Gene

KWMTBOMO04893  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008063

Annotation

membrane_alanyl_aminopeptidase-like_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):1019895-1033903      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor

Location in the cell

PlasmaMembrane   Reliability : 3.158

CDS

ATGCAACGAATATTTGTAATAGCAATAGCATGTCTTCTAGCGAGGACGTCTGGTACCGACACAAATTACAGACTGAACACTCCAATAGTACCAAAAGCGTATACAATTATCATTACACCATACTTTGACACCGGTGACCGCAATGCCTTTACGTTTGATGGAGAAGTCAGCATCACGCTCACCACGACAGCAGTGACAAAGCAAATTAAGCTACACTCGGAAGATCTGAATTTTGTCGCTGACAATGTAACTGTAAGTGGTGCCAGTGGAGATATAGCATTAGCTAACACGGAACCGCTTATCTTTGATGCAAACTATACGTTTGTTTATATTAATTTGGCGTCGGAATTACAAGTTGGCGTAGAGTATACACTGACTATTTCGTATAGGGGACCTATACGTGAGGACTTGAATGGATTTTACAGGAATTATTACTTTGAGAACGGCGTTAAAAAATGGTTGGGCGCGACACAAATGGAGCCTACACACGCGAGGAAGGCGTTCCCATGTTTTGATGAGCCTGGTCTTAAAGCCACTTTCACCCTGATTGTTGACCGACCGCAAAACTACAAACCCTCCTTGGCTAACACTAAGCTGCAGACTACAGTGACCCTGTCAAATGGTTATGTTAGGGAAGTATTCTACCCTACTCCGATAATGCCTACTTATTTAGTGGCTTTTATGGTATCTCAATTTGACGCAGCCCTAGCTGACTCTACAAATGGAAGAGAGTTTGCAGTCTACACCAGACCAGAGGCAGTTAACCAAAGCTCTTATACGTTTGACTTCGGCACCAGAGTAGAGAAAGCTTTGAGTGATTTTTATGGTATCGACTATTACTCAGTTGACAGTAATCTGAAGCTGGATCATGTGGCTCTGCCAGATTTTAGGGCTGGTGCAATGGAAAACTGGGGTTTGGTCAAATACAGGGAAGCATTGCTCCTATACGTGCCAGAGGAATCCACCCCGTATTACAAGTACAGAGTTGCTCAAATCGTAGCTCATGAAACCACACATATGTGGTTTGGTAATTTGGTAACGTGTCACTGGTGGAGCAATACGTGGCTGAATGAGGGCTTTGCCAATTACTTCCAAGATTACATCACTGCGCTTATTGAACCAGAAGTGGGCTCAGCTAATCAACTGGTCATAGGCTCAGTGTATTCGGCCTACGGCGCTGATAATTCTCCGTCGTCGGCGCCCATCACGAACAACGACGTGAATTCACCGGCCGAAATCAGCGGTCACTTCGGGACGATCACCTACCAGAAGGGCGGTTCCGTGATCCGGATGATGCATCATTTCATTGGCGACGTCGCCTTCAAATACGCACTGCACGAGTATTTGGACGTAAACCGATTCGGTTCGGGATATCCAGAGTTGCTGTATTCAGCTCTAGAGAACGGCGTTAAGAATAACAACTCCTTAGCTTCCTACCCCGGAATCAGCATTACCGATGTAATGAAGACCTGGATCACTCAAGCAGGCCATCCTTTGCTTCACGTCCATGTTAACTACACCGATGACACTGTAACTCTAACTCAGAAAAGATTCTACATCAATTCTTCGCACTCATCGAATGAAACGTACAGCATCCCAATAACTTACACGACCGGACAATCACCTGATTTCGAGAACACCAAACCAGTTTTCGTAATGACGGGGAAGACACATGAGTTCCAAATTACAAACATCAGCAAAACACATACTTGGGTAATATTCAACATTCAGGAGACAGGTTTCTACAGAGTAACTTACGATGAGCACACCTGGGAGCATATAGGTGGGGCTCTGAAAGGATCCAGTCGAGAAAAAATACATCATCTTAATCGCGCCAAAATAGTCAACGATCTCTTCGATCTATATTACGCTGATGAGGTCAGCTTTAGTCTTCTAATCGAAACCCTGGAATTCTTAAAAGAAGAAACTGAAAATGCAGTGTGGTTTGCAGCTATCAAAGGTTTAAATAAACTATGGAACAGTTACCTCGGTGATTCCGCTCTGGAAGACATCGAGAGATTAGCGCTGAAGTTTATTGATAATGCTATAACAACGATTGGGTACGAAGTGAGGGCTACAGATGATTTCTCGACACTAACAAACCGACTGCAGTTATTGGAATTTGCATGCAAAATTGGTCATCAGGGATGTATTGAAAATACTGTGTCCGCATTTAAGCGGTTCAAAGATACTGGAGTTAGCGTTTCGCCAAGTTTACGACCAGTCACCTACTGCAGTGGTCTTCGGTTCGGTGATGCATCCGATTATGAGTTTCTGTGGGAGCGAATGTCAACGACCAATGTGGCTAATGAAGCCAGAGTCATCTCTGGGGTGTTAGGATGCAGCACAGATGAAGGAAGTCTTGAGAAATTCCTTTTCTCGGTTAAAGAAGAGAACAGTCCGATAAGGACACAAGATCTGACTGTTCCACTGACCGGCGTCTTGTCTAACCACAGTCATATATACATAGTAATGGACAGCTTGAAGCAGAACTACAGCGCGTGGAGTTCCATTCACACATCAATGGACACAATTTTAAGCACTGTAGCAGCGGCTTTGCATACAGACGATGATTTTACGGATATGGAAACCTGGCTCTCAATTTGCACGGAATGCACTGAACAAAGCAAATTAAGTGCGAGAACTGCTTTGAGTGGCGCTCGGGCTGCCTCGGACTGGTCAAAGAAGCATCGGGAAGAAATAGTCAGCGCTTTGAAGAGCGGATCTTTGGTGAACGCGCCATCTCTGATTCTTTTCATTTTGAGCATTGTAGTAGTATTATTTAAATTTTAA

