Gene

KWMTBOMO05038

Pre Gene Modal

BGIBMGA012535

Annotation

PREDICTED:_desert_hedgehog_protein_B_[Papilio_machaon]

Location

Bomo_Chr9(+):6276587-6324821      View in EpiBrowser

Full name

Hedgehog protein       + More
Tiggy-winkle hedgehog protein      

Alternative Name

Sonic hedgehog protein B

Location in the cell

Mitochondrial   Reliability : 1.302

CDS

ATGCTTGCTCATGGGTGTCGGGCGGCAAGCAAGGGATGCAAGTTCAGGCTCGGTGGTGGACGTGCAGTTGAGTCGGGTTGTGGCAGTTGCTCTCAGTGTCGCTCAAGTCGCGGCGCGCGGTGGTCGTGCGTCGAGCGCGTGTGGAGTGATGTCTGCGAGATGAGGCTCTCGCTGGTGCTTCTGTGGTTGGGTGCGGCGGCGGCATGCGGCCCGGGCCGCGGTTTCAACCGTCGCCACGGACCGCGCCGCATCACCCCCCTTGTCTTTGGCCAGCACGATCCGAATGTTAGCGAAAATAAGAACACCGCCAGTGGTCCTCCCGAGGGCCGCATCACCAGAGATGACGAGAGATTTAAAGACTTAGTGCCTAATTATAATCCGGATATAGACTTTAGGGACGACGAAGGCACTGGCGCTGATCGTCTAATGACTCAGAGATGCAAGGAGAAATTAAACACTCTCGCAATCAGCGTTATGAACCAGTGGCCGGGAGTGCGGCTCCGTGTGATCGAAGGTTGGGACGAAGAGAATAATCATCTAGACAAGTCTCTCCACTACGAGGGTCGGGCTGTGGACTTAACCACCAGTGACCGAGACCGCAGCAAATACGGTATGCTGGCCCGCCTCGCTGTCGAAGCCGGCTTTGACTGGGTCTTCTATGAAAGCCGGTCTTACATTCATTGTTCTGTTAAAACAGAATCATCTGTGGGAACTGGTGCTGGCTGTTTCCCTGGCGGCTCCGTAGTTCACACTGAGAAAGGACCGAAGGATATAGCTGCCTTGCAGAAGGGAGACAAGGTCTTAGCAGCTGATGATAATGGCATGATGATTTATTCTAAGGTGCTAACATTCATCGATCGTGATCCTAATGCAACTCGACAGTTCATCGAGATAACTGCGGAGAATGGTGTTGCGATCACAACGACGCCCTCACATTTGCTCCTTCTCGCTGCAGCTGACGGTTGGCGCGATGTCTTTGCAGCTAACATCAAAGAGGGAGACGTACTATTGACAAGAGGTCGAAGTGATGTTATGAGGCCCTCGAGAGTAACGAGAACTCGTATCCTCACGAAACGAGGTGTTTTTGCCCCGCTTACCAAAGCCGGCACTATCATAGTGGATGACGTTCTGGCGTCATGCTACGCGCTAGTACGCAGTCATTCGCTTGCGCATGTTGCGATGGCACCATTGCGATGGCTTTCCAGTTGGAGCACTTCTTCAGAAACGACCAAAGGCGTCCACTGGTACGCGAGCGCGCTTTACTCTTTCGGCGACTACGTATTACCAGCATCGTATAGATATCGATAA

Protein

MLAHGCRAASKGCKFRLGGGRAVESGCGSCSQCRSSRGARWSCVERVWSDVCEMRLSLVLLWLGAAAACGPGRGFNRRHGPRRITPLVFGQHDPNVSENKNTASGPPEGRITRDDERFKDLVPNYNPDIDFRDDEGTGADRLMTQRCKEKLNTLAISVMNQWPGVRLRVIEGWDEENNHLDKSLHYEGRAVDLTTSDRDRSKYGMLARLAVEAGFDWVFYESRSYIHCSVKTESSVGTGAGCFPGGSVVHTEKGPKDIAALQKGDKVLAADDNGMMIYSKVLTFIDRDPNATRQFIEITAENGVAITTTPSHLLLLAAADGWRDVFAANIKEGDVLLTRGRSDVMRPSRVTRTRILTKRGVFAPLTKAGTIIVDDVLASCYALVRSHSLAHVAMAPLRWLSSWSTSSETTKGVHWYASALYSFGDYVLPASYRYR

Description

Intercellular signal essential for a variety of patterning events during development.

