Gene

KWMTBOMO05049

Pre Gene Modal

BGIBMGA012563

Annotation

Uncharacterized_protein_OBRU01_16851_[Operophtera_brumata]

Location

Bomo_Chr9(-):6542598-6543892      View in EpiBrowser

Full name

Protein spindle-F      

Location in the cell

Nuclear   Reliability : 3.679

CDS

ATGGATACTTCTTCAATAGTAAGTTTTAATAACGACTCTACATTCCAAGCCACTCTTAAAGGCGACTACAATCACCACAGTGTTCACGAGTTGGCTCTTCATGCCATGAGGGATCGTTGTCTATTACTACAACGCAGAATAAATGTTTTGGAGAATGACAACATGCGCTTAAAACTTGATGCTACAAGAAATAATGAAAATATTGCTTTTCATGATGATGACAAACTTGACCTACTCCAGAAAATAGCTGAGCTTAATAAACAGAAGTCGCAATTGATGCATCACGTTTTTATGGTGTCATGTGAGAATAGAAACCTATGGAATAAAATATCAACTATCAAGAATTGTAATAAACCTAATAAAGAAAATGTGAAAAACCCATTAGTTCGTACCAATACCTACATCCAAAGCACACCTAAAACAAGTGTAAATTATCAAGAAAAGTATTCTGAATCAAGCTTGGAAGAAATATCTCTGAAATTAATAAATAGCTATATTCAGGAAAAGTCTAATTTAGTTGATCAATATGAACAAATGGCTCAACTTCATAGGGATGAAGATATGTTAAATGTAGATTCTATTGGTTTTACATACTTAGAAGATCCTGCAATGGAATCTTTAAAGGATATTATTTCTCAGACAGAAAAAGTGCAATCTCTGAGAAAAGAGGTAATTCAGCAAGAAAATGATCTTAAAGTAATATTAGCAAGATTTGAGACTATTGTGGCAGAAGGATATAAGTGTCCAACTTGTATTACAAATAATACCAAAGTTGTGTCTTCAGAAAATAAACAAATTGAAACAAGTGATAGTCTTATGAATTGGGAAACACCAGCTGATTCCAGTTCTTGCAATAATAACTTCAGTGATATCAACACCTCTGTTATAAAAGAAAGTATTATTGAAGAAAAAGAAGAAGATAACGAGCCTTTTGATAAAATATGCCCTATGTGTGGACAAACATTCCAAAAAGATACTGAGTTTTCAGAGTTCAGAGTACATGTAGAAAGCCATTTTACAGGTGAAACAGAACCAGATTCCTTAATAGATAATTTTGAAAATATTCCTAGTTCTTTTGAAAATGCATTATAG

Protein

MDTSSIVSFNNDSTFQATLKGDYNHHSVHELALHAMRDRCLLLQRRINVLENDNMRLKLDATRNNENIAFHDDDKLDLLQKIAELNKQKSQLMHHVFMVSCENRNLWNKISTIKNCNKPNKENVKNPLVRTNTYIQSTPKTSVNYQEKYSESSLEEISLKLINSYIQEKSNLVDQYEQMAQLHRDEDMLNVDSIGFTYLEDPAMESLKDIISQTEKVQSLRKEVIQQENDLKVILARFETIVAEGYKCPTCITNNTKVVSSENKQIETSDSLMNWETPADSSSCNNNFSDINTSVIKESIIEEKEEDNEPFDKICPMCGQTFQKDTEFSEFRVHVESHFTGETEPDSLIDNFENIPSSFENAL

Description

Plays a role in oocyte axis determination and microtubule organization during oogenesis (PubMed:16540510, PubMed:24019068). Also required for polarized organization of the bristle (PubMed:19917727). Required, with jvl, for activation of the kinase IKKepsilon in the germ line (PubMed:24019068). Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein (PubMed:26092846). Involved in dendrite pruning in larval sensory neurons during metamorphosis (PubMed:26540204).

Subunit

Forms homooligomers (PubMed:26540204). Interacts with the dynein light chain ctp (PubMed:16540510). Interacts (via C-terminus) with IKKepsilon; this leads to phosphorylation of spn-F (PubMed:18796167, PubMed:26092846). Forms ternary complexes with ctp and IKKepsilon; this is required for spn-F redistribution from puncta in larval neurons and for dendrite pruning (PubMed:26092846, PubMed:26540204). Interacts with ctp and IKKepsilon through distinct regions (PubMed:26092846). Interacts (via C-terminus) with jvl (PubMed:24019068).

