Gene

KWMTBOMO04892  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008062

Annotation

PREDICTED:_membrane_alanyl_aminopeptidase-like_[Bombyx_mori]

Location

Bomo_Chr9(+):1004765-1017049      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor

Location in the cell

PlasmaMembrane   Reliability : 2.89

CDS

ATGCATCATCTGACAAAATTCTGCCTTCTGGCCGCTTTGGCTCTTGTCAGAACTGATTTCCCACTGGACACAGACGAACCAGTCAATCGAAGTAATGTTGATGAAACTATTTATCGAGTGCCCGAAGATTTAGATCCCATACATTTTGACGTGGAGATCACTCCTTATTTTGAAGCAACACAGACTGATGAAGCATTTACCTTTGATGGTATTGCCACGATTCGGCTTAGGGCTGTAAAAGACAATCTGAATGCACTCATCATTCAAGAGAACGTTCGACACATCGTCGCAGTCAGTCTGACCAATACTGATGGAGTTCCGATTCGCTTGAATACGAGGAACCCGTTTGAACGCATAAGAGCTTACCACTTTTTGAAGATTAATCTTGCTGAAGGCGTTACTTTAGTCAACGGTCAAATTTACATATTGACTATCGAATATATTGGTAACATCAACGAAACCCCACTTTCTCGAGGAGTATTCAGAGGGAATTACATCGGTGATGATGGAAAATTGCATTGGTACGCGGCAACACACTTACAGCCAACAAACGCCAGACAAGCATTCCCGAGCTTCGACGAGCCCGGCTTTAAGTCTACTTTCAATATCATCGTCAACAGACCTGCTCATTTCACCGAGACTTATTCCAACATGCCAATCAGGCAGACCATACCAATTGGCGACCGCGTTAAAGAAATCTTTCACACTACTCCCAGAATGTCAGCCTATCTAGTTACATTCCATATAAGTGAAGAATTCACCGTTATTGCTGACAATAATGATCCTGTGAGGTCGTATAGAATTCTTGCAAGACCGAACGCCAAAGGTCAAGGTGAATATGCCTTGGAAGTCGGGCCCCCGCTAACCAAGTGGTTAGAAGAATATTTGAATATCGATTATTATAGTATGCAATCTTTTATGAAAAACGATCAGATTGCTTCGCCGTTTTGGGCTTCTGGAGCTACTGAGAATTGGGGCTTGGTTACTTACAGAGAAGTTCGTCTCCTTTACGAACAAGGCGAAACAAATGCACTAGACAAAATGTACATCGGAACTATCACCGCTCATGAACTCGCTCACAAGTGGTTCGGAAACTTGATCACGGCCAGGTGGTGGGATAACGTGTGGATTAACGAAGGTTTTGCCAGCTACTTTGAATACTTCGCTATGGATGGTGTTGATCCCGAATTAGAACTAGCTGATCAATTCAACTTGATGTACATGCAAAGCGCATTATCCACCGACGCTTCTGCATCCACCAGAGCTTTACGTCATACCGTGAACAGTCCAGCTCAAGTCACTGGTCATTTTTCTGGAATCAGTTATTCTAAAGGAGCTTCCTTCCTGTTAATGATGAAGCACTTGGTTACAGAAGATACATTTAAGAAGGCTTTGAATTATTTCCTCATAGATAGGTCATTTGAGTACGCCTCGCCGGAAAATTTATATTCTGCTTTTGTGAGAGCAGTACGCGAAGATAATACACTGGAAACTACTTTCGACGTTGAAGAATTCATGAAGTACTGGGTTGACGAGCCTGGATTTCCTCTTCTGGATGTTGCAGTCAATACAGAAACCGGAGTTATCAGCCTTAAGCAGGAGCGCTTCTTCATAAGTACCAGTGCAACACAAACTAATCAAATCTGGCCAATTCCGTTGACCTACACAACTGGTAGCAACCCTAACTGGAACTCCCTGCGACCTTTGCACATAATGACCGCTCAGAATGATGAAATACGTATAACACCTGGAAACCAATGGGTCATCTTTAATGTACAACAAAAAGGCATCTACAGAGTGAACTATAATCAAGAAAACTGGGAACGTCTCGCTAATGCTTTAAGCGAAGATCATACCAATATACATCATTTGAACAGAGCACAGATCGTCGATGATGTATTCGCGCTGATGAGATCAGAGAAGCTAAGTTTCGATCTTGGTTTTCGTGTTTTGGACTTCCTCAAGAAAGACACCAGTTACTATGTTTGGTATCCGGCCGTCACTGGATTCGGTTGGCTAAGGAACCGATTTCTGCATATGCCTGATGTGTTGGCCGAATTTAATACAATTCTCTACACCTTCCTAGAAGCAGTCATTGCAGATCTTGGTTACGATGTAGTTGACGGCGAACCCCTCACAAGGACCTTGAATAGATTTTTCGTTTTGTCATTTGCGTGTAATATTGGGCATGATGGTTGCATTTCTAATGCTATTCAGAAGTTCAATGCTTTGAGGACTAGTGGTACCAGCGTCAATCCTAACCTGAGACGCCATGTTTTCTGCTCTGGTCTCCTTGAAGGTGGTTACAATGAGTGGCGATTCCTATATGAGCGCAGAAAGAACTCGAATAACCAAGGTGACGAGGTCGCTATGCTCAGATCTCTTGGGTGCACCACGAACCCCCAGGCTCGACAGGAATACTTAAGCATGATTTTGAGTGACGATGTCAAAGCTCAAGATAGAGTGAATGCTCTCACATTCTTCTATATGGGAGACCGTTCCAACGCTAATGTAGCCCTGCAGTACTTGAAGGAGAACTTCGAGGAAATCAGACAAGGAGTCGTTCTCCCCGCTTGGTTCGATAACGTTATTTCTAATTTGGCTTCCTATTTGAACGAAGAAGGACTCGAAGATATGGAATCTTGGCTTCGGGCCAACCAAAACATGATACCCAACTTCAACGTTGGACTAAACGCTATAAACTCGGCAAGAACAAGCATGCAATGGGGAACTGACAGAGCACAGGAGATTCTGAAAGCAGCCAGAGGCTCTGCTGTTACCGTATTGCCAACATTCATGCTGTTGGTCCCAACATTAGCCATGCTCGTTTTGAAGTAG

