Gene

KWMTBOMO04884

Pre Gene Modal

BGIBMGA008019

Annotation

AF173553_1_V-ATPase_110_kDa_integral_membrane_subunit_[Manduca_sexta]

Location

Bomo_Chr9(-):842536-893945      View in EpiBrowser

Full name

V-type proton ATPase subunit a      

Location in the cell

PlasmaMembrane   Reliability : 4.866

CDS

ATGGGCTCCATGTTCAGGAGCGAGGAGATGGTCCTCTGTCAGCTCTTCGTTCAGCCGGAGGCGGCTTACGTCTCCATGTACGAGCTAGGAGAAGCTGGTATTGCTCAATTCCGAGATTTGAATCCACACGTAAATGACTTCCAAAGAAGATACGTAAGTGAAGTTCGCCGCTGCAGCGAGATGGAACGCAAGCTGCGATGGGTGAGTGGAGAGCTACCGGAGCCTCCTCCTCCGCCCATACCCTCGCGACGGATGCTCAGTCCACGAGAGATCAATATGCTAGAGGAAAAAATTGATTACATCGAATCAGAAATCCAAGAGATGACAAAAAACGCTCGAAACCTCAAAAGCGACTACCTTTCCTTGATAGAGCTGAAACTTCTCATAGAGAAAACACAGACCTTCTTCCAAGATCACAGCGCCCAGAGGAAACTGTCGGCCACCGTTCAGATCTACAACAATGACGCTGTTTTCGGGCACCTCGGCTTCATCGCGGGAACAGTGGCCACATCCAGGGTGCCTTCGTTTGAAAGGATGCTATGGAGGATATCGCACGGGAACATATTCTTCAAACAGGCACAGATCGATCAGCCTCTAAAAGATCCCATTACGGGTCACGAACTACAAAAGACTGTCTTCGTAGTATTCTTCCACGGTGAGCAGATCAAGTTGAGAGTGAAGAAGGTCTGCTTTGGGTTTAAAGCTACTCTGTACCCATGCCCTGCGACGTATAAGGACCAGCAAGAAATGCTGTCTGGAGTCGAAACGAGGATCAAGGACTTAGAAATGGTACTAGACCAGACAGAGCAGCACAGACGATTGGTCCTCACCAATATAGCAGGAGACATCAGCACGTGGATGCTGGCCGTAAGGAAGGAGAAGGCCATCTACCATACCCTCAACATGTTCAGCATGGACATCATTAAGAAATGCCTCATCGCTGAATGCTGGGTTCCAAAAAGTGATCTTTACATTGCCCAGAAGGCTCTGGATGATGGAGTGAAAGCAAGTGGCAGTCCCATTCCATCCATCCTCCACCACGTGCCAACCAGAGAAATACCACCCACTTTTAACAGAACCAACAAATTCACGAGGGGATTTCAAACTCTTATTGATTCCTATGGAATCGCCAGCTACAGAGAAGTAAATCCAGCGCTATACACAATCATAACATTCCCGTTTCTGTTCGCCGTCATGTTCGGCGACGTAGGCCATGGACTTATCATGACTGCCTTTTCTGCGATCATCGTTATATACGAGAAGAGACTCTCGAAGAATAAATCGGACAACGAAATATGGAACATTTTCTTTGCCGGACGATACATTATCTTACTGATGGGAATATTCTCTGTCTATACCGGTTTGATCTACAACGACATGTTCTCGAAGTCTCTGAATCTGTTCGGAAGTAGTTGGATGAACGTTTACGATAGTGAAACCCTTGCGAATCATACATCGTTGGAATTGGATCCGGCTGTGGCCTACACTCAAACGCCATATCCTTTCGGCTTGGACCCGGCGTGGCAGTTCGCCACGAACAACATAATATTTTTGAATTCATTCAAAATGAAACTGTCCATTATATTCGGCGTACTGCACATGGCGTTCGGTGTGACAATGAGTGTGGTAAACTTCAATTTCTTCAGGAAGCCGGAAATGATTTATCTCCAGTACGTGCCGCAAATTCTGTTTCTGATGCTGCTGTTCTGGTACCTCTGTATATTGATGTTCATGAAGTGGACCATGTACTCCGCCACGGCGACAGACCCGACATACGGTACGTCTTGTGCCCCATCAGTCCTAATAACCTTCATCAACATGATGCTGCTGAAGGGCTCTGAGGACAGCCCTCCGTGTAAGGCGATGATGTTCGACGGCCAGGACGCATTGCAGAAGTTATTCTTGACGCTTGGCTTCCTTTGCATTCCGATAATGTTATTCGGGAAACCGGCATTCTTGTTCTGGCAAGCCCGTAACCGGAAGCGCCACGAGGTGGGCGGGGAGCGCGGGGAGGTGCCGGCGGGGGCCGGCGGGGGTGCGGGGGCGGCGGGGGAGCTGCTGATCACGCAGGCGATACACACCATAGAGTACGTGCTGGGCACCGTCTCGCACACCGCCTCCTACCTGCGCCTCTGGGCCCTCTCCCTCGCGCACGCACAGCTGTCGGCCGTGCTGTGGCAGCGCGTGCTCCGCTACGGCCTGGCCAGGAGTCTGGCGGGCTCCGTCACCATGTACGTGGGGTTCGCGGTGTGGGCCTTCTTCACGCTCGCCATCCTCGTCCTCATGGAAGGACTGTCTGCCTTCCTGCACACGCTGCGGTTGCACTGGGTCGAGTTCATGAGTAAGTTCTACGACGGACAAGGATACGCTTTCATGCCGTTCTCATTCGCGGCCATCATAGAGCACGACGACGAGGAACTGGCGCAAAATGGCGCGCCGCCCGAGAAGAAAGACGAAGAATATTAA

