Gene

KWMTBOMO04891

Pre Gene Modal

BGIBMGA008061

Annotation

aminopeptidase_N-3_[Bombyx_mori]

Location

Bomo_Chr9(+):993725-1003987      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor

Location in the cell

PlasmaMembrane   Reliability : 3.402

CDS

ATGTCCAAGCTTTTACTACTGTGTTTGGCGATTTTCGGCCTAACATCGGCTGACCACCCAGCATGGCACAGAGATTTCGAACCAATCCCCATAACTGACAATACAACGAGAAGCATTGAACAGGTTTATAGATTACCAGAGACAGTTAAACCATTGGAATACGATATTTATTTAGATTTGTACTTCGCTGAAAGAACAGACAGGCCCTTCAGTTATGATGGTAGAGAGACCATCATTATAGAGGCAGTAGCAGAAGGCGTGACTCAAATTGTTCTACATTCAAACGTGGACAGCATCAACGCTGTTTCTGTGCTAACGGAAGGTGGCGCACCATTCCCAGTTAATACAAGGGAGCCTTTCACACTGGAGCCTCAGTATCATTTCCTAAAAATTAATTTGAACGAACCCCTTGTTGTTGGACAGAAATACTCTTTGTATATTGAATATTCTAGCACAATGAACGAAGGCCCAATGAAGAGGGGTATTTGGAGGGGATGGTACATCGACAACGATGGTACAGAAAGGATCTACGCGACAACACATTTCCAGCCGTATAATGCGAGACAGGCATTCCCATGCTGGGACGAGCCACTGTTCAAGTCAGTCTTCAAACTCCACGTCTCGAAGCCAAAATCCTACACCGGCACGTTCTCAAACACTGGCGTCGAAACTTTTAGGTTTGAAGAAGCTGATCGCATTCGAAGCAATTTTCTGGCGACACCAAAAATGTCTTCGTACCTGGTTACGTTTCTTGTTAGCGAAACTTTCCAAGTATTGGCCGAGGACACTTCCTTCACTCCGCCTGTAAGGATCATTGGCCGGTCCAACACAGCAGGTCTTGCCGACCACGCATTGGAACTAGCAGTCCGTATGACCAGATACTATGATGAATATTTCGGGATTCCGTACTCAACGCTGCATCCAAATCTGCTCAATGATCATATTTCTTCCCCTGATTGGGCTTCGGCTGGCACAGAAAATTGGGGAATGGTCAGTTATAGGGAACTCTACCTCATCATTGATCCTCGTGAAACCGTCATGTCCGTGGAGCATTACGCTGCCACGTTGGTCTCCCACGAGCTCGCGCACAAATGGTTCGGTAACCTGATCACATGTTACTGGTGGAGCAACACTTGGATCAACGAAGGCTTTGCCAGTTACTTCGGGTACATTCCCACCTCTCAGATGTTTCCCGAGTATGAGCATCATGAGCACTTTAACGCCCGCTACGTTTCGTCATCGCTATCGTTCGACTCTGGCGTCAGCACCGTGCCTCTGAACCATGACGTAAACACACCAGCCCAAGTCACCGGCCACTTTGGAACCATCAGTTACTCTAAGGGCGCCGTATTCCTCAGGATGACTGCTGACATCATCACCGATGAGACTTTCCGAAAAGCTTGCCGTTACTTCTTGATTAATAACGCTTTCGAACCAACGGATCAATACGACTTATTGAAAGCTTTCAATCAAGCTATAATAGAAGACGGAAGTGTGTCTCAATATTCCAATTTTAACTTTGAAGAGTACTACCGCATTTGGGTCAACGAACCCGGATATCCGTTGCTGACGGTTACGGTTGACCATGGTGACGGAACTATTACTCTCAGTCAGGAACGATTCTTCTTGAGTGCATCTGCTACCCCGACAGACCATATATATCCAATTCCTATCACATATAGTAGTAAAAGCAATAATAACTTTGACAACGTCCGACCGGTCCATATAATGACCACTAAGACTGATGCTTTCAATGTTGGAGTTAAAGGAGAGTGGGTTATCTTCAACAATCTTCAACACGGACATTATAGAGTTACATATGATGATACAACATGGAATTTGATAGCAGATGCTTTGCTTAACGAAAGAGAGTCTATTCATCATCTAAATAGAGCTGAGATTGTGGATGACATCTTCGCCCTCATGAGGTCGGGCAGAATGACTTACAGTTTTGGTTTCAAAATCCTTCGCTTCTTGCGCAGTGAATCTAATTACCACGTGTGGGATGCAGCCATCACTGGCTACACTTGGTTGAGAAATAGACTCAGACATTTACCAGATCAAGCTACGTTTGACGCTTACATTCTGGAATTAATGGAAACAGTCATTAATACTTATGGCTTTGATGCCGCGGCTAATGAGCCTCCTACAACGAGTATGGCAAGACAAACTGTACTACAATTCGCTTGCAACCTTGGACACACAAAGTGCATCCAAGAATCGTACGACAAATTCAGAGAAATGAGAAGTGGTAAATGGGTTAGTCCTCAGATACGTCGTAACGTCTATATGACTGGCATGAGAGAGGGAGACAGTTCAGATTTCGAATACTTACTAAACCGTTTTCGACAATCGAACTTTGCTAACGATCAGCTAGAAATGCTCAGAGGATTGGGAGCTTCTAAAGATTCTCAATTATTGACTCGATACTTGCAGTTGACCTTGACTAGGGAGGTGAGATCGCACGATAAAGCTACTTCCTTCAACTACGCTCTGCTCGGTAACCAAGAGAACGCTAACACGGTTCTCCAGTTCGTGAAGAACAATATTGCTGCTATAAGAACGGCATACATTGAAGACGCTCCACCAACTCCAGTGCATACAGCTTTGTCTAATCTCGCTGCTTACCTTGATGAATCAGGTCTAGACGAATATGAAACTTGGCTACGTTCCACACAGACCAACATACCGCAGTACAATAGTGCGCTCTCAGCAATTAATTCGGCTCGGAGTAACATTGCTTGGGGCACTGCTAATGCCGAAATGTTATTAGCTGCTGCACGGGACAGTGCAACCGCAGTTGTGACGTCTGCTGCATTATTGGCTATAACTACACTGTTTGCTTTAATAATGTAA

