Gene

KWMTBOMO05052

Pre Gene Modal

BGIBMGA012562

Annotation

nicotinic_acetylcholine_receptor_subunit_alpha_4_isoform_2_precursor_[Bombyx_mori]

Location

Bomo_Chr9(-):6588245-6627312      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.69

CDS

ATGACCACGAACCTGTGGGTAGAGCAGTCCTGGTATGACTACAAGCTGCGCTGGGAGCCTAAGGAGTACGGGGGCGTCCACATGCTTCACGTACCCTCCGATCATATTTGGAGACCAGACATCGTCCTTTACAACAATGCTGACGGCAACTTCGAAGTAACATTGGCGACCAAGGCGACTATCTACCACCAGGGGCTTGTGGAATGGAAGCCGCCTGCTATATACAAGTCTTCCTGTGAAATAGATGTGGAATATTTTCCTTTCGACGAGCAAACGTGCGTTCTTAAATTTGGTAGCTGGACGTACGACGGATTCAAGGTTGACCTGCGGCACATGGATGAACAAGCTGGCAGCAACGTTGTTTCAGTCGGGGTCGACCTCTCCGAGTTCTACATGTCAGTTGAATGGGATATATTGGAAGTACCAGCAGTCAGGAACGAAAAATTTTACACGTGTTGCGATGAGCCGTACTTGGACATCACTTTCAACATCACGATGCGCCGGAAAACATTGTTTTACACCGTCAACATTATAATTCCTTGTATGGGAATATCTTTTCTAACCGTTCTAACATTTTATCTGCCGTCAGACAGCGGGGAAAAGGTAACATTGTCTATATCGATACTCATCAGTCTACACGTGTTTTTCCTCTTGGTTGTCGAAATTATTCCTCCCACCTCCCTGGTTGTACCGCTGCTCGGAAAATACCTAATTTTCGCCATGATCCTAGTTTCGATCAGTATATGCGTAACGGTGGTCGTTCTCAACGTCCACTTCAGGTCACCGCAGACACATCGAATGGCGCCTTGGGTGAAAAGAGTATTCATTCACATTCTGCCCCGATTGCTCTTTATGAAACGACCCCAGTACAAGTTCGATACAACGAGATCTCGTTACACTGCATGCGGTGTTGTGGTACGCTGCGGTGGGACAGCCAGACCCTTGTATCCGTACCGTCTGGCGGCAGCGGACGACGACTGCTGTGCGCCGGGCGCCTGGCCCCCACCTGCCGCACCCCCTCCTCGACCGCTCACTCGAACGCCTAGCAAAGAAGACTTGACACACACCACATATTTAAATTCAGGAATTGACAGCAATCGACTGGGCGGTAGTTGCATGCTGCACGGCTCGAGCGAGGTGGTGGGCGGCGGATTGGCCGGGGTGAGTGTGGAGGAGGAGATTCTGAGTCCGGTGCCGGATCCGCCGCCCGGCTTCAGTCACTCCGCTTGTCCGCCGGAGGTCCATCGAACCTGTTTCTGTGTTCGATTCATCGCTGAGCACACGAAAATGCTTGAAGATTCTACTAAGGTGAAAGAAGATTGGAAGTACGTGGCGATGGTTCTTGACAGACTGTTTCTGTGGATCTTTACACTGGCCGTACTGGTTGGTACGGCTGGGATTATTCTTCAGGCTCCTACACTGTACGATGACCGAGTGCCCATAGACAAGCATTTTAATCAGTACGCAACGTCCACCTTAGTACGGTGTCCACCTCCCGTATAG

Protein

MTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYHQGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQAGSNVVSVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHRMAPWVKRVFIHILPRLLFMKRPQYKFDTTRSRYTACGVVVRCGGTARPLYPYRLAAADDDCCAPGAWPPPAAPPPRPLTRTPSKEDLTHTTYLNSGIDSNRLGGSCMLHGSSEVVGGGLAGVSVEEEILSPVPDPPPGFSHSACPPEVHRTCFCVRFIAEHTKMLEDSTKVKEDWKYVAMVLDRLFLWIFTLAVLVGTAGIILQAPTLYDDRVPIDKHFNQYATSTLVRCPPPV

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.

