Gene

KWMTBOMO04888  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008059

Annotation

aminopeptidase_N_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):964075-968333      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor
BTBP1

Location in the cell

PlasmaMembrane   Reliability : 2.257

CDS

ATGATTGTTACACAGGAAAGATGGGAACGCAATACTGGCGTTTCACAATTCCCGAGCCTATGGCACATACCGATCACCTGGACTAGGGCTGGAGCTCCCGAATTCGAAGACTTGAAACCATCGCAATTCATCTCGCAACAAGTGACCTCCATTAACAGAGGCACCACTGGGTTGGAGTGGGTAATATTCAACAAGCAAGAAGCCGGCTTCTACAGAGTCAACTACGACGATACCAATTGGGCTCTCCTGACTAGAGCTTTGAGGTCGTCGTCCCGAACTGCCATTCATCAACTGAACCGTGCTCAGATTGTGGACGATATTTTCCAATTGGCCCGAGCAAATGTGATGAAGTACAACAGAGCATTCAACATTCTATCCTTCCTGCAATTTGAAGACGAATATGCTCCATGGTTGGCGGCCATCAGTGGCTTCAACTTCCTCATCAGGAGACTGGCTCATGATTCTACTAATGCGGCACTTTTACAAAAACTTATTCTAGAACTAAGTCCCGCGGTAGTAGCTAAACTGGGTTACCTAGAGCCAGAGAATGGCTCCTACATGACTGATCTTCAAAGAATGTACGTAATGGAATTCCTTTGTAACGTGGGACACGAAGAATGCAATAACTTTGGAACCCAGGCCTTCCGAAGGTGGAGCACCGGTACTTTGTAA

Protein

MIVTQERWERNTGVSQFPSLWHIPITWTRAGAPEFEDLKPSQFISQQVTSINRGTTGLEWVIFNKQEAGFYRVNYDDTNWALLTRALRSSSRTAIHQLNRAQIVDDIFQLARANVMKYNRAFNILSFLQFEDEYAPWLAAISGFNFLIRRLAHDSTNAALLQKLILELSPAVVAKLGYLEPENGSYMTDLQRMYVMEFLCNVGHEECNNFGTQAFRRWSTGTL

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

O76803   H9JEW2   O76122   Q11001   Q9U7N8   A0A0N0P9U6   + More
A0A212EJU6   A0A194QIU5   V5NPR9   D2KHN5   Q19TV9   V5NQ96   D2KHN4   O16851   A2IBT7   G3ESV3   D0UYB1   D0UYB2   A1E3B4   E8Z5C9   Q9NHZ9   Q4G6A5   A0A2H1WAG0   E0A209   A0A194QKB6   F6K6Z9   Q962B4   A0A2W1BR38   Q95WL0   A0A1B0RHN6   B2LRS7   A0A1B0RHN3   Q6UY55   A0A1L5JK78   Q8WSZ2   Q6R3M5   Q8ITD4   B2LRS8   Q6UY54   Q2L9Z0   A0A3S2TRJ1   Q9U6W2   A0A384RYH7   Q6R3M6   Q6T3W2   Q6T3W3   A4D0J3   A0A2Z3YKX3   K9MBJ8   M4M1W4   A0A212EJT4   G3ESV8   A0A3S2M847   A0A2Z3YJS3   H8YHV9   G3ESW0   Q8T7M0   I3VR77   Q6Y0Y6   A4D0J5   A1E3B6   G3ESV2   G3ESV9   E8Z5S9   E0A211   Q9XYV2   A0A286LPZ6   A7YAH7   Q9GT75   A5JJU1   A0A2A4IXQ9   E8Z9T8   Q8T3I0   A0A096XIT2   Q11000   Q9U8B0   R4HHS0   Q95UF9   Q8ITD3   Q5UVJ2   Q7Z267   G9C5G2   Q7Z266   Q8MU78   A0A2W1BU00   Q9NHZ7   A0A024AX72   F6K6Z4   A0A2A4J832   A0A2W1BSE9   Q8MU79   Q7Z268   Q8MUT5   A0A2H1V7F0   Q963G0   Q86QI6   Q4G6A3   Q9NHZ8   D5G3H6  

EC Number

3.4.11.-

Pubmed

9931470    19121390    9729121    7629076    26354079    22118469    + More
24045122    17402938    10380100    24121099    20420910    11439249    15978131    20685334    28756777    19376227    27940541    12441000    10543783    15857766    12023048    10406091    10989294    7592988    10366728    20005949   