Protein

MSKLLLLCLAIFGLTSADHPAWHRDFEPIPITDNTTRSIEQVYRLPETVKPLEYDIYLDLYFAERTDRPFSYDGRETIIIEAVAEGVTQIVLHSNVDSINAVSVLTEGGAPFPVNTREPFTLEPQYHFLKINLNEPLVVGQKYSLYIEYSSTMNEGPMKRGIWRGWYIDNDGTERIYATTHFQPYNARQAFPCWDEPLFKSVFKLHVSKPKSYTGTFSNTGVETFRFEEADRIRSNFLATPKMSSYLVTFLVSETFQVLAEDTSFTPPVRIIGRSNTAGLADHALELAVRMTRYYDEYFGIPYSTLHPNLLNDHISSPDWASAGTENWGMVSYRELYLIIDPRETVMSVEHYAATLVSHELAHKWFGNLITCYWWSNTWINEGFASYFGYIPTSQMFPEYEHHEHFNARYVSSSLSFDSGVSTVPLNHDVNTPAQVTGHFGTISYSKGAVFLRMTADIITDETFRKACRYFLINNAFEPTDQYDLLKAFNQAIIEDGSVSQYSNFNFEEYYRIWVNEPGYPLLTVTVDHGDGTITLSQERFFLSASATPTDHIYPIPITYSSKSNNNFDNVRPVHIMTTKTDAFNVGVKGEWVIFNNLQHGHYRVTYDDTTWNLIADALLNERESIHHLNRAEIVDDIFALMRSGRMTYSFGFKILRFLRSESNYHVWDAAITGYTWLRNRLRHLPDQATFDAYILELMETVINTYGFDAAANEPPTTSMARQTVLQFACNLGHTKCIQESYDKFREMRSGKWVSPQIRRNVYMTGMREGDSSDFEYLLNRFRQSNFANDQLEMLRGLGASKDSQLLTRYLQLTLTREVRSHDKATSFNYALLGNQENANTVLQFVKNNIAAIRTAYIEDAPPTPVHTALSNLAAYLDESGLDEYETWLRSTQTNIPQYNSALSAINSARSNIAWGTANAEMLLAAARDSATAVVTSAALLAITTLFALIM

