Gene

KWMTBOMO04887  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008059

Annotation

aminopeptidase_N_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):960345-962579      View in EpiBrowser

Full name

Aminopeptidase       + More
Membrane alanyl aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
CryIA(C) receptor
BTBP1

Location in the cell

PlasmaMembrane   Reliability : 3.531

CDS

ATGGCATCTCGCTGGTTTTACTTCCTCGTGGGCGTAGCCTTCTTACAAACTTCACTAACGTTAAGCCCCATACCAGTACCAGAAGATGAGTGGGTTGAATTTGCGAGGATGCTTCGGGATCCGGCGTTTCGTCTTCCAACGACCACACGCCCGAGACATTATCAAGTAACACTGACTCCATATTTCGATGTTGTACCAGCCAACGTGAACCCCTTCACTTTTGACGGCGAAGTTACTATTTACACTTCTCCCACAGTAGCAAACGTTAACGAAGTTGTTATCCACTGCAACGACTTGACCATTCAAAGCCTCTCAATTGGCTACCAAAGTGGAACGAATGTGGTAGATATAACAGCGACCGGCCAGACTTTCGCCTGTGAGATGCCTTTCAGTTTCCTTAGAATCAGAACCACTGAAGCTTTAGTACTCAATAGAGAATACATAATTAAAAGCACTTTTAGAGGAAATCTGCAAACTAACATGAGAGGCTTTTACAGAAGTTGGTACGTTGATAGCACCGGTAGGAGATGGATGGGTACTACCCAATTCCAACCTGGTCATGCTCGCCAAGCGTTCCCTTGTTACGATGAGCCTGGATTCAAAGCCACCTTTGATATTACCATGAACAGAGAAGAATCCTTCAGTCCGACTATTTCAAACATGCCTATTAGAACGACCAACACTCTTGCAAATGGTCGCGTTTCTGAAACTTTTTGGACGACACCGGTTACCTCTACCTATTTGTTGGCTTTTATCGTTTCACATTACACTGTTGTCTCTACTAACAACAATGCTCTACGACCCTTCGATATCTATGCCCGTAACAATGTTGGTCGCACTGGTGATTGGTCTTTGGAGATCGGAGAGAAACTTTTGGAGGCTATGGAGGCATACACTCAAATTCCATATTATACAATGGCCGAAAATATTAACATGAAACAAGCGGCAATTCCTGATTTCTCTGCTGGTGCTATGGAAAACTGGGGTCTGTTGACTTACAGGGAAGCTTTGATACTTTATGATCCGTTGAATTCAAACCATTTCTACAAACAGCGCGTGGCTAACATCGTAGCCCACGAAATAGCTCATATGTGGTTTGGAAATTTGGTCACTTGCGCCTGGTGGGACAACTTGTGGCTAAACGAAGGCTTTGCTAGATTCTATCAATATTATTTGACGGCATCGGTTGCACCTGAGCTGGGCTATGAGACGCGTTTTATCGTTGAGCAAGTCCAAATGGCCATGTTCTCGGATTCCGTTGACACCGCTCATGCACTGACAGATCTCAATGTAAATGATCCGACCACAGTCAGCGCGCACTTTTCTACAATAACCTACGCGAGAGGTGCTGCCATTCTCAGGATGACTCAACACTTACTTGGAGTCGAAACCTTCGTTAAAGGCCTCCGCAACTATCTCCGTGAAAGGTTTGATCTGTTAAATGTTAAAGGGTTGAATGGGTAA

Protein

MASRWFYFLVGVAFLQTSLTLSPIPVPEDEWVEFARMLRDPAFRLPTTTRPRHYQVTLTPYFDVVPANVNPFTFDGEVTIYTSPTVANVNEVVIHCNDLTIQSLSIGYQSGTNVVDITATGQTFACEMPFSFLRIRTTEALVLNREYIIKSTFRGNLQTNMRGFYRSWYVDSTGRRWMGTTQFQPGHARQAFPCYDEPGFKATFDITMNREESFSPTISNMPIRTTNTLANGRVSETFWTTPVTSTYLLAFIVSHYTVVSTNNNALRPFDIYARNNVGRTGDWSLEIGEKLLEAMEAYTQIPYYTMAENINMKQAAIPDFSAGAMENWGLLTYREALILYDPLNSNHFYKQRVANIVAHEIAHMWFGNLVTCAWWDNLWLNEGFARFYQYYLTASVAPELGYETRFIVEQVQMAMFSDSVDTAHALTDLNVNDPTTVSAHFSTITYARGAAILRMTQHLLGVETFVKGLRNYLRERFDLLNVKGLNG

