SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05010  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA008116
Annotation
PREDICTED:_CTP_synthase_[Amyelois_transitella]
Full name
CTP synthase       + More
Multifunctional fusion protein      
Alternative Name
UTP--ammonia ligase
CTP synthetase
Location in the cell
Cytoplasmic   Reliability : 2.269
 

Sequence

CDS
ATGCCGGATATGAAATATATTCTTGTGACTGGTGGCGTTATAAGTGGTGTTGGAAAAGGTGTAATCGCAAGTTCTTTTGGCACAATCTTAAAAAGCTGCGGTATTGATGTAACTTCTATCAAAATCGATCCGTATATCAATATAGATGCAGGAACGTTTTCTCCCTACGAGCACGGTGAAGTGTATGTCTTAGATGACGGTGGCGAAGTTGACCTTGATCTTGGCAATTATGAGCGCTTCTTGGACATAACTCTGCATAGAGATAATAATATAACAACGGGAAAGATTTATCAACAGGTTATAGAACGAGAGAGAAGAGGAGATTATTTAGGAAAAACTGTTCAAGTTATCCCACACATTACTGATGCTATCCAAGAATGGGTACAGAGAGTCGCACATATTCCGGTGACATCAAATAATGCACCTCCTAGAGTGTGTATAATAGAGCTTGGTGGCACAATAGGTGACATAGAAGGAATGTCATTTGTAGAGGCATTTAGACAATTTCAATTCCGTGTGAAGAGAGAAAACTTTTGCTGTGCTCATGTGTCTTTAGTGCCAATGCCCAAATCAACTGGGGAACCTAAAACGAAACCTACACAATCATCAGTCAGAGAGTTGAGAGGCCTGGGCTTGTCACCAGATTTGATCCTGTGTCGCTCTGAAAAGCCCATTAATCATAATGTGAAAGAGAAAATATCAAACTTTTGCCATGTTGCTCCAGAACAGGTTATATGCATTCATGATTTGACTTCGGTTTACCATGTACCGCTGCTAATGGAAGCACAAGGAGTTGTCCAATATCTGAATGAGAGATTGATACTCAATATATCAATGCCTAGACCAAGCAGATTCATGCGTAAGTGGCGTAATCTAGCTAAACGAGTAGACAATTTGCGTAAAGAGGTAAATATAGCACTTGTAGGAAAATACACAAAACTTGAAGACAGCTATGCCAGTGTCACTAAAGCATTACAGCATTCATGCATTGCAACTGGATGTAAACTGAATCTCACATACATTGAAGCTGTTAATTTGGAGAAACAGATGAAAATCGATGATCCTGTAAACTACCATAAAGCTTGGCAGGATTTATGTAAAAGCGATGGTGTAATAGTTCCTGGTGGATTCGGACAACGAGGTATGGAAGGTAAAATAGAGGCGTGTCAGTGGTGCAGAGAAACACAAAAACCAATGCTGGGCATTTGCCTGGGCTTACAAGCTGCTGTCATAGAATTTGCTAGAAACGTTCTCGGGTTAAAAGGAGCTAATAGTACAGAAGTAGATCCAGCATGTGAAGATAAACTGGTGATTGACATGCCTGAACACCATCCTGGTAATCTTGGTGGTACAATGAGACTCGGAAAAAGAAATACTTATTTAGAACCTAGTATAGTAAGCCAGTTATACAAAAAAGAAGTCATAGAAGAGCGCCACAGACACCGTTATGAAGTGAACCCAGAATACACAGATCGTCTTGAAGCAGCTGGCCTCAACTTCGTCGGAAAAGATGACACTGGAACAAGAATGGAAGTAGCTATAATAAAAGACCACCCATATTATGTAACTGTGCAATTTCATCCAGAATATTTGTCAAGGCCTCTATCTCCGAGTCCCACATTTTTGGGTCTTATTCTGGCATCTTTGGGCAAACTGAAATCATACATGAACAGAGGGTGTCGTCTTAGTCCAAGAAATCAATCTGATGTTAGCTCTGACGAAGAAGATTTGTCTGTGTCTTCAATCAGTTTATCAGATGAAAACACAATCATAGAGAATGGTAAAGAAGAAAATTTAACAACAAACTTGAAGAAAATGAATGGTCAAGTTAATGGTAACACTGGTTAA
Protein
MPDMKYILVTGGVISGVGKGVIASSFGTILKSCGIDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGGEVDLDLGNYERFLDITLHRDNNITTGKIYQQVIERERRGDYLGKTVQVIPHITDAIQEWVQRVAHIPVTSNNAPPRVCIIELGGTIGDIEGMSFVEAFRQFQFRVKRENFCCAHVSLVPMPKSTGEPKTKPTQSSVRELRGLGLSPDLILCRSEKPINHNVKEKISNFCHVAPEQVICIHDLTSVYHVPLLMEAQGVVQYLNERLILNISMPRPSRFMRKWRNLAKRVDNLRKEVNIALVGKYTKLEDSYASVTKALQHSCIATGCKLNLTYIEAVNLEKQMKIDDPVNYHKAWQDLCKSDGVIVPGGFGQRGMEGKIEACQWCRETQKPMLGICLGLQAAVIEFARNVLGLKGANSTEVDPACEDKLVIDMPEHHPGNLGGTMRLGKRNTYLEPSIVSQLYKKEVIEERHRHRYEVNPEYTDRLEAAGLNFVGKDDTGTRMEVAIIKDHPYYVTVQFHPEYLSRPLSPSPTFLGLILASLGKLKSYMNRGCRLSPRNQSDVSSDEEDLSVSSISLSDENTIIENGKEENLTTNLKKMNGQVNGNTG