Uniprot

A8CGK6   A8CGK4   A0A194PF20   A0A2A4JAQ6   A0A0H4TRF4   A0A2H1WY12   + More
A0A3L8DTL6   A0A158P1J6   A0A151XGV6   A0EIZ3   A8DIR5   A0A139WNF6   A0A151IEC4   D3UA16   E0VB18   H6TY10   A0A2Z4N5S0   A0A0C9R563   A0A348BSV4   A0A195DU32   A0EIZ4   A8DIS0   D6WAI3   W6EL36   D5FNB0   H6TY11   A0A084VV12   A0A182WQJ6   B0WWU0   A0A1S4FV60   A0A348BSV5   Q16N27   Q66T33   A0A0M4EGU1   A0A1J1HN15   A0A0Q9WXH8   B4N973   A0A1D8GS69   Q7QET3   A0A067RA92   A0A0P9BLU4   A0A0J9S0G2   Q9NFR5   A0A224AV79   A0A2S2R0G7   A2TM51   M1FN37   G9L5U5   A0A2H8TRU4   A8JNX5   Q5F2K3   A0A0U2GTV6   A6N8Q9   B3NEI9   Q9U939   A5YVF0   B4K4F6   B4JYV8   A0A1I8NWG1   A0A0Q9WTR7   A0A224AVZ1   A2TM52   G9L5X0   A0A1B0FI68   A0A154PPE6   A0A0J9S072   A6N8R0   A0A0S0WNY8   A0A0A1WQH3   A0A0K8UN00   G9F9Q2   A0A0K8W3T7   A0A1J1HPX3   W8BPC7   A0A232FIS8   A0A1B6D1Z3   A0A087ZWN1   A0A0P5IN88   A0A0P4Y0F8   A0A0P6FE70   A0A0M9ACP3   A0A0P5J172   A0A0N8NYW8   A0A139WN89   A0A139WN87   A0A226DLM0   A0A0A9YZS4   A0A0K0QSP6   A0A182LRU0   A0A0J9S1P2   A0A154PLB9   Q5F2K6   J9K473   E2AG17   A0A088A8Z8   A0A0C9RZ38   A0A0A9Z480   R4JK58   A0A0A9YUC9   E2C7L3  

Pubmed

17868469    26354079    30249741    21347285    17065616    17880682    + More
19320762    18362917    19820115    20087392    20075255    20566863    25701599    24438588    17510324    12364791    14747013    15676276    17210077    17994087    24845553    22936249    11044730    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10386991    25830018    24495485    28648823    25401762    20798317   

EMBL

EU082078    EU143795    ABV45515.1    ABV72686.1    EU082077    ABV45514.1    + More
KQ459606    KPI91299.1    NWSH01002106    PCG69165.1    KP711046    RSAL01000007    AKQ12742.1    RVE54064.1    ODYU01011930    SOQ57963.1    QOIP01000004    RLU23503.1    ADTU01006263    ADTU01006264    ADTU01006265    ADTU01006266    ADTU01006267    ADTU01006268    ADTU01006269    ADTU01006270    ADTU01006271    ADTU01006272    KQ982138    KYQ59633.1    DQ026033    AAY87892.1    EF526083    EU930057    ABS86905.1    ACM09852.1    KQ971312    KYB29325.1    KQ977877    KYM99031.1    FJ821432    ACY82686.1    DS235021    EEB10574.1    JN390945    AFA28128.1    MF612143    AWX65631.1    GBYB01007922    JAG77689.1    LC389178    BBE49557.1    KQ980390    KYN16267.1    DQ026034    KJ939591    AAY87893.1    AJE70262.1    EF526084    ABS86906.1    EEZ99194.2    KF873582    AHJ11211.1    FJ821433    ACY82687.1    JN390946    AFA28129.1    ATLV01017141    ATLV01017142    KE525157    KFB41806.1    DS232152    EDS36201.1    LC389179    BBE49558.1    CH477841    EAT35760.1    AY705397    AAAB01008846    AAU12506.1    EAL41278.3    CP012526    ALC45408.1    CVRI01000012    CRK89445.1    CH933806    KRG00700.1    CH964232    EDW81620.1    KU557778    AOT81840.1    AY705398    AAU12507.1    EAA06397.4    KK852591    KDR20702.1    CH902623    KPU72683.1    CM002912    KMZ01298.1    AJ272159    CAB77445.1    LC215867    BBA21162.1    GGMS01014272    MBY83475.1    EF363703    ABM97502.1    JQ690274    AFP55259.1    JQ003562    AEV54112.1    GFXV01005112    MBW16917.1    AE014296    ABW08585.2    AJ880084    CAI54101.1    KT328072    ALB27750.1    EF626658    ABR21380.1    CH954178    EDV52824.2    AJ236788    CAB52299.1    EF590120    ABQ58863.1    EDW13908.1    CH916378    EDV98573.1    KRF99499.1    LC215868    BBA21163.1    EF363704    ABM97503.1    JQ008945    AEV54113.1    CCAG010001331    KQ434984    KZC13128.1    KMZ01297.1    EF626659    ABR21381.1    ALI30497.1    GBXI01013609    JAD00683.1    GDHF01025676    GDHF01024353    JAI26638.1    JAI27961.1    JN052924    AEM05861.1    GDHF01006553    JAI45761.1    CRK89444.1    GAMC01003560    GAMC01003559    JAC02996.1    NNAY01000145    OXU30585.1    GEDC01017569    JAS19729.1    GDIQ01212841    LRGB01002993    JAK38884.1    KZS05134.1    GDIP01243808    JAI79593.1    GDIQ01050515    JAN44222.1    KQ435691    KOX81166.1    GDIQ01212842    JAK38883.1    KPU72684.1    KYB29327.1    KYB29326.1    LNIX01000017    OXA45501.1    GBHO01007016    JAG36588.1    KR021292    AKR16132.1    AXCM01000646    AXCM01000647    AXCM01000648    AXCM01000649    KMZ01300.1    KQ434943    KZC12264.1    AJ880081    CAI54098.1    ABLF02039784    ABLF02039787    GL439206    EFN67627.1    GBYB01013316    JAG83083.1    GBHO01007014    JAG36590.1    KC153234    AGK89908.1    GBHO01007012    JAG36592.1    GL453383    EFN76089.1   

