Gene

KWMTBOMO04886  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008059

Annotation

aminopeptidase_N-6_[Bombyx_mori]

Location

Bomo_Chr9(+):943525-957278      View in EpiBrowser

Full name

Membrane alanyl aminopeptidase       + More
Aminopeptidase      

Alternative Name

Aminopeptidase N-like protein
BTBP1
CryIA(C) receptor

Location in the cell

PlasmaMembrane   Reliability : 4.085

CDS

ATGGCGAATTACAAGGTCATTATCTTCTTGGCGGCGTGCGTGTTAGCACAGGCTTTCCCCGATGAACCAATTTACAGGACAAACAACACAATATTTCTTGACGAGAAACTAGAAGGGGAAATCTTTGAGGATATTGAGGCTTTTGAAAATATTGATAGAAGTATTGCCGCTAGTACATACAGACTGCCCACAACCACCAGACCTCTTCATTACAACGTGCTTTGGGCTATTGATATCTCCAGGCTAACCTTCTCTGGCACCGTTGAAATCCAGCTGTACGCCACTCGGGCTAACGTAAGCGAGATAGTTATTCATGCCGACGACCTGGAAATCACATCCGTGATTCTCAGACAAGGAACCGTCACGACACCCTCCACTTACACCCTCCAGAAAGAGTTACAGTTCCTGAGACTGCGCCTTAATACGGGCACTCTCGTCTTCAATGCTGCTTCTCCTGTGATTTACACACTGACCATTGATTTCGCTGCTCGCTTACGTACCGACATGTATGGTATTTACCGGACCTGGTTCCGGAATAGCACTAATGACGTCACAAGATGGATGGCCTCTACACAGTTCCAAGCGACATCCGCTCGTTACGCTTTCCCTTGTTACGACGAGCCCAGTTTTAAAGCAACTTTTCATATTACGATCAGACGTCCGACCACCCACAGAAGTTGGTCGTGCACAAACATCAGAGAAACACGAGTTTCAACCGTAACGGGCTATCAAGATGACATTTACAACAGAACTCCATTAATGTCTACGTATTTGATTGCTCTTATTGTTGCTGAATACGAATCTTTGGAGCAGCGTCAAAACGGTGTCTTGAGCATCCACCCTAATTTAAAGATGACGCAGGCTTCAATTCCCGATTTTTCAGCTGGTGCTATGGAAAATTGGGGTCTGCTTACTTACAGAGAAGCATACTTAATGTACGATGAGAACCATACCAATGGCTACTTCAAACAGTTGATCGCTTACATCCTTTCTCACGAGATCGCCCATATGTGGTATGGAAACCTCGTTACTTGCGACTGGTGGGATGTTTTATGGCTGAACGAAGGTTTTGCTCGCTACTACCAATACTTCCTCACTGACTGGGTTGAAGATTACATGGGTCTTGGAACTCGATTCATTGTAGAGCAAATTCACACGTCCCTTTTGTCTGACTCGGCCAACAGCCCTCAGCCTTTGACCAACCCAGGTGTTGGCAGCCCCGCATCAGTGAGTGCCATGTTCTCGACCATTTCATACAACAAGGGTGCAGCTGTGATTAGAATGACTGAGCATTTCCTAGGCTTCGAAGTACATAGACAAGGCTTGAACAACTATCTGATTGAGAGATCTTTTGACACTGCTTTACCTATCCATCTCTTCCAAACCCTTGAAGTCAGCGCTAGAGCAGCTGGAGCTTTATCAGCATACGGACCAGATTTTTCTTTTGTTGACTATTACAAGAGTTGGACTGAACAGAGCGGTCACCCAGTACTTAACGTTCAAGTTAACCACCAGACTGGGGATATGACTATCTACCAGCGTCGTTTCAACATCAACACTGGTTACTCGAATGTCAACACCAACTACATCGTGCCTATCACTTTTGCCACTGCCCGCAACCCTAACTTCGCCAACACAAAGCCTACTCATGTCCTCACCAAAGCTGTTACTGTTATCAACAGAGGATCTGTTGGAGATGAATGGGTTATTTTCAATAAACAGCAGACTGGTTTCTACAGAGTCAACTATGATGACTACACTTGGAATCTCATTGTTATTGCTCTACGCGGCCCTCAAAGAACTCAAATTCACGAATACAATAGAGCACAGATCGTTAACGACGTCTTTCAATTCGCTCGCTCTGGTCTCATGACCTACAACAGAGCCTTCAACATTCTTTCTTTCCTTGAGAATGAAACTGAATACGCTCCGTGGGTCGCAGCTATTACTGGATTCAACTGGATCAGGAATCGTCTTGTGGGAACCGCCCACCTCACCACTTTGAATAATCTGATCGCCCGTTGGTCTTCGAATCTGATGAACCAGCTCACCTACTCTCCAATTCCCAACGAGTCCTTCATGAGGTCTTACCTCAGATATCAGCTGGCTCCTCTACTTTGTAACATCAACGTGGCAGCCTGTCGTACTGCAGCTACTACTCAGTTCCAAGCTCTTCGTGTTAACGGACAAGAAGTACCAGTGGACAATCGCAACTGGGTTTATTGCAACGCTCTTCGTGACGGCACTGAAGCGGACTTCAACTTTTTGTACCAGAGATTCCAAAGCCACGATGTATACACTGAAAAGATTCAAATCCTCTGGGTCCTTGGCTGCACTCCTCATGCTAACTCATTGAACACTCTTCTCAACGCCATCGTCCAGGATAACATCATCATCCGTCCTCAAGACTACACTAATGCCTTCAACAACGCTGTCTCTGGAAACGAAGGCAACACCCAGATAGCTTTCCGGTTCATCCAGAACAATTTGGCTGCCGTCACAGCTGCGTTCCAAAGTGTCGCAACTCCACTATCATACGTCTCATCCAGATTAAGAACGGAAGCTGAAATTGTTTCATTCCAAAATTGGGCGACTCAGAACCAGGTAGCGTTGGGTGATGCTTACCAAGCTGTGTTCCGCGGAGCCGAGACTTCCCGTGAAAGCATTGCTTGGGCTTCCTTAGTTCAAAACGACATGAACAGCTACTTCGTCACCGGAGACACGGTCTATGAAGCCTCTACTGCTGCAAACGTGATCACATCACCATCCACTACAGTAACTCCACCCAACCTGGTGGAGCCTGCGACTCCAAGCCTTCCAGTGCCTGATGCAGCACCAGTCTCTACTTTCTTATCTGTAGCTGTTGTGGCTTTAGTCGCTGTGGTTAACTTGATTATGTAG