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

chain  Aminopeptidase
propeptide  Activation peptide

Uniprot

O76803   H9JEW2   O76122   Q9U7N8   Q11001   A0A194QKB6   + More
A0A194QIU5   A0A2W1BR38   Q6UY54   Q962B4   Q6UY55   Q9NHZ9   Q8WSZ2   A0A1L5JK78   Q6R3M5   A0A1B0RHN3   Q6R3M6   Q6T3W2   Q9U6W2   B2LRS7   B2LRS8   A0A0L7LCB7   A0A1B0RHN6   Q6T3W3   D0UYB1   A0A212EJU6   D2KHN4   O16851   D0UYB2   D2KHN5   G3ESV3   Q8ITD4   E8Z5C9   Q95WL0   V5NPR9   Q19TV9   V5NQ96   E0A209   Q2L9Z0   A0A3S2TRJ1   A4D0J3   A0A384RYH7   F6K6Z9   Q4G6A5   Q9GT75   A0A286LPZ6   K9MBJ8   G3ESW0   M4M1W4   A0A3S2M847   Q9XYV2   Q8T7M0   I3VR77   A0A2Z3YJS3   G9C5G2   Q8T3I0   A0A096XIT2   E8Z5S9   G3ESV2   A0A3G1QXU4   I3VR76   E0A211   H8YHV9   Q11000   Q9U8B0   O17484   O17485   R4HHS0   A0A2Z3YKX3   A0A2A4IXL1   H9JEW6   A0A194QD77   Q7Z266   E8Z7I6   Q9NHZ7   A0A2W1BPB2   A0A2W1BU00   A0A212EJS3   G3ESV6   A0A194QK74   Q8MU78   Q95UF9   Q7Z267   A0A212EJT4   A0A2H1VVU0   A0A0K8U3X8   A0A0K8WLP7   A0A182QDN7   A4D0J5   A0A182KXW9   A0A182L699   A0A1A9W2N5   A0A024AX72   A0A182GA81   A0A0A1X3Y1   G3ESV9   F5HLF3   E8Z9T8  

EC Number

3.4.11.-

Pubmed

9931470    19121390    9729121    7629076    26354079    28756777    + More
11439249    27940541    10543783    19376227    26227816    22118469    10380100    24121099    12441000    20420910    24045122    17402938    20685334    15857766    15978131    10989294    10406091    12023048    7592988    10366728    10732989    20966253    26483478    25830018    12364791    14747013    17210077   

EMBL

AF084257    JQ061146    AAC33301.1    AFK85020.1    BABH01023388    BABH01023389    + More
BABH01023390    AB007038    BAA32475.1    AF123313    AAF07223.1    X89081    AB007039    KQ461198    KPJ05977.1    KQ459185    KPJ03376.1    KZ149969    PZC76114.1    AY358035    AAQ57406.1    AY038607    AAK85538.1    AY358034    AAQ57405.1    AF217248    AAF37558.1    AF441377    AAL34109.1    KY210882    APO15796.1    AY515310    AAS00451.1    KM360190    AKH49606.1    AY515309    AAS00450.1    AY437833    AAR20814.1    AF173552    AAF08254.1    EU568874    ACC68683.1    EU568875    ACC68682.1    JTDY01001695    KOB73138.1    KM360182    AKH49598.1    AY437832    AAR20813.1    GQ927479    ACX85726.2    AGBW02014405    OWR41735.1    GU213039    ADA59491.1    AF020389    AAB70755.1    GQ927480    ACX85727.2    GU213040    ADA59492.1    JF339038    AEO12690.1    AF521659    AAN75693.1    EU878375    ACJ64827.1    AF317620    AAL26895.1    KF537663    AHA90590.1    DQ444715    ABE02186.1    KF537664    AHA90591.1    HM231316    ADL38968.1    DQ342305    ABC69855.3    RSAL01000014    RVE53192.1    AY836579    AAX39863.1    KP053647    AKO62648.1    HM357836    AEA76302.1    AY218842    AAP44964.1    AF276241    AAF99701.1    MF425653    ASU92545.1    JQ088280    AFU51580.1    JF339040    AEO12697.1    JQ747495    AGG36452.1    RVE53193.1    AF126442    AAD31183.1    AF352574    AAL83943.1    JQ061148    AFK85022.1    KY949256    AWT22998.1    HQ853294    ADZ05466.1    AY095259    AAM13691.1    KF689688    AHW57924.1    FJ492806    ACT35083.1    AEO12689.1    KY949259    AWT23001.1    JQ061147    AFK85021.1    HM231318    ADL38970.1    JF519739    AEB96253.1    U35096    AF109692    AAF01259.2    AF034483    AAC36148.1    AF034484    AAC36147.1    HQ636624    AEL22855.1    KY949255    AWT22997.1    NWSH01005085    PCG64451.1    BABH01023392    BABH01023393    KPJ03374.1    AY279537    AAP37953.1    FJ647796    ACV04931.1    AF217250    AAF37560.1    PZC76121.1    PZC76116.1    OWR41737.1    JF339039    AEO12693.1    KPJ05973.1    AF535166    AAN04900.1    AY052651    AAL14117.2    AY279536    AAP37952.1    OWR41734.1    ODYU01004747    SOQ44949.1    GDHF01031289    JAI21025.1    GDHF01000302    JAI52012.1    AXCN02001184    AY836581    AAX39865.1    KJ143755    AHZ08543.1    JXUM01050790    KQ561662    KXJ77886.1    GBXI01008934    JAD05358.1    AEO12696.1    AAAB01008888    EGK97114.1    FJ896130    ADA57169.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000037510    UP000007151    UP000283053    + More
UP000218220    UP000075886    UP000075882    UP000091820    UP000069940    UP000249989    UP000007062   