EMBL

AF084257    JQ061146    AAC33301.1    AFK85020.1    BABH01023388    BABH01023389    + More
BABH01023390    AB007038    BAA32475.1    X89081    AB007039    AF123313    AAF07223.1    KQ459417    KPJ01109.1    AGBW02014405    OWR41735.1    KQ459185    KPJ03376.1    KF537663    AHA90590.1    GU213040    ADA59492.1    DQ444715    ABE02186.1    KF537664    AHA90591.1    GU213039    ADA59491.1    AF020389    AAB70755.1    EF190464    ABM66442.1    JF339038    AEO12690.1    GQ927479    ACX85726.2    GQ927480    ACX85727.2    EF103942    ABL01481.1    EU878375    ACJ64827.1    AF217248    AAF37558.1    AY218842    AAP44964.1    ODYU01007373    SOQ50075.1    HM231316    ADL38968.1    KQ461198    KPJ05977.1    HM357836    AEA76302.1    AY038607    AAK85538.1    KZ149969    PZC76114.1    AF317620    AAL26895.1    KM360182    AKH49598.1    EU568874    ACC68683.1    KM360190    AKH49606.1    AY358034    AAQ57405.1    KY210882    APO15796.1    AF441377    AAL34109.1    AY515310    AAS00451.1    AF521659    AAN75693.1    EU568875    ACC68682.1    AY358035    AAQ57406.1    DQ342305    ABC69855.3    RSAL01000014    RVE53192.1    AF173552    AAF08254.1    KP053647    AKO62648.1    AY515309    AAS00450.1    AY437833    AAR20814.1    AY437832    AAR20813.1    AY836579    AAX39863.1    KY949255    AWT22997.1    JQ088280    AFU51580.1    JQ747495    AGG36452.1    OWR41734.1    JF339040    AEO12695.1    RVE53193.1    KY949256    AWT22998.1    JF519739    AEB96253.1    AEO12697.1    AF352574    AAL83943.1    JQ061148    AFK85022.1    AY193789    AAP33526.1    AY836581    AAX39865.1    EF103944    ABL01483.1    AEO12689.1    AEO12696.1    FJ492806    ACT35083.1    HM231318    ADL38970.1    AF126442    AAD31183.1    MF425653    ASU92545.1    EU137839    ABV01346.1    AF276241    AAF99701.1    EF538427    ABQ51393.1    NWSH01005016    PCG64491.1    FJ896130    ADA57169.1    AY095259    AAM13691.1    KF689688    AHW57924.1    U35096    AF109692    AAF01259.2    HQ636624    AEL22855.1    AY052651    AAL14117.2    AF521660    AAN75694.1    AY603414    AAT99437.1    AY279536    AAP37952.1    HQ853294    ADZ05466.1    AY279537    AAP37953.1    AF535166    AAN04900.1    PZC76116.1    AF217250    AAF37560.1    KJ143755    AHZ08543.1    HM357831    AEA76297.1    NWSH01002538    PCG68029.1    PZC76117.1    AF535165    AAN04899.1    AY279534    AAP37950.1    AF511038    AAM44056.1    ODYU01000825    SOQ36184.1    AF378666    AAK58066.1    AY181026    AAO23562.1    AY218844    AAP44966.1    AF217249    AAF37559.1    FJ997340    ADF43505.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000283053    UP000218220    + More

PRIDE

O76803    H9JEW2    O76122    Q11001    E8Z5C9    Q8T7M0    + More
I3VR77    E8Z5S9    E8Z9T8    Q11000    Q9U8B0   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR034016   M1_APN-typ        + More
IPR001930   Peptidase_M1       
IPR033581   APN2       
IPR042097   Aminopeptidase_N-like_N       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR008936   Rho_GTPase_activation_prot       

SUPFAM

SSF48350   SSF48350       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

O76803   H9JEW2   O76122   Q11001   Q9U7N8   A0A0N0P9U6   + More
A0A212EJU6   A0A194QIU5   V5NPR9   D2KHN5   Q19TV9   V5NQ96   D2KHN4   O16851   A2IBT7   G3ESV3   D0UYB1   D0UYB2   A1E3B4   E8Z5C9   Q9NHZ9   Q4G6A5   A0A2H1WAG0   E0A209   A0A194QKB6   F6K6Z9   Q962B4   A0A2W1BR38   Q95WL0   A0A1B0RHN6   B2LRS7   A0A1B0RHN3   Q6UY55   A0A1L5JK78   Q8WSZ2   Q6R3M5   Q8ITD4   B2LRS8   Q6UY54   Q2L9Z0   A0A3S2TRJ1   Q9U6W2   A0A384RYH7   Q6R3M6   Q6T3W2   Q6T3W3   A4D0J3   A0A2Z3YKX3   K9MBJ8   M4M1W4   A0A212EJT4   G3ESV8   A0A3S2M847   A0A2Z3YJS3   H8YHV9   G3ESW0   Q8T7M0   I3VR77   Q6Y0Y6   A4D0J5   A1E3B6   G3ESV2   G3ESV9   E8Z5S9   E0A211   Q9XYV2   A0A286LPZ6   A7YAH7   Q9GT75   A5JJU1   A0A2A4IXQ9   E8Z9T8   Q8T3I0   A0A096XIT2   Q11000   Q9U8B0   R4HHS0   Q95UF9   Q8ITD3   Q5UVJ2   Q7Z267   G9C5G2   Q7Z266   Q8MU78   A0A2W1BU00   Q9NHZ7   A0A024AX72   F6K6Z4   A0A2A4J832   A0A2W1BSE9   Q8MU79   Q7Z268   Q8MUT5   A0A2H1V7F0   Q963G0   Q86QI6   Q4G6A3   Q9NHZ8   D5G3H6  

PDB

4WZ9     E-value=7.57375e-25,     Score=279

KEGG

692563    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn1, Apn; aminopeptidase N

GO

GO:0008237   GO:0004177   GO:0008270   GO:0005886   GO:0031225   GO:0016021   GO:0007165  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

Length:

223

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27155

Exp number, first 60 AAs:

0.01209

Total prob of N-in:

0.23546

outside

1  -  223

 

 

Pi

123.105725

Theta

145.025074

Tajima's D

-0.662684

CLR

30.194337

CSRT

0.2006399680016

Interpretation

Uncertain