Silkworm Genome Informatics Database

Gene

KWMTBOMO05073

Pre Gene Modal

BGIBMGA012548

Annotation

60S_ribosomal_export_protein_NMD3_[Papilio_xuthus]

Location

Bomo_Chr9(+):7054468-7068985 View in EpiBrowser

Full name

Sphingomyelin phosphodiesterase

Location in the cell

Cytoplasmic Reliability : 1.501 Nuclear Reliability : 1.702

CDS

ATGGATATTGATATACTGAAAGAACATGAAAAGAAATCTTTCCCGGGACAGGGTATGGTGTCTAACAAACACGTGATTGCTGACGTCTGGATCGTTAAAGCCAGCGAATTAGGCATGGACATTAGTCCCGTACACACTAGGACGCATCTAGGACACATCCTGAAACCGGGCGACACCGTTCTAGGATATAATTTAAGTGAATCAAACGTTAATGATACAAATTTCGATAAACTGGATCGAAGTAACATCCCCGACGTGTTTTTGGTGAAAAAGTTCTATGGTGAAAAGTCGGCTCGGAGGAGAGCACGTGCTTGGAAACTCAAACACATGGCCGAAGAGTTTCACGAAGGCCTCAGCTCCACTAATGATGACTACAATGACTTCCTTGATGATCTCGAAGAGGATCCTGCATTCAGACAGAATGTTAATATTTTTAAAGATACTAGCAGAATTGCTGTGGATACAGACGAGATCGATCCGTCACTTCCTCGTATTACACTGGCCGAAATGCTCGACGATTTAACTATTGAAGATGTGGAAATGAGCGACGTTGAGGTCGTGAACTCATTTACCAGACCTACAGCGTGTCAAGACTATATAAGGTTGGAGCGCCGTCGTTATCGTTCATTGGCGGGTGAAAGACCGGCCAAAATGAAATTCCTTGTGGTAGTTTTAGTATTGGTGAGCTCTAGTTTTGCAAACCGGCTTATTTCATTAGAAACAGTAGAAGATGTTCTAAAGAAAATACTGGTTAATGATCTGAGTGAAGAAGACAAAAGCCTACTAGAAGATATTATTGAAATCTTGCATAGACCTGAATACGTTTCTGAAAATTCTATTCAATACGCCAGTCCAACTAGAACGACCCTAGACTGCGTCATCTGTCGGAGTGCTTTCAGAACTGCTATACAGGGACTCAAAGCTGGGCAAACTGAAGAAGAATTGTCGAATGTTATATCTACACTTTGTATAACATTAGGAATTGCTGGTTATGGCGTTTGCAAAGGAGCTGTTTCACTTAACATACCAATAATTCGTTACATTGTCAAAAATGAACCACAAGCTACAGCAGAAGCATTTTGTGGTTTAGTGCTACAAAACGTTGGAAACCCGAATAACTGTCCCTTTGACGATCAACGATTTGAGTGGGAGGTAACCCTCCCCGCGCCTCCTGCTGTGGAAGCCGTGCCAGTTTTCGAAACTAAACCATTGACGATTGCGATAATCACCGACGCTCATCTCGATCCTCTTTATGAAGCTTTCGGAGTGGCTGATTGCGATGAACCGGTATGCTGTAGAATAGGACAAAGACCTGCAAGTAATTACATTTACAAATCGCACATCGACGAGTCTGTTGTCGCAGAGAGCTTAACTAATGTTACTGGAGAAATAAAATTGAATTTGAACGTTGCACCAAAGATCAGAGAGTTGAGGAAGAAGTCACAAACCAGATTTTGGAATCGGCACACAGCACCGGCTGGTTATTGGGGTGATTACAGGAACTGTGACTCCCCTATTTGGGCTTTCGATGATGTTATTGATAGAATAGCAGAGACACATAAGAACATAGATGTTTTGTACTACATCGGTGACACTATTGATCACGGTGTTTGGGAAACGTCTTATGAACTAATTAATGACATGAACCGATATTTAATCGAAAAAATTAGGAAAACCTTTGGAGATGACGTACAGGTTATACCTGTACTAGGAAACCACGAATCTCAACCTACCAATCAGTTTGCTCCCTCAAGGGTAATTGGAGATCATTTGAATACTACTTGGCTTTATGAAGGGTTAGTTGATAAATGGGGATTCTATTTGACTGAAGACTCTAAAAGGACATTACTTGAACGCGGAGAATTCTCTCAGTTGGTGAGACCCGGTCTGAGGGTTATCGTACTCAACAATAATGTCGCTTATAGATATAACTGGTGGCTAGTTTATGACCCCTTGGACGCAAAGAAACATTTAGATTGGTTAGTTGAAGAATTATACAAAGCAGAAATAGCCGGAGAGAAAGTTCACATACTGGCACACATACCTCCTGGAGTTCACGACCTCACATACACTTGGACTAGAGAATATAACAAAATAGTTAACAGATTCACCAACACAATAGCCGCTGAATTCAATGGGCACACTCATTCTGATGAGTTCAAAGTATTCTACAATCAGCAAGGTACACCAATTAACGTTGCGTGGGGAGGAGGTAGTGCCACCAGCTACACGTTCTACAATCTAAATTATAAGATTGCTACTATAAACACTCGGACATTCGAACCTCTGAATATCGTGAACTATGCTTACAATCTAACGGAAGCTAATTTAACTCCAAACCGAAGGCCGCATTGGTTCCAACTATACGATATGAAGAATACGTTCGGTCTCACAGATTTGTCGGCAGTGTCAATGAACGATTTAGTTTACAAAATGGTAACTACAAACAAAGAATATTTGGAAAAATACGCAGCTTTTTATTCAAAATTAAGCGACACACGTTGGCCAAATTGTAATATTAACTGCAAGCTGGACAACCTTTGCAAAATTGTTGTAACTGTTTTATGGGAAAGGCAAAGATGTGAAGAGCTTCGGCAACTGTATTCTGTATCTTAA

