Gene

KWMTBOMO04917

Pre Gene Modal

BGIBMGA008010

Annotation

PREDICTED:_5-aminolevulinate_synthase?_nonspecific?_mitochondrial_[Papilio_machaon]

Location

Bomo_Chr9(-):1486665-1488359      View in EpiBrowser

Full name

5-aminolevulinate synthase      

Alternative Name

5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase

Location in the cell

Mitochondrial   Reliability : 2.5

CDS

ATGCCTTGTCCGTTTTTGGGATCGTTGAACCAAGCGTTCGTGAAAAATTATGGTGCGACCCTGATGAAGCAGTACGGAAATTATTGCCCGATTATATCTCGTGGATTTCGTTCTTTGGGAAATGACGAAACCAAATGCCCCTTCATTCAGCAAAACTCTATCATTTCGGAAGCTCCTAAGGAAATGACCGAGGACATCGCGGAACCTGCGACTCCGTACCACTACGAGAACTTTTTCCACGACCAGATCAACGCTAAAAAAAGGGACTACTCCTATCGCGTTTTTAGAAAGGTGTCTCGTTTGGCTGCTGATGGAGTATATCCGAAAGCCCTGGAGGGGCCTGAAAATCGTAGAGTAACTGTCTGGTGTGCCAATGATTACTTAGGGATGTCCCGTCACCCAACTGTGCAGGATGCTGCTGTCAACGCTATCAAATCCTATGGAACAGGAGCAGGTGGTACAAGGAATATTGCTGGAAACTCCCAGATGACTGAGAAGCTTGAAGGAGAAATTGCAAAACTGCATAAGAAGCCTGCAGCATTAATATTTAGTTCTTGCTTTGTAGCTAACGACGCTACTTTATCTACATTAGCAAAAATACTGCCTGATTGCATAGTTTACTCGGATGCAGGAAATCATGCTTCTATGATACAAGGAATCCGGAACAGCCGAGCCCCTAAGCATATCTTCAGGCACAACGATCCAAACCACCTACGGAAGTTATTGGCCGACTCTCCCAAAGGTGTACCAAAGCTAGTTGTATTTGAAACTGTTCATTCCATGAGTGGTGCTATATGTCCTTTAGAAGAAATGTGCAATATAGCACATGATTATGGAGCTTTAACTTTTGTTGATGAAGTGCATGCTGTTGGCTTGTATGGAAAACATGGTGCGGGTATAGGAGAAGAGAGAGGTTTGCAAGACAAAATAGACATTGTATCGGGGACACTGGGAAAGGCTTATGGTAATGTCGGAGGATATATCGCAGGTTCCTCCCTCCTGGTGGACACTATAAGGTCTCTAGCACCGGGTTTCATTTTTACTACAGCATTACCGCCACCGGTTCTGGCTGGCTCCCTGGCAGCTATAAGGCTTTTAGCTAGTGAAGAAGGACGGAATCTACGAGCTAAGCACCAGGCCATAGTGCGCTATTTGAAACTGTCATTGCTCGTGGCCGGTTTGCCACAGTTACCATCCGTGAGTCACATAGTGCCCGTTCCTATCAAAGGGGCCGATAAAGTGGCCCTCGTTGCCGAATCTCTAATGAAGAGGGGCCACTACGTGCAGGCTATCAACTATCCCACGGTGGCGCGCGGCGATGAGCGGCTGCGGTTCGCGCCGGGCCCCTACCACACGCCCGAAATGATAGACAACCTGATCACGGCACTCATTGAATCATTCCATGAGAATAACATACGCTTCAGTGAGTTTATGATAAACGGCACTTGCCGCGAATGCAGCATGGAGTACAAGGTGGACATCGGCTACGAGGAGCCCCTCAAATACCCGATGCAAGTCGCCTAG

Protein

MPCPFLGSLNQAFVKNYGATLMKQYGNYCPIISRGFRSLGNDETKCPFIQQNSIISEAPKEMTEDIAEPATPYHYENFFHDQINAKKRDYSYRVFRKVSRLAADGVYPKALEGPENRRVTVWCANDYLGMSRHPTVQDAAVNAIKSYGTGAGGTRNIAGNSQMTEKLEGEIAKLHKKPAALIFSSCFVANDATLSTLAKILPDCIVYSDAGNHASMIQGIRNSRAPKHIFRHNDPNHLRKLLADSPKGVPKLVVFETVHSMSGAICPLEEMCNIAHDYGALTFVDEVHAVGLYGKHGAGIGEERGLQDKIDIVSGTLGKAYGNVGGYIAGSSLLVDTIRSLAPGFIFTTALPPPVLAGSLAAIRLLASEEGRNLRAKHQAIVRYLKLSLLVAGLPQLPSVSHIVPVPIKGADKVALVAESLMKRGHYVQAINYPTVARGDERLRFAPGPYHTPEMIDNLITALIESFHENNIRFSEFMINGTCRECSMEYKVDIGYEEPLKYPMQVA

Catalytic Activity

glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Uniprot

H9JER3   A0A194QK95   I4DJ23   A0A2W1BMJ2   A0A2A4JMZ7   A0A212F2Y5   + More
A0A2H1W9H0   A0A0L7KTN9   D6WM57   A0A1Y1JX71   A0A1Y1JY98   A0A1B6M8P8   A0A0A9YFK2   A0A182NFT7   A0A2J7R0S3   A0A2J7R0S1   R4G4W8   A0A1Q3FGM7   A0A2M3ZFK6   J9K1I0   A0A1Q3FGM8   A0A182R372   A0A182Q9Q0   A0A2M4CWP2   A0A2M3ZYS1   A0A0V0G4Y4   A0A067QKL0   A0A2M4CWI5   A0A182VXF2   A0A182F9E1   A0A2M4CLH6   A0A2M4CMR6   A0A2M4BIJ6   A0A2M4BI95   B0WKL5   A0A182XE54   A0A2S2NRS4   Q170W7   A0A2S2PHG2   W5J7K5   A0A2M4CN34   A0A2M4CM01   A0A2M3ZYH2   A0A1B6M3E6   A0A2H8TJ22   A0A182VMR4   A0A182UC13   A0A182HJ70   Q7QBG3   A0A182GMH5   A0A023EV39   A0A336LUW3   A0A0K8TPZ1   A0A069DZ71   A0A182IJK9   A0A034WKZ9   W8BNW7   A0A336LUL0   A0A224XAU0   A0A182JXI1   A0A336LZS4   A0A0A1XDK3   A0A084WE55   A0A0K8UCB6   A0A336M6S5   A0A336LYD4   N6U816   U4UNN1   J3JWY5   R4WJT1   A0A2R7VNA7   E9I891   A0A182XWV4   A0A1L8E2U4   A0A1J1IQH1   A0A0L0CN59   A0A1J1IQP2   A0A232EXI3   A0A226DLE7   A0A026WPI3   A0A151JYW2   A0A151J0E1   K7IPW4   F4WPP7   A0A1D2M963   E2BHC8   B4J662   A0A2M3YZB7   A0A1B6CIU8   A0A1A9ZRB8   A0A1B6CM76   E0VLY6   A0A1W4V1J5   A0A0C9RB12   A0A0C9RT18   A0A1B6DJQ6   E2AL19   B4PAB3   A0A182M654  

EC Number

2.3.1.37

Pubmed

19121390    26354079    22651552    28756777    22118469    26227816    + More
18362917    19820115    28004739    25401762    26823975    24845553    17510324    20920257    23761445    12364791    14747013    17210077    26483478    24945155    26369729    26334808    25348373    24495485    25830018    24438588    23537049    22516182    23691247    21282665    25244985    26108605    28648823    24508170    20075255    21719571    27289101    20798317    17994087    20566863    17550304   

EMBL

BABH01023427    KQ461198    KPJ05957.1    AK401291    KQ459185    BAM17913.1    + More
KPJ03355.1    KZ149993    PZC75511.1    NWSH01000969    PCG73351.1    AGBW02010653    OWR48097.1    ODYU01007169    SOQ49710.1    JTDY01005927    KOB66475.1    KQ971343    EFA03355.2    GEZM01102097    JAV51975.1    GEZM01102096    JAV51976.1    GEBQ01007665    JAT32312.1    GBHO01015324    GBRD01006663    GDHC01016228    JAG28280.1    JAG59158.1    JAQ02401.1    NEVH01008217    PNF34433.1    PNF34432.1    ACPB03014603    GAHY01001010    JAA76500.1    GFDL01008335    JAV26710.1    GGFM01006532    MBW27283.1    ABLF02016305    GFDL01008344    JAV26701.1    AXCN02000244    GGFL01005453    MBW69631.1    GGFK01000328    MBW33649.1    GECL01003004    JAP03120.1    KK853326    KDR08456.1    GGFL01005451    MBW69629.1    GGFL01002009    MBW66187.1    GGFL01002010    MBW66188.1    GGFJ01003640    MBW52781.1    GGFJ01003639    MBW52780.1    DS231974    EDS29946.1    GGMR01007235    MBY19854.1    CH477465    EAT40489.1    GGMR01016039    MBY28658.1    ADMH02002112    ETN58855.1    GGFL01002130    MBW66308.1    GGFL01002131    MBW66309.1    GGFK01000295    MBW33616.1    GEBQ01009526    JAT30451.1    GFXV01002300    MBW14105.1    APCN01002128    AAAB01008879    EAA08478.5    JXUM01074640    JXUM01074641    JXUM01074642    JXUM01074643    GAPW01000726    JAC12872.1    UFQT01000207    SSX21725.1    GDAI01001397    JAI16206.1    GBGD01001150    JAC87739.1    AXCP01007734    GAKP01004494    JAC54458.1    GAMC01006023    JAC00533.1    SSX21726.1    GFTR01006919    JAW09507.1    SSX21727.1    GBXI01004818    JAD09474.1    ATLV01023152    KE525341    KFB48499.1    GDHF01028304    JAI24010.1    SSX21728.1    SSX21729.1    APGK01039068    APGK01039069    KB740967    ENN76791.1    KB632399    ERL94722.1    BT127753    AEE62715.1    AK417860    BAN21075.1    KK854004    PTY09037.1    GL761538    EFZ23201.1    GFDF01001135    JAV12949.1    CVRI01000057    CRL02463.1    JRES01000153    KNC33778.1    CRL02464.1    NNAY01001758    OXU23010.1    LNIX01000017    OXA45818.1    KK107138    EZA57935.1    KQ981456    KYN41571.1    KQ980638    KYN14920.1    GL888252    EGI63831.1    LJIJ01002575    ODM89515.1    GL448287    EFN84897.1    CH916367    EDW01920.1    GGFM01000807    MBW21558.1    GEDC01024033    GEDC01015295    JAS13265.1    JAS22003.1    GEDC01022721    JAS14577.1    DS235283    EEB14392.1    GBYB01005505    JAG75272.1    GBYB01010651    JAG80418.1    GEDC01011387    JAS25911.1    GL440429    EFN65872.1    CM000158    EDW92439.1    AXCM01002727   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000037510    + More
UP000007266    UP000075884    UP000235965    UP000015103    UP000007819    UP000075900    UP000075886    UP000027135    UP000075920    UP000069272    UP000002320    UP000076407    UP000008820    UP000000673    UP000075903    UP000075902    UP000075840    UP000007062    UP000069940    UP000075880    UP000075881    UP000030765    UP000019118    UP000030742    UP000076408    UP000183832    UP000037069    UP000215335    UP000198287    UP000053097    UP000078541    UP000078492    UP000002358    UP000007755    UP000094527    UP000008237    UP000001070    UP000092445    UP000009046    UP000192221    UP000000311    UP000002282    UP000075883   

PRIDE

H9JER3   

Pfam

PF00155   Aminotran_1_2        + More
PF09029   Preseq_ALAS
PF07690   MFS_1

Interpro

IPR015424   PyrdxlP-dep_Trfase        + More
IPR004839   Aminotransferase_I/II       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR010961   4pyrrol_synth_NH2levulA_synth       
IPR015118   5aminolev_synth_preseq       
IPR020846   MFS_dom       
IPR011701   MFS       
IPR036259   MFS_trans_sf       

SUPFAM

SSF53383   SSF53383        + More
SSF103473   SSF103473       

Gene 3D

3.40.640.10     3.90.1150.10    

CDD

cd06174  MFS

ProteinModelPortal

H9JER3   A0A194QK95   I4DJ23   A0A2W1BMJ2   A0A2A4JMZ7   A0A212F2Y5   + More
A0A2H1W9H0   A0A0L7KTN9   D6WM57   A0A1Y1JX71   A0A1Y1JY98   A0A1B6M8P8   A0A0A9YFK2   A0A182NFT7   A0A2J7R0S3   A0A2J7R0S1   R4G4W8   A0A1Q3FGM7   A0A2M3ZFK6   J9K1I0   A0A1Q3FGM8   A0A182R372   A0A182Q9Q0   A0A2M4CWP2   A0A2M3ZYS1   A0A0V0G4Y4   A0A067QKL0   A0A2M4CWI5   A0A182VXF2   A0A182F9E1   A0A2M4CLH6   A0A2M4CMR6   A0A2M4BIJ6   A0A2M4BI95   B0WKL5   A0A182XE54   A0A2S2NRS4   Q170W7   A0A2S2PHG2   W5J7K5   A0A2M4CN34   A0A2M4CM01   A0A2M3ZYH2   A0A1B6M3E6   A0A2H8TJ22   A0A182VMR4   A0A182UC13   A0A182HJ70   Q7QBG3   A0A182GMH5   A0A023EV39   A0A336LUW3   A0A0K8TPZ1   A0A069DZ71   A0A182IJK9   A0A034WKZ9   W8BNW7   A0A336LUL0   A0A224XAU0   A0A182JXI1   A0A336LZS4   A0A0A1XDK3   A0A084WE55   A0A0K8UCB6   A0A336M6S5   A0A336LYD4   N6U816   U4UNN1   J3JWY5   R4WJT1   A0A2R7VNA7   E9I891   A0A182XWV4   A0A1L8E2U4   A0A1J1IQH1   A0A0L0CN59   A0A1J1IQP2   A0A232EXI3   A0A226DLE7   A0A026WPI3   A0A151JYW2   A0A151J0E1   K7IPW4   F4WPP7   A0A1D2M963   E2BHC8   B4J662   A0A2M3YZB7   A0A1B6CIU8   A0A1A9ZRB8   A0A1B6CM76   E0VLY6   A0A1W4V1J5   A0A0C9RB12   A0A0C9RT18   A0A1B6DJQ6   E2AL19   B4PAB3   A0A182M654  

PDB

6HRH     E-value=1.46498e-135,     Score=1238

KEGG

101738292    K00643 5-aminolevulinate synthase [EC:2.3.1.37] | (RefSeq) 5-aminolevulinate synthase, nonspecific,

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006782   GO:0003870   GO:0005759   GO:0030170   GO:0016874   GO:0016021   GO:0006778   GO:0055085   GO:0033014   GO:0040003   GO:0003824   GO:0009058   GO:0007166   GO:0006032   GO:0005515   GO:0016742  

Subcellular location

Mitochondrion matrix  

Length:

507

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.724

Exp number, first 60 AAs:

0.00078

Total prob of N-in:

0.00068

outside

1  -  507

 

 

Pi

29.262511

Theta

137.890996

Tajima's D

-2.481397

CLR

162.847911

CSRT

0.000549972501374931

Interpretation

Possibly Positive selection