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

H9JEW4   I3VR74   A0A194QIU5   S4VAT7   A0A286LPZ8   A0A212EJS8   + More
G0ZL62   B8PYI5   A0A2W1BM31   A0A2Z3YJ90   A0A2H1WZJ8   A0A2A4J7T7   A0A076VHN0   A0A194QR18   R9QYQ9   I3VR73   H9JEW5   A0A2A4IYF9   A0A194QEK1   S4VDN0   G9C5G3   Q7Z0W1   A0A2W1BR73   G3ESV7   Q6Q2I1   Q962B3   D3YJ04   D3YJ03   Q6PWP5   D2KHN2   A0A076YIK8   D2KHN1   O46156   A0A212EJS3   A0A076VDI4   G0ZL61   Q6J4J3   K9MBC9   Q0PDN2   Q963G0   A0A2W1BSE9   O77046   Q8MU79   Q7Z268   A4D0J6   A0A2A4J832   Q86QI6   Q8MUT5   Q8T5Q4   Q9NHZ8   G9C5G4   B2LS41   Q95WL1   B5A8X9   E8Z923   O16851   G9C7N4   A0A3S2P5X4   F2YWM1   D2KHN5   Q964F9   D2KHN4   H9JEW3   I3VR72   Q6UY55   Q4G6A2   Q962B4   Q6UY54   A0A2W1BR38   A0A212EJU6   A0A0L7L4F8   G3ESV3   A0A1B0RHN6   Q9U7N8   Q11001   E8Z5C9   D0UYB1   A0A1B0RHN3   O76803   E0A209   Q9U6W2   F6K6Z9   D0UYB2   A0A2H1WAU1   A0A1L5JK78   Q9NHZ9   B2LRS7   Q95WL0   Q6R3M5   Q6R3M6   B2LRS8   Q8WSZ2   A0A384RYH7   Q6T3W2   A4D0J3   H9JEW2   O76122   Q6T3W3  

EC Number

3.4.11.-

Pubmed

19121390    26354079    22118469    21844358    18549954    28756777    + More
24932922    24121099    21840855    17402938    15857766    11439249    20420910    10380100    12200317    15978131    26227816    7629076    9931470    20685334    10543783    27940541    19376227    9729121   

EMBL

BABH01023391    BABH01023392    JQ061145    AFK85019.1    KQ459185    KPJ03376.1    + More
KC776602    AGO57906.1    MF425655    ASU92547.1    AGBW02014405    OWR41736.1    JF303658    AEA29694.1    EU328183    ACA35025.1    KZ149969    PZC76119.1    KY949258    AWT23000.1    ODYU01012236    SOQ58437.1    NWSH01002538    PCG68031.1    KF900125    AIK27006.1    KQ461198    KPJ05976.1    JX101320    AGG36501.1    JQ061144    AFK85018.1    NWSH01005085    PCG64448.1    KPJ03375.1    KC776603    AGO57907.1    HQ853295    ADZ05467.1    AY279535    AY346383    AAP37951.1    AAQ24379.1    PZC76115.1    JF339039    AEO12694.1    AY564236    AAS75551.1    AY038608    AAK85539.1    GU479677    ADD39718.1    GU479676    ADD39717.1    AY573579    AAS82738.1    GU213037    ADA59489.1    KM034756    AIK67332.1    GU213036    ADA59488.1    AJ222699    CAA10950.1    OWR41737.1    KF900124    AIK27005.1    JF303657    AEA29693.1    AY601813    AAT45356.1    JQ088281    AFU51581.1    DQ872666    ABH07377.2    AF378666    AAK58066.1    PZC76117.1    AB013400    BAA33715.1    AF535165    AAN04899.1    AY279534    AAP37950.1    AY836582    AAX39866.1    PCG68029.1    AY181026    AAO23562.1    AF511038    AAM44056.1    AF498996    AAM18718.1    AF217249    AAF37559.1    HQ853296    ADZ05468.1    EU571948    ACB87202.2    AF317619    AAL26894.1    EU826126    ACF34998.2    FJ694793    ACV74256.1    AF020389    AAB70755.1    HQ901596    ADZ57273.1    RSAL01000014    RVE53191.1    JF509138    ADZ74247.1    GU213040    ADA59492.1    AF320764    AAK69605.1    GU213039    ADA59491.1    JQ061143    AFK85017.1    AY358034    AAQ57405.1    AY218845    AAP44967.1    AY038607    AAK85538.1    AY358035    AAQ57406.1    PZC76114.1    OWR41735.1    JTDY01003068    KOB70211.1    JF339038    AEO12690.1    KM360182    AKH49598.1    AF123313    AAF07223.1    X89081    AB007039    EU878375    ACJ64827.1    GQ927479    ACX85726.2    KM360190    AKH49606.1    AF084257    JQ061146    AAC33301.1    AFK85020.1    HM231316    ADL38968.1    AF173552    AAF08254.1    HM357836    AEA76302.1    GQ927480    ACX85727.2    ODYU01007373    SOQ50076.1    KY210882    APO15796.1    AF217248    AAF37558.1    EU568874    ACC68683.1    AF317620    AAL26895.1    AY515310    AAS00451.1    AY515309    AAS00450.1    EU568875    ACC68682.1    AF441377    AAL34109.1    KP053647    AKO62648.1    AY437833    AAR20814.1    AY836579    AAX39863.1    BABH01023388    BABH01023389    BABH01023390    AB007038    BAA32475.1    AY437832    AAR20813.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000053240    UP000283053    + More
UP000037510   

