Gene

KWMTBOMO05065  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012556

Annotation

PREDICTED:_importin_subunit_alpha-7_[Papilio_xuthus]

Location

Bomo_Chr9(-):7009113-7020537      View in EpiBrowser

Full name

Importin subunit alpha      

Location in the cell

Cytoplasmic   Reliability : 2.07

CDS

ATGTCTGGAGGTCACAAACATCGCTACAAGAATGTTGGACTGAGTGCTGACGAACTTCGTCGGCGCCGAGAAGAAGAAGGAGTTCAACTTAGAAAACAAAAAAGGGAACAGCAGTTATTTAAAAGAAGAAATGTTAATCTACCTGGAACCAATGCTGCTGGAGCTGCTTCACAGGAGGACATCAATATTTCACCATCAGATTGCATCACTCCAGATATGGTTTTAGCTGTCTACTTAGATAATCCTGAAGAACAAGTCATAGCAACACAAAAGTTCAGAAAGCTTCTAAGTAAGGAACCTAATCCTCCAATTGATGCAGTTATACAATCTGGAATTGTACCAAAATTTATTGAATTCCTGACAAACCATAAGAATCCAACCTTACAGTTTGAGGCGGCATGGGCGCTGACAAACATCGCCTCGGGTTCGTCAGGACAAACTCGTATCGTAGTGGATTATGGCGCAGTAAATGTGCTGGTAGGACTATTGAGTGGCTCTACGGAGAACGTGTGCGAGCAGGCAGTTTGGGCCCTTGGAAACATCGCTGGAGACTCGCCCTACTGCCGAGATATCGTCCTCGCAGCTGGCGTTCTCCCACCCTTGCTTGACATTTTAAATAAGTACACGAAATTGTCAATGACGAAAAATGCTGTTTGGACGTTGTCGAATTTGTGCAGAGGCAAAAATCCTCCCACAAATTTCGAAACAGTTGCACCAGCTATTCCAGTATTAGCGCGTCTTCTACATCATACAGATGCAGATGTTCTGAGCGACGCATGTTGGGCACTCTCATATTTATCAGATGGTCCGAACGAGAAAATTCAAGCTGTGATCGATGCCGGTGTTTGCAGAAGACTTGTTGAGCTACTGATGCACAACAAATCGACGGTTGTCAGTGCGGCTTTGCGCGCGGTCGGGAACATCGTGACCGGCAACGACGCCCAGACTCAGACAGTGCTCAACTGCAACCCGCTGCCCAACCTATACGGCCTCTTGCAGTCCTTCACCGAGACTCTGCGTAAGGAGGCCTGTTGGACTCTCTCCAACATCACTGCCGGAAATGCCGCGCAAATACAGGCGGTTATAGATGCTAATATCTTCCCATTTTTACTAGACATATTGAGACACGCTGAATTTAAAACTAGGAAAGAAGCAGCGTGGGCTATAACAAATGCGACGAGTGGCGGTACGAACACTCAAATAAGGTATTTAGTAGAACAAGGTTGCATACCGGCTTTATGCGATCTGTTGACGCTCACGGATGCGAAAACCGTGCTGGTAGCACTAAATGGTATAGACAATATTTTAAAAGCTGGTCAACAAACAGACCTACGCGATAATCGTTATGCGGTGCTAGTTGAAGAATGTTTAGGATTGAACAAAATCGAATTTCTACAATCCCACGAAAATCTCGACATTTATCAAAAATCATTTGAAATTATCGAAAATTACTTCGGGTCCGAGGAGGAAGATGGCAGATTGGCGCCAGCTGTGTCTTCCACTACCAATCAATTTCAGTTCAACACCGACCAATCGGTGCCCATGGGCGGCTTTCAGTTTTAA