Protein

MHHLTKFCLLAALALVRTDFPLDTDEPVNRSNVDETIYRVPEDLDPIHFDVEITPYFEATQTDEAFTFDGIATIRLRAVKDNLNALIIQENVRHIVAVSLTNTDGVPIRLNTRNPFERIRAYHFLKINLAEGVTLVNGQIYILTIEYIGNINETPLSRGVFRGNYIGDDGKLHWYAATHLQPTNARQAFPSFDEPGFKSTFNIIVNRPAHFTETYSNMPIRQTIPIGDRVKEIFHTTPRMSAYLVTFHISEEFTVIADNNDPVRSYRILARPNAKGQGEYALEVGPPLTKWLEEYLNIDYYSMQSFMKNDQIASPFWASGATENWGLVTYREVRLLYEQGETNALDKMYIGTITAHELAHKWFGNLITARWWDNVWINEGFASYFEYFAMDGVDPELELADQFNLMYMQSALSTDASASTRALRHTVNSPAQVTGHFSGISYSKGASFLLMMKHLVTEDTFKKALNYFLIDRSFEYASPENLYSAFVRAVREDNTLETTFDVEEFMKYWVDEPGFPLLDVAVNTETGVISLKQERFFISTSATQTNQIWPIPLTYTTGSNPNWNSLRPLHIMTAQNDEIRITPGNQWVIFNVQQKGIYRVNYNQENWERLANALSEDHTNIHHLNRAQIVDDVFALMRSEKLSFDLGFRVLDFLKKDTSYYVWYPAVTGFGWLRNRFLHMPDVLAEFNTILYTFLEAVIADLGYDVVDGEPLTRTLNRFFVLSFACNIGHDGCISNAIQKFNALRTSGTSVNPNLRRHVFCSGLLEGGYNEWRFLYERRKNSNNQGDEVAMLRSLGCTTNPQARQEYLSMILSDDVKAQDRVNALTFFYMGDRSNANVALQYLKENFEEIRQGVVLPAWFDNVISNLASYLNEEGLEDMESWLRANQNMIPNFNVGLNAINSARTSMQWGTDRAQEILKAARGSAVTVLPTFMLLVPTLAMLVLK