PRIDE

H9JEW4    I3VR74    I3VR73    H9JEW5    O77046    E8Z923    + More
H9JEW3    I3VR72    Q11001    E8Z5C9    O76803    H9JEW2    O76122   

Pfam

PF11838   ERAP1_C        + More
PF01433   Peptidase_M1

Interpro

IPR001930   Peptidase_M1        + More
IPR034016   M1_APN-typ       
IPR042097   Aminopeptidase_N-like_N       
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR033581   APN2       
IPR008936   Rho_GTPase_activation_prot       
IPR027268   Peptidase_M4/M1_CTD_sf       

SUPFAM

SSF48350   SSF48350       

Gene 3D

2.60.40.1730     1.10.390.10    

CDD

cd09601  M1_APN_2

ProteinModelPortal

H9JEW4   I3VR74   A0A194QIU5   S4VAT7   A0A286LPZ8   A0A212EJS8   + More
G0ZL62   B8PYI5   A0A2W1BM31   A0A2Z3YJ90   A0A2H1WZJ8   A0A2A4J7T7   A0A076VHN0   A0A194QR18   R9QYQ9   I3VR73   H9JEW5   A0A2A4IYF9   A0A194QEK1   S4VDN0   G9C5G3   Q7Z0W1   A0A2W1BR73   G3ESV7   Q6Q2I1   Q962B3   D3YJ04   D3YJ03   Q6PWP5   D2KHN2   A0A076YIK8   D2KHN1   O46156   A0A212EJS3   A0A076VDI4   G0ZL61   Q6J4J3   K9MBC9   Q0PDN2   Q963G0   A0A2W1BSE9   O77046   Q8MU79   Q7Z268   A4D0J6   A0A2A4J832   Q86QI6   Q8MUT5   Q8T5Q4   Q9NHZ8   G9C5G4   B2LS41   Q95WL1   B5A8X9   E8Z923   O16851   G9C7N4   A0A3S2P5X4   F2YWM1   D2KHN5   Q964F9   D2KHN4   H9JEW3   I3VR72   Q6UY55   Q4G6A2   Q962B4   Q6UY54   A0A2W1BR38   A0A212EJU6   A0A0L7L4F8   G3ESV3   A0A1B0RHN6   Q9U7N8   Q11001   E8Z5C9   D0UYB1   A0A1B0RHN3   O76803   E0A209   Q9U6W2   F6K6Z9   D0UYB2   A0A2H1WAU1   A0A1L5JK78   Q9NHZ9   B2LRS7   Q95WL0   Q6R3M5   Q6R3M6   B2LRS8   Q8WSZ2   A0A384RYH7   Q6T3W2   A4D0J3   H9JEW2   O76122   Q6T3W3  

PDB

4WZ9     E-value=5.05738e-101,     Score=943

KEGG

101744250    no KO assigned | (RefSeq) membrane alanyl aminopeptidase-like

GO

GO:0016021   GO:0008237   GO:0008270   GO:0004177   GO:0007165   GO:0005886   GO:0031225   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824   GO:0006508  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 17,         Likelihood:  0.998326

 

 

Length:

951

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.22569

Exp number, first 60 AAs:

0.14312

Total prob of N-in:

0.00789

outside

1  -  930

TMhelix

931  -  950

inside

951  -  951

 

 

Pi

214.306356

Theta

209.309108

Tajima's D

-0.516143

CLR

0.238226

CSRT

0.239538023098845

Interpretation

Uncertain