Gene

KWMTBOMO04966  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007988

Annotation

inorganic_pyrophosphatase_[Bombyx_mori]

Location

Bomo_Chr9(-):3629380-3640298      View in EpiBrowser

Full name

Inorganic pyrophosphatase      

Alternative Name

Nucleosome-remodeling factor 38 kDa subunit
Pyrophosphate phospho-hydrolase

Location in the cell

Cytoplasmic   Reliability : 1.822

CDS

ATGTCACTTTCACGTTGCGTTTGTGCCGCAGCTGTTCCGGTTTGCCGGTCGATAGCAAGACGATTGTGCGCTGTTAAAGAACCGACACGTGTAACTTGTTCAATTAATTCGACTGCCACACTAAAAACTCAAGTAAGGATGTACATCGTAGAAGAAAGAGGATCACCTTACACTCCTGACTATCGTGTATTCTTCAAGGATGAAGGCGGCCCTATATCGCCCATGCACGACATTCCACTATGGGCCGACAAAGCTCAACGCCTCGTCAACATGGTAGTAGAAGTACCTAGATGGACCAATGCGAAAATGGAGATCAGCCTCGGGGAGGCCCTCAATCCTATCAAGCAGGACGTAAAGAAAGGCAACCTTCGGTTCGTGAACAACGTCTTCCCTCATCGCGGCTACATCTGGAATTACGGTGCCCTGCCGCAGACCTGGGAGAATCCTAATCACGTCGACCCTGACACGGGCGCGAGGGGCGACAACGACCCGGTTGACGTCATCGAAATCGGTGAGCGCGTCGCGAGTCGCGGTGACGTTTACCCCGTAAAGATCCTCGGTACGCTAGCTCTCATCGACGAAGGCGAGACCGATTGGAAGCTGATAGCGATCGATTCCCGGGACCCGAACGCGGAGAAGTTGAACGATGTACAAGACGTGGAGACGTTGTTCCCTGGCCTCCTCCGCGCCACCGTCGAGTGGTTCAGACTCTACAAAGTTCCGGACGGCAAGCCGGTGAACAAGTTCGCGTTTGACGGCGAAGCTAAGAACGCAGAGTTCGCTTACAAAGTCGTTGACGAGGTTCACGAATTTTGGAAGAGTCTCATCAGCGGCAACGTTCCTGACGCAACCGATATAAACAAAATGAACGTGTCAGTGAGCGGCAGCGTGGACCGGGCGGAGCGCTCCGAAGCCGCCGCGGTGTTGGCGAAGGCTCCAACGCTCGGGCAGCCCGCCGCCATACCGCAGACAGTTGACAAGTGGCACTTCCTCGCGAACCTATAG

Protein

MSLSRCVCAAAVPVCRSIARRLCAVKEPTRVTCSINSTATLKTQVRMYIVEERGSPYTPDYRVFFKDEGGPISPMHDIPLWADKAQRLVNMVVEVPRWTNAKMEISLGEALNPIKQDVKKGNLRFVNNVFPHRGYIWNYGALPQTWENPNHVDPDTGARGDNDPVDVIEIGERVASRGDVYPVKILGTLALIDEGETDWKLIAIDSRDPNAEKLNDVQDVETLFPGLLRATVEWFRLYKVPDGKPVNKFAFDGEAKNAEFAYKVVDEVHEFWKSLISGNVPDATDINKMNVSVSGSVDRAERSEAAAVLAKAPTLGQPAAIPQTVDKWHFLANL

Description

Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite.

Catalytic Activity

diphosphate + H2O = H(+) + 2 phosphate

Cofactor

Mg(2+)

Subunit

Component of the NURF complex composed of Caf1, E(bx), Nurf-38 and Iswi.

Miscellaneous

The ATPase activity of NURF is stimulated by the presence of nucleosomes rather than by free DNA.

Similarity

Belongs to the PPase family.

Keywords

Chromatin regulator   Complete proteome   Cytoplasm   Direct protein sequencing   Hydrolase   Magnesium   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Inorganic pyrophosphatase

