Gene

KWMTBOMO04978

Annotation

pyruvate_kinase_[Danaus_plexippus]

Location

Bomo_Chr9(-):3974773-3976849      View in EpiBrowser

Full name

Pyruvate kinase      

Location in the cell

Mitochondrial   Reliability : 1.498

CDS

ATGATAACTCGACAGGAATTAGGTTCTGATATAACACCGAAGAAGCTAGTCATTGCTCAGAAGAATATGATTGCACGTGCGAATAAGGCTAACGTTCCGGTCTGTGTCAACGCACATCTCCTAAGCAGCATGAGATACAAAAAATTACCACTAAGAGCGGAACTTTTGGATGTGGCGAACTGCATTCTGGATGGTGCCGACACTCTTGAATTATCTGCTGAAACAGCGGTCGGTCTGTACCCAGTCGACACTGTTGCCTGTTTAGCCAGTGCCTGTAAAGAAGCTGAAGCCTGCATCTGGTCTAAGCAGATTTTTCACGATTTTGTCGATAAGACGCCGATCCCGTGCGATCAAGCAACCGGTGTTGGATTAGCCGCGGTACTGGCAGCGCAGCGGTCATTAGCGGCCGCCATAATTGTCGTCACCACAACCGGGAAATCGGCGCAAATTGTATCTAAATACGGACCGAGATGTCCCATTATAGGTGTAACTAGATACGCTGCTATAGCTAGACAATTGCACTTGTGGAGAGGAATCATACCGCTTATTTTTGAGGGTACTTAA

Protein

MITRQELGSDITPKKLVIAQKNMIARANKANVPVCVNAHLLSSMRYKKLPLRAELLDVANCILDGADTLELSAETAVGLYPVDTVACLASACKEAEACIWSKQIFHDFVDKTPIPCDQATGVGLAAVLAAQRSLAAAIIVVTTTGKSAQIVSKYGPRCPIIGVTRYAAIARQLHLWRGIIPLIFEGT

Catalytic Activity

ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate

Similarity

Belongs to the pyruvate kinase family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

Uniprot

A0A212FH64   A0A194PDF2   A0A2A4JE60   A0A194QKG4   A0A2H1V847   A0A0L7L0B6   + More
A0A1B6MST3   A0A182SYI1   A0A1Y9GJY2   Q7PPE7   A0A1Y9GJK0   A0A084W7S0   A0A182UE55   D6WXE6   A0A139WDM5   A0A182NN15   A0A182RED7   A0A1S4GLJ9   A0A182XDN4   A0A182IDE2   A0A1B6KVA1   A0A182VFI7   A0A182LNM2   A0A182QGD3   A0A182KAF7   A0A182FAJ1   A0A2M4CU89   A0A182MNQ6   A0A182JJQ1   A0A2M3ZYS8   A0A182VPN6   A0A2M3ZYS6   T1DN39   W5JLV6   A0A182PWA9   A0A182YG83   A0A2M3YXR0   A0A2M3ZFB9   Q16LP4   A0A2M3YXN9   Q16LP5   A0A0J7K3Z0   Q16F38   A0A0J7NMP8   E9J2S7   A0A1B6CT72   A0A1B6DMR8   A0A023EVC5   E2AJ75   A0A240SY09   A0A026WCK1   A0A158NID4   A0A154PSS0   A0A151HZ28   A0A151XDE9   A0A151J4F0   A0A151JZ74   H9IZ23   A0A3L8DTT9   A0A1Q3FL43   A0A195C2R8   B0WL21   A0A1Q3FKT7   A0A1Q3FKV4   A0A212FLH1   A0A194QBK5   A0A1Q3FL39   W8BPB9   A0A1B6GSY1   A0A1L8E1V8   A0A182H1Q2   A0A1B6GQK1   W8BUX5   A0A0K8TLX8   A0A2R7VZN0   A0A1L8E288   A0A1X9QDT2   A0A1W5YLK4   E2BFQ8   A0A1B6F736   A0A2Z5REH9   A0A226EGV1   R4WDM9   A0A0K8SRD7   A0A0K8SR30   A0A0A9XHK7   A0A0A9YKR8   A0A2Z5REH8   F4WXV2   A0A2H1V6Z8   A0A067R9U1   A0A0A9YVU7   A0A0L7QJZ6   U5ESC2   A0A0N1ITM9   I4DJQ4   A0A1I8NY84   A0A1D2NHX8   A0A1I8NY83   A0A170YTJ4  

EC Number

2.7.1.40

Pubmed

22118469    26354079    26227816    12364791    24438588    18362917    + More
19820115    20966253    20920257    23761445    25244985    17510324    30578824    21282665    24945155    20798317    24508170    21347285    19121390    30249741    24495485    26483478    26369729    26760975    23691247    25401762    26823975    21719571    24845553    22651552    27289101   

