Gene

KWMTBOMO05017  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012577

Annotation

PREDICTED:_probable_E3_ubiquitin-protein_ligase_HERC4_[Bombyx_mori]

Location

Bomo_Chr9(-):5654942-5674897      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 2.325

CDS

ATGTTTTGTTGGGGCAATGCAACTCATCATGAACTGTGCATCGACGGTTCACAAATAACTGATTTGGTTATCAAGCCCACATTATCAAAATGGAAAGAAAGTGATCACATACAAGCAGTAGCAGCTGGCGAATTCCATAGCTTATACCTCTCAAACAGTGGTCATTTATATTCATGTGGAAATAATGATGTGGGTCAGTTAGGACGTCAAACTGAATCTGACAATGGAAAGAATCCAGCTTTAGTGGAAACATTTAAAGACTGCACAATATCGACAATAGCATGTGGCCTTCAACATTCTTTAGCTATAGATGAATGGGGGCAGCCTTTCAGTTGGGGCTCTGACAGTATGGGGCAACTTGGCAATAACCTTGGCGCTCATGCTCAGGACAAACCTAAATTTGTCAAAGGGTTAGCAACCAAAAATGTAATACAAGTAGCTTGTGGAGCCTATCATTCTGTGGCATTAACAAACAGTGGTGATCTCTACTCATGGGGTGCAAATAGTTATGGACAATGTGGTTTAGGAACTATATCAAACAAGGAAATGTCACCTCAACACATTTCATCATTAATTGGTGTACCTATTGCCTTAATAGCATGTGGCAATAACCATACATTTGTGCTATCAAAATCAGGTGCGGTTTTTGGATGGGGTAAAAACACTCATGGACAACTTGGTCTTCAAGACGTTGAAAACAAATGCTATCCCACTCACCTAAAAACATTGAGAAATGTGAAGGTATGTCACATAGCGTGTGGTGAAGATTTCACTGTTTTCTTGACATTGGACGGTGGTGTGTTCACATGTGGAACTGGTGAATACGGGCAGACTGGACATGGTACGACTAGAGATGAGCTTGTTCCAAGAAAGATTGTCGAGCTGATGGGCAGTACAGTGACGCAGATAGCGTGCGGACGACGGCACTTGCTGTGTCGCGTCGGCGAGCGAATCCTGGCTTGCGGTTACGGAGCGCGAGGTCAACTTGGCTGTCCGCACATGGCGTTCGCGCTGGTCCCGACACCTGTACCGTTCACACCCAACGACGAATCTCCGTTTTCACCTGAAATCTTCAAGGGTCCGATTAAAGTGTTCGCGGGAGGTGACCACAGCTTCGTGGTATTGAAAGGCGACAAGTCCGGGCCGGTCGACTACCGCACTCCGGACCACAGGAAGCAAATACTCACGCTCACTCTACCGAAGCTAGCCGCGTGTCAAGTCTTCAAAGATAAAGATTTCGTTAATCAGGATTTAATGGCGTACTTAGAGACGGTGTTCGGTTCGCTGGCGTGTGTGAACGCGTCCTTCCTGCTGCCGAGCAACGGACACTACTGTTGCAACACCAAAATGCCGGGCGTCGACCTTAGCAAAGCCGAGGAGGCGTTCTCGTTGATCAGCCGATTCGAAAACACGTCCATCAAGGAACTAATATTCAGTCACTTAACGGATAATATAATTAAGAAAATGAAGCCCTCTCCACCGGATGCTGAAGCTCTAAGAATGTTTCTAATATTACCGCTATATCACGAGATGAGAAATCCCAGACGCCATACCCAGCTACAGGGTCCCTTTGCTGAAGCCTTCAACAACTTGTCTACTCATCCTCAAAAAATAGTCAACTTATGGTGGGAGGCGCAGACGACGGAGTACTTTGAGATGCTCGTAGATATATTCAAAAGCGTCGTTGTGTACGAACTTATGCAGCCTGTAGTTAGATCGACTAAGAAAGTGCAATTCAAACACAGCACCGTACAGATATTGAACACGTTGTCGTCGCTGAACAAGATCAACTTCACGAACCCGAAGCTACCTAAAATACCGGCTGAATGTTTCTACATAGAGGACTTGTGTGATCACGTTGACATCGCTTCTGATTATATTAACTGGTTGTCGGACCAAACTTCTACCCAGACGCACATGTGCAATTACGCTTTCCTGTTCGACGTCCAATGCAAGTCGTTGCTGCTGAAGATCGATCAGCAGCTACAAATGCAGATCGCCATAAGCAGGGCCACCACGCAAATCTTCACGAGGCTCTTCATGGATCCGACCTACGAGTATCAGAGGGATCAGTTCCTCAACCTGACCGTCTCGAGGAACCATATCGTCAGGGACACCATGCTGCAGATAAGCAACCATGACACTTCACAACTGAAGAAACCGCTCAGAGTCGAGTTTATTGGCGAAGAAGCGGAAGATGCCGGTGGCGTTAAAAAAGAATTCTTCATGCTACTGCTCAAGGAAATATTTGATCCCGTATACGGTATGTTCAAGCAATCCGAGGAGACGAACATGATTTGGTTTTCAAATAATCCATTCGAAGATGACGTCATGTATTATGTGATTGGGGCCATTTACGGACTTGCCATATACAATTCGATTATTATATACGTTCCGTTCCCGTTAGTTTTGTATAAGAAAATTCTCGGCGAATCTGTTATGATGGACGATTTGTCAGATTTGTATCCAACGTTAGCCAATAGTTTGAAAAGTTTATTGGAATATACAGACGATGACGTAGAGGAGGTGTTCGGACTGTGTTTCGCCGTGAACACTGAAGTGTTTGATCAAATACAAGTGAATCCACTGAAAGAGGACGGAGAGAATATACCTGTGACGCGCGAAAATAAAGCCGAATACGTTGAGTTGTACGTGGACTTTTTGCTCAATAAATCTGTGGAGAATCAATTTAAAGCTTTCAATCAAGGTTTCCAGAAGGTGTGCGGGGGTAGAATAATAAAGCTGTTTAGATCTCACGAATTGATGTCCGTTGTCATCGGAAACGAGGAGTACGACTGGGAAATGTTTCAGAACAATTGTGAATACAAGAATGGATACTCTGAAACTGATCAACAAATCAGATGGTTCTGGGAAACGTTCCACGAGCTGCCGCTTGAAGATAAGAAGAAATTTTTGCTTTTCTTAACCGGCAGCGATCGTGTTCCGATACAAGGAATGAGGGACATTAAAATAAGAATTCAACCAGTGGCAGACGACAGGTTCTTCCCGGTGGCCCACACTTGCTTCAATCTTCTAGATCTCCCGCGTTACAAGACTAAAGAGAGGCTCAAGTATTATCTTCTGCAGGCCATTCAGCAGACGCAGGGCTTCTCGCTGGTCTGA

