Gene

KWMTBOMO04883

Pre Gene Modal

BGIBMGA008056

Annotation

PREDICTED:_katanin_p60_ATPase-containing_subunit_A-like_1_[Bombyx_mori]

Location

Bomo_Chr9(+):816476-836646      View in EpiBrowser

Full name

Katanin p60 ATPase-containing subunit A1      

Alternative Name

p60 katanin

Location in the cell

Mitochondrial   Reliability : 1.795 Nuclear   Reliability : 2.068

CDS

ATGACGAATGACCTGAAAGCTTCAACGAGCGAGAAGGAGGCACGGGGCTCCTGGCCGAGGAGGGACGACCTCAAGATTGAGTTCGGGTTCGGAATGCCTCTAGGGGCCATGAGTGCTCATCCAGCTTTCCACTCCGCTTGGGACATCGCTTGCCCATCTTCAGGCTTTCATCAGATGGCTCGTATGATGGACCGTATGATGGTGGAGAGCCTCCAGCCGTTTGGCTTCGCTAGGATGACGGCAAGACAGCGTGGTGATAGTCGTGATCATCAGCCTCCACGTGATGGTCTACAGACAGAGCGCCCTGATACGAGGAAGGAGCGGGCGAAGAATCATTCCAATACGCACGCCGCCACTGGTACCAGACATCCTCCTACACAAATAGTGAAACCAACTCAGTCGAATACATTTCTAGATCAGTCACAAGAGCAAAATAAACAAACGGACCCCACGACTGAGAAATGGGCGGGATCGTTACGGAAACGCGACCCTGACATCCAGCCGACCTTGCCGTCCATTGTCGCTAGAAAGACCTCTTCATCTTCAGTGGGCAGTGGAAGGAAGACCAGGTCTGTGGAAAGGATGCCCCGACAACGTGTAAGGCAGTTGGCTCCAATTAAACCGATTGTTAGAAAGGCTGAAGCGTCAGAAGGACAAGATGTTACAATTTATGAGAAGGATGAAAAAACATTCGATGCGACCGGCTATGAAATGCATCTAGTGGAGACCCTAGAGAGAGATATATTGCAGAGGAATCCTGATGTGCGCTGGAAGGATGTCATTGGATTGGACGATGCAAAAGCCGTGCTACAAGAGGCGATGGTCCTGCCTTTAGTGATGCCTGATTACTTTAAGGGTATAAGGAGACCTTGGAAGGGCGTGCTCCTCACAGGACCTCCGGGTACAGGGAAGACATTGCTCGCGAGGGCTGTGGCCACAGAGTGTAGAACCACTTTCTTTAATGTATCTTCGGCCACACTCACTTCGAAGTACAGGGGAGATTCTGAGAAATTGGTCAGACTTCTTTTTGACATGGCGTCTTTCTACGCGCCCAGCACGATCTTCTTGGACGAGGTGGACTCATTGTGCGCGGTCCGCGGTGCTGACTCCGAGCACGAGGCCTCGCGACGATTCAAAGCAGAGCTGCTCATACAAATGGACGGGCTTGCTGCCGTATTCAACCAAGATAAAATCATAATGGTATTAGCCGCGACCAACCATCCGTGGGACATCGACGAAGCCTTCAGAAGGAGGTTTGAGAAGAGGATCTACATTGGCCTTCCAGATGAGCCGACGCGTGTGAAACTTCTGAAGCTGTGTCTCCGAGAAGTCGCGCTAGCGGAAGATGTAGATCTAGTGGATCTGGCAACTAAATTGGACGGTTATAGCGGATCTGACATCTGCAACTTGTGCCGGGATGCCGCAATGATGACGATGCGTCGTAAGATAGCCGGTAAGAGTCCGGATCAGATCCGCAGACTGAAGCGCTCCGAGCTGGAGGCGCCGGTGTCGGCGGCCGACCTGGGCGCCTCCGCGGACAAGACGCGGCGCACGGTGAGCCCCGCCGACGTGGCGCGCTACTCCTCCTGGATGCAGCGCCACGGCTGCTCCTAG

