Gene

KWMTBOMO05011  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008117

Annotation

PREDICTED:_vacuolar_protein_sorting-associated_protein_13C_[Bombyx_mori]

Location

Bomo_Chr9(+):5453511-5468986      View in EpiBrowser

Full name

Angiotensin-converting enzyme       + More
Vacuolar protein sorting-associated protein 13      

Location in the cell

Cytoplasmic   Reliability : 3.024

CDS

ATGGTATTTGAGTCTATTGTGGTTGATGTCCTGAACAGATTCCTCGGTGATTATGTAGAGAATTTGAACAGATCACAGTTAAAATTCGGAATATGGGGCGGGGATGTTGTTTTGGAGAATCTGGTACTAAAACAGAATGCTTTGGAGGAGCTGAACATTCCTGTGCAAACAGTTTATGGACATTTGGGTAAACTTGTCCTCAAAATACCGTGGAAGAATCTGTATGGTGCATCAGTGGAAGCTACTATTGAACGACTTTTTTTGATTGTCAATCCATCTGCTGAAGTAAAGTATGATGCTGATAAAGAAGAGAAAATGGCTCTGTCAGCAAAGCAAGCAGAGCTTAGGAGAGTCGAAGAGGCAAAGAAGAAAGAGGCAGAAAAAGATCAAAATAAACTCGACGAGACCTTCGTCGAGAAATTGGTAACGCAAATTATTAAAAATGTTCAATTGAAGATTACCGACATTCACATTAGATACGAAGATAGCATAACCAATCCGAAGACGCCATTTTCTTTCGGTATCACCCTCCACAATCTGTCCGTCCATACCACCGATGAGAACTGGAAAAAGGCTGTTATACAAGAAGCCGTAACAAAAATCTTTAAGATTTTAGATTTAGAAGGTCTGGCGATATACTGGAATCCAAAAACCGATTTATATTCCAAATGCGGCCCCCAAGAAATCAAATCAAAGTTGGAACAAGAAATCGCTACGAAATCATCAAAACCCAGCTTCTATAATTATGCTCTCGGACCAATAAATGCGACCGCGAAACTCAAACTCAATCCAAAGCCTGAAGGTGACACCCCTAAGTTTAGCATCCCCAAAGTGATTTTGGATCTTCACATGGAACAATTGTCTGTAAATTTGAACAAAGCACAGTACCAAGATATGATGCTGCTGGCTGACTCGATGGACAGAATGAGCAAAGGAGCCCCTTACAGGAAATACCGTCCAGACCTAAAATCATTCAGAGGTCACTATAAAGAATGGTGGCATTTTGCTTATAATTGCATTCTCGAAGAAGAAGTTCGCCGTCGCCGTAGAAACTGGAAATGGTCTCATATGTTAGCTCATAGGCAGCTGTGTAAGGATTACGCATCGGCGTATCAAAGCAAGTTGATCAACAAGGGGAAAATATCGCCAGAGCAACAGGCTCTAGTGGAAAAAGCCGAAAAACATTTGGACTTGTTGAATTTGGTTGTTATCAGACAGAGGATTGAATTAGAGGTGGAGCGTCTTGGTAAACTACAACAGGAAGCGAAGAAATCTAAAGGCTGGTTCGGTGGGTGGTGGTCCGGTAGCAGCACCAAGGATGACGAAACTACCGATGGAACCGCGATAATGAAACAATTCGAGAAGGCGATGACTTCAGAGGAAAAGGAGAAACTGTTCCGTGCCATAGATTACCAGGAGAATACTGCTCCTCTGCATCTGCCCGTTGAATACGTGGCCATCGAGGGGCGTTTCAAACTTGATAGATTACAAGTCGCCGTCAACGACGTGGCCGAGGTTTTGAAGGCGTGTGTCGATAATGTTGAGGTCGATATGAAGCAACGGCCCAGCGCCAACGCTTTGAGGTTGGACATACAAATGCAAAGCTTTAGTGTGACCGGTGTTCAACAAGACGAGTTTCTTCCGAAACTAGTAACATCGAAGGAAGTCACAAACGATGTCAATTTATTGAATGTCGTATTTGAAACTAATCCCTTGGATGGTGCTTGTGATCAACGAGTGAAAGTGTCCGCCAAGCCACTACAGATTGTTTACGATGCCCAAACTGTTATCGAAATAGTTAATGTGTTTAAACCACCCACCGAATCTACAGCTTTAACTACGTGA