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

I3VR73   H9JEW5   A0A194QEK1   A0A2A4IYF9   S4VDN0   A0A2W1BR73   + More
Q962B3   Q7Z0W1   G0ZL61   G9C5G3   G3ESV7   D3YJ03   Q6Q2I1   Q6PWP5   O46156   D2KHN2   D3YJ04   D2KHN1   A0A076YIK8   Q6J4J3   A0A212EJS3   K9MBC9   A0A2H1WZJ8   A0A076VDI4   A0A0L7L4F8   S4VAT7   G0ZL62   A0A286LPZ8   A0A194QIU5   A0A2Z3YJ90   A0A212EJS8   I3VR74   A0A076VHN0   H9JEW4   B8PYI5   A0A2W1BM31   A0A2A4J7T7   R9QYQ9   A4D0J6   Q95WL1   G9C5G4   A0A2A4J832   Q963G0   Q7Z268   Q8MU79   A0A2W1BSE9   A0A194QR18   B2LS41   Q86QI6   Q9NHZ8   Q8MUT5   Q0PDN2   E8Z923   B5A8X9   Q8T5Q4   Q4G6A2   A0A3S2P5X4   G9C7N4   Q964F9   F2YWM1   O77046   A0A2H1WAU1   O16851   E0A209   D2KHN4   Q9U7N8   D2KHN5   Q11001   O76803   Q9U6W2   F6K6Z9   H9JEW3   I3VR72   I3VR76   V5NPR9   Q19TV9   V5NQ96   Q95WL0   A1E3B7   A0A2H1VVU0   A0A2A4IXL1   Q9NHZ9   H9JEW2   D0UYB2   D0UYB1   G3ESV3   A0A384RYH7   E8Z5C9   A0A2W1BR38   O76122   Q962B4   A0A1B0RHN6   A0A3G1QXU4   A0A1B0RHN3   Q6UY55  

EC Number

3.4.11.-

Pubmed

19121390    26354079    28756777    21840855    21844358    24121099    + More
22118469    24932922    26227816    18549954    15857766    11439249    17402938    20420910    15978131    12200317    10380100    20685334    7629076    9931470    10543783    24045122    9729121   

EMBL

JQ061144    AFK85018.1    BABH01023392    KQ459185    KPJ03375.1    NWSH01005085    + More
PCG64448.1    KC776603    AGO57907.1    KZ149969    PZC76115.1    AY038608    AAK85539.1    AY279535    AY346383    AAP37951.1    AAQ24379.1    JF303657    AEA29693.1    HQ853295    ADZ05467.1    JF339039    AEO12694.1    GU479676    ADD39717.1    AY564236    AAS75551.1    AY573579    AAS82738.1    AJ222699    CAA10950.1    GU213037    ADA59489.1    GU479677    ADD39718.1    GU213036    ADA59488.1    KM034756    AIK67332.1    AY601813    AAT45356.1    AGBW02014405    OWR41737.1    JQ088281    AFU51581.1    ODYU01012236    SOQ58437.1    KF900124    AIK27005.1    JTDY01003068    KOB70211.1    KC776602    AGO57906.1    JF303658    AEA29694.1    MF425655    ASU92547.1    KPJ03376.1    KY949258    AWT23000.1    OWR41736.1    JQ061145    AFK85019.1    KF900125    AIK27006.1    BABH01023391    EU328183    ACA35025.1    PZC76119.1    NWSH01002538    PCG68031.1    JX101320    AGG36501.1    AY836582    AAX39866.1    AF317619    AAL26894.1    HQ853296    ADZ05468.1    PCG68029.1    AF378666    AAK58066.1    AY279534    AAP37950.1    AF535165    AAN04899.1    PZC76117.1    KQ461198    KPJ05976.1    EU571948    ACB87202.2    AY181026    AAO23562.1    AF217249    AAF37559.1    AF511038    AAM44056.1    DQ872666    ABH07377.2    FJ694793    ACV74256.1    EU826126    ACF34998.2    AF498996    AAM18718.1    AY218845    AAP44967.1    RSAL01000014    RVE53191.1    HQ901596    ADZ57273.1    AF320764    AAK69605.1    JF509138    ADZ74247.1    AB013400    BAA33715.1    ODYU01007373    SOQ50076.1    AF020389    AAB70755.1    HM231316    ADL38968.1    GU213039    ADA59491.1    AF123313    AAF07223.1    GU213040    ADA59492.1    X89081    AB007039    AF084257    JQ061146    AAC33301.1    AFK85020.1    AF173552    AAF08254.1    HM357836    AEA76302.1    JQ061143    AFK85017.1    JQ061147    AFK85021.1    KF537663    AHA90590.1    DQ444715    ABE02186.1    KF537664    AHA90591.1    AF317620    AAL26895.1    EF103945    ABL01484.1    ODYU01004747    SOQ44949.1    PCG64451.1    AF217248    AAF37558.1    BABH01023388    BABH01023389    BABH01023390    GQ927480    ACX85727.2    GQ927479    ACX85726.2    JF339038    AEO12690.1    KP053647    AKO62648.1    EU878375    ACJ64827.1    PZC76114.1    AB007038    BAA32475.1    AY038607    AAK85538.1    KM360182    AKH49598.1    KY949259    AWT23001.1    KM360190    AKH49606.1    AY358034    AAQ57405.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000037510    UP000053240    + More
UP000283053   