Keywords

Cell projection   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Differentiation   Neurogenesis   Oogenesis   Phosphoprotein   Reference proteome  

Feature

chain  Protein spindle-F

Uniprot

H9JSQ2   A0A1E1VZH5   A0A2H1WY25   A0A2A4JB15   A0A0L7L1S4   A0A212FGB0   + More
A0A194PD87   S4PMK0   A0A0N1IDK0   A0A026VX30   E9ILB4   A0A195FFQ6   K7JBK5   A0A0J7KF41   A0A2J7QZU3   A0A151ICJ7   E2C653   A0A195B722   A0A158NGP1   A0A195DYE1   B3M083   A0A232ET12   A0A154P201   A0A2A3E5V8   A0A1W4U735   A0A0C9RXC0   A0A0N0BFH2   A0A1B6MBL2   A0A088ATS5   B4QSL2   B3P7Q8   B4N9V4   Q9V9Y9   A0A0B4KI68   B4PNC1   A0A151XAD4   A0A0K8TRW9   A0A0L7QLJ4   A0A224XES0   A0A0V0G735   A0A069DTA2   A0A1B6HA10   A0A3B0JLD6   B4LVZ7   B4GNR7   A0A1L8DDH8   A0A1L8DD54   A0A1B6DK04   R4G3I4   A0A0P4VLP5   Q170X0   A0A0A1WZ58   A0A1W4WGM6   U5EPG8   A0A023F955   Q16FL2   A0A1S4G2Q0   A0A1J1HU07   W8BWA6   A0A084VQI6   D6WAF5   A0A034WJZ2   B4K4J0   A0A182JKT5   B0X3C0   A0A0L0CGW8   A0A0K8WLM0   A0A182GP67   A0A0M4EKY2   A0A1B0BMH1   A0A1A9XTF3   A0A1A9VVE5   A0A1Q3FC96   Q29BC4   A0A1Y1KVV5   A0A1A9ZJI7   A0A182RH78   A0A0A9WMW4   T1P7X8   A0A1B0F9Y8   B4JI20   A0A1I8MHQ0   A0A1A9WRP7   A0A336L256   A0A182FJP7   A0A182K102   A0A182P6V2   A0A182SRJ7   A0A182W478   A0A0C9S016   A0A1I8NUB5  

Pubmed

19121390    26227816    22118469    26354079    23622113    24508170    + More
30249741    21282665    20075255    20798317    21347285    17994087    28648823    10731132    12537572    12537569    16540510    18796167    19917727    24019068    26092846    26487782    26540204    12537568    12537573    12537574    16110336    17569856    17569867    17550304    26369729    26334808    27129103    17510324    25830018    25474469    24495485    24438588    18362917    19820115    25348373    26108605    26483478    15632085    28004739    25401762    26823975    25315136   

EMBL

BABH01032150    GDQN01010931    JAT80123.1    ODYU01011930    SOQ57961.1    NWSH01002106    + More
PCG69161.1    JTDY01003516    KOB69432.1    AGBW02008688    OWR52774.1    KQ459606    KPI91296.1    GAIX01000136    JAA92424.1    KQ461133    KPJ08872.1    KK107681    QOIP01000006    EZA48061.1    RLU21588.1    GL764074    EFZ18619.1    KQ981625    KYN39062.1    AAZX01016879    LBMM01008504    KMQ88821.1    NEVH01009067    PNF34095.1    KQ978053    KYM97781.1    GL452926    EFN76573.1    KQ976574    KYM80296.1    ADTU01015162    KQ980107    KYN17629.1    CH902617    EDV42040.2    NNAY01002346    OXU21495.1    KQ434803    KZC05956.1    KZ288357    PBC27090.1    GBYB01013745    JAG83512.1    KQ435803    KOX73072.1    GEBQ01006670    JAT33307.1    CM000364    EDX15109.1    CH954182    EDV52966.1    CH964232    EDW81709.2    AE014297    AY061046    AAL28594.1    AGB96517.1    CM000160    EDW99203.2    KQ982339    KYQ57341.1    GDAI01000933    JAI16670.1    KQ414915    KOC59497.1    GFTR01005459    JAW10967.1    GECL01002220    JAP03904.1    GBGD01001913    JAC86976.1    GECU01036190    JAS71516.1    OUUW01000005    SPP81152.1    CH940650    EDW66502.2    CH479186    EDW38800.1    GFDF01009694    JAV04390.1    GFDF01009695    JAV04389.1    GEDC01011274    JAS26024.1    ACPB03017998    GAHY01001651    JAA75859.1    GDKW01000557    JAI56038.1    CH477463    EAT40539.1    GBXI01009973    JAD04319.1    GANO01004770    JAB55101.1    GBBI01001188    JAC17524.1    CH478417    EAT33022.1    CVRI01000015    CRK89974.1    GAMC01009009    JAB97546.1    ATLV01015217    KE525003    KFB40230.1    KQ971312    EEZ98008.1    GAKP01003056    JAC55896.1    CH933806    EDW13942.2    DS232312    EDS39812.1    JRES01000501    KNC30744.1    GDHF01000327    JAI51987.1    JXUM01014884    JXUM01014885    JXUM01014886    KQ560415    KXJ82528.1    CP012526    ALC47958.1    JXJN01016920    GFDL01009922    JAV25123.1    CM000070    EAL27074.2    GEZM01072487    GEZM01072486    JAV65502.1    GBHO01037430    GBHO01037429    GDHC01000922    JAG06174.1    JAG06175.1    JAQ17707.1    KA644634    AFP59263.1    CCAG010006238    CH916369    EDV93940.1    UFQS01001455    UFQT01001455    SSX11014.1    SSX30635.1    GBYB01013741    JAG83508.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000053268    UP000053240    + More
UP000053097    UP000279307    UP000078541    UP000002358    UP000036403    UP000235965    UP000078542    UP000008237    UP000078540    UP000005205    UP000078492    UP000007801    UP000215335    UP000076502    UP000242457    UP000192221    UP000053105    UP000005203    UP000000304    UP000008711    UP000007798    UP000000803    UP000002282    UP000075809    UP000053825    UP000268350    UP000008792    UP000008744    UP000015103    UP000008820    UP000192223    UP000183832    UP000030765    UP000007266    UP000009192    UP000075880    UP000002320    UP000037069    UP000069940    UP000249989    UP000092553    UP000092460    UP000092443    UP000078200    UP000001819    UP000092445    UP000075900    UP000092444    UP000001070    UP000095301    UP000091820    UP000069272    UP000075881    UP000075885    UP000075901    UP000075920    UP000095300   