PRIDE

O76803    H9JEW2    O76122    Q11001    E8Z5C9    Q8T7M0    + More
I3VR77    E8Z5S9    I3VR76    Q11000    Q9U8B0    H9JEW6    E8Z7I6    E8Z9T8   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR034016   M1_APN-typ        + More
IPR001930   Peptidase_M1       
IPR033581   APN2       
IPR042097   Aminopeptidase_N-like_N       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR011030   Lipovitellin_superhlx_dom       

SUPFAM

SSF48431   SSF48431       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

O76803   H9JEW2   O76122   Q9U7N8   Q11001   A0A194QKB6   + More
A0A194QIU5   A0A2W1BR38   Q6UY54   Q962B4   Q6UY55   Q9NHZ9   Q8WSZ2   A0A1L5JK78   Q6R3M5   A0A1B0RHN3   Q6R3M6   Q6T3W2   Q9U6W2   B2LRS7   B2LRS8   A0A0L7LCB7   A0A1B0RHN6   Q6T3W3   D0UYB1   A0A212EJU6   D2KHN4   O16851   D0UYB2   D2KHN5   G3ESV3   Q8ITD4   E8Z5C9   Q95WL0   V5NPR9   Q19TV9   V5NQ96   E0A209   Q2L9Z0   A0A3S2TRJ1   A4D0J3   A0A384RYH7   F6K6Z9   Q4G6A5   Q9GT75   A0A286LPZ6   K9MBJ8   G3ESW0   M4M1W4   A0A3S2M847   Q9XYV2   Q8T7M0   I3VR77   A0A2Z3YJS3   G9C5G2   Q8T3I0   A0A096XIT2   E8Z5S9   G3ESV2   A0A3G1QXU4   I3VR76   E0A211   H8YHV9   Q11000   Q9U8B0   O17484   O17485   R4HHS0   A0A2Z3YKX3   A0A2A4IXL1   H9JEW6   A0A194QD77   Q7Z266   E8Z7I6   Q9NHZ7   A0A2W1BPB2   A0A2W1BU00   A0A212EJS3   G3ESV6   A0A194QK74   Q8MU78   Q95UF9   Q7Z267   A0A212EJT4   A0A2H1VVU0   A0A0K8U3X8   A0A0K8WLP7   A0A182QDN7   A4D0J5   A0A182KXW9   A0A182L699   A0A1A9W2N5   A0A024AX72   A0A182GA81   A0A0A1X3Y1   G3ESV9   F5HLF3   E8Z9T8  

PDB

4WZ9     E-value=1.32799e-69,     Score=669

KEGG

692563    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn1, Apn; aminopeptidase N

GO

GO:0008237   GO:0004177   GO:0008270   GO:0005886   GO:0031225   GO:0016021   GO:0042277   GO:0043171   GO:0005737   GO:0006508   GO:0070006   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.945718

 

 

Length:

487

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

13.66068

Exp number, first 60 AAs:

12.97698

Total prob of N-in:

0.58007

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  487

 

 

Pi

174.84907

Theta

173.168675

Tajima's D

-0.144633

CLR

0.586181

CSRT

0.327683615819209

Interpretation

Uncertain