Proteomes

UP000053268    UP000218220    UP000283053    UP000279307    UP000005205    UP000075809    + More
UP000007266    UP000078542    UP000002358    UP000009046    UP000078492    UP000030765    UP000075920    UP000002320    UP000008820    UP000007062    UP000092553    UP000183832    UP000009192    UP000007798    UP000027135    UP000007801    UP000000803    UP000008711    UP000001070    UP000095300    UP000092444    UP000076502    UP000215335    UP000005203    UP000076858    UP000053105    UP000198287    UP000075883    UP000007819    UP000000311    UP000008237   

PRIDE

A8CGK6    A8CGK4    Q9NFR5    A8JNX5   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR006029   Neurotrans-gated_channel_TM        + More
IPR006202   Neur_chan_lig-bd       
IPR036734   Neur_chan_lig-bd_sf       
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036719   Neuro-gated_channel_TM_sf       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006201   Neur_channel       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8CGK6   A8CGK4   A0A194PF20   A0A2A4JAQ6   A0A0H4TRF4   A0A2H1WY12   + More
A0A3L8DTL6   A0A158P1J6   A0A151XGV6   A0EIZ3   A8DIR5   A0A139WNF6   A0A151IEC4   D3UA16   E0VB18   H6TY10   A0A2Z4N5S0   A0A0C9R563   A0A348BSV4   A0A195DU32   A0EIZ4   A8DIS0   D6WAI3   W6EL36   D5FNB0   H6TY11   A0A084VV12   A0A182WQJ6   B0WWU0   A0A1S4FV60   A0A348BSV5   Q16N27   Q66T33   A0A0M4EGU1   A0A1J1HN15   A0A0Q9WXH8   B4N973   A0A1D8GS69   Q7QET3   A0A067RA92   A0A0P9BLU4   A0A0J9S0G2   Q9NFR5   A0A224AV79   A0A2S2R0G7   A2TM51   M1FN37   G9L5U5   A0A2H8TRU4   A8JNX5   Q5F2K3   A0A0U2GTV6   A6N8Q9   B3NEI9   Q9U939   A5YVF0   B4K4F6   B4JYV8   A0A1I8NWG1   A0A0Q9WTR7   A0A224AVZ1   A2TM52   G9L5X0   A0A1B0FI68   A0A154PPE6   A0A0J9S072   A6N8R0   A0A0S0WNY8   A0A0A1WQH3   A0A0K8UN00   G9F9Q2   A0A0K8W3T7   A0A1J1HPX3   W8BPC7   A0A232FIS8   A0A1B6D1Z3   A0A087ZWN1   A0A0P5IN88   A0A0P4Y0F8   A0A0P6FE70   A0A0M9ACP3   A0A0P5J172   A0A0N8NYW8   A0A139WN89   A0A139WN87   A0A226DLM0   A0A0A9YZS4   A0A0K0QSP6   A0A182LRU0   A0A0J9S1P2   A0A154PLB9   Q5F2K6   J9K473   E2AG17   A0A088A8Z8   A0A0C9RZ38   A0A0A9Z480   R4JK58   A0A0A9YUC9   E2C7L3  

PDB

6CNK     E-value=4.88952e-94,     Score=880

KEGG

100126154    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa4, Achr4a; nicotinic acetylch

GO

GO:0045211   GO:0030054   GO:0022848   GO:0004888   GO:0016021   GO:0006811   GO:0007268   GO:0034220   GO:0050877   GO:0042391   GO:0007165   GO:0043005   GO:0005887   GO:0045202   GO:0030431   GO:0005892   GO:0015464   GO:0005230   GO:0004889   GO:0005216   GO:0006810   GO:0016020   GO:0016742   GO:0003824  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

500

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

88.7462100000001

Exp number, first 60 AAs:

0.00032

Total prob of N-in:

0.20861

outside

1  -  171

TMhelix

172  -  194

inside

195  -  200

TMhelix

201  -  223

outside

224  -  237

TMhelix

238  -  257

inside

258  -  450

TMhelix

451  -  473

outside

474  -  500

 

 

Pi

202.504042

Theta

171.122959

Tajima's D

0.308954

CLR

0.394403

CSRT

0.451427428628569

Interpretation

Uncertain