Protein

MGSMFRSEEMVLCQLFVQPEAAYVSMYELGEAGIAQFRDLNPHVNDFQRRYVSEVRRCSEMERKLRWVSGELPEPPPPPIPSRRMLSPREINMLEEKIDYIESEIQEMTKNARNLKSDYLSLIELKLLIEKTQTFFQDHSAQRKLSATVQIYNNDAVFGHLGFIAGTVATSRVPSFERMLWRISHGNIFFKQAQIDQPLKDPITGHELQKTVFVVFFHGEQIKLRVKKVCFGFKATLYPCPATYKDQQEMLSGVETRIKDLEMVLDQTEQHRRLVLTNIAGDISTWMLAVRKEKAIYHTLNMFSMDIIKKCLIAECWVPKSDLYIAQKALDDGVKASGSPIPSILHHVPTREIPPTFNRTNKFTRGFQTLIDSYGIASYREVNPALYTIITFPFLFAVMFGDVGHGLIMTAFSAIIVIYEKRLSKNKSDNEIWNIFFAGRYIILLMGIFSVYTGLIYNDMFSKSLNLFGSSWMNVYDSETLANHTSLELDPAVAYTQTPYPFGLDPAWQFATNNIIFLNSFKMKLSIIFGVLHMAFGVTMSVVNFNFFRKPEMIYLQYVPQILFLMLLFWYLCILMFMKWTMYSATATDPTYGTSCAPSVLITFINMMLLKGSEDSPPCKAMMFDGQDALQKLFLTLGFLCIPIMLFGKPAFLFWQARNRKRHEVGGERGEVPAGAGGGAGAAGELLITQAIHTIEYVLGTVSHTASYLRLWALSLAHAQLSAVLWQRVLRYGLARSLAGSVTMYVGFAVWAFFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYDGQGYAFMPFSFAAIIEHDDEELAQNGAPPEKKDEEY

Description

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.

Similarity

Belongs to the V-ATPase 116 kDa subunit family.

Uniprot

Q9NJA4   A0A212EGQ2   A0A2W1BWJ3   A0A194QCV9   A0A194QKQ6   A0A2H1W9Q1   + More
A0A194QD04   H9IYU7   A0A1E1WPT2   A0A194RMC5   A0A1B1UZP4   A0A212ESI2   A0A1Q3FCP1   B4QUE6   U5EY09   A0A2J7RKU2   A0A182R647   A0A2H8TPX0   A0A182QWU8   A0A182VZ95   A0A182PGR3   A0A182M9P0   B4I290   A0A2M4A171   A0A2M4A1G6   Q9VE75   A0A1W4U7R6   A0A182NS68   B4PLX2   A0A182IX69   B3LW99   A0A182WSF2   A0A2C9GQN9   A0A182L9N2   A0A182F7K3   Q7PKS7   A0A182USZ7   A0A182UDQ6   A0A3B0KN56   W5JMD3   A0A2M4BEH6   A0A023EW58   B4M3Z5   A0A1I8NRD1   Q299L9   A0A1L8DEM8   A0A2M3YYN2   B4G5D7   Q16HE2   A0A182YAM6   A0A1B6MKV2   A0A1L8DEX4   A0A2M3YYH4   A0A067RRK3   A0A0M5J4P9   A0A1B6MPW5   B4K928   Q8T5K2   T1PG42   A0A195CD36   B4N9D9   A0A0K8TQR7   D6WCX7   B4JF18   A0A1L8EDB7   A0A1L8EDJ5   A0A1J1HJB8   A0A0K8UV85   A0A195BIS9   A0A034VLS7   A0A087ZUG7   A0A336KNK4   A0A336M7G7   A0A1A9VER2   W8BF11   A0A1A9ZXN1   E0V9Q8   A0A1B0BJB3   A0A182K5C5   U4U2F9   N6TTR3   A0A182M1T3   V9ILL6   A0A0A9Z8V9   A0A182V6H6   A0A0A1X2U8   A0A0L7QWI4   A0A195DP30   A0A2C9GQN1   K7J2E3   A0A0A9ZE97   A0A0K8T8E8   A0A182YAM5   A0A1Y1JSJ5   A0A224X7A5   A0A182L9N3   A0A1Y1JVN1  

