Gene

KWMTBOMO04890  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008060

Annotation

PREDICTED:_aminopeptidase_N_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr9(+):975135-991507      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor

Location in the cell

PlasmaMembrane   Reliability : 3.75

CDS

ATGCTGCTGCCCACTGTACTATGTATCCTAATTGGAACCGGCCTCGCCGTCCCCATGGACGAGCTGAGGTCCAACCTCGAGTGGATGGACTACAGCACCAACGTGGCCGAGTCAGCTTACCGACTCCTCGACACTATCCAGCCTAGAACTATGAGAGTGGACCTAGATGTCTTCTTAAACGAAGCTAGGTTTGATGGTATCGTTAGCATGGATATTGAGGTTCTAGCGAGCAACATTGAACAGATCGTGTTCCACCAGAACGTGGTCTCTATCCAGGGTGTGAATTTGGTTACCGCCCGTGGTGATCCAGTGGGATTAAAATTCCCGGATCCGTTCACTATTGACAGACATTACGAGCTCCTGCTGATCAACCTCGCCCAACCAATCGCTGCTGGTAATTACACCGTCACAGTGAGGTATCGCGGTCAAATCAATACCAATCCTGTTGATAGAGGTTTTTACCGAGGTTACTATTACGTCAACAATCAGCTCAGATATTATGCTACCACACAATTCCAGCCATTCCATGCTAGGAAGGCCTTCCCGTGCTTCGACGAGCCCCAGTTTAAATCAATATACATCATTTCAATCACCCGAGACAGGAGCCTTAGTCCGACATACTCGAACATGCCTATATCTAACACAGAAACCCCTTCTACCAACCGCGTCAAAGAGACGTTCTTCCCAACTCCCATCGTCTCTTCTTACTTGGTAGCGTTCCACGTAAGCGATTTTGTTGAAACCAGTCTCACCGGTACCGACTCTCGTCCATTCGGAATAATTTCTCGCCAAGGTGTAACGTCTCAACATGAATATGCCGCCAAAATCGGTTTGAAGATTACCGACAAACTTGATGATTACTTTGGAATCTTGTACCACGAGATGGGTCAGGGTACGATTATGAAGAACGATCACATTGCCTTACCTGATTTCCCATCTGGTGCGATGGAGAACTGGGGAATGGTTAACTACAGAGAAGCGTACCTGCTCTACGATCCACAGCACACGAATTTAATCAATAAGATCTTCATCGCCACCATCATGGCTCACGAATTAGCTCACAAGTGGTTCGGCAACCTTGTCACATGTTTCTGGTGGAGCAACTTGTGGCTCAACGAGTCCTTTGCTAGCTTCTACGAATACTTCGGTGCTCATTACGCGGATCCTTCTTTGGAACTAGACGACCAATTTGTTGTGGACTACGTACACAGTGCTCTGACGTGGGATGCCGGAACTGGTGCGACGCCGATGAACTGGACCGAAGTGTCTAATAATTCATCGATCTCTTCCCACTTCAGTACAACAAGCTACGCCAAGGGCGCTTCGGTTCTCAGGATGATGGAGCATTTCCTCGGTTCCAGAACTTTCAGGAACGGCCTGAGATACTACCTCAGAGACAATGCTTACGGCATTGGTACTCCTGCGGACTTGTACGCCGCTTTGAGAAGAGCTGCCTCTGAAGACCACGTTTTCGCTCGTGACTTCCCTAACGTCGATGTCGGAGAAATTCTAGACAGCTGGGTCCAAAATCCAGGGTCACCCGTCATTAATGTAGAATTTAACACAAACAATGGCGTTATCACTTTGACTCAGGAGCGTTTCCTCCTCACTGGATCACGAGACCAGCTTTGGCGAATTCCTATCACCTGGACTGATGCAACGACCCGTAATTTCTCCAACACCAGACCCAGCTTAATTATGAACACCAGAACTGTCAACATCCAGGGTAACGCCGGCCAACACTGGGTGATGTTGAACATCGCTCAATCTGGTTTGTACCGTGTCAACTATGACGACAGCACTTGGCAGCGAATTGCTGCTTTCCTCCGAACCAACAGAGAGGCAGTTCACAAACTAAACAGAGCTCAAATCGTCAACGACGTTTTGTTCTTCATTCGAGCTGGTAAGATCACCACGTCTCGCGCTTTCGACGTGTTATCATTCCTGGAAAATGAGAGAGACTATTACGTTTGGGCTGGCGCTATCACGCAACTCGAATGGATTCGCAGGAGACTGGAACATTTGCCTCAAGCGCATGAAGCTTTCACAGCTTACACTCTGGATCTTCTTAGAAACGTGATCAATCACCTGGGATACAACGAACGCGCAACCGACTCCACATCAACCATTCTCAACAGAATGCAGATCTTGAACCTCGCCTGCAACCTCGGGCATTCCGGCTGCATCAGCGACAGTCTTCAGAAATGGAGACAGTTTAGGAACAATCCGACCAATTTGGTCCCAGTGAATTCTCGGCGCTACGTGTACTGTGTTGGTGTTCGTCAAGGCAACTCCAGTGACTACAACTTCCTCTTCGAGCGGTACAATGCTTCCCAGAACACAGCCGACATGGTCGTTATGCTGCGAGCTCTCGCTTGTACTAGAGACACAAACTCATTGCAACATTACATGTTCCAGTCAATGCACAACGATAGGATCCGCATCCACGACCGTACGAACGCCTTTAGTTATGCTCTACAAGGCAACAGGGAGAATTTGCCTATCGTTCTCAACTTCCTGTATCAAAACTTTGCGGCTATTCGCACCAGCTACGGAGGTGAAGCTCGTCTCGTCACAGCTGTTAATGCAATATCTGGGTTCCTAACTGATTTCGCAATAATAAGAGAGTTCCAATCTTGGGTATACGCCAACCAGCTAGCTCTCGGCACCGCCTTCTCCACAGGAGTTTCTGTCATTAATTCTGCCATCAGCAACCTCGAATGGGGCAACGCTGAAGCCACTGACATTTATAACTTCCTGTTGGCTAGGAGCTCATCAACCACCGTTACCTCATCCTTCATTCTAATGATCACTGCATTAGTCGTTAAAATGTTTCATTAG