Summary

Description
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells.
Catalytic Activity
ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate
ATP + H2O = ADP + H(+) + phosphate
Similarity
Belongs to the CTP synthase family.
Belongs to the MCM family.
Belongs to the tetraspanin (TM4SF) family.
Keywords
ATP-binding   Complete proteome   Glutamine amidotransferase   Ligase   Nucleotide-binding   Pyrimidine biosynthesis   Reference proteome   Alternative splicing   Cytoplasm   Phosphoprotein  
Feature
chain  CTP synthase
splice variant  In isoform 2.
EC Number
6.3.4.2
EMBL
BABH01033960    RSAL01000238    RVE43696.1    KQ461198    KPJ06049.1    AGBW02008979    + More
OWR52006.1    KQ458665    KPJ05607.1    GL446721    EFN87324.1    GL439602    EFN66971.1    KQ435207    KZC15058.1    KQ768090    OAD53195.1    GBYB01007010    JAG76777.1    KQ982911    KYQ49336.1    GEBQ01028780    GEBQ01002421    JAT11197.1    JAT37556.1    KQ977104    KYN05794.1    GL888818    EGI57937.1    KQ981864    KYN34215.1    NNAY01000851    OXU26207.1    KQ976662    KYM78596.1    ADTU01014870    JTDY01001331    KOB74172.1    GL768221    EFZ11752.1    GEDC01025174    JAS12124.1    GECU01002014    JAT05693.1    KK852570    KDR21167.1    GANO01001234    JAB58637.1    KZ288408    PBC26117.1    KK107109    EZA59245.1    KA647267    AFP61896.1    KQ414663    KOC65329.1    GBHO01037402    GBHO01037398    GBHO01021399    GDHC01014352    JAG06202.1    JAG06206.1    JAG22205.1    JAQ04277.1    GBRD01015081    JAG50745.1    GBHO01037420    GBHO01021394    GBHO01015902    GBRD01017605    GBRD01015080    GDHC01018634    GDHC01014950    JAG06184.1    JAG22210.1    JAG27702.1    JAG48222.1    JAP99994.1    JAQ03679.1    GAMC01019401    GAMC01019399    JAB87156.1    GAKP01011316    GAKP01011315    JAC47636.1    GFTR01007385    JAW09041.1    GBGD01000902    JAC87987.1    GECL01003000    JAP03124.1    GBXI01009108    JAD05184.1    GDAI01002188    JAI15415.1    GFDL01013374    JAV21671.1    GFDL01013255    JAV21790.1    GFDL01013232    JAV21813.1    AJWK01025249    GFDL01013455    JAV21590.1    ACPB03002180    GAPW01000437    JAC13161.1    CH379069    KRT07523.1    JXUM01031409    KQ560921    KXJ80340.1    CH902618    KPU78835.1    DS232592    EDS43846.1    KQ979568    KYN20929.1    GDKW01001179    JAI55416.1    CM000159    KRK01929.1    CH964154    EDW79900.2    CM002912    KMY99692.1    CH954178    EDV51823.2    OUUW01000002    SPP76014.1    ATLV01014758    KE524984    KFB39529.1    CH940647    KRF84856.1    AE014296    AHN58092.1    CH477342    EAT43066.1    AY058581    BT003255    LJIG01022703    KRT79153.1    GFDF01002855    JAV11229.1    UFQT01001277    SSX29824.1    UFQS01001006    UFQT01001006    SSX08503.1    SSX28419.1    CH933809    KRG06778.1    GEFM01002942    JAP72854.1    GANP01006704    JAB77764.1    AAAB01008980    EAA13811.4    GEZM01011195    JAV93600.1    APCN01005737    APCN01005738    APCN01005739    GFWV01018790    MAA43518.1    CCAG010023096    CCAG010023097    AXCN02000647    GEFH01003198    JAP65383.1    GFPF01006950    MAA18096.1    GACK01006839    JAA58195.1    GEDV01009951    JAP78606.1    GACK01006834    JAA58200.1   
Pfam
PF06418   CTP_synth_N        + More
PF00117   GATase
PF17855   MCM_lid
PF12619   MCM2_N
PF00493   MCM
PF17207   MCM_OB
PF14551   MCM_N
PF00335   Tetraspanin
Interpro
IPR033828   GATase1_CTP_Synthase        + More
IPR004468   CTP_synthase       
IPR017456   CTP_synthase_N       
IPR029062   Class_I_gatase-like       
IPR017926   GATASE       
IPR027417   P-loop_NTPase       
IPR018525   MCM_CS       
IPR027925   MCM_N       
IPR041562   MCM_lid       
IPR033762   MCM_OB       
IPR008045   MCM2       
IPR031327   MCM       
IPR001208   MCM_dom       
IPR012340   NA-bd_OB-fold       
IPR000301   Tetraspanin       
IPR018499   Tetraspanin/Peripherin       
IPR008952   Tetraspanin_EC2_sf       
SUPFAM
SSF52540   SSF52540        + More
SSF52317   SSF52317       
SSF50249   SSF50249       
SSF48652   SSF48652       
Gene 3D
PDB
5U03     E-value=0,     Score=1881

Ontologies

Topology

Subcellular location
Nucleus  
Cytoplasm  
Membrane  
Length:
615
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
11.40801
Exp number, first 60 AAs:
11.29401
Total prob of N-in:
0.50151
POSSIBLE N-term signal
sequence
outside
1  -  615
 
 

Population Genetic Test Statistics

Pi
241.000668
Theta
170.286027
Tajima's D
0.357369
CLR
1.124248
CSRT
0.469476526173691
Interpretation
Uncertain
Copyright@ 2018-2023    Any Comments and suggestions mail to:zhuzl@cqu.edu.cn   渝ICP备19006517号

渝公网安备 50010602502065号