SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO04966  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007988
Annotation
inorganic_pyrophosphatase_[Bombyx_mori]
Full name
Inorganic pyrophosphatase      
Alternative Name
Nucleosome-remodeling factor 38 kDa subunit
Pyrophosphate phospho-hydrolase
Location in the cell
Cytoplasmic   Reliability : 1.822
 

Sequence

CDS
ATGTCACTTTCACGTTGCGTTTGTGCCGCAGCTGTTCCGGTTTGCCGGTCGATAGCAAGACGATTGTGCGCTGTTAAAGAACCGACACGTGTAACTTGTTCAATTAATTCGACTGCCACACTAAAAACTCAAGTAAGGATGTACATCGTAGAAGAAAGAGGATCACCTTACACTCCTGACTATCGTGTATTCTTCAAGGATGAAGGCGGCCCTATATCGCCCATGCACGACATTCCACTATGGGCCGACAAAGCTCAACGCCTCGTCAACATGGTAGTAGAAGTACCTAGATGGACCAATGCGAAAATGGAGATCAGCCTCGGGGAGGCCCTCAATCCTATCAAGCAGGACGTAAAGAAAGGCAACCTTCGGTTCGTGAACAACGTCTTCCCTCATCGCGGCTACATCTGGAATTACGGTGCCCTGCCGCAGACCTGGGAGAATCCTAATCACGTCGACCCTGACACGGGCGCGAGGGGCGACAACGACCCGGTTGACGTCATCGAAATCGGTGAGCGCGTCGCGAGTCGCGGTGACGTTTACCCCGTAAAGATCCTCGGTACGCTAGCTCTCATCGACGAAGGCGAGACCGATTGGAAGCTGATAGCGATCGATTCCCGGGACCCGAACGCGGAGAAGTTGAACGATGTACAAGACGTGGAGACGTTGTTCCCTGGCCTCCTCCGCGCCACCGTCGAGTGGTTCAGACTCTACAAAGTTCCGGACGGCAAGCCGGTGAACAAGTTCGCGTTTGACGGCGAAGCTAAGAACGCAGAGTTCGCTTACAAAGTCGTTGACGAGGTTCACGAATTTTGGAAGAGTCTCATCAGCGGCAACGTTCCTGACGCAACCGATATAAACAAAATGAACGTGTCAGTGAGCGGCAGCGTGGACCGGGCGGAGCGCTCCGAAGCCGCCGCGGTGTTGGCGAAGGCTCCAACGCTCGGGCAGCCCGCCGCCATACCGCAGACAGTTGACAAGTGGCACTTCCTCGCGAACCTATAG
Protein
MSLSRCVCAAAVPVCRSIARRLCAVKEPTRVTCSINSTATLKTQVRMYIVEERGSPYTPDYRVFFKDEGGPISPMHDIPLWADKAQRLVNMVVEVPRWTNAKMEISLGEALNPIKQDVKKGNLRFVNNVFPHRGYIWNYGALPQTWENPNHVDPDTGARGDNDPVDVIEIGERVASRGDVYPVKILGTLALIDEGETDWKLIAIDSRDPNAEKLNDVQDVETLFPGLLRATVEWFRLYKVPDGKPVNKFAFDGEAKNAEFAYKVVDEVHEFWKSLISGNVPDATDINKMNVSVSGSVDRAERSEAAAVLAKAPTLGQPAAIPQTVDKWHFLANL

Summary

Description
Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite.
Catalytic Activity
diphosphate + H2O = H(+) + 2 phosphate
Cofactor
Mg(2+)
Subunit
Component of the NURF complex composed of Caf1, E(bx), Nurf-38 and Iswi.
Miscellaneous
The ATPase activity of NURF is stimulated by the presence of nucleosomes rather than by free DNA.
Similarity
Belongs to the PPase family.
Keywords
Chromatin regulator   Complete proteome   Cytoplasm   Direct protein sequencing   Hydrolase   Magnesium   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation  
Feature
chain  Inorganic pyrophosphatase
EC Number
3.6.1.1
EMBL
BABH01023630    BABH01023631    HM012809    ADQ89808.1    KZ150479    PZC70732.1    + More
NWSH01007242    PCG63030.1    AGBW02011129    OWR47181.1    RSAL01000248    RVE43533.1    KQ461198    KPJ05927.1    KQ459566    KPI99608.1    KQ971311    EEZ98942.2    GALX01002481    JAB65985.1    UFQT01000456    SSX24554.1    AXCM01000643    JTDY01002418    KOB71450.1    ATLV01021211    KE525314    KFB46126.1    GFDF01001817    JAV12267.1    GFDF01001818    JAV12266.1    GGFK01003801    MBW37122.1    GGFK01003653    MBW36974.1    BT127170    AEE62132.1    AXCN02000304    NEVH01003502    PNF40596.1    ADMH02002195    ETN57880.1    GGFJ01006571    MBW55712.1    GGFJ01006516    MBW55657.1    GFDL01002653    JAV32392.1    GGFL01006541    MBW70719.1    PNF40595.1    GGFL01006527    MBW70705.1    GANO01003348    JAB56523.1    GGFL01006525    MBW70703.1    GGFM01001918    MBW22669.1    GGFL01006542    MBW70720.1    CM000071    EDY69489.2    CH963848    EDW73845.2    GAPW01002025    JAC11573.1    APGK01053204    KB741222    KB631665    ENN72408.1    ERL85141.1    DQ440278    ABF18311.1    AAAB01008851    EAL40975.4    AXCP01007741    APCN01002203    DS235879    EEB19937.1    CH477266    EAT45523.1    GEZM01057450    JAV72331.1    EGK96617.1    EGK96620.1    EGK96621.1    FX985689    BBA84427.1    JXUM01042241    JXUM01042242    JXUM01042243    JXUM01042244    KQ561316    KXJ79016.1    KK852898    KDR14150.1    EGK96619.1    EAT45524.1    GAMD01002949    JAA98641.1    QCYY01001832    ROT74936.1    CP012524    ALC40757.1    GL732642    EFX69116.1    LJIG01015964    KRT82023.1    LRGB01000311    KZS19865.1    GDIP01198842    JAJ24560.1    JH431630    GDIQ01116101    JAL35625.1    GDIQ01047468    JAN47269.1    GDIQ01147933    JAL03793.1    GDIP01198841    JAJ24561.1    GDIQ01079907    JAN14830.1    GFDG01000387    JAV18412.1    CM000158    EDW92557.2    OUUW01000001    SPP74065.1    GFDG01000386    JAV18413.1    GFDG01001699    JAV17100.1    GFDG01002884    JAV15915.1    CVRI01000019    CRK90407.1    GFDG01002575    JAV16224.1    GDIQ01047467    JAN47270.1    KQ435944    KOX68266.1    GDIP01244905    JAI78496.1    GDIP01058217    JAM45498.1    GEZM01057451    JAV72330.1    BT133451    AFH89824.1    AF085600    AF085601    AE013599    AY075479    GDIQ01234451    JAK17274.1    PNF40599.1    GDIQ01059071    JAN35666.1    GDIQ01059072    JAN35665.1    CM002911    KMY96370.1    CH933808    EDW09194.2    CH954179    EDV57023.2    CM000362    EDX08570.1   
Pfam
PF00719   Pyrophosphatase
Interpro
IPR008162   Pyrophosphatase        + More
IPR036649   Pyrophosphatase_sf       
SUPFAM
SSF50324   SSF50324       
Gene 3D
PDB
2IHP     E-value=5.0733e-89,     Score=835

Ontologies

Topology

Subcellular location
Cytoplasm  
Nucleus  
Length:
334
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00135
Exp number, first 60 AAs:
0.000910000000000001
Total prob of N-in:
0.02609
outside
1  -  334
 
 

Population Genetic Test Statistics

Pi
306.042
Theta
169.566121
Tajima's D
1.300746
CLR
0.344945
CSRT
0.736013199340033
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
28556443 GYIWNYGALPQTWENPNHVDPDTGAR 100.00 1e-13
28556443 GSPYTPDYR 100.00 1e-13
28556443 GDNDPVDVIEIGER 100.00 1e-13
26822097 MYIVEER 96.15 3e-13
26280517 GVVKDIIHDPGR 96.15 3e-13
25044914 GYITDVDCR 96.15 3e-13
27102218 IIGTIAIIDEGETDWK 96.15 3e-13
28467696 GYITPQSNQVIIFFR 96.15 3e-13
28556443 WHFLANL 100.00 3e-10
26822097 FVNNVFPHR 95.45 7e-10
26280517 VFEIIK 95.45 7e-10
25044914 VFFDVTVDDAPIGK 95.45 7e-10
27102218 NAEFAYK 95.45 7e-10
28467696 VFFHTDAAQAVGK 95.45 7e-10
28556443 DEGGPISPMHDIPLWADK 100.00 5e-07
28556443 ATVEWFR 100.00 5e-07
28556443 APTLGQPAAIPQTVDK 100.00 5e-07
28556443 ILGTLALIDEGETDWK 100.00 5e-05
28556443 ILGTLALIDEGETDWK 100.00 5e-05
28556443 GYIWNYGALPQTWENPNHVDPDTGAR 100.00 5e-05
28556443 GYIWNYGALPQTWENPNHVDPDTGAR 100.00 5e-05
28556443 LNDVQDVETLFPGLLR 100.00 5e-05
28556443 ILGTLALIDEGETDWK 100.00 5e-05
28556443 ILGTLALIDEGETDWK 100.00 5e-05
28556443 APTLGQPAAIPQTVDK 100.00 7e-04
28556443 VFFKDEGGPISPMHDIPLWADK 100.00 7e-04
28556443 YSTNVQNLPR 100.00 7e-04
28556443 SEAAAVLAK 100.00 0.003
28556443 MNVSVSGSVDR 100.00 0.003
26822097 MEISIGEAINPIKQDVK 100.00 0.006
26280517 GDGPIAIIIAPTR 100.00 0.006
25044914 GDKPVVAGR 100.00 0.006
27102218 FVNNVFPHR 100.00 0.006
28467696 GDKVTFCEPIDPAK 100.00 0.006
28556443 FVNNVFPHR 100.00 0.006
28556443 DEGGPISPMHDIPLWADK 100.00 0.006
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