Protein

MLLPTVLCILIGTGLAVPMDELRSNLEWMDYSTNVAESAYRLLDTIQPRTMRVDLDVFLNEARFDGIVSMDIEVLASNIEQIVFHQNVVSIQGVNLVTARGDPVGLKFPDPFTIDRHYELLLINLAQPIAAGNYTVTVRYRGQINTNPVDRGFYRGYYYVNNQLRYYATTQFQPFHARKAFPCFDEPQFKSIYIISITRDRSLSPTYSNMPISNTETPSTNRVKETFFPTPIVSSYLVAFHVSDFVETSLTGTDSRPFGIISRQGVTSQHEYAAKIGLKITDKLDDYFGILYHEMGQGTIMKNDHIALPDFPSGAMENWGMVNYREAYLLYDPQHTNLINKIFIATIMAHELAHKWFGNLVTCFWWSNLWLNESFASFYEYFGAHYADPSLELDDQFVVDYVHSALTWDAGTGATPMNWTEVSNNSSISSHFSTTSYAKGASVLRMMEHFLGSRTFRNGLRYYLRDNAYGIGTPADLYAALRRAASEDHVFARDFPNVDVGEILDSWVQNPGSPVINVEFNTNNGVITLTQERFLLTGSRDQLWRIPITWTDATTRNFSNTRPSLIMNTRTVNIQGNAGQHWVMLNIAQSGLYRVNYDDSTWQRIAAFLRTNREAVHKLNRAQIVNDVLFFIRAGKITTSRAFDVLSFLENERDYYVWAGAITQLEWIRRRLEHLPQAHEAFTAYTLDLLRNVINHLGYNERATDSTSTILNRMQILNLACNLGHSGCISDSLQKWRQFRNNPTNLVPVNSRRYVYCVGVRQGNSSDYNFLFERYNASQNTADMVVMLRALACTRDTNSLQHYMFQSMHNDRIRIHDRTNAFSYALQGNRENLPIVLNFLYQNFAAIRTSYGGEARLVTAVNAISGFLTDFAIIREFQSWVYANQLALGTAFSTGVSVINSAISNLEWGNAEATDIYNFLLARSSSTTVTSSFILMITALVVKMFH