Similarity

Belongs to the hedgehog family.

Keywords

Autocatalytic cleavage   Calcium   Cell membrane   Complete proteome   Developmental protein   Hydrolase   Lipoprotein   Membrane   Metal-binding   Palmitate   Protease   Reference proteome   Secreted   Signal   Zinc  

Feature

chain  Hedgehog protein

Uniprot

A0A2A4JC83   A0A3S2P767   A0A158NGS9   A0A195FEJ8   A0A151XCU2   A0A195DXS7   + More
A0A1J1HKS3   A3KNS3   A0A3L8DMY3   A0A2D0T6V3   A0A067R8L6   Q4PLX4   A0A1W5B7X1   B0S8K0   A0A3B4C6K3   W5MY62   K7J545   A0A060XSJ4   A0A3B4V456   W5K3H2   A0A3B4YMP6   A0A0B5JJZ7   Q90419   A0A2D0R5M0   A0A3B4Y7R0   Q6DBX7   A0A3R5VPV7   A0A139WM49   A0A3Q1B3K7   A2I5E3   A0A3P8UMD8   A0A3B4DSA4   A0A3B4C2C0   A0A1S3MZ68   E0V9Q6   A0A218UU38   A0A3B3DM54   A0A3P8UEE7   A0A0F8AQM8   A0A3B3SRJ0   A0A3B3SRJ5   A0A3P8U565   A0A3B4E4T1   M4A8D0   A0A3B3TCB6   A0A3B4CS27   A0A3B3TC00   A0A3N0YFI8   A0A3P8T8U1   A0A3Q0RSL2   A0A3Q1EN99   A0A3Q3Q8Q8   W5L125   A0A3Q3J1S2   A0A087YJ84   A0A3B5AJA7   A0A3B3YHY1   A0A3Q1GFL6   A0A3Q1BMS1   A0A3B4TGL1   A0A3Q3IT37   A0A3Q1JKA7   A0A3Q1DC99   A0A3P8XAG3   Q7Z264   A0A3Q3M4K9   A0A3Q3IQ44   A0A1S3P0K9   A0A1J0M5P1   A0A3B3CWC5   A0A3Q2YFQ0   B0WA40   A0A1W5AJS0   D3GA16   H3ATP8   A0A060YW61   Q2PXN1   A0A3N0XVC3   A0A2I4CCS1   A0A1S3R293   I3K2G6   A0A060YSW3   A0A2I4CB57   A0A3Q1ASU4   A0A3Q2CGS2   A0A3M0JVK2   H2M3V5   A0A3P9M4Y1   A0A1S3LY80   A0A3P8UI02   A0A3B3H8Y2   A0A3P9M3Y5   A0A1A6HVP4   Q6SCJ6   A0A3P9HQ24   A0A3P9HQ07   A0A060W0I4   G3PSE1  

Pubmed

21347285    30249741    24845553    16292774    23594743    20075255    + More
24755649    25329095    26190107    7583153    8917540    18362917    19820115    17187056    24487278    20566863    29451363    25835551    29240929    23542700    25069045    15365834    27832738    17559649    9215903    17318658    25186727    17554307   