EMBL

AGBW02008537    OWR53070.1    KQ459606    KPI91277.1    NWSH01001903    PCG69730.1    + More
KQ461198    KPJ06022.1    ODYU01000922    SOQ36414.1    JTDY01003837    KOB68932.1    GEBQ01001009    JAT38968.1    APCN01005967    AAAB01008952    EAA10555.6    ATLV01021293    KE525316    KFB46264.1    KQ971361    EFA08832.2    KYB25941.1    GEBQ01024610    JAT15367.1    AXCN02001590    GGFL01004734    MBW68912.1    AXCM01000245    GGFK01000396    MBW33717.1    GGFK01000395    MBW33716.1    GAMD01003210    JAA98380.1    ADMH02000764    GGFL01004376    ETN65121.1    MBW68554.1    GGFM01000290    MBW21041.1    GGFM01006434    MBW27185.1    CH477898    EAT35243.1    GGFM01000291    MBW21042.1    EAT35242.1    LBMM01014568    KMQ85133.1    CH478516    EAT32846.1    LBMM01003236    KMQ93775.1    GL768000    EFZ12877.1    GEDC01020559    JAS16739.1    GEDC01010333    JAS26965.1    GAPW01000661    JAC12937.1    GL439967    EFN66515.1    AJWK01004665    AJWK01004666    AJWK01004667    KK107293    EZA53406.1    ADTU01016559    ADTU01016560    ADTU01016561    ADTU01016562    ADTU01016563    ADTU01016564    KQ435161    KZC14923.1    KQ976702    KYM77205.1    KQ982294    KYQ58406.1    KQ980157    KYN17435.1    KQ981432    KYN41677.1    BABH01010950    BABH01010951    BABH01010952    QOIP01000005    RLU23178.1    GFDL01006821    JAV28224.1    KQ978379    KYM94483.1    DS231979    EDS30184.1    GFDL01006824    JAV28221.1    GFDL01006857    JAV28188.1    AGBW02007775    OWR54577.1    KQ459220    KPJ02928.1    GFDL01006859    JAV28186.1    GAMC01005788    JAC00768.1    GECZ01004238    JAS65531.1    GFDF01001448    JAV12636.1    JXUM01023189    JXUM01023190    KQ560654    KXJ81422.1    GECZ01005099    JAS64670.1    GAMC01005787    JAC00769.1    GDAI01002239    JAI15364.1    KK854197    PTY12947.1    GFDF01001335    JAV12749.1    KY412773    ARQ20739.1    KX147661    ARI45065.1    GL448039    EFN85446.1    GECZ01024076    JAS45693.1    FX983728    BAX07227.1    LNIX01000004    OXA56448.1    AK417674    BAN20889.1    GBRD01012428    GBRD01012427    GBRD01012426    GBRD01012425    GBRD01012424    GBRD01012422    GBRD01010042    GBRD01010040    GBRD01010039    GBRD01010038    GBRD01006700    GBRD01006699    JAG55786.1    GBRD01010044    GBRD01010041    GBRD01002395    JAG55783.1    GBHO01024498    GBHO01023780    GBHO01010803    GBHO01010230    GBHO01006495    GBHO01006493    JAG19106.1    JAG19824.1    JAG32801.1    JAG33374.1    JAG37109.1    JAG37111.1    GBHO01010825    GBHO01010824    GBHO01010805    GBHO01010307    GBHO01010289    GBHO01009918    GDHC01007241    JAG32779.1    JAG32780.1    JAG32799.1    JAG33297.1    JAG33315.1    JAG33686.1    JAQ11388.1    FX983727    BAX07226.1    GL888432    EGI60975.1    ODYU01000813    SOQ36162.1    KK852651    KDR19430.1    GBHO01023781    GBHO01023776    GBHO01023775    GBHO01010806    GBHO01009950    GBHO01006502    GBHO01006497    JAG19823.1    JAG19828.1    JAG19829.1    JAG32798.1    JAG33654.1    JAG37102.1    JAG37107.1    KQ415008    KOC58948.1    GANO01002423    JAB57448.1    KQ435775    KOX74974.1    AK401522    BAM18144.1    LJIJ01000034    ODN04873.1    GEMB01002976    JAS00227.1   

