Gene

KWMTBOMO04899  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008018

Annotation

membrane_alanyl_aminopeptidase-like_[Bombyx_mori]

Location

Bomo_Chr9(-):1089868-1094184      View in EpiBrowser

Full name

Aminopeptidase      

Location in the cell

PlasmaMembrane   Reliability : 2.922

CDS

ATGGCCCGGAGAAAGTATAAGTGGAAATTCACTTTCTTCTATTTCTTGATACTATTGAACATTTTCACGAATTGTTTACCAATCGACAAGAAATTAAGGCAGACCACGAACGATGCTACATTCTCAGATTCGAATCCAGACGCAAACTCAGCTGAGTCCCACTTGTCCCAGCCGGATACTTTTGATGAAAAAACTAAGTTTATCCCAGAGGATGATTCGAAACGAACTGCGATTGTGTCAACTAATGCAGAAAGAAATCAGGCAGGAGAAACTGTCAGACCAGGTCAGACGATTAGTAGCTACGAAGTGGAAATCACCATAGAAGAAAATCGTTTCAAAGGAAGAGCCGTTATTGAATTGGAACTGGATGCCAATACGAGGGATGACCCCATAAAATTATATTCAGAGGATCTAGATGTAACCAGTGTACGGACCGGGGTCTTTACGGAAGCCAACAGCTTAGCAGCCACTTTCAGACTTAGAGATGGTTTTTTGGAGATCACTCCCGTACAGAGTACTACTTCATACGTTGTTGTGGTGGAATATACTGGAATACTAAGGAATGACGGCAACGGTATCTATCGCGGTGAAGGAAATGGCGTGTCATACCTGGCAATGAACCTACACCCTACACATGCGCGGCGCGTGTTTCCTTGCTTCGATGAACCTAACGAGGCAGCCAACATACGTTTCACGTTCAATGACGTCGAATTTAATAATATCGTCACAAATTCATTGCCCGAAGAAAATGCAGAGAATCGGTTCCGCGCCCTCGCCAGTTCTCCCCACAGGTGGGGAATGATCGCCCACGATTTCATTAATCTTAATATACCAACAACGGACGTGCTGTTGGTAGGACGACCGGGCCTCAGTAACCAAGATTCGCAAGCTTCATTAGCTATCAATGCATTCTTCAGCTTCCTGAACGAATGGACAGAAAAGCCTTACTTCGAGATCATTCTTAACCAGGAAAGTAGGATGCACGTTATCGCCTTACCCGATGTAGATCGTGACTGGCATGCTCTATCCATTGTTGGCATTTGGGAACCATATTTGTTGATGGAAACGACAGCTTCTGTTAAACAAAGAAAAACGGCGCTTGTGAAGATAGCAGAAACCATGGCGAAGCAGTGGTTTGGATACGTCATGTACCCCGAGAACTGGAGATTTGAATGGGTCTGTTAG

Protein

MARRKYKWKFTFFYFLILLNIFTNCLPIDKKLRQTTNDATFSDSNPDANSAESHLSQPDTFDEKTKFIPEDDSKRTAIVSTNAERNQAGETVRPGQTISSYEVEITIEENRFKGRAVIELELDANTRDDPIKLYSEDLDVTSVRTGVFTEANSLAATFRLRDGFLEITPVQSTTSYVVVVEYTGILRNDGNGIYRGEGNGVSYLAMNLHPTHARRVFPCFDEPNEAANIRFTFNDVEFNNIVTNSLPEENAENRFRALASSPHRWGMIAHDFINLNIPTTDVLLVGRPGLSNQDSQASLAINAFFSFLNEWTEKPYFEIILNQESRMHVIALPDVDRDWHALSIVGIWEPYLLMETTASVKQRKTALVKIAETMAKQWFGYVMYPENWRFEWVC

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Feature

chain  Aminopeptidase

Uniprot

I3VR82   H9JES1   A0A194QR13   A0A2W1BM20   A0A194QD33   A0A2H1VVS9   + More
A0A212EJS2   A0A286LQ00   A0A2A4J290   A0A2H1VG23   A0A0L7LHA5   E2BB80   A0A3A4VBH3   D6WBB0   A0A1F6V3Z0   Q16ZL6   A0A017TCZ3   K7INE4   A0A1M3N3Y2   A0A0P6ET91   A0A232EWK1   A0A1F6Y568   A0A1F5JQ82   A0A1S4FIM9   A0A2H0UB43   A0A0G1GT22   A0A352BEA5   A0A0T6BAA6   A0A1F5KPK5   A0A182H3I7   A0A2P6N3L2   A0A0G0QRZ6   A0A2W0AY25   W7L7A4   A0A182HSV0   A0A2W0C125   A0A3Q3BI68   A0A210PQ87   A0A2E6LF19   Q7QC91   A0A0P5QDI9   A0A0P5PZM3   A0A0P5DDZ9   A0A1F6WY42   A0A0F2LTP9   A0A0P5CKV4   A0A1J1IMJ3   A0A0P6A6Q7   A0A0P5VUF0   A0A0P5K4F5   A0A0P6FNJ7   A0A2A3ELA7   A0A0N8BG95   A0A0P5D0N1   A0A0P5LKV9   A0A0P6BZ76   A0A0P5MJ75   A0A0P5MJN9   A0A0P6G6P9   A0A0P5ZUC5   A0A0N8AXC2  

