Gene

KWMTBOMO04967

Pre Gene Modal

BGIBMGA007987

Annotation

peptidoglycan_recognition_protein_S2_[Bombyx_mori]

Location

Bomo_Chr9(-):3642175-3645918      View in EpiBrowser

Full name

Peptidoglycan-recognition protein       + More
Peptidoglycan recognition protein      
Peptidoglycan-recognition protein SA      
Peptidoglycan recognition protein 1      

Alternative Name

Protein semmelweis
Peptidoglycan recognition protein short

Location in the cell

Extracellular   Reliability : 3.056

CDS

ATGTTGGTTGCACCGTCTCTATTATTTTTGGTGTTCTTGGTGAGTTTCGGAACCCTGAATGCAGCGTCCGAATGCGGCGAAATTCCCATCACCGAATGGAGTGGCACGGAGTCACGTCGTAAACAACCTCTGAAGAGTCCTATTGACTTGGTGGTGATACAACACACGGTATCCAACGATTGCTTTACAGATGAAGAGTGTTTGCTAAGCGTAAATTCTCTACGACAACATCATATGCTTCTGGCTGGGTTCAAGGACTTGGGCTATTCATTCGTGGCTGGAGGCAACGGAAAAATTTATGAAGGAGCGGGATGGAACCATATCGGTGCTCACACATTGCACTACAATAATATATCCATAGGGATCGGTTTCATTGGAGACTTTAGGGAGAAGCTGCCGACCCAGCAGGCACTGCAGGCGGTCCAAGACTTTTTAGCCTGTGGAGTTGAAAATAACTTATTGACTGAAGACTACCACGTCGTTGGTCACCAGCAGTTGATAAACACGCTAAGTCCTGGAGCTGTACTGCAATCAGAAATCGAAAGTTGGCCCCATTGGCTTGATAATGCTCGAAAAGTACTGGGTTAA

Protein

MLVAPSLLFLVFLVSFGTLNAASECGEIPITEWSGTESRRKQPLKSPIDLVVIQHTVSNDCFTDEECLLSVNSLRQHHMLLAGFKDLGYSFVAGGNGKIYEGAGWNHIGAHTLHYNNISIGIGFIGDFREKLPTQQALQAVQDFLACGVENNLLTEDYHVVGHQQLINTLSPGAVLQSEIESWPHWLDNARKVLG

Description

Binds specifically to peptidoglycan and triggers the propenoloxidase cascade which is an important insect defense mechanism.
Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Catalytic Activity

H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl

Biophysicochemical Properties

21.4 uM for GlcNAc-MurNAc(anhydro)-L-Ala-gamma-D-Glu-meso-DAP-D-Ala

Subunit

Monomer.
Homodimer; disulfide-linked.

Similarity

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Keywords

Direct protein sequencing   Disulfide bond   Immunity   Innate immunity   Signal   Complete proteome   Reference proteome   3D-structure   Hydrolase   Protease   Secreted   Antibiotic   Antimicrobial   Glycoprotein   Polymorphism   Pyrrolidone carboxylic acid  

Feature

chain  Peptidoglycan-recognition protein
sequence variant  In dbSNP:rs34180629.

Uniprot

H9JEP0   W6EL05   Q8WSZ1   Q9BLL1   A0A2W1BT81   A0A2H1WXQ3   + More
A0A346RAC5   A0A212ESF3   A0A194QJS3   A0A194QKT5   E7DN56   B7SFX0   A0A194QR53   W8JAI9   A0A2W1BLP2   O76537   Q0Q026   A0A2A4IX89   B2CZ95   Q8ITT1   A0A212FB31   I4DNW9   A0A194QM25   A0A194QFH8   E5D600   O97369   H9JEU1   Q9XTN0   A0A1Y1M729   Q86RS6   A0A346RAC4   Q86D95   A0A1W4XAW5   A0A2I6B3J1   K7J710   A0A088AJM6   E2BUB1   A0A067QQY1   D7ELY4   A0A0T6ATH0   D2CNK4   A0A1I8NFN3   A0A0U3SX80   A0A3B0KUJ9   A0A0L7KJ86   Q29IN1   A0A125S9Y2   Q0Q025   Q0KKW5   X2JEI8   Q9VYX7   A0A1B0GIX7   A0A1W4UNB6   B4R346   A0A154PIJ2   V5GVK1   A0A1B6GU90   B3NUC2   B4H2R6   B4MAP1   E7DN57   A0A067R4L8   A0A0K8VR92   A0A0M3QYU6   A0A2P8YB58   J3JTK0   Q32S43   B4PY99   A0A067QGE8   A0A2J7Q6X9   V9L8U0   F4WCD8   A0A0C9QKJ8   I3N1R2   A0A067QHE0   A0A1J0M178   B4JXA3   A0A212DE23   F4WMQ9   N6U014   C7AHV4   A0A2R9BV11   H2QGM5   E9J784   B3MY97   A0A158NQ59   A0A0Q9WUD5   A0A0Q5U7H0   H2NZA6   A0A0Q9WW31   A0A2Y9DVG0   T1E303   H8YU85   O75594   V5GS37   A0A1A9Z640   A0A1A9VBQ1   A0A1B0G8B0  

