Gene

KWMTBOMO04889  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008059

Annotation

aminopeptidase_N_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):969495-970749      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor
BTBP1

Location in the cell

Extracellular   Reliability : 1.901

CDS

ATGCGCCCGTGGGTGTACTGCGCTGGACTACGTCACGGCACGGCGGAAGACTTCAACTTCTTCTGGAATCGCTACCTTCAGGAAGATCTGTCCAGTGAGAAGGTGGTAATGCTCAACGTTGCTGGCTGTACTACTGACCAGGCCAGTCTGAATCGATTCCTGGATGCGATTGTCTCAGGAAACGACGATATTAGACCACAAGACTACAATGCTGCTCTAACCTCCGCTATTACATCCAATGAGATAAACACTCTGAGAGCTTTCCAATGGCTCAGGAACAACGTTGACCAGGCGACCAGAACCCTAGGCAGCGTTTCCACGATCTTGAACACAATAATTGGACGTCTCCTCAACGAGGAACAGATAAATGAGGTTTCGAACTGGTTGACGGCCAACCAAAACACCCTGGGAGCCACATACAGCACGGCGCTACGAGCTATCGAGACCACGCGGTCGAACCTCGTCTGGTCACAGCAGAGAATTTCAGAATTCACGAACTACTTCGAGTCAGGCTACGTGGAGGATGTCATTGAGGAGATCACCGAGGCACCGCCTACTGCTCCCCCGACCGCCCCACCAACCGATGAGCACACGGCCCACCTGACGGTGAGTGGTGGCCCATGGACTTGA

Protein

MRPWVYCAGLRHGTAEDFNFFWNRYLQEDLSSEKVVMLNVAGCTTDQASLNRFLDAIVSGNDDIRPQDYNAALTSAITSNEINTLRAFQWLRNNVDQATRTLGSVSTILNTIIGRLLNEEQINEVSNWLTANQNTLGATYSTALRAIETTRSNLVWSQQRISEFTNYFESGYVEDVIEEITEAPPTAPPTAPPTDEHTAHLTVSGGPWT

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

O76803   O76122   H9JEW2   Q11001   Q9U7N8   A0A0N0P9U6   + More
A4D0J3   A0A1B0RHN6   A1E3B4   Q962B4   A0A2W1BR38   Q19TV9   D0UYB2   G3ESV3   E8Z5C9   A0A194QIU5   D0UYB1   Q9U6W2   Q95WL0   A2IBT7   Q6UY54   Q6UY55   B2LRS7   A0A1B0RHN3   B2LRS8   V5NPR9   A0A1L5JK78   V5NQ96   Q8WSZ2   A0A384RYH7   A0A194QKB6   Q9NHZ9   E0A209   A0A3S2TRJ1   Q2L9Z0   O16851   A0A212EJU6   Q6R3M5   Q6T3W2   Q6R3M6   F6K6Z9   Q4G6A5   A0A2H1WAG0   A0A0L7LCB7   A4D0J5   Q9XYV2   Q6Y0Y6   A0A2Z3YKX3   E0A211   Q8ITD4   Q8T3I0   I3VR77   Q8T7M0   E8Z5S9   O17485   O17484   G3ESV8   A0A2Z3YJS3   H8YHV9   Q9GT75   Q9U8B0   G3ESW0   A5JJU1   A7YAH7   G3ESV9   A1E3B6   G3ESV2   R4HHS0   E8Z9T8   A0A096XIT2   G9C5G2   A0A024AX72   A0A286LPZ6   M4M1W4   Q9NHZ7   K9MBJ8   A0A2A4IXQ9   A0A3S2M847   Q11000   A0A212EJT4   A0A2W1BU00   Q7Z267   Q7Z266   A0A2J7PPF3   A0A2J7PPF0   Q8ITD3   T1PKU5   T1PLE0   Q8MU78   A0A1B0CGE2   A0A1I8MMF4   Q4G6A3   Q5UVJ2   E8Z7I6  

EC Number

3.4.11.-

Pubmed

9931470    9729121    19121390    7629076    26354079    15857766    + More
28756777    17402938    24121099    20420910    10543783    19376227    24045122    27940541    11439249    20685334    10380100    22118469    15978131    26227816    10406091    12441000    12023048    10732989    10989294    10366728    7592988    25315136   