Protein

MQRIFVIAIACLLARTSGTDTNYRLNTPIVPKAYTIIITPYFDTGDRNAFTFDGEVSITLTTTAVTKQIKLHSEDLNFVADNVTVSGASGDIALANTEPLIFDANYTFVYINLASELQVGVEYTLTISYRGPIREDLNGFYRNYYFENGVKKWLGATQMEPTHARKAFPCFDEPGLKATFTLIVDRPQNYKPSLANTKLQTTVTLSNGYVREVFYPTPIMPTYLVAFMVSQFDAALADSTNGREFAVYTRPEAVNQSSYTFDFGTRVEKALSDFYGIDYYSVDSNLKLDHVALPDFRAGAMENWGLVKYREALLLYVPEESTPYYKYRVAQIVAHETTHMWFGNLVTCHWWSNTWLNEGFANYFQDYITALIEPEVGSANQLVIGSVYSAYGADNSPSSAPITNNDVNSPAEISGHFGTITYQKGGSVIRMMHHFIGDVAFKYALHEYLDVNRFGSGYPELLYSALENGVKNNNSLASYPGISITDVMKTWITQAGHPLLHVHVNYTDDTVTLTQKRFYINSSHSSNETYSIPITYTTGQSPDFENTKPVFVMTGKTHEFQITNISKTHTWVIFNIQETGFYRVTYDEHTWEHIGGALKGSSREKIHHLNRAKIVNDLFDLYYADEVSFSLLIETLEFLKEETENAVWFAAIKGLNKLWNSYLGDSALEDIERLALKFIDNAITTIGYEVRATDDFSTLTNRLQLLEFACKIGHQGCIENTVSAFKRFKDTGVSVSPSLRPVTYCSGLRFGDASDYEFLWERMSTTNVANEARVISGVLGCSTDEGSLEKFLFSVKEENSPIRTQDLTVPLTGVLSNHSHIYIVMDSLKQNYSAWSSIHTSMDTILSTVAAALHTDDDFTDMETWLSICTECTEQSKLSARTALSGARAASDWSKKHREEIVSALKSGSLVNAPSLILFILSIVVVLFKF