EC Number

3.4.17.13

Pubmed

19121390    25797797    28756777    29910977    22118469    26354079    + More
21167833    9707603    16857061    22651552    9755476    10207004    8662762    28004739    16640722    12225919    20075255    29396863    20798317    24845553    18362917    19820115    25315136    26694822    26227816    15632085    17994087    17434328    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11106397    14738318    12537569    11742401    12032070    14684822    14722090    15448690    16399077    15223330    15361936    29403074    22516182    16269728    17550304    24402279    21719571    29294181    23537049    19387012    22722832    16136131    21282665    21347285    24330624    12975309    15057824    15489334    11461926    16354652    15769462   

EMBL

BABH01023631    KF906541    AHJ11178.1    AF441723    AAL32058.1    AB017520    + More
BAB33295.1    KZ149974    PZC75970.1    ODYU01011865    SOQ57853.1    MH200915    AXS59125.1    AGBW02012798    OWR44425.1    KQ459144    KPJ03701.1    KQ461198    KPJ06009.1    HQ260963    ADU33184.1    EU289210    ABZ81267.1    KPJ06011.1    KF954940    AHK59818.1    PZC75969.1    AF076481    DQ666505    ABG72708.1    NWSH01005638    PCG64086.1    EU557313    ACB45568.1    AF394587    AAN15786.1    AGBW02009391    OWR50928.1    AK403178    BAM19609.1    KPJ06010.1    KPJ03700.1    GU182905    ADR51143.1    AF035445    AAD02029.1    BABH01023291    AB016605    AB016249    GEZM01038634    JAV81582.1    AF413061    AAO21502.1    MH200914    AXS59124.1    AF413068    AAO21509.1    MG570190    AUI41055.1    GL450619    EFN80739.1    KK853478    KDR07310.1    DS497945    EFA12467.1    LJIG01022861    KRT78342.1    EU399240    ACB32179.1    KU218682    ALX00062.1    OUUW01000021    SPP89506.1    JTDY01009650    KOB63145.1    CH379063    EAL32622.2    KT725231    AME17978.1    DQ666506    ABG72709.1    AB232695    BAF03522.1    AE014298    AHN59598.1    AF207540    AF207541    AJ556551    AJ556552    AJ556553    AJ556554    AJ556555    AJ556556    AJ556557    AJ556558    AJ556559    AJ556560    AJ556561    AY075293    AJWK01017804    AJWK01017805    CM000366    EDX17648.1    KQ434924    KZC11632.1    GALX01002754    JAB65712.1    GECZ01003856    JAS65913.1    CH954180    EDV46037.2    CH479204    EDW30633.1    CH940655    EDW66300.1    HQ260964    ADU33185.1    KK852704    KDR18042.1    GDHF01010961    JAI41353.1    CP012528    ALC48229.1    PYGN01000736    PSN41492.1    BT126557    AEE61521.1    AY956814    AAY27976.1    CM000162    EDX01961.1    KDR07311.1    NEVH01017450    PNF24335.1    JW875796    AFP08313.1    GL888070    EGI68118.1    GBYB01004084    JAG73851.1    AGTP01097044    KK853387    KDR07939.1    KX342009    APD13821.1    CH916376    EDV95379.1    MKHE01000004    OWK16479.1    GL888218    EGI64536.1    APGK01054672    APGK01054673    KB741251    ENN71867.1    FJ546159    ACT66863.1    AJFE02059320    AACZ04019598    NBAG03000399    PNI28802.1    GL768424    EFZ11322.1    CH902632    EDV32591.1    ADTU01022971    CH940647    KRF84516.1    CH954178    KQS43684.1    ABGA01274545    ABGA01400468    ABGA01400469    NDHI03003467    PNJ40971.1    KRF84512.1    GALA01000820    JAA94032.1    JF915527    AFD54029.1    AF076483    AF242517    AY358936    AC007785    BC096154    BC096155    BC096156    BC096157    BC101845    BC101847    GALX01005413    JAB63053.1    CCAG010000228   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000192223    + More
UP000002358    UP000005203    UP000008237    UP000027135    UP000007266    UP000095301    UP000268350    UP000037510    UP000001819    UP000000803    UP000092461    UP000192221    UP000000304    UP000076502    UP000008711    UP000008744    UP000008792    UP000092553    UP000245037    UP000002282    UP000235965    UP000007755    UP000005215    UP000001070    UP000019118    UP000240080    UP000002277    UP000007801    UP000005205    UP000001595    UP000248480    UP000005640    UP000092445    UP000078200    UP000092444   