Protein

MFCWGNATHHELCIDGSQITDLVIKPTLSKWKESDHIQAVAAGEFHSLYLSNSGHLYSCGNNDVGQLGRQTESDNGKNPALVETFKDCTISTIACGLQHSLAIDEWGQPFSWGSDSMGQLGNNLGAHAQDKPKFVKGLATKNVIQVACGAYHSVALTNSGDLYSWGANSYGQCGLGTISNKEMSPQHISSLIGVPIALIACGNNHTFVLSKSGAVFGWGKNTHGQLGLQDVENKCYPTHLKTLRNVKVCHIACGEDFTVFLTLDGGVFTCGTGEYGQTGHGTTRDELVPRKIVELMGSTVTQIACGRRHLLCRVGERILACGYGARGQLGCPHMAFALVPTPVPFTPNDESPFSPEIFKGPIKVFAGGDHSFVVLKGDKSGPVDYRTPDHRKQILTLTLPKLAACQVFKDKDFVNQDLMAYLETVFGSLACVNASFLLPSNGHYCCNTKMPGVDLSKAEEAFSLISRFENTSIKELIFSHLTDNIIKKMKPSPPDAEALRMFLILPLYHEMRNPRRHTQLQGPFAEAFNNLSTHPQKIVNLWWEAQTTEYFEMLVDIFKSVVVYELMQPVVRSTKKVQFKHSTVQILNTLSSLNKINFTNPKLPKIPAECFYIEDLCDHVDIASDYINWLSDQTSTQTHMCNYAFLFDVQCKSLLLKIDQQLQMQIAISRATTQIFTRLFMDPTYEYQRDQFLNLTVSRNHIVRDTMLQISNHDTSQLKKPLRVEFIGEEAEDAGGVKKEFFMLLLKEIFDPVYGMFKQSEETNMIWFSNNPFEDDVMYYVIGAIYGLAIYNSIIIYVPFPLVLYKKILGESVMMDDLSDLYPTLANSLKSLLEYTDDDVEEVFGLCFAVNTEVFDQIQVNPLKEDGENIPVTRENKAEYVELYVDFLLNKSVENQFKAFNQGFQKVCGGRIIKLFRSHELMSVVIGNEEYDWEMFQNNCEYKNGYSETDQQIRWFWETFHELPLEDKKKFLLFLTGSDRVPIQGMRDIKIRIQPVADDRFFPVAHTCFNLLDLPRYKTKERLKYYLLQAIQQTQGFSLV

Uniprot

H9JSR6   A0A2A4J1M4   A0A212EVR6   A0A0N1PGC6   A0A3S2P7H9   A0A194QKY1   + More
A0A1W4X5Q9   D6W9I3   A0A2J7Q0N6   A0A1Y1NCD0   A0A2J7Q0N2   A0A1Y1NEM8   A0A067QLX8   E0VG83   A0A182V393   A0A182R9U6   A0A182P132   A0A2C9GS90   Q7PT00   A7URT7   A0A1B6FXJ2   A0A1B6ECJ7   A0A0K8SYD2   A0A0K8SYP3   A0A182Y317   A0A0K8SYD6   A0A1B6ME28   A0A1B6L8H2   A0A1Q3F9M7   A0A1B6G8R1   A0A1Q3F9S7   E2C7G3   A0A224XIS4   A0A182M4V1   A0A023F3C0   A0A182JTG2   A0A1B6KL25   B0X7X1   A0A1B6KIM6   A0A151JBP9   A0A0P4VZS4   A0A182ILN7   A0A084WRP8   A0A2M4AHB6   A0A182WWM0   A0A0V0G4T3   A0A182FGC0   E2AGG4   A0A2M4AHL9   A0A158NRC6   T1IG46   A0A182WHX5   F4WB37   A0A2M4CYM4   A0A1A9V478   A0A195FJJ8   A0A1I8PEI6   W5JA25   A0A088A9B2   A0A2A3EG75   A0A0J7KIS1   A0A151XF13   Q178R9   A0A151IFJ4   A0A1I8MYV6   A0A1I8PEQ1   A0A1I8MYV4   A0A182N9R9   A0A1Y1NBS2   A0A0L7RJK0   A0A336LTB2   A0A0K8V8N7   A0A1A9WLI1   K7JBL0   A0A1B6DL92   A0A0L0BV94   W8B7F6   A0A0C9QA00   A0A0C9R532   A0A232EEZ9   A0A034VTP6   A0A026WFJ0   A0A2J7Q0R0   B4N542   A0A0M9A7M4   A0A1L8DT79   B4L0N9   A0A2R7WA38   A0A0Q9XLF7   A0A0M4E846   A0A0Q9XNC5   B4LG71   A0A1W4W7A3   A0A0Q9WI37   A0A154PMR7   B4PD71   A0A1W4W6F3   A0A195BFI9   A0A0R1DU99  

Pubmed

19121390    22118469    26354079    18362917    19820115    28004739    + More
24845553    20566863    12364791    14747013    17210077    25244985    26823975    20798317    25474469    27129103    24438588    21347285    21719571    20920257    23761445    17510324    25315136    20075255    26108605    24495485    28648823    25348373    24508170    17994087    17550304   