Protein

MANYKVIIFLAACVLAQAFPDEPIYRTNNTIFLDEKLEGEIFEDIEAFENIDRSIAASTYRLPTTTRPLHYNVLWAIDISRLTFSGTVEIQLYATRANVSEIVIHADDLEITSVILRQGTVTTPSTYTLQKELQFLRLRLNTGTLVFNAASPVIYTLTIDFAARLRTDMYGIYRTWFRNSTNDVTRWMASTQFQATSARYAFPCYDEPSFKATFHITIRRPTTHRSWSCTNIRETRVSTVTGYQDDIYNRTPLMSTYLIALIVAEYESLEQRQNGVLSIHPNLKMTQASIPDFSAGAMENWGLLTYREAYLMYDENHTNGYFKQLIAYILSHEIAHMWYGNLVTCDWWDVLWLNEGFARYYQYFLTDWVEDYMGLGTRFIVEQIHTSLLSDSANSPQPLTNPGVGSPASVSAMFSTISYNKGAAVIRMTEHFLGFEVHRQGLNNYLIERSFDTALPIHLFQTLEVSARAAGALSAYGPDFSFVDYYKSWTEQSGHPVLNVQVNHQTGDMTIYQRRFNINTGYSNVNTNYIVPITFATARNPNFANTKPTHVLTKAVTVINRGSVGDEWVIFNKQQTGFYRVNYDDYTWNLIVIALRGPQRTQIHEYNRAQIVNDVFQFARSGLMTYNRAFNILSFLENETEYAPWVAAITGFNWIRNRLVGTAHLTTLNNLIARWSSNLMNQLTYSPIPNESFMRSYLRYQLAPLLCNINVAACRTAATTQFQALRVNGQEVPVDNRNWVYCNALRDGTEADFNFLYQRFQSHDVYTEKIQILWVLGCTPHANSLNTLLNAIVQDNIIIRPQDYTNAFNNAVSGNEGNTQIAFRFIQNNLAAVTAAFQSVATPLSYVSSRLRTEAEIVSFQNWATQNQVALGDAYQAVFRGAETSRESIAWASLVQNDMNSYFVTGDTVYEASTAANVITSPSTTVTPPNLVEPATPSLPVPDAAPVSTFLSVAVVALVAVVNLIM