Pubmed

22118469    28756777    26354079    19121390    17994087    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    18057021    20966253    12364791    14747013    17210077    20920257    23761445    24945155    26483478    15632085    17510324    25244985    24845553    12060762    25315136    26369729    18362917    19820115    25348373    24495485    20566863    23537049    25401762    26823975    25830018    20075255    28004739   

EMBL

AF173553    AAF28474.1    AGBW02015053    OWR40651.1    KZ149969    PZC76113.1    + More
KQ459185    KPJ03378.1    KQ461198    KPJ05979.1    ODYU01006919    SOQ49194.1    KQ459220    KPJ02860.1    BABH01010757    BABH01010758    BABH01010759    GDQN01008557    GDQN01001991    JAT82497.1    JAT89063.1    KQ459984    KPJ18978.1    KU550964    ANW09710.1    AGBW02012778    OWR44452.1    GFDL01009700    JAV25345.1    CM000364    EDX12446.1    GANO01000631    JAB59240.1    NEVH01002707    PNF41457.1    GFXV01004235    MBW16040.1    AXCN02000267    AXCM01006747    CH480820    EDW54647.1    GGFK01001212    MBW34533.1    GGFK01001312    MBW34633.1    AF132183    AE014297    AAD34771.1    AAF55552.2    CM000160    EDW95904.1    CH902617    EDV42677.1    KPU79847.1    APCN01000888    AAAB01008987    EAA43151.2    OUUW01000013    SPP88009.1    ADMH02001150    ETN63909.1    GGFJ01002077    MBW51218.1    JXUM01123189    JXUM01123190    JXUM01123191    JXUM01123192    GAPW01000216    JAC13382.1    CH940652    EDW59356.1    KRF78813.1    CM000070    EAL27684.1    GFDF01009183    JAV04901.1    GGFM01000600    MBW21351.1    CH479179    EDW24803.1    CH478180    EAT33671.1    GEBQ01024009    GEBQ01003411    JAT15968.1    JAT36566.1    GFDF01009184    JAV04900.1    GGFM01000527    MBW21278.1    KK852470    KDR23260.1    CP012526    ALC46094.1    GEBQ01009678    GEBQ01002003    JAT30299.1    JAT37974.1    CH933806    EDW14441.1    KRG01017.1    AJ439060    CAD27758.1    KA646853    AFP61482.1    KQ977935    KYM98717.1    CH964232    EDW80572.1    GDAI01000904    JAI16699.1    KQ971311    EEZ99071.2    CH916369    EDV93299.1    GFDG01002069    JAV16730.1    GFDG01002067    JAV16732.1    CVRI01000006    CRK88011.1    GDHF01029529    GDHF01021876    JAI22785.1    JAI30438.1    KQ976467    KYM84195.1    GAKP01016222    JAC42730.1    UFQS01000635    UFQT01000635    SSX05612.1    SSX25971.1    SSX05611.1    SSX25970.1    GAMC01006625    JAB99930.1    DS234995    EEB10093.1    JXJN01015358    KB631625    ERL84786.1    APGK01052546    KB741213    ENN72620.1    AXCM01012792    JR053567    AEY61965.1    GBHO01001932    GDHC01015774    JAG41672.1    JAQ02855.1    GBXI01008638    JAD05654.1    KQ414710    KOC62988.1    KQ980713    KYN14244.1    AAZX01007551    GBHO01001936    GDHC01018959    JAG41668.1    JAP99669.1    GBRD01003998    JAG61823.1    GEZM01101879    JAV52239.1    GFTR01008140    JAW08286.1    GEZM01101880    GEZM01101878    JAV52238.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000005204    UP000000304    UP000235965    + More
UP000075886    UP000075920    UP000075885    UP000075883    UP000001292    UP000000803    UP000192221    UP000075884    UP000002282    UP000075880    UP000007801    UP000076407    UP000075840    UP000075882    UP000069272    UP000007062    UP000075903    UP000075902    UP000268350    UP000000673    UP000069940    UP000008792    UP000095300    UP000001819    UP000008744    UP000008820    UP000076408    UP000027135    UP000092553    UP000009192    UP000095301    UP000078542    UP000007798    UP000007266    UP000001070    UP000183832    UP000078540    UP000005203    UP000078200    UP000092445    UP000009046    UP000092460    UP000075881    UP000030742    UP000019118    UP000053825    UP000078492    UP000002358   