Protein

MDIDILKEHEKKSFPGQGMVSNKHVIADVWIVKASELGMDISPVHTRTHLGHILKPGDTVLGYNLSESNVNDTNFDKLDRSNIPDVFLVKKFYGEKSARRRARAWKLKHMAEEFHEGLSSTNDDYNDFLDDLEEDPAFRQNVNIFKDTSRIAVDTDEIDPSLPRITLAEMLDDLTIEDVEMSDVEVVNSFTRPTACQDYIRLERRRYRSLAGERPAKMKFLVVVLVLVSSSFANRLISLETVEDVLKKILVNDLSEEDKSLLEDIIEILHRPEYVSENSIQYASPTRTTLDCVICRSAFRTAIQGLKAGQTEEELSNVISTLCITLGIAGYGVCKGAVSLNIPIIRYIVKNEPQATAEAFCGLVLQNVGNPNNCPFDDQRFEWEVTLPAPPAVEAVPVFETKPLTIAIITDAHLDPLYEAFGVADCDEPVCCRIGQRPASNYIYKSHIDESVVAESLTNVTGEIKLNLNVAPKIRELRKKSQTRFWNRHTAPAGYWGDYRNCDSPIWAFDDVIDRIAETHKNIDVLYYIGDTIDHGVWETSYELINDMNRYLIEKIRKTFGDDVQVIPVLGNHESQPTNQFAPSRVIGDHLNTTWLYEGLVDKWGFYLTEDSKRTLLERGEFSQLVRPGLRVIVLNNNVAYRYNWWLVYDPLDAKKHLDWLVEELYKAEIAGEKVHILAHIPPGVHDLTYTWTREYNKIVNRFTNTIAAEFNGHTHSDEFKVFYNQQGTPINVAWGGGSATSYTFYNLNYKIATINTRTFEPLNIVNYAYNLTEANLTPNRRPHWFQLYDMKNTFGLTDLSAVSMNDLVYKMVTTNKEYLEKYAAFYSKLSDTRWPNCNINCKLDNLCKIVVTVLWERQRCEELRQLYSVS

Description

Converts sphingomyelin to ceramide.

Catalytic Activity

H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine

Cofactor

Zn(2+)

Similarity

Belongs to the acid sphingomyelinase family.