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Keywords

Aminopeptidase   Cell membrane   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Signal   Zinc  

Feature

propeptide  Activation peptide
chain  Membrane alanyl aminopeptidase

Uniprot

I3VR77   Q8T7M0   H9JEW2   Q8T3I0   A0A194QKB6   G3ESW0   + More
G3ESV9   Q9GT75   E8Z9T8   E8Z5S9   A5JJU1   A7YAH7   G3ESV2   K9MBJ8   R4HHS0   E0A211   Q9NHZ7   M4M1W4   A0A0L7LCB7   Q9XYV2   Q11000   A4D0J5   G9C5G2   A0A3S2M847   H8YHV9   A0A096XIT2   Q7Z266   Q7Z267   A0A2W1BU00   Q8MU78   Q95UF9   A0A024AX72   A0A2Z3YJS3   Q6Y0Y6   A0A286LPZ6   Q9U8B0   Q8ITD3   O17485   O17484   A0A212EJT4   A0A2Z3YKX3   Q5UVJ2   Q4G6A3   A0A2H1V7F0   A1E3B6   A0A194QIU5   O16851   D2KHN5   D2KHN4   A0A212EJU6   Q19TV9   V5NQ96   V5NPR9   O76803   Q9NHZ9   Q962B4   Q4G6A5   F6K6Z9   A0A2W1BR38   Q9U6W2   B2LRS7   Q8WSZ2   Q95WL0   B2LRS8   A0A1L5JK78   A0A1B0RHN3   Q6UY54   Q6UY55   A0A1B0RHN6   Q11001   A0A384RYH7   Q9U7N8   E0A209   G3ESV3   Q6R3M5   Q6R3M6   D0UYB1   E8Z5C9   A4D0J3   Q6T3W2   O76122   D0UYB2   Q6T3W3   A0A3S2TRJ1   Q2L9Z0   A0A2H1WAG0   Q8ITD4   W8AMJ2   A0A3G1QXU4   A0A0K8U3X8   A0A0K8WLP7   A0A0A1XS95   A0A034WY81   A0A194QK74  

EC Number

3.4.11.-

Pubmed

12023048    19121390    26354079    24121099    10989294    20420910    + More
20685334    11439249    26227816    10406091    7592988    15857766    28756777    10366728    12441000    10732989    22118469    15978131    10380100    17402938    24045122    9931470    10543783    19376227    27940541    7629076    9729121    24495485    25830018    25348373   

EMBL

JQ061148    AFK85022.1    AF352574    AAL83943.1    BABH01023388    BABH01023389    + More
BABH01023390    AY095259    AAM13691.1    KQ461198    KPJ05977.1    JF339040    AEO12697.1    AEO12696.1    AF276241    AAF99701.1    FJ896130    ADA57169.1    FJ492806    ACT35083.1    EF538427    ABQ51393.1    EU137839    ABV01346.1    JF339038    AEO12689.1    JQ088280    AFU51580.1    HQ636624    AEL22855.1    HM231318    ADL38970.1    AF217250    AAF37560.1    JQ747495    AGG36452.1    JTDY01001695    KOB73138.1    AF126442    AAD31183.1    U35096    AY836581    AAX39865.1    HQ853294    ADZ05466.1    RSAL01000014    RVE53193.1    JF519739    AEB96253.1    KF689688    AHW57924.1    AY279537    AAP37953.1    AY279536    AAP37952.1    KZ149969    PZC76116.1    AF535166    AAN04900.1    AY052651    AAL14117.2    KJ143755    AHZ08543.1    KY949256    AWT22998.1    AY193789    AAP33526.1    MF425653    ASU92545.1    AF109692    AAF01259.2    AF521660    AAN75694.1    AF034484    AAC36147.1    AF034483    AAC36148.1    AGBW02014405    OWR41734.1    KY949255    AWT22997.1    AY603414    AAT99437.1    AY218844    AAP44966.1    ODYU01000825    SOQ36184.1    EF103944    ABL01483.1    KQ459185    KPJ03376.1    AF020389    AAB70755.1    GU213040    ADA59492.1    GU213039    ADA59491.1    OWR41735.1    DQ444715    ABE02186.1    KF537664    AHA90591.1    KF537663    AHA90590.1    AF084257    JQ061146    AAC33301.1    AFK85020.1    AF217248    AAF37558.1    AY038607    AAK85538.1    AY218842    AAP44964.1    HM357836    AEA76302.1    PZC76114.1    AF173552    AAF08254.1    EU568874    ACC68683.1    AF441377    AAL34109.1    AF317620    AAL26895.1    EU568875    ACC68682.1    KY210882    APO15796.1    KM360190    AKH49606.1    AY358035    AAQ57406.1    AY358034    AAQ57405.1    KM360182    AKH49598.1    X89081    AB007039    KP053647    AKO62648.1    AF123313    AAF07223.1    HM231316    ADL38968.1    AEO12690.1    AY515310    AAS00451.1    AY515309    AAS00450.1    GQ927479    ACX85726.2    EU878375    ACJ64827.1    AY836579    AAX39863.1    AY437833    AAR20814.1    AB007038    BAA32475.1    GQ927480    ACX85727.2    AY437832    AAR20813.1    RVE53192.1    DQ342305    ABC69855.3    ODYU01007373    SOQ50075.1    AF521659    AAN75693.1    GAMC01016580    JAB89975.1    KY949259    AWT23001.1    GDHF01031289    JAI21025.1    GDHF01000302    JAI52012.1    GBXI01000527    JAD13765.1    GAKP01000229    JAC58723.1    KPJ05973.1   

