SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05077  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA012550
Annotation
PREDICTED:_NEDD8-activating_enzyme_E1_catalytic_subunit_[Amyelois_transitella]
Full name
Signal peptidase complex catalytic subunit SEC11       + More
NEDD8-activating enzyme E1 catalytic subunit      
Alternative Name
NEDD8-activating enzyme E1C
Ubiquitin-activating enzyme E1C
Ubiquitin-like modifier-activating enzyme 3
Location in the cell
Cytoplasmic   Reliability : 1.656
 

Sequence

CDS
ATGACTTCAGAATCTCAAACGGCTGATTATCAAAATAGGAGATGGCAACATATAAGGAAGCTGCTGGAAAGATCTGGTCCTTTCTGCCATCCAGATTTTGAAGCTTCAGCAGAAATTCTAAATTTCATCATGAACTGTTGTAAAGTTCTCATTGTTGGGGCAGGTGGTCTTGGTTGTGAATTATTGAAAGATTTAGCCTTAATGGGCTTCAAAAAGTTACATATTGTAGATATGGATACAATAGAACTATCAAATTTAAACCGGCAATTTTTGTTCAGAAGAAATGATATTGGCCTACCTAAAGCTAAATGTGCTGTGGAATTTGTCAATAAAAGAGTTCCTGGGTGTGAAGCTGTAGCTCACCACTGTGCCATTCAGGACCTTGATGAAGATTTTTATAGACAATTTCACATTGTTGTTTGTGGGCTTGACTCAATTATTGCTCGGAGATGGCTTAATGGAATGCTGGTATCCTTGTTGCAGTACAATGATGACAGAAGTTTGGACCAGAGTAGTGTAATTCCAATGGTGGATGGAGGTACTGAGGGATTTAAAGGCAATGCTAGAGTTATATTACCTGGCATGAGTGCATGTATTGAGTGTACTTTAGATCTATATCCCCCACAAAAAACTTTCCCTTTGTGCACCATTGCTAACACTCCAAGATTACCAGAACATTGTATCGAATATGTTAAAGTAATTCAATGGGCAAAGGAGAATCCATGGGGTAGTTCAACAACTTTAGATGGTGATGATCCACAGCATGTCGTGTGGGTGTATGAAAAGGCCCAAGAAAGGGCAATGAAGCATGGGATTGCTAATGTTACATACAGGTTGACCCAAGGAGTTTTAAAGAACATTATACCTGCTGTTGCCAGTACTAATGCTGCTATAGCTGCTGCTTGTGCTACAGAGGTATTTAAACTAGCTTCATCTTGTTGTGTGAATATGAACAACTACATGGTACTGAATATGGCTGATGGTGTGTATACATATACATTTAGTGCAGAGAAAAGGCCTGATTGCGTTGCTTGTTGCAATTCTACTAGGGTTATGAAAATCGATCCTGATGCTACATTACAATATATTTATACAAAACTTTGCGAAGATCAAGCTTATTTGATGAAGAGTCCAGGCATAACCACTGTAATTAATGGATGCAATAAAACATTATACATGTCATCTATTAAGAGCATTGAAGAAAGGACAAAAGATAATTTAAAGAAGAAATTAACAGATTTGGGTTTGTTTAATGGTGCTGATATATTAGTAGCAGATGTGACTACTCCTAACACCATAACCATAAAATTAAAATTCGAAACTCTTGATGTTGATATGACTAAATAA
Protein
MTSESQTADYQNRRWQHIRKLLERSGPFCHPDFEASAEILNFIMNCCKVLIVGAGGLGCELLKDLALMGFKKLHIVDMDTIELSNLNRQFLFRRNDIGLPKAKCAVEFVNKRVPGCEAVAHHCAIQDLDEDFYRQFHIVVCGLDSIIARRWLNGMLVSLLQYNDDRSLDQSSVIPMVDGGTEGFKGNARVILPGMSACIECTLDLYPPQKTFPLCTIANTPRLPEHCIEYVKVIQWAKENPWGSSTTLDGDDPQHVVWVYEKAQERAMKHGIANVTYRLTQGVLKNIIPAVASTNAAIAAACATEVFKLASSCCVNMNNYMVLNMADGVYTYTFSAEKRPDCVACCNSTRVMKIDPDATLQYIYTKLCEDQAYLMKSPGITTVINGCNKTLYMSSIKSIEERTKDNLKKKLTDLGLFNGADILVADVTTPNTITIKLKFETLDVDMTK