Feature

chain Sphingomyelin phosphodiesterase

Uniprot

H9JSN7 A0A194PDA5 A0A1E1WGG9 A0A3S2NSP0 A0A2H1WIG0 A0A194RNU4 + More
A0A212EJQ9 A0A336MNC1 A0A336LTD4 A0A182QGC5 A0A084VTE0 A0A182UUK1 A0A182TMG6 A0A182H0B4 Q16WS5 A0A182XFF5 A0A182I846 A0A1S4FLD6 Q176G5 Q7QH66 A0A182L7R1 A0A182YF40 A0A182NG45 A0A3G5BIM6 A0A1B0CTP1 A0A182RGI5 A0A1I8QE44

EC Number

3.1.4.12

Pubmed

19121390 26354079 22118469 24438588 26483478 17510324 + More
12364791 14747013 17210077 20966253 25244985 30400621

EMBL

BABH01032097 KQ459606 KPI91316.1 GDQN01004950 JAT86104.1 RSAL01000248 + More
RVE43538.1 ODYU01008886 SOQ52863.1 KQ459896 KPJ19508.1 AGBW02014409 OWR41716.1 UFQT01001824 SSX31912.1 UFQS01000177 UFQT01000177 SSX00810.1 SSX21190.1 AXCN02001191 ATLV01016349 KE525079 KFB41234.1 JXUM01101111 KQ564624 KXJ72005.1 CH477555 EAT39058.1 APCN01002618 CH477387 EAT42051.1 AAAB01008817 EAA05348.4 MK075235 AYV99638.1 AJWK01027792 AJWK01027793 AJWK01027794

Proteomes

UP000005204 UP000053268 UP000283053 UP000053240 UP000007151 UP000075886 + More
UP000030765 UP000075903 UP000075902 UP000069940 UP000249989 UP000008820 UP000076407 UP000075840 UP000007062 UP000075882 UP000076408 UP000075884 UP000092461 UP000075900 UP000095300

PRIDE

H9JSN7

Pfam

PF00149 Metallophos + More
PF04981 NMD3

Interpro

IPR041805   ASMase/PPN1_MPP        + More
IPR011001   Saposin-like
IPR029052   Metallo-depent_PP-like
IPR008139   SaposinB_dom
IPR004843   Calcineurin-like_PHP_ApaH
IPR011160   Sphingomy_PDE
IPR039768   Nmd3
IPR007064   Nmd3_N

SUPFAM

SSF47862 SSF47862

Gene 3D

3.60.21.10

CDD

cd00842 MPP_ASMase

ProteinModelPortal

H9JSN7 A0A194PDA5 A0A1E1WGG9 A0A3S2NSP0 A0A2H1WIG0 A0A194RNU4 + More
A0A212EJQ9 A0A336MNC1 A0A336LTD4 A0A182QGC5 A0A084VTE0 A0A182UUK1 A0A182TMG6 A0A182H0B4 Q16WS5 A0A182XFF5 A0A182I846 A0A1S4FLD6 Q176G5 Q7QH66 A0A182L7R1 A0A182YF40 A0A182NG45 A0A3G5BIM6 A0A1B0CTP1 A0A182RGI5 A0A1I8QE44

PDB

5JG8 E-value=2.59958e-64, Score=626

KEGG

101744890 K12350 sphingomyelin phosphodiesterase [EC:3.1.4.12] | (RefSeq) sphingomyelin phosphodiesterase 1-li

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0006685 GO:0004767 GO:0046872 GO:0016798 GO:0016787 GO:0043023 GO:0016021 GO:0005615 GO:0061750 GO:0005764 GO:0008081 GO:0046513 GO:0046034 GO:0005524 GO:0015986 GO:0045261 GO:0046933 GO:0016616 GO:0046168 GO:0016491 GO:0003824

PANTHER

PTHR12746

Length:

871

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.755129999999999

Exp number, first 60 AAs:

0.00189

Total prob of N-in:

0.02046

outside

1 - 871

Pi

26.793945

Theta

194.178015

Tajima's D

-1.281889

CLR

203.706402

CSRT

0.088295585220739

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics