Gene

KWMTBOMO04900  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008017

Annotation

aminopeptidase_N-7_[Bombyx_mori]

Location

Bomo_Chr9(-):1097291-1127064      View in EpiBrowser

Full name

Aminopeptidase       + More
Aminopeptidase N      

Alternative Name

Apn2
Microsomal aminopeptidase
Apn1

Location in the cell

PlasmaMembrane   Reliability : 3.796

CDS

ATGTCAGTTTATTCATTGATCCTGCCAATACCGTCAGTTTCAACGGGAAGGAGCAGCAACGAAAACTTGTTTGCTAGTTTCACTCTAGCAACTGATGATACGCATTTTTTGAGAATCAGTACCAGAACACAGCTCCTTCCAGACCAGCCGTATATTGTGAACATTGATTATGAATCTAAATACGCGCCCAACATGTTCGGAGTATATGTATCTACATACCAACAAAATGGACGAACTGTAAATCTGGTAACTTCTCAACTTCAACCAACGTTTGCCCGCCGTGCATTCCCTTGCTACGATGAGCCGGCTATCAAAGCTATTTTCAGAACTACCATATACGCACCAGCAGCCTACACGGTTGTTAGGCACAATACTCCCGAAAGAGCTGTCCCATTGAAGGAGGACGTGGCGGGTTACGTGAAGCACGAGTTTGAAGACACCCTCGTAATGTCGACGTACCTGCTCGCCTATCTCGTGTCGAACTTCGAGCACGTTAGCAACGAGCAAAACCCCATCTACAGAGTCCCCTTCAGGGTATATTCTAGGCCAGGAACCCAGACCAACGCAGCCTTCGCAATGGACTTCGGACAAAAGAACATGGTCGCTTTGGAAGCGTACAACGAATTCCCTTATGCTTTCCCTAAATTAGATAAAGCAGCCGTTCCCGATTTTGCTGCGGGTGCCATGGAGAACTGGGGTCTTGTCATTTACAGGGAAGTGGCATTGCTGGTGACGGAAGGTGTAACGACCACAGCGACCAGGCAGAACATTGCCAGGATTATCTGCCACGAGAATGTGCACATGTGGTACGGCAATGAAGTGGGTCCGCTGTCCTGGACTTACACTTGGCTCAACGAAGGTTTCGCAACGTTCTTCGAGAGTTTCGCCACTGATTTGGTACTTCCGGAATGGCGTATGATGGAGCAGTTTGTGGTGACCATGCAGAATGTGTTCCAATCGGATGCTGTTCTCACTATCAACCCCATGACGCACGCGGTCTACACTCCTTCTCAGATCATGGGACAATTTAACGCCATTGCCTATCAAAAATCCGGCTCGGTGATCAGAATGTTGCATCATTTCCTGACACCGGAAATATTCAGACGAGGTCTCGTTATTTACATCATTAACAACTCCCGTCGTGCTGCCGGGCCGTCAGACTTATATGCTGCTCTCCAACAAGCCCTGGATGCGTCCGACCACAGCATCCCGTACTCGATCTCCAATGTGATGAACAGATGGGTCAACCAGGGAGGGTTCCCAGTGTTGAACGTGAGAAAGAGCGCCCCGAACGCTAATTCGGTCTTTATTTCTCAGGAGCGATATCTCACAGACCGCTCTCTGACGTCAACGGACCGTTGGCATGTGCCAGTCAACTGGGTGCTGTCTTCCAACATTGATTTCTCTGACACAAAACCCCAAGGTTGGATCCCACCGTCGTTCCCTGCCACCTCGATCGACATTCCTGGATTGGCAAACGCCGAATGGTTCATTTTTAACAAGCAACAGACTGGCTACTACCGCGTGAACTACGATCCGGAGAACTGGGCGGCCCTCGCAAGAGTCTTACAGACCAATCATGCCGTTATCCATCTCCTCAATCGCGCTCAGATTCTTGACGATTCCTTCAACATGGCCAGAAATGGGCGCCTGAATTACAACCTTCCCTTCGAGATTTCTCGATACCTGATCAACGAGAAAGATTACATTCCCTGGGCTGCCATTAACCCTGCCTTCAATTACTTAGATATCGTTCTAACCGGATCTTCAGTATACAATTTGTTTAGGGAGTATCTTCTGACACTGACTGCACCTCTATATGACGAAATTGGTTGGGAGGCGACTGCCAACGAGGAGCATGTTATGGCTTACCACAGAAATATCATATTGGACATCAATTGTCGTCTCGGAAACCAGAGATGCGTCACCAGAGCCCAGGAACTGTTGGAGCAGTTCCGAAATAATCCAACTCAAAGACTGAACCCGGATTTACAAAACACAGTGTACTGTTCCGGTCTACGTGGCGGTGATAGAGATAATTTCAATTTCCTTTGGGAGCAATATTTGGCTAGCTCTGATTCAAGCGAGCAAAACATCCTCCTCAATGCTCTGGGATGTACTTCGAACCCTGAACTGCGTACCTTCTACATGAACCAAGTTATCGATGCCAACTCACCAGTGAGGGAACAAGACCGGCACACAATTCTCGTCTCTGTCATCAACTCTAGTCCAGAGAACATGGACGCTGCCTTAGAATTCGTCATTGAAAACTTCCACAGGATCCAACCGAGGGTGCAAGGCCTCACCGGGACCACTAACATATTAAATGCCTTCGCAAGAAGACTGACCACAGAAACGCATGCTGAAAGGATAAACCAGCTGATCAGTCGTCACCAAGCCATCTTAACAGCTGGAGAACAAGCATCCATCTCAGCTATCAGAGAGCACATCGCAGCTTCGATAGCTTGGGGTAAAGACAATGCTGCTGTTGTAGAGGACTGGCTTGAAGACAACTACGGAGAACCCAAGCCGGAGGAACCATCCGCAGCACATTCTACGACGGCTGGTTTTATTGTTTTGCTATCTGCTTTTGTCGCTTTCTTTAACATTCATTAA

Protein

MSVYSLILPIPSVSTGRSSNENLFASFTLATDDTHFLRISTRTQLLPDQPYIVNIDYESKYAPNMFGVYVSTYQQNGRTVNLVTSQLQPTFARRAFPCYDEPAIKAIFRTTIYAPAAYTVVRHNTPERAVPLKEDVAGYVKHEFEDTLVMSTYLLAYLVSNFEHVSNEQNPIYRVPFRVYSRPGTQTNAAFAMDFGQKNMVALEAYNEFPYAFPKLDKAAVPDFAAGAMENWGLVIYREVALLVTEGVTTTATRQNIARIICHENVHMWYGNEVGPLSWTYTWLNEGFATFFESFATDLVLPEWRMMEQFVVTMQNVFQSDAVLTINPMTHAVYTPSQIMGQFNAIAYQKSGSVIRMLHHFLTPEIFRRGLVIYIINNSRRAAGPSDLYAALQQALDASDHSIPYSISNVMNRWVNQGGFPVLNVRKSAPNANSVFISQERYLTDRSLTSTDRWHVPVNWVLSSNIDFSDTKPQGWIPPSFPATSIDIPGLANAEWFIFNKQQTGYYRVNYDPENWAALARVLQTNHAVIHLLNRAQILDDSFNMARNGRLNYNLPFEISRYLINEKDYIPWAAINPAFNYLDIVLTGSSVYNLFREYLLTLTAPLYDEIGWEATANEEHVMAYHRNIILDINCRLGNQRCVTRAQELLEQFRNNPTQRLNPDLQNTVYCSGLRGGDRDNFNFLWEQYLASSDSSEQNILLNALGCTSNPELRTFYMNQVIDANSPVREQDRHTILVSVINSSPENMDAALEFVIENFHRIQPRVQGLTGTTNILNAFARRLTTETHAERINQLISRHQAILTAGEQASISAIREHIAASIAWGKDNAAVVEDWLEDNYGEPKPEEPSAAHSTTAGFIVLLSAFVAFFNIH

Catalytic Activity

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactor

Zn(2+)

Subunit

Binds to CRY1AB5.

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Disulfide bond   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Removed in mature form

Uniprot

H9JES0   I3VR78   O76151   P91885   A0A286LPZ7   A0A194QLY2   + More
Q9XYV3   B2D0I7   E8Z5D0   A3RIW4   A0A2W1BMG1   B6CMF1   Q5EFF2   B5A8Y0   A4D0J4   P91887   Q4G6A4   Q6Q2I0   D2KHN3   E0A210   A0A2H1VG23   A0A3S2LTZ5   A0A212EJU3   A0A2Z3YIN5   A0A2A4J3L5   A0A2J7RAG9   A0A2J7RAH0   A0A2J7PPF0   A0A2P8Y405   E2BB79   A0A2J7RAG5   A0A182GWW7   Q95PB9   Q8T4T6   Q16L31   U5EWR8   A0A0M9A6N6   Q95P62   A0A1S4J3H9   Q8T4T7   K7IT85   A0A0P4VSA7   A0A026W0P7   K7INE5   A0A087ZUG8   A0A3L8E4L7   A0A0M4ED13   A0A1I8P6R0   A0A069DXK6   A0A2P2I2Q6   A0A224X6F7   E2ALT1   A0A2A3EJS2   X1WUZ5   A0A1Q3FS18   A0A2S2NGP8   A0A1I8MFJ3   A0A146LYB5   A0A0V0G738   A0A0K8R857   T1P8B3   A0A232EWK0   A0A310SPN7   E0VS71   A0A2J7PPF3   A0A182GA80   A0A195F0B1   A0A1W4XT18   A0A212EJQ4   A0A2H8TGE4   B0W1Y2   A0A034V8K5   A0A2R7VTS0   A0A194QK79   A0A195BIK5   T1I7S8   A0A084WR42   A0A232FJ88   A0A0C9R2S6   B4M146   A0A1W4VQT7   A0A195DN33   B4K976   A0A1B6GWM4   A0A1W0XDI0   A0A067QSR5   E2BB86   A0A194QD38   B4NJ06   A0A195DN37   A0A182KFB7   A0A2J7RAG3   A0A0L7QWL2   B4JF64   A0A1I8P0F0   Q178P2  

EC Number

3.4.11.-
3.4.11.2

Pubmed

19121390    9972296    9342226    26354079    10406091    20420910    + More
28756777    18549954    18760362    15857766    15978131    20685334    22118469    29403074    20798317    26483478    17510324    14513362    20075255    27129103    24508170    30249741    26334808    25315136    26823975    28648823    20566863    25348373    24438588    17994087    24845553   

EMBL

BABH01023399    BABH01023400    BABH01023401    BABH01023402    JQ061149    AFK85023.1    + More
AB011497    BAA32140.1    X97877    MF425654    ASU92546.1    KQ461198    KPJ05970.1    AF126443    AAD31184.1    EU564811    ACB47287.1    EU878376    ACJ64828.1    EF417486    ABN64103.1    KZ149969    PZC76118.1    EU325551    ACB54941.1    AY894814    AAW72993.1    EU826127    ACF34999.1    AY836580    AAX39864.1    X97878    AY218843    AAP44965.1    AY564237    AAS75552.1    GU213038    ADA59490.1    HM231317    ADL38969.1    ODYU01002173    SOQ39332.1    RSAL01000228    RVE43927.1    AGBW02014405    OWR41740.1    KY949254    AWT22996.1    NWSH01003448    PCG66278.1    NEVH01006570    PNF37826.1    PNF37825.1    NEVH01023278    PNF18181.1    PYGN01000952    PSN39002.1    GL446946    EFN87052.1    PNF37829.1    JXUM01094214    KQ564112    KXJ72771.1    AF378117    AAK55416.1    AY064079    AAL85580.1    KF021690    CH477924    AGT95895.1    EAT35030.1    GANO01001287    JAB58584.1    KQ435724    KOX78330.1    AF390100    AAK73351.1    AY064078    AAL85579.1    AAZX01003317    GDKW01001137    JAI55458.1    KK107589    EZA48634.1    QOIP01000001    RLU27566.1    CP012526    ALC45616.1    GBGD01000333    JAC88556.1    IACF01002668    LAB68313.1    GFTR01008371    JAW08055.1    GL440629    EFN65601.1    KZ288223    PBC31977.1    ABLF02030670    ABLF02030672    GFDL01004812    JAV30233.1    GGMR01003721    MBY16340.1    GDHC01006045    JAQ12584.1    GECL01002882    JAP03242.1    GADI01006478    JAA67330.1    KA644849    AFP59478.1    NNAY01001852    OXU22728.1    KQ760397    OAD60666.1    DS235745    EEB16227.1    PNF18179.1    JXUM01050786    JXUM01050787    JXUM01050788    JXUM01050789    KQ561662    KXJ77885.1    KQ981905    KYN33597.1    OWR41732.1    GFXV01001305    MBW13110.1    DS231824    EDS27418.1    GAKP01020867    JAC38085.1    KK854013    PTY09335.1    KPJ05978.1    KQ976467    KYM84197.1    ACPB03005577    ATLV01025918    KE525402    KFB52686.1    NNAY01000153    OXU30528.1    GBYB01001141    JAG70908.1    CH940650    EDW67457.1    KQ980713    KYN14242.1    CH933806    EDW14489.1    GECZ01002996    JAS66773.1    MTYJ01000002    OQV25529.1    KK853596    KDR06435.1    EFN87059.1    KQ459185    KPJ03377.1    CH964272    EDW84908.1    KYN14241.1    PNF37828.1    KQ414710    KOC62990.1    CH916369    EDV93345.1    CH477360    EAT42699.1   

Proteomes

UP000005204    UP000053240    UP000283053    UP000007151    UP000218220    UP000235965    + More
UP000245037    UP000008237    UP000069940    UP000249989    UP000008820    UP000053105    UP000002358    UP000053097    UP000005203    UP000279307    UP000092553    UP000095300    UP000000311    UP000242457    UP000007819    UP000095301    UP000215335    UP000009046    UP000078541    UP000192223    UP000002320    UP000078540    UP000015103    UP000030765    UP000008792    UP000192221    UP000078492    UP000009192    UP000027135    UP000053268    UP000007798    UP000075881    UP000053825    UP000001070   

PRIDE

H9JES0    I3VR78    O76151    E8Z5D0    P91887    A0A087ZUG8    + More

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR001930   Peptidase_M1        + More
IPR034016   M1_APN-typ       
IPR042097   Aminopeptidase_N-like_N       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR033581   APN2       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

H9JES0   I3VR78   O76151   P91885   A0A286LPZ7   A0A194QLY2   + More
Q9XYV3   B2D0I7   E8Z5D0   A3RIW4   A0A2W1BMG1   B6CMF1   Q5EFF2   B5A8Y0   A4D0J4   P91887   Q4G6A4   Q6Q2I0   D2KHN3   E0A210   A0A2H1VG23   A0A3S2LTZ5   A0A212EJU3   A0A2Z3YIN5   A0A2A4J3L5   A0A2J7RAG9   A0A2J7RAH0   A0A2J7PPF0   A0A2P8Y405   E2BB79   A0A2J7RAG5   A0A182GWW7   Q95PB9   Q8T4T6   Q16L31   U5EWR8   A0A0M9A6N6   Q95P62   A0A1S4J3H9   Q8T4T7   K7IT85   A0A0P4VSA7   A0A026W0P7   K7INE5   A0A087ZUG8   A0A3L8E4L7   A0A0M4ED13   A0A1I8P6R0   A0A069DXK6   A0A2P2I2Q6   A0A224X6F7   E2ALT1   A0A2A3EJS2   X1WUZ5   A0A1Q3FS18   A0A2S2NGP8   A0A1I8MFJ3   A0A146LYB5   A0A0V0G738   A0A0K8R857   T1P8B3   A0A232EWK0   A0A310SPN7   E0VS71   A0A2J7PPF3   A0A182GA80   A0A195F0B1   A0A1W4XT18   A0A212EJQ4   A0A2H8TGE4   B0W1Y2   A0A034V8K5   A0A2R7VTS0   A0A194QK79   A0A195BIK5   T1I7S8   A0A084WR42   A0A232FJ88   A0A0C9R2S6   B4M146   A0A1W4VQT7   A0A195DN33   B4K976   A0A1B6GWM4   A0A1W0XDI0   A0A067QSR5   E2BB86   A0A194QD38   B4NJ06   A0A195DN37   A0A182KFB7   A0A2J7RAG3   A0A0L7QWL2   B4JF64   A0A1I8P0F0   Q178P2  

PDB

4WZ9     E-value=1.62901e-122,     Score=1128

KEGG

692370    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn2; aminopeptidase N

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008237   GO:0004177   GO:0008270   GO:0031225   GO:0005886   GO:0016021   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824   GO:0006508  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

Length:

871

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.29196

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.00007

outside

1  -  871

 

 

Pi

241.413237

Theta

169.520407

Tajima's D

1.532915

CLR

0.329373

CSRT

0.7961601919904

Interpretation

Uncertain