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

I3VR76   H9JEW6   G3ESV6   E8Z7I6   A0A2A4IXL1   A0A2H1VVU0   + More
A0A2W1BPB2   A0A194QK74   A0A194QD77   A0A3G1QXU4   A0A212EJS3   A2TN62   A0A0L7L408   O16851   D2KHN5   D2KHN4   Q9U6W2   H9JEW2   O76803   A4D0J3   Q9U7N8   Q11001   A0A212EJU6   F6K6Z9   Q962B4   A0A2W1BR38   A0A1L5JK78   A0A1B0RHN6   O76122   Q95WL0   Q6UY54   Q6R3M6   Q6UY55   A0A1B0RHN3   B2LRS7   Q8WSZ2   A0A3S2TRJ1   Q2L9Z0   B2LRS8   Q9NHZ9   A0A194QIU5   Q6R3M5   Q6T3W3   V5NPR9   D0UYB1   Q19TV9   V5NQ96   G3ESV3   Q6T3W2   D0UYB2   E8Z5C9   Q4G6A5   A0A194QEK1   E0A209   Q8ITD4   A4D0J6   A0A384RYH7   G9C5G4   I3VR73   G9C5G3   A0A2A4IYF9   H9JEW5   Q962B3   Q7Z0W1   Q0PDN2   A0A2W1BR73   A0A076VDI4   W8AMJ2   G3ESW0   A0A1W4XT18   Q95WL1   A0A0K8WLP7   G0ZL61   A0A0K8U3X8   Q6PWP5   O46156   D3YJ04   A0A182QDN7   A0A076YIK8   A0A212EJT4   A0A034WY81   A0A2H1WAU1   B2LS41   D2KHN2   Q6J4J3   D3YJ03   Q8T7M0   I3VR77   O17484   C5H690   F5HLF4   D2KHN1   Q6Q2I1   W5JJJ6   Q964F9   F5HLF3   O17485   K9MBJ8   F2YWM1   E8Z5S9  

EC Number

3.4.11.-

Pubmed

19121390    24121099    20420910    28756777    26354079    22118469    + More
17609853    26227816    10380100    10543783    9931470    15857766    7629076    27940541    9729121    19376227    11439249    24045122    17402938    15978131    20685334    12441000    24932922    24495485    21840855    21844358    25348373    12023048    10732989    18826260    12364791    14747013    17210077    20920257    23761445    12200317   

EMBL

JQ061147    AFK85021.1    BABH01023392    BABH01023393    JF339039    AEO12693.1    + More
FJ647796    ACV04931.1    NWSH01005085    PCG64451.1    ODYU01004747    SOQ44949.1    KZ149969    PZC76121.1    KQ461198    KPJ05973.1    KQ459185    KPJ03374.1    KY949259    AWT23001.1    AGBW02014405    OWR41737.1    EF372603    ABN04204.1    JTDY01003068    KOB70213.1    AF020389    AAB70755.1    GU213040    ADA59492.1    GU213039    ADA59491.1    AF173552    AAF08254.1    BABH01023388    BABH01023389    BABH01023390    AF084257    JQ061146    AAC33301.1    AFK85020.1    AY836579    AAX39863.1    AF123313    AAF07223.1    X89081    AB007039    OWR41735.1    HM357836    AEA76302.1    AY038607    AAK85538.1    PZC76114.1    KY210882    APO15796.1    KM360182    AKH49598.1    AB007038    BAA32475.1    AF317620    AAL26895.1    AY358035    AAQ57406.1    AY515309    AAS00450.1    AY358034    AAQ57405.1    KM360190    AKH49606.1    EU568874    ACC68683.1    AF441377    AAL34109.1    RSAL01000014    RVE53192.1    DQ342305    ABC69855.3    EU568875    ACC68682.1    AF217248    AAF37558.1    KPJ03376.1    AY515310    AAS00451.1    AY437832    AAR20813.1    KF537663    AHA90590.1    GQ927479    ACX85726.2    DQ444715    ABE02186.1    KF537664    AHA90591.1    JF339038    AEO12690.1    AY437833    AAR20814.1    GQ927480    ACX85727.2    EU878375    ACJ64827.1    AY218842    AAP44964.1    KPJ03375.1    HM231316    ADL38968.1    AF521659    AAN75693.1    AY836582    AAX39866.1    KP053647    AKO62648.1    HQ853296    ADZ05468.1    JQ061144    AFK85018.1    HQ853295    ADZ05467.1    PCG64448.1    AY038608    AAK85539.1    AY279535    AY346383    AAP37951.1    AAQ24379.1    DQ872666    ABH07377.2    PZC76115.1    KF900124    AIK27005.1    GAMC01016580    JAB89975.1    JF339040    AEO12697.1    AF317619    AAL26894.1    GDHF01000302    JAI52012.1    JF303657    AEA29693.1    GDHF01031289    JAI21025.1    AY573579    AAS82738.1    AJ222699    CAA10950.1    GU479677    ADD39718.1    AXCN02001184    KM034756    AIK67332.1    OWR41734.1    GAKP01000229    JAC58723.1    ODYU01007373    SOQ50076.1    EU571948    ACB87202.2    GU213037    ADA59489.1    AY601813    AAT45356.1    GU479676    ADD39717.1    AF352574    AAL83943.1    JQ061148    AFK85022.1    AF034483    AAC36148.1    EU827528    ACJ10211.1    AAAB01008888    EGK97115.1    GU213036    ADA59488.1    AY564236    AAS75551.1    ADMH02001252    ETN63468.1    AF320764    AAK69605.1    EGK97114.1    AF034484    AAC36147.1    JQ088280    AFU51580.1    JF509138    ADZ74247.1    FJ492806    ACT35083.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000283053    UP000192223    UP000075886    UP000007062    UP000000673   