Proteomes

UP000005204    UP000053240    UP000037510    UP000283053    UP000007151    UP000053268    + More

PRIDE

I3VR77    Q8T7M0    H9JEW2    E8Z9T8    E8Z5S9    Q11000    + More
Q9U8B0    O76803    Q11001    E8Z5C9    O76122   

Pfam

PF01433   Peptidase_M1        + More
PF11838   ERAP1_C

Interpro

IPR034016   M1_APN-typ        + More
IPR001930   Peptidase_M1       
IPR042097   Aminopeptidase_N-like_N       
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR033581   APN2       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

I3VR77   Q8T7M0   H9JEW2   Q8T3I0   A0A194QKB6   G3ESW0   + More
G3ESV9   Q9GT75   E8Z9T8   E8Z5S9   A5JJU1   A7YAH7   G3ESV2   K9MBJ8   R4HHS0   E0A211   Q9NHZ7   M4M1W4   A0A0L7LCB7   Q9XYV2   Q11000   A4D0J5   G9C5G2   A0A3S2M847   H8YHV9   A0A096XIT2   Q7Z266   Q7Z267   A0A2W1BU00   Q8MU78   Q95UF9   A0A024AX72   A0A2Z3YJS3   Q6Y0Y6   A0A286LPZ6   Q9U8B0   Q8ITD3   O17485   O17484   A0A212EJT4   A0A2Z3YKX3   Q5UVJ2   Q4G6A3   A0A2H1V7F0   A1E3B6   A0A194QIU5   O16851   D2KHN5   D2KHN4   A0A212EJU6   Q19TV9   V5NQ96   V5NPR9   O76803   Q9NHZ9   Q962B4   Q4G6A5   F6K6Z9   A0A2W1BR38   Q9U6W2   B2LRS7   Q8WSZ2   Q95WL0   B2LRS8   A0A1L5JK78   A0A1B0RHN3   Q6UY54   Q6UY55   A0A1B0RHN6   Q11001   A0A384RYH7   Q9U7N8   E0A209   G3ESV3   Q6R3M5   Q6R3M6   D0UYB1   E8Z5C9   A4D0J3   Q6T3W2   O76122   D0UYB2   Q6T3W3   A0A3S2TRJ1   Q2L9Z0   A0A2H1WAG0   Q8ITD4   W8AMJ2   A0A3G1QXU4   A0A0K8U3X8   A0A0K8WLP7   A0A0A1XS95   A0A034WY81   A0A194QK74  

PDB

4WZ9     E-value=1.40002e-103,     Score=965

KEGG

100127057    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) Apn3; aminopeptidase N3

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008237   GO:0004177   GO:0008270   GO:0016021   GO:0031225   GO:0005886   GO:0015991   GO:0033179   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824   GO:0006508  

PANTHER

PTHR11533:SF246  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.987262

 

 

Length:

966

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

19.75723

Exp number, first 60 AAs:

0.28236

Total prob of N-in:

0.11928

outside

1  -  966

 

 

Pi

226.691156

Theta

158.351975

Tajima's D

-1.431783

CLR

0.473208

CSRT

0.0694465276736163

Interpretation

Uncertain