Summary

Description
Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
Catalytic Activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
Subunit
Component of the signal peptidase complex.
Heterodimer of uba3 and nae1. Interacts with nedd8, ube2f and ube2m (By similarity).
Miscellaneous
Arg-210 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.
Similarity
Belongs to the peptidase S26B family.
Belongs to the AB hydrolase superfamily. Lipase family.
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
Belongs to the gastrin/cholecystokinin family.
Keywords
ATP-binding   Complete proteome   Ligase   Nucleotide-binding   Reference proteome   Ubl conjugation pathway  
Feature
chain  NEDD8-activating enzyme E1 catalytic subunit
EC Number
3.4.21.89
6.2.1.-
EMBL
RSAL01000026    RVE52056.1    GAIX01003604    JAA88956.1    ODYU01009595    SOQ54135.1    + More
KQ459896    KPJ19504.1    KQ459606    KPI91320.1    AK404006    BAM20089.1    BABH01032096    ADMH02000391    ETN66743.1    GGFK01009193    MBW42514.1    CH477862    EAT35524.1    JXUM01077073    KQ562985    KXJ74704.1    GANO01001997    JAB57874.1    APCN01002931    AXCM01004441    AJVK01001342    DS232614    EDS44108.1    DS232468    EDS42198.1    AAAB01008900    EAA09425.1    GFDL01012968    JAV22077.1    GEZM01087693    JAV58530.1    AXCN02000962    GFDF01004428    JAV09656.1    GECZ01025764    JAS44005.1    GEDC01023209    JAS14089.1    GBHO01008502    GBHO01008501    GBRD01002464    GDHC01006004    JAG35102.1    JAG35103.1    JAG63357.1    JAQ12625.1    GDKW01001723    JAI54872.1    KZ288206    PBC33074.1    NEVH01015820    PNF26642.1    GEBQ01030978    JAT08999.1    KK854218    PTY13245.1    DS497675    EFA11744.1    PYGN01001375    PSN35307.1    GECU01000148    JAT07559.1    GECZ01007087    JAS62682.1    GL446282    EFN88138.1    KK852476    KDR23046.1    DS235021    EEB10599.1    GDHF01028746    JAI23568.1    GL442298    EFN63604.1    KA648254    AFP62883.1    GAKP01007587    JAC51365.1    GBXI01004373    JAD09919.1    KQ435944    KOX68215.1    BC165593    AAI65593.1    BC045372    LBMM01003542    KMQ93403.1    GG666557    EEN55720.1    GAMC01008987    JAB97568.1    GL888331    EGI62684.1    NEDP02000459    OWF55844.1    HACG01042084    CEK88949.1    HAEB01012866    HAEC01006753    SBQ59393.1    EAAA01000397    KQ982750    KYQ51264.1    KQ980055    KYN17979.1    HAED01008973    HAEE01009468    SBR29518.1    CAAE01014729    CAG04014.1    CVRI01000054    CRL00088.1    HAEI01005164    HAEH01014100    SBR99123.1    HAEF01009259    HAEG01015664    SBR48154.1    HADZ01006877    HAEA01010240    SBP70818.1    HADW01001255    HADX01009312    SBP31544.1    HADY01015704    HAEJ01019484    SBS59941.1    RQTK01000085    RUS88358.1    GBKC01002339    JAG43731.1    KK107295    EZA53115.1   
Pfam
PF08825   E2_bind        + More
PF00899   ThiF
PF00717   Peptidase_S24
PF00151   Lipase
PF00557   Peptidase_M24
Interpro
IPR033127   UBQ-activ_enz_E1_Cys_AS        + More
IPR014929   E2_binding       
IPR035985   Ubiquitin-activating_enz       
IPR000594   ThiF_NAD_FAD-bd       
IPR030468   Uba3       
IPR023318   Ub_act_enz_dom_a_sf       
IPR019758   Pept_S26A_signal_pept_1_CS       
IPR036286   LexA/Signal_pep-like_sf       
IPR001733   Peptidase_S26B       
IPR015927   Peptidase_S24_S26A/B/C       
IPR019756   Pept_S26A_signal_pept_1_Ser-AS       
IPR029058   AB_hydrolase       
IPR013818   Lipase/vitellogenin       
IPR033906   Lipase_N       
IPR000734   TAG_lipase       
IPR000994   Pept_M24       
IPR036005   Creatinase/aminopeptidase-like       
IPR004545   PA2G4       
IPR036388   WH-like_DNA-bd_sf       
IPR036390   WH_DNA-bd_sf       
IPR013152   Gastrin/cholecystokinin_CS       
SUPFAM
SSF69572   SSF69572        + More
SSF51306   SSF51306       
SSF53474   SSF53474       
SSF46785   SSF46785       
SSF55920   SSF55920       
Gene 3D
PDB
2NVU     E-value=8.32251e-158,     Score=1429

Ontologies

Topology

Subcellular location
Endoplasmic reticulum membrane  
Secreted  
Length:
448
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.5602
Exp number, first 60 AAs:
1.17091
Total prob of N-in:
0.07733
outside
1  -  448
 
 

Population Genetic Test Statistics

Pi
4.699553
Theta
12.570161
Tajima's D
-1.704213
CLR
247.156569
CSRT
0.0351982400879956
Interpretation
Uncertain
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