PRIDE

I3VR73    H9JEW5    I3VR74    H9JEW4    E8Z923    O77046    + More
Q11001    O76803    H9JEW3    I3VR72    I3VR76    H9JEW2    E8Z5C9    O76122   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR014782   Peptidase_M1_dom        + More
IPR024571   ERAP1-like_C_dom       
IPR042097   Aminopeptidase_N-like_N       
IPR034016   M1_APN-typ       
IPR001930   Peptidase_M1       
IPR033581   APN2       
IPR027268   Peptidase_M4/M1_CTD_sf       
IPR008936   Rho_GTPase_activation_prot       
IPR011030   Lipovitellin_superhlx_dom       

SUPFAM

SSF48350   SSF48350        + More
SSF48431   SSF48431       

Gene 3D

2.60.40.1730     1.10.390.10    

CDD

cd09601  M1_APN_2

ProteinModelPortal

I3VR73   H9JEW5   A0A194QEK1   A0A2A4IYF9   S4VDN0   A0A2W1BR73   + More
Q962B3   Q7Z0W1   G0ZL61   G9C5G3   G3ESV7   D3YJ03   Q6Q2I1   Q6PWP5   O46156   D2KHN2   D3YJ04   D2KHN1   A0A076YIK8   Q6J4J3   A0A212EJS3   K9MBC9   A0A2H1WZJ8   A0A076VDI4   A0A0L7L4F8   S4VAT7   G0ZL62   A0A286LPZ8   A0A194QIU5   A0A2Z3YJ90   A0A212EJS8   I3VR74   A0A076VHN0   H9JEW4   B8PYI5   A0A2W1BM31   A0A2A4J7T7   R9QYQ9   A4D0J6   Q95WL1   G9C5G4   A0A2A4J832   Q963G0   Q7Z268   Q8MU79   A0A2W1BSE9   A0A194QR18   B2LS41   Q86QI6   Q9NHZ8   Q8MUT5   Q0PDN2   E8Z923   B5A8X9   Q8T5Q4   Q4G6A2   A0A3S2P5X4   G9C7N4   Q964F9   F2YWM1   O77046   A0A2H1WAU1   O16851   E0A209   D2KHN4   Q9U7N8   D2KHN5   Q11001   O76803   Q9U6W2   F6K6Z9   H9JEW3   I3VR72   I3VR76   V5NPR9   Q19TV9   V5NQ96   Q95WL0   A1E3B7   A0A2H1VVU0   A0A2A4IXL1   Q9NHZ9   H9JEW2   D0UYB2   D0UYB1   G3ESV3   A0A384RYH7   E8Z5C9   A0A2W1BR38   O76122   Q962B4   A0A1B0RHN6   A0A3G1QXU4   A0A1B0RHN3   Q6UY55  

PDB

4WZ9     E-value=6.80331e-118,     Score=1088

KEGG

101744250    no KO assigned | (RefSeq) membrane alanyl aminopeptidase-like

GO

GO:0008270   GO:0004177   GO:0008237   GO:0016021   GO:0007165   GO:0005886   GO:0031225   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824   GO:0006508  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.970958

 

 

Length:

945

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

16.30398

Exp number, first 60 AAs:

0.00133

Total prob of N-in:

0.00372

outside

1  -  945

 

 

Pi

196.782057

Theta

153.467768

Tajima's D

0.08308

CLR

1.273479

CSRT

0.395330233488326

Interpretation

Uncertain