Protein

MSGGHKHRYKNVGLSADELRRRREEEGVQLRKQKREQQLFKRRNVNLPGTNAAGAASQEDINISPSDCITPDMVLAVYLDNPEEQVIATQKFRKLLSKEPNPPIDAVIQSGIVPKFIEFLTNHKNPTLQFEAAWALTNIASGSSGQTRIVVDYGAVNVLVGLLSGSTENVCEQAVWALGNIAGDSPYCRDIVLAAGVLPPLLDILNKYTKLSMTKNAVWTLSNLCRGKNPPTNFETVAPAIPVLARLLHHTDADVLSDACWALSYLSDGPNEKIQAVIDAGVCRRLVELLMHNKSTVVSAALRAVGNIVTGNDAQTQTVLNCNPLPNLYGLLQSFTETLRKEACWTLSNITAGNAAQIQAVIDANIFPFLLDILRHAEFKTRKEAAWAITNATSGGTNTQIRYLVEQGCIPALCDLLTLTDAKTVLVALNGIDNILKAGQQTDLRDNRYAVLVEECLGLNKIEFLQSHENLDIYQKSFEIIENYFGSEEEDGRLAPAVSSTTNQFQFNTDQSVPMGGFQF

Description

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.

Subunit

Forms a complex with importin subunit beta-1.

Similarity

Belongs to the importin alpha family.

Feature

chain  Importin subunit alpha

Uniprot

H9JSP5   A0A2H1WUS7   A0A194PDA1   A0A194RQ33   S4P9R3   A0A067QVS9   + More
C3ZM42   A0A1B6EA95   A0A1B6CHT0   A0A1W4WN60   A0A1Y1MB72   A0A1S3K1S4   A0A0C9QJY4   D6W9A9   A0A195DZ18   A0A1L8DVL4   V5IAW6   A0A0P4WIZ3   R4WIV6   V3ZIQ4   A0A151WF69   A0A195CNE6   A0A2C9JSW4   E2BFQ0   A0A088ADV7   E2AIW7   A0A232F6U0   T1JNP4   K7J229   A0A210QQE3   A0A0L7RGC9   E9IK25   A0A2A3E4P7   A0A0K8TSX9   A0A069DVD9   A0A0V0G4G9   A0A3S3PSP9   A0A3S3Q899   A0A154PDF8   A0A195FIK1   A0A158P3T6   A0A1B0D5K2   Q16RM6   A0A026WBC9   F4X1X7   A0A023FAH7   A0A023EW85   A0A336MLX2   A0A1D2NMF1   A0A1Q3F6Z5   T1E2K1   B0XED8   A0A2T7P5Z3   T1I4H6   E0VI76   A0A310SF11   A0A1E1XDK0   A0A2R5LK61   A0A293M2S1   A0A131YGZ8   L7M7V7   A0A084W9X3   A0A1E1XR73   A0A182ME99   A0A023FXN9   A0A023GL04   U4UUP6   A0A182KGB8   A0A182PJV8   T1JQG0   A0A182V492   A0A182UD96   A0A182LJW1   Q7Q7B4   K1PV79   A0A182QTT6   N6UJ04   A0A2P2I6Q2   A0A0L8I999   A0A0A9XP06   A0A3N0Y051   A0A2H8U0D0   V5IFT4   B7P1M7   K7FKR6   A0A182J1H1   E7F7U9   A0A2M4BK85   A0A0P6CKU5   F2CYU8   J9JV64   A0A2M4AEP1   A0A0P5X7K0   A0A182R2Q6   U5EYF9   A0A2M3Z1T0   W5JQ68   W5M2Y3   R7U2V7   A0A0P6B6P0  

Pubmed

19121390    26354079    23622113    24845553    18563158    28004739    + More
18362917    19820115    23691247    23254933    15562597    20798317    28648823    20075255    28812685    21282665    26369729    26334808    21347285    17510324    24508170    30249741    21719571    25474469    24945155    26483478    27289101    24330624    20566863    28503490    26830274    25576852    24438588    29209593    23537049    20966253    12364791    14747013    17210077    22992520    25401762    26823975    25765539    17381049    23594743    21415278    20920257    23761445   