EMBL

NWSH01002050    PCG69308.1    RSAL01000007    RVE54075.1    ADTU01015197    ADTU01015198    + More
KQ981625    KYN39105.1    KQ982294    KYQ58196.1    KQ980107    KYN17678.1    CVRI01000009    CRK88629.1    BC133983    AAI33984.1    QOIP01000006    RLU21583.1    KK852865    KDR14772.1    DQ066428    AAY68016.1    BX942813    AHAT01034473    AAZX01000353    AAZX01013691    FR905933    CDQ82237.1    KM655588    AJG05934.1    U30710    U68237    BC078321    AAH78321.1    MH168557    QAA78721.1    KQ971317    KYB28973.1    EF100667    ABM66102.1    DS234995    EEB10091.1    MUZQ01000145    OWK56872.1    KQ041128    KKF30256.1    RJVU01044706    ROL44611.1    AYCK01016599    AYCK01016600    AY281133    AAP38181.1    KX365116    APD15679.1    DS231868    EDS40773.1    FJ603040    ACU45353.1    AFYH01119219    FR914690    CDQ93225.1    DQ296048    ABB99398.1    RJVU01059775    ROJ66287.1    AERX01016233    FR919121    CDQ94938.1    QRBI01000123    RMC04765.1    LZPO01008088    OBS82311.1    AY460200    AAR19208.1    FR904297    CDQ58100.1   

Proteomes

UP000218220    UP000283053    UP000005205    UP000078541    UP000075809    UP000078492    + More
UP000183832    UP000279307    UP000221080    UP000027135    UP000192224    UP000000437    UP000261440    UP000018468    UP000002358    UP000193380    UP000261420    UP000018467    UP000261360    UP000007266    UP000257160    UP000265120    UP000087266    UP000009046    UP000197619    UP000261560    UP000265080    UP000261540    UP000002852    UP000261340    UP000257200    UP000261600    UP000028760    UP000261400    UP000261480    UP000265040    UP000265140    UP000261660    UP000264820    UP000002320    UP000008672    UP000192220    UP000005207    UP000265020    UP000269221    UP000001038    UP000265180    UP000092124    UP000265200    UP000007635   

Pfam

PF01085   HH_signal        + More
PF01079   Hint

Interpro

IPR009045   Hedgehog_sig/DD-Pept_Zn-bd_sf        + More
IPR036844   Hint_dom_sf       
IPR033385   IHH       
IPR006141   Intein_N       
IPR003587   Hint_dom_N       
IPR001657   Hedgehog       
IPR003586   Hint_dom_C       
IPR000320   Hedgehog_signalling_dom       
IPR001767   Hedgehog_Hint       
IPR002812   DHQ_synth       

SUPFAM

SSF55166   SSF55166        + More
SSF51294   SSF51294       

Gene 3D

3.30.1380.10    

ProteinModelPortal

A0A2A4JC83   A0A3S2P767   A0A158NGS9   A0A195FEJ8   A0A151XCU2   A0A195DXS7   + More
A0A1J1HKS3   A3KNS3   A0A3L8DMY3   A0A2D0T6V3   A0A067R8L6   Q4PLX4   A0A1W5B7X1   B0S8K0   A0A3B4C6K3   W5MY62   K7J545   A0A060XSJ4   A0A3B4V456   W5K3H2   A0A3B4YMP6   A0A0B5JJZ7   Q90419   A0A2D0R5M0   A0A3B4Y7R0   Q6DBX7   A0A3R5VPV7   A0A139WM49   A0A3Q1B3K7   A2I5E3   A0A3P8UMD8   A0A3B4DSA4   A0A3B4C2C0   A0A1S3MZ68   E0V9Q6   A0A218UU38   A0A3B3DM54   A0A3P8UEE7   A0A0F8AQM8   A0A3B3SRJ0   A0A3B3SRJ5   A0A3P8U565   A0A3B4E4T1   M4A8D0   A0A3B3TCB6   A0A3B4CS27   A0A3B3TC00   A0A3N0YFI8   A0A3P8T8U1   A0A3Q0RSL2   A0A3Q1EN99   A0A3Q3Q8Q8   W5L125   A0A3Q3J1S2   A0A087YJ84   A0A3B5AJA7   A0A3B3YHY1   A0A3Q1GFL6   A0A3Q1BMS1   A0A3B4TGL1   A0A3Q3IT37   A0A3Q1JKA7   A0A3Q1DC99   A0A3P8XAG3   Q7Z264   A0A3Q3M4K9   A0A3Q3IQ44   A0A1S3P0K9   A0A1J0M5P1   A0A3B3CWC5   A0A3Q2YFQ0   B0WA40   A0A1W5AJS0   D3GA16   H3ATP8   A0A060YW61   Q2PXN1   A0A3N0XVC3   A0A2I4CCS1   A0A1S3R293   I3K2G6   A0A060YSW3   A0A2I4CB57   A0A3Q1ASU4   A0A3Q2CGS2   A0A3M0JVK2   H2M3V5   A0A3P9M4Y1   A0A1S3LY80   A0A3P8UI02   A0A3B3H8Y2   A0A3P9M3Y5   A0A1A6HVP4   Q6SCJ6   A0A3P9HQ24   A0A3P9HQ07   A0A060W0I4   G3PSE1  