Protein

MVFESIVVDVLNRFLGDYVENLNRSQLKFGIWGGDVVLENLVLKQNALEELNIPVQTVYGHLGKLVLKIPWKNLYGASVEATIERLFLIVNPSAEVKYDADKEEKMALSAKQAELRRVEEAKKKEAEKDQNKLDETFVEKLVTQIIKNVQLKITDIHIRYEDSITNPKTPFSFGITLHNLSVHTTDENWKKAVIQEAVTKIFKILDLEGLAIYWNPKTDLYSKCGPQEIKSKLEQEIATKSSKPSFYNYALGPINATAKLKLNPKPEGDTPKFSIPKVILDLHMEQLSVNLNKAQYQDMMLLADSMDRMSKGAPYRKYRPDLKSFRGHYKEWWHFAYNCILEEEVRRRRRNWKWSHMLAHRQLCKDYASAYQSKLINKGKISPEQQALVEKAEKHLDLLNLVVIRQRIELEVERLGKLQQEAKKSKGWFGGWWSGSSTKDDETTDGTAIMKQFEKAMTSEEKEKLFRAIDYQENTAPLHLPVEYVAIEGRFKLDRLQVAVNDVAEVLKACVDNVEVDMKQRPSANALRLDIQMQSFSVTGVQQDEFLPKLVTSKEVTNDVNLLNVVFETNPLDGACDQRVKVSAKPLQIVYDAQTVIEIVNVFKPPTESTALTT

Description

Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system. May function as part of a lysosomal degradation pathway.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M2 family.
Belongs to the VPS13 family.

Keywords

Complete proteome   Endosome   Membrane   Protein transport   Reference proteome   Transport  

Feature

chain  Angiotensin-converting enzyme

Uniprot

H9JF20   A0A0N0PAP2   A0A3S2LSU5   A0A194QM57   A0A2A4JAS4   A0A2J7PX54   + More
A0A067RTP5   A0A2P8Y000   D6WCW1   A0A182NLZ6   A0A1Y1M0H6   A0A182X4A3   A0A1Q3FGD3   A0A182QNC8   A0A182VBQ3   A0A1Q3FGM4   A0A182HPA7   A0A182YFP8   A0A182RA29   A0A182MPK1   A0A182JW81   A0A182WB65   A0A1B6CUA0   A0A182LB90   A0A0P6JRN7   A0A1B0DB55   V5GY02   A0A182FL84   A0A0J7KFM8   A0A182G3T1   W5J689   A0A2H8TP76   A0A2M4CVW7   A0A2H8TPG9   A0A034UZL6   A0A0K8U502   A0A0K8U197   J9K7I7   W8AJ52   A0A1L8DVL7   E1ZV01   A0A232F955   A0A0A1WPJ5   A0A0N0BCF1   A0A310S5Y6   A0A0L7RCF4   B3MHR1   A0A0P8XPG8   A0A1J1ITZ1   A0A069DYI3   A0A224XG50   A0A2A3EL42   A0A087ZQS4   B3N9W8   A0A154PLH2   T1J4H6   A0A195CYF9   A0A1B6LDL1   A0A1B6KWT9   B4MIP9   A0A336L615   A0A3L8DLF8   A0A0T6BDC0   A0A1B6F8B5   A0A1B6F435   A0A158NM97   K7IXV4   A0A151JY96   A0A151JQF4   A0A182TV09   A0A3Q0IN20   A0A0J9R7H7   A1Z713   E2B476   B4P1S0   A0A3B0J6P6   A0A3B0J766   A0A1B6HNH7   A0A195B550   B4LJ91   A0A1W4UZM7   Q28YJ6   A0A0L0C3R9   A0A182IQ42   B4J7Y5   A0A182PLD4   A0A026WHS8   T1HV00   A0A0M4EAE9   T1P7V0   A0A1I8NHV4   A0A1I8PU10   A0A1B0CQG7   W4XCY0   B4KPQ2   A0A0V1E0W9   A0A0V1MIN1   A0A2C9LLG7  