EMBL

BABH01032102    ODYU01011211    SOQ56810.1    KQ459606    KPI91311.1    KQ459896    + More
KPJ19514.1    GAIX01003634    JAA88926.1    KK852898    KDR14157.1    GG666644    EEN46298.1    GEDC01026489    GEDC01002442    GEDC01002249    JAS10809.1    JAS34856.1    JAS35049.1    GEDC01024347    GEDC01007807    JAS12951.1    JAS29491.1    GEZM01036246    JAV82861.1    GBYB01003839    GBYB01003840    JAG73606.1    JAG73607.1    KQ971312    EEZ98471.1    KQ980044    KYN18113.1    GFDF01003600    JAV10484.1    GALX01000470    JAB67996.1    GDRN01025101    JAI67731.1    AK417415    BAN20630.1    KB203566    ESO84112.1    KQ983227    KYQ46435.1    KQ977513    KYN02238.1    GL448039    EFN85438.1    GL439905    EFN66646.1    NNAY01000882    OXU26077.1    JH431832    NEDP02002412    OWF50939.1    KQ414596    KOC69910.1    GL763924    EFZ19048.1    KZ288416    PBC26051.1    GDAI01000360    JAI17243.1    GBGD01001108    JAC87781.1    GECL01003164    JAP02960.1    NCKU01000393    NCKU01000380    RWS15670.1    RWS15718.1    NCKU01000378    RWS15728.1    KQ434878    KZC09861.1    KQ981523    KYN40495.1    ADTU01008444    AJVK01025368    AJVK01025369    CH477702    EAT37062.1    KK107293    QOIP01000005    EZA53397.1    RLU22669.1    GL888558    EGI59513.1    GBBI01000221    JAC18491.1    JXUM01073564    GAPW01000959    KQ562782    JAC12639.1    KXJ75137.1    UFQS01000834    UFQT01000834    UFQT01001683    SSX07147.1    SSX31414.1    LJIJ01000005    ODN06458.1    GFDL01011715    JAV23330.1    GALA01001190    JAA93662.1    DS232821    EDS25912.1    PZQS01000006    PVD28839.1    ACPB03017461    DS235184    EEB13082.1    KQ769818    OAD52809.1    GFAC01001873    JAT97315.1    GGLE01005689    MBY09815.1    GFWV01008661    MAA33390.1    GEDV01010785    JAP77772.1    GACK01004934    JAA60100.1    ATLV01021960    KE525326    KFB47017.1    GFAA01001670    JAU01765.1    AXCM01000076    GBBL01001061    JAC26259.1    GBBM01000852    JAC34566.1    KB632375    ERL93916.1    CAEY01000437    AAAB01008960    EAA11775.4    JH816746    EKC25623.1    AXCN02000347    APGK01003575    APGK01003576    APGK01016207    APGK01016208    APGK01022874    APGK01022875    KB740449    KB739778    KB735342    ENN80631.1    ENN82123.1    ENN83397.1    IACF01004096    LAB69691.1    KQ416223    KOF98061.1    GBHO01042336    GBHO01022230    GBHO01022228    GBHO01022227    GBRD01001538    GBRD01001536    GDHC01016373    GDHC01000473    JAG01268.1    JAG21374.1    JAG21376.1    JAG21377.1    JAG64283.1    JAQ02256.1    JAQ18156.1    RJVU01057109    ROK35742.1    GFXV01008169    MBW19974.1    GANP01007882    JAB76586.1    ABJB010569153    DS616928    EEC00499.1    AGCU01086793    AGCU01086794    CU633192    GGFJ01004324    MBW53465.1    GDIQ01089752    JAN04985.1    AK356804    BAJ88019.1    ABLF02024422    GGFK01005912    MBW39233.1    GDIP01076348    LRGB01000115    JAM27367.1    KZS20722.1    GANO01002024    JAB57847.1    GGFM01001712    MBW22463.1    ADMH02000839    ETN64894.1    AHAT01009461    AMQN01001859    KB306105    ELU00208.1    GDIP01019429    JAM84286.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000027135    UP000001554    UP000192223    + More
UP000085678    UP000007266    UP000078492    UP000030746    UP000075809    UP000078542    UP000076420    UP000008237    UP000005203    UP000000311    UP000215335    UP000002358    UP000242188    UP000053825    UP000242457    UP000285301    UP000076502    UP000078541    UP000005205    UP000092462    UP000008820    UP000053097    UP000279307    UP000007755    UP000069940    UP000249989    UP000094527    UP000002320    UP000245119    UP000015103    UP000009046    UP000030765    UP000075883    UP000030742    UP000075881    UP000075885    UP000015104    UP000075903    UP000075902    UP000075882    UP000007062    UP000005408    UP000075886    UP000019118    UP000053454    UP000001555    UP000007267    UP000075880    UP000000437    UP000007819    UP000076858    UP000075900    UP000000673    UP000018468    UP000014760   