EMBL

BABH01032256    NWSH01004216    PCG65340.1    AGBW02012137    OWR45576.1    KQ458665    + More
KPJ05602.1    RSAL01000238    RVE43700.1    KQ461198    KPJ06054.1    KQ971312    EEZ98497.1    NEVH01019964    PNF22147.1    GEZM01007124    JAV95359.1    PNF22148.1    GEZM01007123    JAV95360.1    KK853169    KDR10359.1    DS235132    EEB12389.1    APCN01003701    AAAB01008807    EAA04764.5    EDO64729.1    GECZ01014863    JAS54906.1    GEDC01001646    JAS35652.1    GBRD01007524    JAG58297.1    GBRD01007525    JAG58296.1    GBRD01007523    GDHC01021356    JAG58298.1    JAP97272.1    GEBQ01029421    GEBQ01005817    JAT10556.1    JAT34160.1    GEBQ01030074    GEBQ01019968    JAT09903.1    JAT20009.1    GFDL01010764    JAV24281.1    GECZ01010934    JAS58835.1    GFDL01010772    JAV24273.1    GL453369    EFN76150.1    GFTR01008485    JAW07941.1    AXCM01000491    GBBI01003006    JAC15706.1    GEBQ01027834    GEBQ01024072    JAT12143.1    JAT15905.1    DS232468    EDS42190.1    GEBQ01028684    GEBQ01016358    JAT11293.1    JAT23619.1    KQ979122    KYN22546.1    GDKW01000508    JAI56087.1    ATLV01026175    KE525407    KFB52892.1    GGFK01006865    MBW40186.1    GECL01003067    JAP03057.1    GL439310    EFN67497.1    GGFK01006950    MBW40271.1    ADTU01023875    ADTU01023876    ACPB03002682    GL888056    EGI68592.1    GGFL01006123    MBW70301.1    KQ981522    KYN40541.1    ADMH02002070    ETN59614.1    KZ288259    PBC30484.1    LBMM01006983    KMQ90144.1    KQ982205    KYQ58984.1    CH477360    EAT42672.1    KQ977771    KYM99968.1    GEZM01007122    JAV95361.1    KQ414580    KOC71050.1    UFQT01000185    SSX21266.1    GDHF01017062    JAI35252.1    AAZX01008745    GEDC01010890    JAS26408.1    JRES01001407    KNC23164.1    GAMC01009425    JAB97130.1    GBYB01011228    JAG80995.1    GBYB01001956    JAG71723.1    NNAY01005177    OXU16925.1    GAKP01012276    JAC46676.1    KK107238    EZA54688.1    PNF22146.1    CH964101    EDW79481.1    KQ435729    KOX77583.1    GFDF01004415    JAV09669.1    CH933809    EDW18116.1    KK854520    PTY16542.1    KRG05986.1    CP012525    ALC42991.1    KRG05985.1    CH940647    EDW69379.1    KRF84349.1    KQ434984    KZC13149.1    CM000159    EDW92819.1    KQ976504    KYM82935.1    KRK00728.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000283053    UP000053240    + More
UP000192223    UP000007266    UP000235965    UP000027135    UP000009046    UP000075903    UP000075900    UP000075885    UP000075840    UP000007062    UP000076408    UP000008237    UP000075883    UP000075881    UP000002320    UP000078492    UP000075880    UP000030765    UP000076407    UP000069272    UP000000311    UP000005205    UP000015103    UP000075920    UP000007755    UP000078200    UP000078541    UP000095300    UP000000673    UP000005203    UP000242457    UP000036403    UP000075809    UP000008820    UP000078542    UP000095301    UP000075884    UP000053825    UP000091820    UP000002358    UP000037069    UP000215335    UP000053097    UP000007798    UP000053105    UP000009192    UP000092553    UP000008792    UP000192221    UP000076502    UP000002282    UP000078540   