Proteomes

UP000007151    UP000053268    UP000218220    UP000053240    UP000037510    UP000075901    + More
UP000075840    UP000007062    UP000030765    UP000075902    UP000007266    UP000075884    UP000075900    UP000076407    UP000075903    UP000075882    UP000075886    UP000075881    UP000069272    UP000075883    UP000075880    UP000075920    UP000000673    UP000075885    UP000076408    UP000008820    UP000036403    UP000000311    UP000092461    UP000053097    UP000005205    UP000076502    UP000078540    UP000075809    UP000078492    UP000078541    UP000005204    UP000279307    UP000078542    UP000002320    UP000069940    UP000249989    UP000008237    UP000198287    UP000007755    UP000027135    UP000053825    UP000053105    UP000095300    UP000094527   

PRIDE

H9IZ23   

Pfam

PF00224   PK        + More
PF02887   PK_C
PF00398   RrnaAD

Interpro

IPR011037   Pyrv_Knase-like_insert_dom_sf        + More
IPR015806   Pyrv_Knase_insert_dom_sf       
IPR036918   Pyrv_Knase_C_sf       
IPR040442   Pyrv_Kinase-like_dom_sf       
IPR015813   Pyrv/PenolPyrv_Kinase-like_dom       
IPR001697   Pyr_Knase       
IPR015795   Pyrv_Knase_C       
IPR015793   Pyrv_Knase_brl       
IPR018209   Pyrv_Knase_AS       
IPR020598   rRNA_Ade_methylase_Trfase_N       
IPR001737   KsgA/Erm       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF50800   SSF50800        + More
SSF51621   SSF51621       
SSF52935   SSF52935       
SSF53335   SSF53335       

Gene 3D

2.40.33.10     3.20.20.60     3.40.1380.20    

CDD

cd00288  Pyruvate_Kinase

ProteinModelPortal

A0A212FH64   A0A194PDF2   A0A2A4JE60   A0A194QKG4   A0A2H1V847   A0A0L7L0B6   + More
A0A1B6MST3   A0A182SYI1   A0A1Y9GJY2   Q7PPE7   A0A1Y9GJK0   A0A084W7S0   A0A182UE55   D6WXE6   A0A139WDM5   A0A182NN15   A0A182RED7   A0A1S4GLJ9   A0A182XDN4   A0A182IDE2   A0A1B6KVA1   A0A182VFI7   A0A182LNM2   A0A182QGD3   A0A182KAF7   A0A182FAJ1   A0A2M4CU89   A0A182MNQ6   A0A182JJQ1   A0A2M3ZYS8   A0A182VPN6   A0A2M3ZYS6   T1DN39   W5JLV6   A0A182PWA9   A0A182YG83   A0A2M3YXR0   A0A2M3ZFB9   Q16LP4   A0A2M3YXN9   Q16LP5   A0A0J7K3Z0   Q16F38   A0A0J7NMP8   E9J2S7   A0A1B6CT72   A0A1B6DMR8   A0A023EVC5   E2AJ75   A0A240SY09   A0A026WCK1   A0A158NID4   A0A154PSS0   A0A151HZ28   A0A151XDE9   A0A151J4F0   A0A151JZ74   H9IZ23   A0A3L8DTT9   A0A1Q3FL43   A0A195C2R8   B0WL21   A0A1Q3FKT7   A0A1Q3FKV4   A0A212FLH1   A0A194QBK5   A0A1Q3FL39   W8BPB9   A0A1B6GSY1   A0A1L8E1V8   A0A182H1Q2   A0A1B6GQK1   W8BUX5   A0A0K8TLX8   A0A2R7VZN0   A0A1L8E288   A0A1X9QDT2   A0A1W5YLK4   E2BFQ8   A0A1B6F736   A0A2Z5REH9   A0A226EGV1   R4WDM9   A0A0K8SRD7   A0A0K8SR30   A0A0A9XHK7   A0A0A9YKR8   A0A2Z5REH8   F4WXV2   A0A2H1V6Z8   A0A067R9U1   A0A0A9YVU7   A0A0L7QJZ6   U5ESC2   A0A0N1ITM9   I4DJQ4   A0A1I8NY84   A0A1D2NHX8   A0A1I8NY83   A0A170YTJ4  

PDB

6DU6     E-value=2.5928e-47,     Score=472

KEGG

101741940    K00873 pyruvate kinase [EC:2.7.1.40] | (RefSeq) pyruvate kinase-like

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00230    Purine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0016301   GO:0000287   GO:0004743   GO:0030955   GO:0005737   GO:0032869   GO:0006096   GO:0000179   GO:0003723   GO:0003824   GO:0008026   GO:0003677   GO:0005515   GO:0016742  

PANTHER

PTHR11817  

Length:

187

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.51561

Exp number, first 60 AAs:

0.01227

Total prob of N-in:

0.11057

outside

1  -  187

 

 

Pi

172.104067

Theta

190.829745

Tajima's D

-0.724061

CLR

0

CSRT

0.195240237988101

Interpretation

Uncertain