PRIDE

H9JSP5    A0A088ADV7   

Pfam

PF16186   Arm_3        + More
PF01749   IBB
PF00514   Arm
PF08534   Redoxin
PF09774   Cid2
PF08231   SYF2

Interpro

IPR036975   Importin-a_IBB_sf        + More
IPR032413   Arm_3       
IPR024931   Importing_su_alpha       
IPR000225   Armadillo       
IPR002652   Importin-a_IBB       
IPR011989   ARM-like       
IPR016024   ARM-type_fold       
IPR037944   PRX5-like       
IPR036249   Thioredoxin-like_sf       
IPR013766   Thioredoxin_domain       
IPR013740   Redoxin       
IPR019171   Caffeine_induced_death_Cid2       
IPR013260   mRNA_splic_SYF2       

SUPFAM

SSF48371   SSF48371        + More
SSF52833   SSF52833       

Gene 3D

1.20.5.690     1.25.10.10    

CDD

cd03013  PRX5_like

ProteinModelPortal

H9JSP5   A0A2H1WUS7   A0A194PDA1   A0A194RQ33   S4P9R3   A0A067QVS9   + More
C3ZM42   A0A1B6EA95   A0A1B6CHT0   A0A1W4WN60   A0A1Y1MB72   A0A1S3K1S4   A0A0C9QJY4   D6W9A9   A0A195DZ18   A0A1L8DVL4   V5IAW6   A0A0P4WIZ3   R4WIV6   V3ZIQ4   A0A151WF69   A0A195CNE6   A0A2C9JSW4   E2BFQ0   A0A088ADV7   E2AIW7   A0A232F6U0   T1JNP4   K7J229   A0A210QQE3   A0A0L7RGC9   E9IK25   A0A2A3E4P7   A0A0K8TSX9   A0A069DVD9   A0A0V0G4G9   A0A3S3PSP9   A0A3S3Q899   A0A154PDF8   A0A195FIK1   A0A158P3T6   A0A1B0D5K2   Q16RM6   A0A026WBC9   F4X1X7   A0A023FAH7   A0A023EW85   A0A336MLX2   A0A1D2NMF1   A0A1Q3F6Z5   T1E2K1   B0XED8   A0A2T7P5Z3   T1I4H6   E0VI76   A0A310SF11   A0A1E1XDK0   A0A2R5LK61   A0A293M2S1   A0A131YGZ8   L7M7V7   A0A084W9X3   A0A1E1XR73   A0A182ME99   A0A023FXN9   A0A023GL04   U4UUP6   A0A182KGB8   A0A182PJV8   T1JQG0   A0A182V492   A0A182UD96   A0A182LJW1   Q7Q7B4   K1PV79   A0A182QTT6   N6UJ04   A0A2P2I6Q2   A0A0L8I999   A0A0A9XP06   A0A3N0Y051   A0A2H8U0D0   V5IFT4   B7P1M7   K7FKR6   A0A182J1H1   E7F7U9   A0A2M4BK85   A0A0P6CKU5   F2CYU8   J9JV64   A0A2M4AEP1   A0A0P5X7K0   A0A182R2Q6   U5EYF9   A0A2M3Z1T0   W5JQ68   W5M2Y3   R7U2V7   A0A0P6B6P0  

PDB

4UAD     E-value=7.31379e-169,     Score=1525

KEGG

101739355    no KO assigned | (RefSeq) importin subunit alpha-7

GO

GO:0061608   GO:0008565   GO:0005634   GO:0006606   GO:0005737   GO:0005829   GO:0005654   GO:0006607   GO:0005643   GO:0008139   GO:0045454   GO:0016491   GO:0015031   GO:0005488   GO:0005515   GO:0016616   GO:0046168   GO:0003824   GO:0140142  

Length:

520

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01748

Exp number, first 60 AAs:

0.00013

Total prob of N-in:

0.00629

outside

1  -  520

 

 

Pi

210.317223

Theta

182.884215

Tajima's D

0.641618

CLR

0.279629

CSRT

0.553622318884056

Interpretation

Uncertain