EC Number

3.4.-.-

Pubmed

19121390    26354079    24845553    29403074    18362917    19820115    + More
28004739    25244985    20966253    26999592    26483478    20920257    23761445    25348373    24495485    20798317    28648823    25830018    17994087    18057021    26334808    30249741    21347285    20075255    22936249    10731132    12537572    28107480    17550304    15632085    26108605    24508170    25315136    15562597   

EMBL

BABH01033962    BABH01033963    BABH01033964    BABH01033965    BABH01033966    BABH01033967    + More
KQ458665    KPJ05606.1    RSAL01000238    RVE43697.1    KQ461198    KPJ06050.1    NWSH01002177    PCG68959.1    NEVH01020861    PNF20916.1    KK852470    KDR23219.1    PYGN01001102    PSN37570.1    KQ971311    EEZ98831.2    GEZM01043725    JAV78881.1    GFDL01008441    JAV26604.1    AXCN02000957    GFDL01008393    JAV26652.1    APCN01002939    AXCM01006669    GEDC01020311    JAS16987.1    GDUN01001099    JAN94820.1    AJVK01000756    AJVK01000757    AJVK01000758    AJVK01000759    AJVK01000760    GALX01003208    JAB65258.1    LBMM01008239    KMQ89031.1    JXUM01007029    JXUM01007030    KQ560229    KXJ83724.1    ADMH02002077    ETN59516.1    GFXV01003995    MBW15800.1    GGFL01005306    MBW69484.1    GFXV01003333    MBW15138.1    GAKP01022491    JAC36461.1    GDHF01030653    JAI21661.1    GDHF01032284    GDHF01032031    GDHF01022201    GDHF01021484    JAI20030.1    JAI20283.1    JAI30113.1    JAI30830.1    ABLF02021408    ABLF02021409    GAMC01020799    GAMC01020798    GAMC01020797    GAMC01020796    JAB85757.1    GFDF01003625    JAV10459.1    GL434335    EFN74999.1    NNAY01000686    OXU26973.1    GBXI01013984    JAD00308.1    KQ435911    KOX68931.1    KQ769179    OAD52957.1    KQ414616    KOC68416.1    CH902619    EDV36898.1    KPU76493.1    KPU76494.1    CVRI01000059    CRL03731.1    GBGD01000007    JAC88882.1    GFTR01008996    JAW07430.1    KZ288226    PBC31869.1    CH954177    EDV59664.2    KQ434960    KZC12683.1    JH431845    KQ977171    KYN05179.1    GEBQ01018189    JAT21788.1    GEBQ01024054    JAT15923.1    CH963719    EDW71988.1    UFQS01001985    UFQT01001985    SSX12864.1    SSX32306.1    QOIP01000007    RLU20668.1    LJIG01001609    KRT85331.1    GECZ01023287    JAS46482.1    GECZ01024835    JAS44934.1    ADTU01020182    ADTU01020183    KQ981561    KYN39826.1    KQ978684    KYN29306.1    CM002911    KMY92020.1    KMY92021.1    AE013599    GL445515    EFN89493.1    CM000157    EDW89206.2    KRJ98276.1    OUUW01000001    SPP75723.1    SPP75722.1    GECU01031474    JAS76232.1    KQ976604    KYM79405.1    CH940648    EDW61527.1    CM000071    EAL25969.3    JRES01001012    KNC26144.1    CH916367    EDW02215.1    KK107238    EZA54619.1    ACPB03002125    ACPB03002126    CP012524    ALC42034.1    KA644701    AFP59330.1    AJWK01023508    AJWK01023509    AAGJ04008378    AAGJ04008379    AAGJ04008380    CH933808    EDW09162.2    JYDR01000139    KRY67388.1    JYDO01000096    KRZ71455.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000053240    UP000218220    UP000235965    + More
UP000027135    UP000245037    UP000007266    UP000075884    UP000076407    UP000075886    UP000075903    UP000075840    UP000076408    UP000075900    UP000075883    UP000075881    UP000075920    UP000075882    UP000092462    UP000069272    UP000036403    UP000069940    UP000249989    UP000000673    UP000007819    UP000000311    UP000215335    UP000053105    UP000053825    UP000007801    UP000183832    UP000242457    UP000005203    UP000008711    UP000076502    UP000078542    UP000007798    UP000279307    UP000005205    UP000002358    UP000078541    UP000078492    UP000075902    UP000079169    UP000000803    UP000008237    UP000002282    UP000268350    UP000078540    UP000008792    UP000192221    UP000001819    UP000037069    UP000075880    UP000001070    UP000075885    UP000053097    UP000015103    UP000092553    UP000095301    UP000095300    UP000092461    UP000007110    UP000009192    UP000054632    UP000054843    UP000076420   