PRIDE

H9IYU7    Q9VE75   

Pfam

PF01496   V_ATPase_I

Interpro

IPR002490   V-ATPase_116kDa_su        + More
IPR026028   V-type_ATPase_116kDa_su_euka       

ProteinModelPortal

Q9NJA4   A0A212EGQ2   A0A2W1BWJ3   A0A194QCV9   A0A194QKQ6   A0A2H1W9Q1   + More
A0A194QD04   H9IYU7   A0A1E1WPT2   A0A194RMC5   A0A1B1UZP4   A0A212ESI2   A0A1Q3FCP1   B4QUE6   U5EY09   A0A2J7RKU2   A0A182R647   A0A2H8TPX0   A0A182QWU8   A0A182VZ95   A0A182PGR3   A0A182M9P0   B4I290   A0A2M4A171   A0A2M4A1G6   Q9VE75   A0A1W4U7R6   A0A182NS68   B4PLX2   A0A182IX69   B3LW99   A0A182WSF2   A0A2C9GQN9   A0A182L9N2   A0A182F7K3   Q7PKS7   A0A182USZ7   A0A182UDQ6   A0A3B0KN56   W5JMD3   A0A2M4BEH6   A0A023EW58   B4M3Z5   A0A1I8NRD1   Q299L9   A0A1L8DEM8   A0A2M3YYN2   B4G5D7   Q16HE2   A0A182YAM6   A0A1B6MKV2   A0A1L8DEX4   A0A2M3YYH4   A0A067RRK3   A0A0M5J4P9   A0A1B6MPW5   B4K928   Q8T5K2   T1PG42   A0A195CD36   B4N9D9   A0A0K8TQR7   D6WCX7   B4JF18   A0A1L8EDB7   A0A1L8EDJ5   A0A1J1HJB8   A0A0K8UV85   A0A195BIS9   A0A034VLS7   A0A087ZUG7   A0A336KNK4   A0A336M7G7   A0A1A9VER2   W8BF11   A0A1A9ZXN1   E0V9Q8   A0A1B0BJB3   A0A182K5C5   U4U2F9   N6TTR3   A0A182M1T3   V9ILL6   A0A0A9Z8V9   A0A182V6H6   A0A0A1X2U8   A0A0L7QWI4   A0A195DP30   A0A2C9GQN1   K7J2E3   A0A0A9ZE97   A0A0K8T8E8   A0A182YAM5   A0A1Y1JSJ5   A0A224X7A5   A0A182L9N3   A0A1Y1JVN1  

PDB

6C6L     E-value=5.35497e-128,     Score=1175

KEGG

105841262    K02154 V-type H+-transporting ATPase subunit a | (RefSeq) V-type proton ATPase 116 kDa subunit a iso

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0000220   GO:0015991   GO:0016021   GO:0015078   GO:0033179   GO:0033181   GO:0046961   GO:0051117   GO:0016471   GO:0007035   GO:0005886   GO:0016787   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR11629  

Length:

821

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

144.13707

Exp number, first 60 AAs:

0.00137

Total prob of N-in:

0.01290

outside

1  -  396

TMhelix

397  -  419

inside

420  -  431

TMhelix

432  -  454

outside

455  -  525

TMhelix

526  -  548

inside

549  -  560

TMhelix

561  -  583

outside

584  -  632

TMhelix

633  -  655

inside

656  -  737

TMhelix

738  -  760

outside

761  -  821

 

 

Pi

198.476418

Theta

161.034872

Tajima's D

0.767026

CLR

0.137366

CSRT

0.599570021498925

Interpretation

Uncertain