PRIDE

H9JEP0    W6EL05    Q8WSZ1    Q9BLL1    H9JEU1    Q9XTN0    + More
Q9VYX7    O75594   

Pfam

PF01510   Amidase_2        + More
PF02205   WH2

Interpro

IPR036505   Amidase/PGRP_sf        + More
IPR015510   PGRP       
IPR017331   Peptidoglycan_recognition       
IPR006619   PGRP_domain_met/bac       
IPR002502   Amidase_domain       
IPR003124   WH2_dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR011011   Znf_FYVE_PHD       

SUPFAM

SSF55846   SSF55846        + More
SSF57903   SSF57903       

Gene 3D

3.40.80.10     3.30.40.10    

CDD

cd06583  PGRP

ProteinModelPortal

H9JEP0   W6EL05   Q8WSZ1   Q9BLL1   A0A2W1BT81   A0A2H1WXQ3   + More
A0A346RAC5   A0A212ESF3   A0A194QJS3   A0A194QKT5   E7DN56   B7SFX0   A0A194QR53   W8JAI9   A0A2W1BLP2   O76537   Q0Q026   A0A2A4IX89   B2CZ95   Q8ITT1   A0A212FB31   I4DNW9   A0A194QM25   A0A194QFH8   E5D600   O97369   H9JEU1   Q9XTN0   A0A1Y1M729   Q86RS6   A0A346RAC4   Q86D95   A0A1W4XAW5   A0A2I6B3J1   K7J710   A0A088AJM6   E2BUB1   A0A067QQY1   D7ELY4   A0A0T6ATH0   D2CNK4   A0A1I8NFN3   A0A0U3SX80   A0A3B0KUJ9   A0A0L7KJ86   Q29IN1   A0A125S9Y2   Q0Q025   Q0KKW5   X2JEI8   Q9VYX7   A0A1B0GIX7   A0A1W4UNB6   B4R346   A0A154PIJ2   V5GVK1   A0A1B6GU90   B3NUC2   B4H2R6   B4MAP1   E7DN57   A0A067R4L8   A0A0K8VR92   A0A0M3QYU6   A0A2P8YB58   J3JTK0   Q32S43   B4PY99   A0A067QGE8   A0A2J7Q6X9   V9L8U0   F4WCD8   A0A0C9QKJ8   I3N1R2   A0A067QHE0   A0A1J0M178   B4JXA3   A0A212DE23   F4WMQ9   N6U014   C7AHV4   A0A2R9BV11   H2QGM5   E9J784   B3MY97   A0A158NQ59   A0A0Q9WUD5   A0A0Q5U7H0   H2NZA6   A0A0Q9WW31   A0A2Y9DVG0   T1E303   H8YU85   O75594   V5GS37   A0A1A9Z640   A0A1A9VBQ1   A0A1B0G8B0  

PDB

5XZ4     E-value=4.57374e-37,     Score=384

KEGG

732851    K01446 peptidoglycan recognition protein | (RefSeq) PGRP-S2, BmPGRP-S2; peptidoglycan recognition pr

GO

GO:0008270   GO:0009253   GO:0045087   GO:0042834   GO:0008745   GO:0016021   GO:0032827   GO:0050830   GO:0019730   GO:0016019   GO:0005615   GO:0005576   GO:0032500   GO:0045752   GO:0038187   GO:0008329   GO:0008233   GO:0006965   GO:0032494   GO:0061844   GO:0031640   GO:0016045   GO:0051714   GO:0003779   GO:0032689   GO:0070062   GO:1904724   GO:0097013   GO:0043312   GO:0044117   GO:0050728   GO:0035580   GO:0006796   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11022  

Subcellular location

Secreted  
Cytoplasmic granule  

SignalP

Position:   1 - 21,         Likelihood:  0.995534

 

 

Length:

195

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.03786

Exp number, first 60 AAs:

1.01471

Total prob of N-in:

0.04533

outside

1  -  195

 

 

Pi

316.150662

Theta

192.47319

Tajima's D

1.988019

CLR

0.222576

CSRT

0.877706114694265

Interpretation

Uncertain