PRIDE

H9JSR6   

Pfam

PF00632   HECT        + More
PF00415   RCC1
PF00781   DAGK_cat

Interpro

IPR035983   Hect_E3_ubiquitin_ligase        + More
IPR000408   Reg_chr_condens       
IPR000569   HECT_dom       
IPR009091   RCC1/BLIP-II       
IPR016064   NAD/diacylglycerol_kinase_sf       
IPR001206   Diacylglycerol_kinase_cat_dom       
IPR017438   ATP-NAD_kinase_N       

SUPFAM

SSF50985   SSF50985        + More
SSF56204   SSF56204       
SSF111331   SSF111331       

Gene 3D

2.130.10.30     3.40.50.10330    

CDD

cd00078  HECTc

ProteinModelPortal

H9JSR6   A0A2A4J1M4   A0A212EVR6   A0A0N1PGC6   A0A3S2P7H9   A0A194QKY1   + More
A0A1W4X5Q9   D6W9I3   A0A2J7Q0N6   A0A1Y1NCD0   A0A2J7Q0N2   A0A1Y1NEM8   A0A067QLX8   E0VG83   A0A182V393   A0A182R9U6   A0A182P132   A0A2C9GS90   Q7PT00   A7URT7   A0A1B6FXJ2   A0A1B6ECJ7   A0A0K8SYD2   A0A0K8SYP3   A0A182Y317   A0A0K8SYD6   A0A1B6ME28   A0A1B6L8H2   A0A1Q3F9M7   A0A1B6G8R1   A0A1Q3F9S7   E2C7G3   A0A224XIS4   A0A182M4V1   A0A023F3C0   A0A182JTG2   A0A1B6KL25   B0X7X1   A0A1B6KIM6   A0A151JBP9   A0A0P4VZS4   A0A182ILN7   A0A084WRP8   A0A2M4AHB6   A0A182WWM0   A0A0V0G4T3   A0A182FGC0   E2AGG4   A0A2M4AHL9   A0A158NRC6   T1IG46   A0A182WHX5   F4WB37   A0A2M4CYM4   A0A1A9V478   A0A195FJJ8   A0A1I8PEI6   W5JA25   A0A088A9B2   A0A2A3EG75   A0A0J7KIS1   A0A151XF13   Q178R9   A0A151IFJ4   A0A1I8MYV6   A0A1I8PEQ1   A0A1I8MYV4   A0A182N9R9   A0A1Y1NBS2   A0A0L7RJK0   A0A336LTB2   A0A0K8V8N7   A0A1A9WLI1   K7JBL0   A0A1B6DL92   A0A0L0BV94   W8B7F6   A0A0C9QA00   A0A0C9R532   A0A232EEZ9   A0A034VTP6   A0A026WFJ0   A0A2J7Q0R0   B4N542   A0A0M9A7M4   A0A1L8DT79   B4L0N9   A0A2R7WA38   A0A0Q9XLF7   A0A0M4E846   A0A0Q9XNC5   B4LG71   A0A1W4W7A3   A0A0Q9WI37   A0A154PMR7   B4PD71   A0A1W4W6F3   A0A195BFI9   A0A0R1DU99  

PDB

1D5F     E-value=4.88996e-78,     Score=745

KEGG

101735782    K10615 E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26] | (RefSeq) probable E3 ubiquitin-protein liga

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0004842   GO:0016874   GO:0016740   GO:0003951   GO:0009898   GO:0051865   GO:0006511   GO:0035331   GO:0061630   GO:0045752   GO:0000209   GO:0045087   GO:1903078   GO:0002225   GO:0006241   GO:0006221   GO:0000387   GO:0000398   GO:0005685   GO:0003677   GO:0005515   GO:0016742   GO:0003824  

Length:

1040

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.70462

Exp number, first 60 AAs:

0.00023

Total prob of N-in:

0.01755

outside

1  -  782

TMhelix

783  -  805

inside

806  -  1040

 

 

Pi

251.710433

Theta

171.263096

Tajima's D

1.492414

CLR

0.350527

CSRT

0.784210789460527

Interpretation

Uncertain