PDB

6DMY     E-value=3.50154e-73,     Score=699

KEGG

101741481    K06224 hedgehog | (RefSeq) Hh, hedgehog; desert hedgehog protein B

PATHWAY

04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0016539   GO:0005615   GO:0007267   GO:0005886   GO:0008233   GO:0007275   GO:0009073   GO:0046872   GO:0003856   GO:0016491   GO:0016021   GO:0001957   GO:0048794   GO:0048795   GO:0001649   GO:0005113   GO:0007224   GO:0048709   GO:0010468   GO:0005509   GO:0001708   GO:0055002   GO:0060956   GO:0048663   GO:0048703   GO:0030900   GO:0030182   GO:0048702   GO:0042063   GO:0045880   GO:0021513   GO:2000063   GO:0014858   GO:0005539   GO:0060516   GO:0048538   GO:0035116   GO:0048645   GO:0007405   GO:0045109   GO:0021978   GO:0045944   GO:0030177   GO:0046638   GO:0008209   GO:2000357   GO:0060685   GO:0048617   GO:0046639   GO:0014706   GO:0060664   GO:2000358   GO:0006897   GO:0097190   GO:0060458   GO:0014003   GO:0060428   GO:0048859   GO:0031016   GO:0051155   GO:0090370   GO:0007411   GO:0002320   GO:0060445   GO:0001755   GO:0060916   GO:0060459   GO:0001658   GO:0007596   GO:0071285   GO:0001570   GO:0048706   GO:0060523   GO:0045121   GO:0060769   GO:0014902   GO:0061189   GO:0060020   GO:0060174   GO:0043010   GO:0042733   GO:0043237   GO:0060463   GO:0060070   GO:0060783   GO:0030539   GO:0060782   GO:0002052   GO:0009986   GO:0061053   GO:0009949   GO:0033092   GO:0060662   GO:0021794   GO:0008270   GO:0032435   GO:0007228   GO:2001054   GO:1904339   GO:0030901   GO:0031012   GO:0007398   GO:0030336   GO:0030878   GO:0060447   GO:0003140   GO:0042307   GO:0030010   GO:0035115   GO:0042481   GO:0021938   GO:0034244   GO:0060484   GO:0048643   GO:0043588   GO:0048557   GO:0060439   GO:1905327   GO:0045059   GO:0060021   GO:0090090   GO:0007442   GO:0042130   GO:0043369   GO:0045445   GO:0051781   GO:0048839   GO:0034504   GO:0072136   GO:0060840   GO:0002076   GO:0021522   GO:0048714   GO:0001947   GO:0021904   GO:0045060   GO:0021930   GO:2000062   GO:0001569   GO:2000729   GO:0006508   GO:0005685   GO:0003677   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11889:SF39  

Subcellular location

Cell membrane   The N-terminal peptide remains associated with the cell surface.   With evidence from 1 publications.
   The C-terminal peptide diffuses from the cell.   With evidence from 1 publications.

Length:

435

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.24550000000001

Exp number, first 60 AAs:

0.5049

Total prob of N-in:

0.10660

outside

1  -  435

 

 

Pi

212.435251

Theta

184.591793

Tajima's D

0.64625

CLR

0.467407

CSRT

0.557322133893305

Interpretation

Uncertain