PRIDE

I3VR76    H9JEW6    E8Z7I6    H9JEW2    O76803    Q11001    + More
O76122    E8Z5C9    I3VR73    H9JEW5    Q8T7M0    I3VR77    E8Z5S9   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR034016   M1_APN-typ        + More
IPR001930   Peptidase_M1       
IPR042097   Aminopeptidase_N-like_N       
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR033581   APN2       
IPR011030   Lipovitellin_superhlx_dom       

SUPFAM

SSF48431   SSF48431       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

I3VR76   H9JEW6   G3ESV6   E8Z7I6   A0A2A4IXL1   A0A2H1VVU0   + More
A0A2W1BPB2   A0A194QK74   A0A194QD77   A0A3G1QXU4   A0A212EJS3   A2TN62   A0A0L7L408   O16851   D2KHN5   D2KHN4   Q9U6W2   H9JEW2   O76803   A4D0J3   Q9U7N8   Q11001   A0A212EJU6   F6K6Z9   Q962B4   A0A2W1BR38   A0A1L5JK78   A0A1B0RHN6   O76122   Q95WL0   Q6UY54   Q6R3M6   Q6UY55   A0A1B0RHN3   B2LRS7   Q8WSZ2   A0A3S2TRJ1   Q2L9Z0   B2LRS8   Q9NHZ9   A0A194QIU5   Q6R3M5   Q6T3W3   V5NPR9   D0UYB1   Q19TV9   V5NQ96   G3ESV3   Q6T3W2   D0UYB2   E8Z5C9   Q4G6A5   A0A194QEK1   E0A209   Q8ITD4   A4D0J6   A0A384RYH7   G9C5G4   I3VR73   G9C5G3   A0A2A4IYF9   H9JEW5   Q962B3   Q7Z0W1   Q0PDN2   A0A2W1BR73   A0A076VDI4   W8AMJ2   G3ESW0   A0A1W4XT18   Q95WL1   A0A0K8WLP7   G0ZL61   A0A0K8U3X8   Q6PWP5   O46156   D3YJ04   A0A182QDN7   A0A076YIK8   A0A212EJT4   A0A034WY81   A0A2H1WAU1   B2LS41   D2KHN2   Q6J4J3   D3YJ03   Q8T7M0   I3VR77   O17484   C5H690   F5HLF4   D2KHN1   Q6Q2I1   W5JJJ6   Q964F9   F5HLF3   O17485   K9MBJ8   F2YWM1   E8Z5S9  

PDB

4WZ9     E-value=1.3484e-113,     Score=1051

KEGG

101736750    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) membrane alanyl aminopeptidase-like

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0008237   GO:0008270   GO:0004177   GO:0005886   GO:0031225   GO:0043171   GO:0042277   GO:0070006   GO:0006508   GO:0005737   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.996249

 

 

Length:

930

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.96033

Exp number, first 60 AAs:

0.08108

Total prob of N-in:

0.00817

outside

1  -  910

TMhelix

911  -  928

inside

929  -  930

 

 

Pi

225.867397

Theta

164.486366

Tajima's D

1.230491

CLR

0.352884

CSRT

0.717214139293035

Interpretation

Uncertain