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

O77046   I3VR72   H9JEW3   Q8T5Q4   A0A2A4J832   Q963G0   + More
Q8MU79   A0A2W1BSE9   B2LS41   Q7Z268   Q8MUT5   Q86QI6   B5A8X9   G9C5G4   E8Z923   Q9NHZ8   Q95WL1   A4D0J6   Q0PDN2   G9C7N4   A0A3S2P5X4   A0A194QIU5   A0A194QR18   Q964F9   F2YWM1   Q4G6A2   A0A2H1WAU1   A0A212EJS8   A1E3B7   A0A194QEK1   I3VR73   S4VDN0   Q7Z0W1   A0A2A4IYF9   Q962B3   A0A2W1BR73   H9JEW5   G9C5G3   O46156   D3YJ04   D2KHN1   D2KHN2   K9MBC9   Q6PWP5   Q6J4J3   G3ESV7   A0A076YIK8   D3YJ03   Q6Q2I1   A0A076VDI4   A0A212EJS3   G0ZL61   B8PYI5   A0A2H1WZJ8   A0A2A4J7T7   A0A2W1BM31   G0ZL62   Q9U6W2   S4VAT7   A0A286LPZ8   O16851   B2LRS7   A0A2W1BR38   Q8WSZ2   D2KHN4   Q962B4   A0A1L5JK78   B2LRS8   A0A212EJU6   D2KHN5   Q6R3M6   F6K6Z9   A0A1B0RHN6   Q9NHZ9   Q6R3M5   H9JEW4   A0A1B0RHN3   O76803   Q6UY54   I3VR74   Q6T3W2   Q6UY55   A0A2Z3YJ90   A0A076VHN0   Q9U7N8   Q11001   Q6T3W3   Q95WL0   A4D0J3   A0A194QD77   H9JEW2   V5NQ96   V5NPR9   O76122   Q19TV9   A0A194QK74   A0A384RYH7   D0UYB1   D0UYB2  

EC Number

3.4.11.-

Pubmed

19121390    28756777    20420910    11439249    15857766    17402938    + More
26354079    12200317    15978131    22118469    24121099    24932922    21840855    21844358    18549954    10543783    10380100    19376227    27940541    9931470    7629076    24045122    9729121   

EMBL

AB013400    BAA33715.1    JQ061143    AFK85017.1    BABH01023391    AF498996    + More
AAM18718.1    NWSH01002538    PCG68029.1    AF378666    AAK58066.1    AF535165    AAN04899.1    KZ149969    PZC76117.1    EU571948    ACB87202.2    AY279534    AAP37950.1    AF511038    AAM44056.1    AY181026    AAO23562.1    EU826126    ACF34998.2    HQ853296    ADZ05468.1    FJ694793    ACV74256.1    AF217249    AAF37559.1    AF317619    AAL26894.1    AY836582    AAX39866.1    DQ872666    ABH07377.2    HQ901596    ADZ57273.1    RSAL01000014    RVE53191.1    KQ459185    KPJ03376.1    KQ461198    KPJ05976.1    AF320764    AAK69605.1    JF509138    ADZ74247.1    AY218845    AAP44967.1    ODYU01007373    SOQ50076.1    AGBW02014405    OWR41736.1    EF103945    ABL01484.1    KPJ03375.1    JQ061144    AFK85018.1    KC776603    AGO57907.1    AY279535    AY346383    AAP37951.1    AAQ24379.1    NWSH01005085    PCG64448.1    AY038608    AAK85539.1    PZC76115.1    BABH01023392    HQ853295    ADZ05467.1    AJ222699    CAA10950.1    GU479677    ADD39718.1    GU213036    ADA59488.1    GU213037    ADA59489.1    JQ088281    AFU51581.1    AY573579    AAS82738.1    AY601813    AAT45356.1    JF339039    AEO12694.1    KM034756    AIK67332.1    GU479676    ADD39717.1    AY564236    AAS75551.1    KF900124    AIK27005.1    OWR41737.1    JF303657    AEA29693.1    EU328183    ACA35025.1    ODYU01012236    SOQ58437.1    PCG68031.1    PZC76119.1    JF303658    AEA29694.1    AF173552    AAF08254.1    KC776602    AGO57906.1    MF425655    ASU92547.1    AF020389    AAB70755.1    EU568874    ACC68683.1    PZC76114.1    AF441377    AAL34109.1    GU213039    ADA59491.1    AY038607    AAK85538.1    KY210882    APO15796.1    EU568875    ACC68682.1    OWR41735.1    GU213040    ADA59492.1    AY515309    AAS00450.1    HM357836    AEA76302.1    KM360182    AKH49598.1    AF217248    AAF37558.1    AY515310    AAS00451.1    KM360190    AKH49606.1    AF084257    JQ061146    AAC33301.1    AFK85020.1    AY358035    AAQ57406.1    JQ061145    AFK85019.1    AY437833    AAR20814.1    AY358034    AAQ57405.1    KY949258    AWT23000.1    KF900125    AIK27006.1    AF123313    AAF07223.1    X89081    AB007039    AY437832    AAR20813.1    AF317620    AAL26895.1    AY836579    AAX39863.1    KPJ03374.1    BABH01023388    BABH01023389    BABH01023390    KF537664    AHA90591.1    KF537663    AHA90590.1    AB007038    BAA32475.1    DQ444715    ABE02186.1    KPJ05973.1    KP053647    AKO62648.1    GQ927479    ACX85726.2    GQ927480    ACX85727.2   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    + More