Uniprot

E5EVW5   A0A2W1B129   A0A2A4IV62   A0A212F0F5   A0A3S2L1J1   A0A194QK65   + More
A0A0N0P9B8   D6WB60   V5G7A2   A0A336M2U3   A0A182MP03   A0A0L7L7W2   A0A084W7D2   A0A1L8E0P8   A0A1L8E0T9   A0A2M4A8Q7   A0A2M4A849   J3JVA3   A0A182QVM7   A0A2J7RIE7   W5J4U0   A0A2M4BRS6   A0A2M4BRE3   A0A1Q3FY31   A0A2M4CZK7   A0A2J7RID2   A0A2M4CZJ7   U5ES97   A0A2M4CZG4   A0A2M3Z2B5   A0A182UM70   A0A2M4CZH0   A0A182NKT6   A0A182PS37   A0A182XK84   A0A1S4F3Z8   B5E1A1   B4MP06   A0A182W0L8   A0A023ER17   N6T450   Q1HR16   A0A1W4W0N7   Q5TU96   A0A182IP54   A0A182UF49   A0A182HJQ4   E0W2T1   A0A1S4F3X2   Q17G61   A0A182K237   A0A1Y1LHG1   A0A182KWW5   F5HK08   F5HK09   A0A347ZJC1   A0A182G395   A0A067R4J7   F5HK07   Q17G60   T1DPX3   A0A3R7PKM8   A0A0M4ETX4   E9HGN3   A0A0T6B569   A0A162QQ82   A0A0P5AHB4   T1IWU8   A0A0P5QV05   A0A0N8E9X5   A0A0P5N2N8   A0A0N7ZYY7   A0A0P6DIU3   A0A1L8EI58   B4PBC5   A0A3B0J073   A0A1L8EIJ7   A0A1L8EEH8   A0A1L8EBC4   A0A1J1HQT6   A0A1L8EC30   A0A0P6FH14   A0A0M8ZR40   A0A0N7ZHH9   A0A0P5YG10   A0A1Y1LIZ8   I0DHK6   O77460   A0A182SHG8   A0A0N8AX26   A0A2J7RID6   A0A0P6FBJ6   A0A0P6ER08   A0A0J9UAG2   B4KQ66   A0A182Y4J5   B3NQM0   A0A1I8M9Y3   A0A1I8P9N4   B4QC15  

EC Number

3.6.1.1

Pubmed

19121390    21457781    28756777    22118469    26354079    18362917    + More
19820115    26227816    24438588    22516182    20920257    23761445    15632085    17994087    24945155    23537049    17204158    12364791    14747013    17210077    20566863    17510324    28004739    20966253    26483478    24845553    21292972    17550304    9784495    10731132    12537572    12537569    8521501    22936249    25244985    25315136   

EMBL

BABH01023630    BABH01023631    HM012809    ADQ89808.1    KZ150479    PZC70732.1    + More
NWSH01007242    PCG63030.1    AGBW02011129    OWR47181.1    RSAL01000248    RVE43533.1    KQ461198    KPJ05927.1    KQ459566    KPI99608.1    KQ971311    EEZ98942.2    GALX01002481    JAB65985.1    UFQT01000456    SSX24554.1    AXCM01000643    JTDY01002418    KOB71450.1    ATLV01021211    KE525314    KFB46126.1    GFDF01001817    JAV12267.1    GFDF01001818    JAV12266.1    GGFK01003801    MBW37122.1    GGFK01003653    MBW36974.1    BT127170    AEE62132.1    AXCN02000304    NEVH01003502    PNF40596.1    ADMH02002195    ETN57880.1    GGFJ01006571    MBW55712.1    GGFJ01006516    MBW55657.1    GFDL01002653    JAV32392.1    GGFL01006541    MBW70719.1    PNF40595.1    GGFL01006527    MBW70705.1    GANO01003348    JAB56523.1    GGFL01006525    MBW70703.1    GGFM01001918    MBW22669.1    GGFL01006542    MBW70720.1    CM000071    EDY69489.2    CH963848    EDW73845.2    GAPW01002025    JAC11573.1    APGK01053204    KB741222    KB631665    ENN72408.1    ERL85141.1    DQ440278    ABF18311.1    AAAB01008851    EAL40975.4    AXCP01007741    APCN01002203    DS235879    EEB19937.1    CH477266    EAT45523.1    GEZM01057450    JAV72331.1    EGK96617.1    EGK96620.1    EGK96621.1    FX985689    BBA84427.1    JXUM01042241    JXUM01042242    JXUM01042243    JXUM01042244    KQ561316    KXJ79016.1    KK852898    KDR14150.1    EGK96619.1    EAT45524.1    GAMD01002949    JAA98641.1    QCYY01001832    ROT74936.1    CP012524    ALC40757.1    GL732642    EFX69116.1    LJIG01015964    KRT82023.1    LRGB01000311    KZS19865.1    GDIP01198842    JAJ24560.1    JH431630    GDIQ01116101    JAL35625.1    GDIQ01047468    JAN47269.1    GDIQ01147933    JAL03793.1    GDIP01198841    JAJ24561.1    GDIQ01079907    JAN14830.1    GFDG01000387    JAV18412.1    CM000158    EDW92557.2    OUUW01000001    SPP74065.1    GFDG01000386    JAV18413.1    GFDG01001699    JAV17100.1    GFDG01002884    JAV15915.1    CVRI01000019    CRK90407.1    GFDG01002575    JAV16224.1    GDIQ01047467    JAN47270.1    KQ435944    KOX68266.1    GDIP01244905    JAI78496.1    GDIP01058217    JAM45498.1    GEZM01057451    JAV72330.1    BT133451    AFH89824.1    AF085600    AF085601    AE013599    AY075479    GDIQ01234451    JAK17274.1    PNF40599.1    GDIQ01059071    JAN35666.1    GDIQ01059072    JAN35665.1    CM002911    KMY96370.1    CH933808    EDW09194.2    CH954179    EDV57023.2    CM000362    EDX08570.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000007266    UP000075883    UP000037510    UP000030765    UP000075886    UP000235965    UP000000673    UP000075903    UP000075884    UP000075885    UP000076407    UP000001819    UP000007798    UP000075920    UP000019118    UP000030742    UP000192221    UP000007062    UP000075880    UP000075902    UP000075840    UP000009046    UP000008820    UP000075881    UP000075882    UP000069940    UP000249989    UP000027135    UP000283509    UP000092553    UP000000305    UP000076858    UP000002282    UP000268350    UP000183832    UP000053105    UP000000803    UP000075901    UP000009192    UP000076408    UP000008711    UP000095301    UP000095300    UP000000304   