EC Number

3.4.11.-

Pubmed

19121390    26354079    28756777    22118469    26227816    20798317    + More
28644444    18362917    19820115    27774985    17510324    20075255    28648823    30148503    26483478    29378020    29899444    24604657    28812685    29337314    12364791    14747013    17210077   

EMBL

JQ061153    AFK85027.1    BABH01023395    BABH01023396    BABH01023397    BABH01023398    + More
KQ461198    KPJ05971.1    KZ149969    PZC76122.1    KQ459185    KPJ03372.1    ODYU01004747    SOQ44951.1    AGBW02014405    OWR41739.1    MF425657    ASU92549.1    NWSH01003448    PCG66277.1    ODYU01002173    SOQ39332.1    JTDY01001142    KOB74749.1    GL446946    EFN87053.1    QZIY01000019    RJQ34644.1    KQ971312    EEZ99298.1    MFTO01000001    OGI64393.1    CH477489    EAT40058.1    ASRX01000014    EYF06797.1    MKVQ01000024    OJY23046.1    GDIQ01071637    JAN23100.1    NNAY01001852    OXU22726.1    MFVU01000024    OGJ01507.1    MFCV01000044    OGE30746.1    PFBK01000008    PIR83629.1    LCHR01000017    KKT37403.1    DNMN01000018    HBB44037.1    LJIG01002688    KRT84252.1    MFDM01000020    OGE42848.1    JXUM01003831    KQ560164    KXJ84068.1    MDYQ01000218    PRP78523.1    LBXY01000002    KKR40106.1    QIBB01000497    PYY10602.1    ASRH01000003    EWG07574.1    APCN01000366    QIBC01000015    PYY19931.1    NEDP02005559    OWF38669.1    PBJQ01000011    MBK77236.1    AAAB01008859    EAA08230.5    GDIQ01121870    JAL29856.1    GDIQ01121869    JAL29857.1    GDIP01162826    JAJ60576.1    MFUR01000010    OGI86809.1    JZWS01000017    KJR79196.1    GDIP01169022    JAJ54380.1    CVRI01000055    CRL01384.1    GDIP01035094    LRGB01002121    JAM68621.1    KZS09066.1    GDIP01109686    JAL94028.1    GDIQ01194840    JAK56885.1    GDIQ01046749    JAN47988.1    KZ288223    PBC31976.1    GDIQ01180699    JAK71026.1    GDIP01162827    JAJ60575.1    GDIQ01193049    JAK58676.1    GDIP01007169    GDIP01007168    GDIQ01035004    JAM96546.1    JAN59733.1    GDIQ01155913    JAK95812.1    GDIQ01162754    JAK88971.1    GDIQ01048296    JAN46441.1    GDIP01039699    JAM64016.1    GDIQ01233683    JAK18042.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000037510    + More
UP000008237    UP000007266    UP000008820    UP000002358    UP000184214    UP000215335    UP000069940    UP000249989    UP000241769    UP000054284    UP000075840    UP000248201    UP000264800    UP000242188    UP000007062    UP000183832    UP000076858    UP000242457   

PRIDE

I3VR82    H9JES1   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR042097   Aminopeptidase_N-like_N        + More
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR001930   Peptidase_M1       
IPR034016   M1_APN-typ       
IPR033581   APN2       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

I3VR82   H9JES1   A0A194QR13   A0A2W1BM20   A0A194QD33   A0A2H1VVS9   + More
A0A212EJS2   A0A286LQ00   A0A2A4J290   A0A2H1VG23   A0A0L7LHA5   E2BB80   A0A3A4VBH3   D6WBB0   A0A1F6V3Z0   Q16ZL6   A0A017TCZ3   K7INE4   A0A1M3N3Y2   A0A0P6ET91   A0A232EWK1   A0A1F6Y568   A0A1F5JQ82   A0A1S4FIM9   A0A2H0UB43   A0A0G1GT22   A0A352BEA5   A0A0T6BAA6   A0A1F5KPK5   A0A182H3I7   A0A2P6N3L2   A0A0G0QRZ6   A0A2W0AY25   W7L7A4   A0A182HSV0   A0A2W0C125   A0A3Q3BI68   A0A210PQ87   A0A2E6LF19   Q7QC91   A0A0P5QDI9   A0A0P5PZM3   A0A0P5DDZ9   A0A1F6WY42   A0A0F2LTP9   A0A0P5CKV4   A0A1J1IMJ3   A0A0P6A6Q7   A0A0P5VUF0   A0A0P5K4F5   A0A0P6FNJ7   A0A2A3ELA7   A0A0N8BG95   A0A0P5D0N1   A0A0P5LKV9   A0A0P6BZ76   A0A0P5MJ75   A0A0P5MJN9   A0A0P6G6P9   A0A0P5ZUC5   A0A0N8AXC2  

PDB

5CU5     E-value=2.20096e-07,     Score=132

KEGG

101737010    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) membrane alanyl aminopeptidase-like

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008270   GO:0004177   GO:0008237   GO:0016021   GO:0043171   GO:0042277   GO:0005737   GO:0070006   GO:0006508   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11533:SF246  

SignalP

Position:   1 - 25,         Likelihood:  0.825796

 

 

Length:

394

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

15.58663

Exp number, first 60 AAs:

15.43842

Total prob of N-in:

0.66942

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  29

outside

30  -  394

 

 

Pi

176.882867

Theta

58.71478

Tajima's D

0.887958

CLR

22.145831

CSRT

0.630668466576671

Interpretation

Uncertain