PRIDE

O77046    I3VR72    H9JEW3    E8Z923    I3VR73    H9JEW5    + More
H9JEW4    O76803    I3VR74    Q11001    H9JEW2    O76122   

Pfam

PF11838   ERAP1_C        + More
PF01433   Peptidase_M1

Interpro

IPR042097   Aminopeptidase_N-like_N        + More
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR001930   Peptidase_M1       
IPR033581   APN2       
IPR034016   M1_APN-typ       
IPR008936   Rho_GTPase_activation_prot       

SUPFAM

SSF48350   SSF48350       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

O77046   I3VR72   H9JEW3   Q8T5Q4   A0A2A4J832   Q963G0   + More
Q8MU79   A0A2W1BSE9   B2LS41   Q7Z268   Q8MUT5   Q86QI6   B5A8X9   G9C5G4   E8Z923   Q9NHZ8   Q95WL1   A4D0J6   Q0PDN2   G9C7N4   A0A3S2P5X4   A0A194QIU5   A0A194QR18   Q964F9   F2YWM1   Q4G6A2   A0A2H1WAU1   A0A212EJS8   A1E3B7   A0A194QEK1   I3VR73   S4VDN0   Q7Z0W1   A0A2A4IYF9   Q962B3   A0A2W1BR73   H9JEW5   G9C5G3   O46156   D3YJ04   D2KHN1   D2KHN2   K9MBC9   Q6PWP5   Q6J4J3   G3ESV7   A0A076YIK8   D3YJ03   Q6Q2I1   A0A076VDI4   A0A212EJS3   G0ZL61   B8PYI5   A0A2H1WZJ8   A0A2A4J7T7   A0A2W1BM31   G0ZL62   Q9U6W2   S4VAT7   A0A286LPZ8   O16851   B2LRS7   A0A2W1BR38   Q8WSZ2   D2KHN4   Q962B4   A0A1L5JK78   B2LRS8   A0A212EJU6   D2KHN5   Q6R3M6   F6K6Z9   A0A1B0RHN6   Q9NHZ9   Q6R3M5   H9JEW4   A0A1B0RHN3   O76803   Q6UY54   I3VR74   Q6T3W2   Q6UY55   A0A2Z3YJ90   A0A076VHN0   Q9U7N8   Q11001   Q6T3W3   Q95WL0   A4D0J3   A0A194QD77   H9JEW2   V5NQ96   V5NPR9   O76122   Q19TV9   A0A194QK74   A0A384RYH7   D0UYB1   D0UYB2  

PDB

4WZ9     E-value=1.89329e-102,     Score=955

KEGG

100127099    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn4, apn3; aminopeptidase N

GO

GO:0004177   GO:0008237   GO:0008270   GO:0016021   GO:0007165   GO:0005886   GO:0031225   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 16,         Likelihood:  0.975817

 

 

Length:

946

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

26.06101

Exp number, first 60 AAs:

0.39885

Total prob of N-in:

0.02216

outside

1  -  946

 

 

Pi

176.053615

Theta

156.869067

Tajima's D

0.183682

CLR

1.762336

CSRT

0.421778911054447

Interpretation

Uncertain