Protein

MTNDLKASTSEKEARGSWPRRDDLKIEFGFGMPLGAMSAHPAFHSAWDIACPSSGFHQMARMMDRMMVESLQPFGFARMTARQRGDSRDHQPPRDGLQTERPDTRKERAKNHSNTHAATGTRHPPTQIVKPTQSNTFLDQSQEQNKQTDPTTEKWAGSLRKRDPDIQPTLPSIVARKTSSSSVGSGRKTRSVERMPRQRVRQLAPIKPIVRKAEASEGQDVTIYEKDEKTFDATGYEMHLVETLERDILQRNPDVRWKDVIGLDDAKAVLQEAMVLPLVMPDYFKGIRRPWKGVLLTGPPGTGKTLLARAVATECRTTFFNVSSATLTSKYRGDSEKLVRLLFDMASFYAPSTIFLDEVDSLCAVRGADSEHEASRRFKAELLIQMDGLAAVFNQDKIIMVLAATNHPWDIDEAFRRRFEKRIYIGLPDEPTRVKLLKLCLREVALAEDVDLVDLATKLDGYSGSDICNLCRDAAMMTMRRKIAGKSPDQIRRLKRSELEAPVSAADLGASADKTRRTVSPADVARYSSWMQRHGCS

Description

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic Activity

n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Similarity

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Belongs to the CRISP family.
Belongs to the AAA ATPase family.

Uniprot

A0A3S2NKC8   A0A194QD82   A0A194QR23   H9JEV9   A0A212EGP7   A0A2W1BM10   + More
A0A2H1W7X2   A0A0L7LVK5   A0A1B6CIC8   B0W341   Q177C8   A0A1B6CXW1   A0A0L0CD63   T1HME4   A0A1B0GEC0   A0A1I8NSQ3   A0A336L4J8   A0A1B0GH48   B3LWD9   A0A2R7X9S4   A0A0P8YGG1   A0A0Q9WG34   A0A1B6HMU4   A0A336MBH7   A0A1B0DLX7   A0A336M4T2   A0A1B6HDV7   Q9VNI0   A0A1I8MC48   A0A0Q9WUU4   A0A0R1E714   B4QXK0   B4NJI3   A0A023F3Q6   A0A0K8VXN7   A0A034VCA9   A0A1B0C2K0   A0A1I8MC52   A0A1W4UYG0   A0A1S4FCZ1   Q4QPP5   A0A0R1E871   A0A1A9X217   B4KAH2   B4I474   A0A1A9YJT2   A0A034VCB3   B4PUY2   B3P2K0   B4G498   A0A224XFB1   B5DWF9   A0A1B0AA24   A0A1W4UJS3   A0A1A9VH43   A0A0M4EPI3   A0A0Q9X0L6   A0A1I8NSQ9   A0A0R3NHU4   A0A0P9A166   A0A0P8Y105   B4LYP5   A0A0A1WMX6   A0A182TIC9   A0A182WYZ4   A0A1B6FQN3   A0A182HJC0   A0A182VQQ6   A0A0Q9WS09   A0A182VL05   B4JG93   A0A182K733   A0A182N587   A0A1B6GCI6   A0A182MKQ4   Q961H1   A0A182RTT0   W8B3K0   A0A3F2Z047   A0A182ITX1   A0A1W4UWS4   A0A0Q9WUU5   E1JJ62   A0A1S3D1F0   A0A0R1E8U3   E0W309   A0A182GX67   A0A2C9NGQ7   A0A0Q9X4R0   A0A182FSJ0   A0A0Q9XB01   A0A1W4UX28   A0A1W4UJA6   A0A0R1E405   A0A182PE66   A0A182Q4L5   A0A0Q9X0P7   A0A1J1IJA5   I5AP40   A0A0Q9XAR9  

EC Number

5.6.1.1

Pubmed

26354079    19121390    22118469    28756777    26227816    17510324    + More
26108605    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    17550304    25474469    25348373    15632085    25830018    24495485    20566863    26483478   