PRIDE

H9JSQ2    Q9V9Y9   

Pfam

PF18112   Zn-C2H2_12

Interpro

IPR041641   CALCOCO1/2_Zn-C2H2       

ProteinModelPortal

H9JSQ2   A0A1E1VZH5   A0A2H1WY25   A0A2A4JB15   A0A0L7L1S4   A0A212FGB0   + More
A0A194PD87   S4PMK0   A0A0N1IDK0   A0A026VX30   E9ILB4   A0A195FFQ6   K7JBK5   A0A0J7KF41   A0A2J7QZU3   A0A151ICJ7   E2C653   A0A195B722   A0A158NGP1   A0A195DYE1   B3M083   A0A232ET12   A0A154P201   A0A2A3E5V8   A0A1W4U735   A0A0C9RXC0   A0A0N0BFH2   A0A1B6MBL2   A0A088ATS5   B4QSL2   B3P7Q8   B4N9V4   Q9V9Y9   A0A0B4KI68   B4PNC1   A0A151XAD4   A0A0K8TRW9   A0A0L7QLJ4   A0A224XES0   A0A0V0G735   A0A069DTA2   A0A1B6HA10   A0A3B0JLD6   B4LVZ7   B4GNR7   A0A1L8DDH8   A0A1L8DD54   A0A1B6DK04   R4G3I4   A0A0P4VLP5   Q170X0   A0A0A1WZ58   A0A1W4WGM6   U5EPG8   A0A023F955   Q16FL2   A0A1S4G2Q0   A0A1J1HU07   W8BWA6   A0A084VQI6   D6WAF5   A0A034WJZ2   B4K4J0   A0A182JKT5   B0X3C0   A0A0L0CGW8   A0A0K8WLM0   A0A182GP67   A0A0M4EKY2   A0A1B0BMH1   A0A1A9XTF3   A0A1A9VVE5   A0A1Q3FC96   Q29BC4   A0A1Y1KVV5   A0A1A9ZJI7   A0A182RH78   A0A0A9WMW4   T1P7X8   A0A1B0F9Y8   B4JI20   A0A1I8MHQ0   A0A1A9WRP7   A0A336L256   A0A182FJP7   A0A182K102   A0A182P6V2   A0A182SRJ7   A0A182W478   A0A0C9S016   A0A1I8NUB5  

KEGG

101740540    no KO assigned | (RefSeq) uncharacterized LOC101740540

GO

GO:1904801   GO:0034613   GO:0008569   GO:0043204   GO:0008407   GO:0030424   GO:0007317   GO:0030425   GO:0016325   GO:0008103   GO:0005794   GO:0005856   GO:0005737   GO:0007314   GO:0007309  

Subcellular location

Cytoplasm   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.
Cytoskeleton   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.
Cell projection   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.
Axon   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.
Dendrite   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.
Perikaryon   Localizes to the minus ends of microtubules in oocytes (PubMed:16540510). Found in a punctate pattern colocalized with IKKepsilon in nurse cells (PubMed:16540510, PubMed:18796167). Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning (PubMed:26540204).   With evidence from 2 publications.

Length:

363

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00922

outside

1  -  363

 

 

Pi

274.441673

Theta

212.803799

Tajima's D

0.924245

CLR

0.055635

CSRT

0.64316784160792

Interpretation

Possibly Positive selection