EMBL

AF084257    JQ061146    AAC33301.1    AFK85020.1    AB007038    BAA32475.1    + More
BABH01023388    BABH01023389    BABH01023390    X89081    AB007039    AF123313    AAF07223.1    KQ459417    KPJ01109.1    AY836579    AAX39863.1    KM360182    AKH49598.1    EF103942    ABL01481.1    AY038607    AAK85538.1    KZ149969    PZC76114.1    DQ444715    ABE02186.1    GQ927480    ACX85727.2    JF339038    AEO12690.1    EU878375    ACJ64827.1    KQ459185    KPJ03376.1    GQ927479    ACX85726.2    AF173552    AAF08254.1    AF317620    AAL26895.1    EF190464    ABM66442.1    AY358035    AAQ57406.1    AY358034    AAQ57405.1    EU568874    ACC68683.1    KM360190    AKH49606.1    EU568875    ACC68682.1    KF537663    AHA90590.1    KY210882    APO15796.1    KF537664    AHA90591.1    AF441377    AAL34109.1    KP053647    AKO62648.1    KQ461198    KPJ05977.1    AF217248    AAF37558.1    HM231316    ADL38968.1    RSAL01000014    RVE53192.1    DQ342305    ABC69855.3    AF020389    AAB70755.1    AGBW02014405    OWR41735.1    AY515310    AAS00451.1    AY437833    AAR20814.1    AY515309    AAS00450.1    HM357836    AEA76302.1    AY218842    AAP44964.1    ODYU01007373    SOQ50075.1    JTDY01001695    KOB73138.1    AY836581    AAX39865.1    AF126442    AAD31183.1    AY193789    AAP33526.1    KY949255    AWT22997.1    HM231318    ADL38970.1    AF521659    AAN75693.1    AY095259    AAM13691.1    JQ061148    AFK85022.1    AF352574    AAL83943.1    FJ492806    ACT35083.1    AF034484    AAC36147.1    AF034483    AAC36148.1    JF339040    AEO12695.1    KY949256    AWT22998.1    JF519739    AEB96253.1    AF276241    AAF99701.1    AF109692    AAF01259.2    AEO12697.1    EF538427    ABQ51393.1    EU137839    ABV01346.1    AEO12696.1    EF103944    ABL01483.1    AEO12689.1    HQ636624    AEL22855.1    FJ896130    ADA57169.1    KF689688    AHW57924.1    HQ853294    ADZ05466.1    KJ143755    AHZ08543.1    MF425653    ASU92545.1    JQ747495    AGG36452.1    AF217250    AAF37560.1    JQ088280    AFU51580.1    NWSH01005016    PCG64491.1    RVE53193.1    U35096    OWR41734.1    PZC76116.1    AY279536    AAP37952.1    AY279537    AAP37953.1    NEVH01023278    PNF18179.1    PNF18181.1    AF521660    AAN75694.1    KA649339    AFP63968.1    KA649519    AFP64148.1    AF535166    AAN04900.1    AJWK01011046    AJWK01011047    AY218844    AAP44966.1    AY603414    AAT99437.1    FJ647796    ACV04931.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000283053    UP000007151    UP000037510    + More
UP000218220    UP000235965    UP000092461    UP000095301   

PRIDE

O76803    O76122    H9JEW2    Q11001    E8Z5C9    I3VR77    + More
Q8T7M0    E8Z5S9    Q9U8B0    E8Z9T8    Q11000    E8Z7I6   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR034016   M1_APN-typ        + More
IPR001930   Peptidase_M1       
IPR033581   APN2       
IPR042097   Aminopeptidase_N-like_N       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

O76803   O76122   H9JEW2   Q11001   Q9U7N8   A0A0N0P9U6   + More
A4D0J3   A0A1B0RHN6   A1E3B4   Q962B4   A0A2W1BR38   Q19TV9   D0UYB2   G3ESV3   E8Z5C9   A0A194QIU5   D0UYB1   Q9U6W2   Q95WL0   A2IBT7   Q6UY54   Q6UY55   B2LRS7   A0A1B0RHN3   B2LRS8   V5NPR9   A0A1L5JK78   V5NQ96   Q8WSZ2   A0A384RYH7   A0A194QKB6   Q9NHZ9   E0A209   A0A3S2TRJ1   Q2L9Z0   O16851   A0A212EJU6   Q6R3M5   Q6T3W2   Q6R3M6   F6K6Z9   Q4G6A5   A0A2H1WAG0   A0A0L7LCB7   A4D0J5   Q9XYV2   Q6Y0Y6   A0A2Z3YKX3   E0A211   Q8ITD4   Q8T3I0   I3VR77   Q8T7M0   E8Z5S9   O17485   O17484   G3ESV8   A0A2Z3YJS3   H8YHV9   Q9GT75   Q9U8B0   G3ESW0   A5JJU1   A7YAH7   G3ESV9   A1E3B6   G3ESV2   R4HHS0   E8Z9T8   A0A096XIT2   G9C5G2   A0A024AX72   A0A286LPZ6   M4M1W4   Q9NHZ7   K9MBJ8   A0A2A4IXQ9   A0A3S2M847   Q11000   A0A212EJT4   A0A2W1BU00   Q7Z267   Q7Z266   A0A2J7PPF3   A0A2J7PPF0   Q8ITD3   T1PKU5   T1PLE0   Q8MU78   A0A1B0CGE2   A0A1I8MMF4   Q4G6A3   Q5UVJ2   E8Z7I6  

PDB

4F5C     E-value=1.53403e-07,     Score=129

KEGG

692563    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn1, Apn; aminopeptidase N

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008237   GO:0004177   GO:0008270   GO:0005886   GO:0031225   GO:0016021  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

Length:

209

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00404

Exp number, first 60 AAs:

0.00014

Total prob of N-in:

0.05985

outside

1  -  209

 

 

Pi

15.617433

Theta

25.288531

Tajima's D

-1.441142

CLR

280.959173

CSRT

0.0647967601619919

Interpretation

Uncertain