PRIDE

E5EVW5    I0DHK6    O77460   

Pfam

PF00719   Pyrophosphatase

Interpro

IPR008162   Pyrophosphatase        + More
IPR036649   Pyrophosphatase_sf       

SUPFAM

SSF50324   SSF50324       

Gene 3D

3.90.80.10    

CDD

cd00412  pyrophosphatase

ProteinModelPortal

E5EVW5   A0A2W1B129   A0A2A4IV62   A0A212F0F5   A0A3S2L1J1   A0A194QK65   + More
A0A0N0P9B8   D6WB60   V5G7A2   A0A336M2U3   A0A182MP03   A0A0L7L7W2   A0A084W7D2   A0A1L8E0P8   A0A1L8E0T9   A0A2M4A8Q7   A0A2M4A849   J3JVA3   A0A182QVM7   A0A2J7RIE7   W5J4U0   A0A2M4BRS6   A0A2M4BRE3   A0A1Q3FY31   A0A2M4CZK7   A0A2J7RID2   A0A2M4CZJ7   U5ES97   A0A2M4CZG4   A0A2M3Z2B5   A0A182UM70   A0A2M4CZH0   A0A182NKT6   A0A182PS37   A0A182XK84   A0A1S4F3Z8   B5E1A1   B4MP06   A0A182W0L8   A0A023ER17   N6T450   Q1HR16   A0A1W4W0N7   Q5TU96   A0A182IP54   A0A182UF49   A0A182HJQ4   E0W2T1   A0A1S4F3X2   Q17G61   A0A182K237   A0A1Y1LHG1   A0A182KWW5   F5HK08   F5HK09   A0A347ZJC1   A0A182G395   A0A067R4J7   F5HK07   Q17G60   T1DPX3   A0A3R7PKM8   A0A0M4ETX4   E9HGN3   A0A0T6B569   A0A162QQ82   A0A0P5AHB4   T1IWU8   A0A0P5QV05   A0A0N8E9X5   A0A0P5N2N8   A0A0N7ZYY7   A0A0P6DIU3   A0A1L8EI58   B4PBC5   A0A3B0J073   A0A1L8EIJ7   A0A1L8EEH8   A0A1L8EBC4   A0A1J1HQT6   A0A1L8EC30   A0A0P6FH14   A0A0M8ZR40   A0A0N7ZHH9   A0A0P5YG10   A0A1Y1LIZ8   I0DHK6   O77460   A0A182SHG8   A0A0N8AX26   A0A2J7RID6   A0A0P6FBJ6   A0A0P6ER08   A0A0J9UAG2   B4KQ66   A0A182Y4J5   B3NQM0   A0A1I8M9Y3   A0A1I8P9N4   B4QC15  

PDB

2IHP     E-value=5.0733e-89,     Score=835

KEGG

101741235    K11726 nucleosome-remodeling factor 38 kDa subunit [EC:3.6.1.1] | (RefSeq) inorganic pyrophosphatase

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)

GO

GO:0000287   GO:0005737   GO:0006796   GO:0004427   GO:0035076   GO:0006351   GO:0042766   GO:0035206   GO:0016589   GO:0005634   GO:0006338   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR10286  

Subcellular location

Cytoplasm  
Nucleus  

Length:

334

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00135

Exp number, first 60 AAs:

0.000910000000000001

Total prob of N-in:

0.02609

outside

1  -  334

 

 

Pi

306.042

Theta

169.566121

Tajima's D

1.300746

CLR

0.344945

CSRT

0.736013199340033

Interpretation

Uncertain