PRIDE

H9JF20    A1Z713   

Pfam

PF12624   Chorein_N        + More
PF06650   SHR-BD
PF16909   VPS13_C
PF16910   VPS13_mid_rpt
PF16908   VPS13
PF09333   ATG_C
PF01027   Bax1-I
PF01401   Peptidase_M2

Interpro

IPR031645   VPS13_C        + More
IPR031642   VPS13_mid_rpt       
IPR031646   VPS13_N2       
IPR026854   VPS13_N       
IPR009543   SHR-BD       
IPR026847   VPS13       
IPR015412   Autophagy-rel_C       
IPR006214   Bax_inhibitor_1-related       
IPR001548   Peptidase_M2       

CDD

cd06461  M2_ACE

ProteinModelPortal

H9JF20   A0A0N0PAP2   A0A3S2LSU5   A0A194QM57   A0A2A4JAS4   A0A2J7PX54   + More
A0A067RTP5   A0A2P8Y000   D6WCW1   A0A182NLZ6   A0A1Y1M0H6   A0A182X4A3   A0A1Q3FGD3   A0A182QNC8   A0A182VBQ3   A0A1Q3FGM4   A0A182HPA7   A0A182YFP8   A0A182RA29   A0A182MPK1   A0A182JW81   A0A182WB65   A0A1B6CUA0   A0A182LB90   A0A0P6JRN7   A0A1B0DB55   V5GY02   A0A182FL84   A0A0J7KFM8   A0A182G3T1   W5J689   A0A2H8TP76   A0A2M4CVW7   A0A2H8TPG9   A0A034UZL6   A0A0K8U502   A0A0K8U197   J9K7I7   W8AJ52   A0A1L8DVL7   E1ZV01   A0A232F955   A0A0A1WPJ5   A0A0N0BCF1   A0A310S5Y6   A0A0L7RCF4   B3MHR1   A0A0P8XPG8   A0A1J1ITZ1   A0A069DYI3   A0A224XG50   A0A2A3EL42   A0A087ZQS4   B3N9W8   A0A154PLH2   T1J4H6   A0A195CYF9   A0A1B6LDL1   A0A1B6KWT9   B4MIP9   A0A336L615   A0A3L8DLF8   A0A0T6BDC0   A0A1B6F8B5   A0A1B6F435   A0A158NM97   K7IXV4   A0A151JY96   A0A151JQF4   A0A182TV09   A0A3Q0IN20   A0A0J9R7H7   A1Z713   E2B476   B4P1S0   A0A3B0J6P6   A0A3B0J766   A0A1B6HNH7   A0A195B550   B4LJ91   A0A1W4UZM7   Q28YJ6   A0A0L0C3R9   A0A182IQ42   B4J7Y5   A0A182PLD4   A0A026WHS8   T1HV00   A0A0M4EAE9   T1P7V0   A0A1I8NHV4   A0A1I8PU10   A0A1B0CQG7   W4XCY0   B4KPQ2   A0A0V1E0W9   A0A0V1MIN1   A0A2C9LLG7  

PDB

6CBC     E-value=1.86364e-44,     Score=453

KEGG

101737991    K19525 vacuolar protein sorting-associated protein 13A/C | (RefSeq) vacuolar protein sorting-associa

GO

GO:0005623   GO:0019898   GO:0045053   GO:0006623   GO:0019538   GO:0031902   GO:0016021   GO:0008237   GO:0004180   GO:0046872  

PANTHER

PTHR16166   PTHR10514  

Subcellular location

Late endosome membrane  

Length:

614

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00016

Exp number, first 60 AAs:

0.0001

Total prob of N-in:

0.00023

outside

1  -  614

 

 

Pi

255.960942

Theta

185.517674

Tajima's D

1.321189

CLR

0

CSRT

0.741662916854157

Interpretation

Uncertain