTAAAATTCGAAACTCTTGATGTTGATATGACTAAATAA
Protein
MTSESQTADYQNRRWQHIRKLLERSGPFCHPDFEASAEILNFIMNCCKVLIVGAGGLGCELLKDLALMGFKKLHIVDMDTIELSNLNRQFLFRRNDIGLPKAKCAVEFVNKRVPGCEAVAHHCAIQDLDEDFYRQFHIVVCGLDSIIARRWLNGMLVSLLQYNDDRSLDQSSVIPMVDGGTEGFKGNARVILPGMSACIECTLDLYPPQKTFPLCTIANTPRLPEHCIEYVKVIQWAKENPWGSSTTLDGDDPQHVVWVYEKAQERAMKHGIANVTYRLTQGVLKNIIPAVASTNAAIAAACATEVFKLASSCCVNMNNYMVLNMADGVYTYTFSAEKRPDCVACCNSTRVMKIDPDATLQYIYTKLCEDQAYLMKSPGITTVINGCNKTLYMSSIKSIEERTKDNLKKKLTDLGLFNGADILVADVTTPNTITIKLKFETLDVDMTK
Summary
Description
Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
Catalytic Activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
Subunit
Component of the signal peptidase complex.
Heterodimer of uba3 and nae1. Interacts with nedd8, ube2f and ube2m (By similarity).
Miscellaneous
Arg-210 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.
Similarity
Belongs to the peptidase S26B family.
Belongs to the AB hydrolase superfamily. Lipase family.
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
Belongs to the gastrin/cholecystokinin family.
Keywords
ATP-binding
Complete proteome
Ligase
Nucleotide-binding
Reference proteome
Ubl conjugation pathway
Feature
chain NEDD8-activating enzyme E1 catalytic subunit
EC Number
3.4.21.89
6.2.1.-
PDB
2NVU
E-value=8.32251e-158,
Score=1429
Ontologies
Topology
Subcellular location
Endoplasmic reticulum membrane
Secreted
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.5602
Exp number, first 60 AAs:
1.17091
Total prob of N-in:
0.07733
Population Genetic Test Statistics