EMBL

RSAL01000014    RVE53198.1    KQ459185    KPJ03379.1    KQ461198    KPJ05981.1    + More
BABH01023380    BABH01023381    AGBW02015053    OWR40650.1    KZ149969    PZC76112.1    ODYU01006919    SOQ49195.1    JTDY01000015    KOB79414.1    GEDC01024072    JAS13226.1    DS231830    EDS30749.1    CH477378    EAT42264.1    GEDC01019133    JAS18165.1    JRES01000562    KNC30181.1    ACPB03001254    CCAG010012182    UFQS01001826    UFQT01001826    SSX12470.1    SSX31913.1    AJWK01003967    AJWK01003968    AJWK01003969    CH902617    EDV43772.1    KK854002    PTY32650.1    KPU80448.1    CH940650    KRF83030.1    GECU01031693    JAS76013.1    UFQT01000344    SSX23408.1    AJVK01016591    AJVK01016592    SSX23407.1    GECU01034836    JAS72870.1    AE014297    BT001274    AAF51954.1    AAN71030.1    CH964272    KRF99918.1    CM000160    KRK03971.1    CM000364    EDX11786.1    EDW83907.1    GBBI01003183    JAC15529.1    GDHF01009019    JAI43295.1    GAKP01018006    GAKP01018004    JAC40946.1    JXJN01024565    BT023721    AAY85121.1    ACZ94822.1    KRK03969.1    CH933806    EDW15685.2    CH480821    EDW55017.1    GAKP01018001    JAC40951.1    EDW97789.1    CH954181    EDV47950.1    CH479179    EDW25136.1    GFTR01006712    JAW09714.1    CM000070    EDY68150.1    CP012526    ALC46764.1    KRG01679.1    KRT00558.1    KPU80447.1    KPU80449.1    EDW66972.1    GBXI01014524    JAC99767.1    GECZ01017247    JAS52522.1    APCN01002144    APCN01002145    APCN01002146    KRF83029.1    CH916369    EDV93660.1    GECZ01016882    GECZ01009623    JAS52887.1    JAS60146.1    AXCM01005290    AY051591    AAF51955.2    AAK93015.1    GAMC01013413    GAMC01013412    JAB93142.1    KRF99919.1    ACZ94821.1    KRK03970.1    DS235881    EEB20015.1    JXUM01094777    JXUM01094778    JXUM01094779    JXUM01094780    JXUM01094781    JXUM01094782    KQ564152    KXJ72677.1    AAZO01007315    KRF99917.1    KRG01681.1    KRK03968.1    AXCN02000164    KRG01680.1    CVRI01000047    CRK98521.1    EIM52725.1    KRG01678.1   

Proteomes

UP000283053    UP000053268    UP000053240    UP000005204    UP000007151    UP000037510    + More
UP000002320    UP000008820    UP000037069    UP000015103    UP000092444    UP000095300    UP000092461    UP000007801    UP000008792    UP000092462    UP000000803    UP000095301    UP000007798    UP000002282    UP000000304    UP000092460    UP000192221    UP000091820    UP000009192    UP000001292    UP000092443    UP000008711    UP000008744    UP000001819    UP000092445    UP000078200    UP000092553    UP000075902    UP000076407    UP000075840    UP000075920    UP000075903    UP000001070    UP000075881    UP000075884    UP000075883    UP000075900    UP000075880    UP000079169    UP000009046    UP000069940    UP000249989    UP000069272    UP000075885    UP000075886    UP000183832   

PRIDE

H9JEV9    Q9VNI0    Q4QPP5    Q961H1    E1JJ62   

Pfam

PF17862   AAA_lid_3        + More
PF09336   Vps4_C
PF00004   AAA
PF00188   CAP

Interpro

IPR015415   Vps4_C        + More
IPR027417   P-loop_NTPase       
IPR003960   ATPase_AAA_CS       
IPR003959   ATPase_AAA_core       
IPR028596   KATNA1       
IPR003593   AAA+_ATPase       
IPR041569   AAA_lid_3       
IPR002413   V5_allergen-like       
IPR014044   CAP_domain       
IPR035940   CAP_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF55797   SSF55797       

Gene 3D

3.40.33.10    

ProteinModelPortal

A0A3S2NKC8   A0A194QD82   A0A194QR23   H9JEV9   A0A212EGP7   A0A2W1BM10   + More
A0A2H1W7X2   A0A0L7LVK5   A0A1B6CIC8   B0W341   Q177C8   A0A1B6CXW1   A0A0L0CD63   T1HME4   A0A1B0GEC0   A0A1I8NSQ3   A0A336L4J8   A0A1B0GH48   B3LWD9   A0A2R7X9S4   A0A0P8YGG1   A0A0Q9WG34   A0A1B6HMU4   A0A336MBH7   A0A1B0DLX7   A0A336M4T2   A0A1B6HDV7   Q9VNI0   A0A1I8MC48   A0A0Q9WUU4   A0A0R1E714   B4QXK0   B4NJI3   A0A023F3Q6   A0A0K8VXN7   A0A034VCA9   A0A1B0C2K0   A0A1I8MC52   A0A1W4UYG0   A0A1S4FCZ1   Q4QPP5   A0A0R1E871   A0A1A9X217   B4KAH2   B4I474   A0A1A9YJT2   A0A034VCB3   B4PUY2   B3P2K0   B4G498   A0A224XFB1   B5DWF9   A0A1B0AA24   A0A1W4UJS3   A0A1A9VH43   A0A0M4EPI3   A0A0Q9X0L6   A0A1I8NSQ9   A0A0R3NHU4   A0A0P9A166   A0A0P8Y105   B4LYP5   A0A0A1WMX6   A0A182TIC9   A0A182WYZ4   A0A1B6FQN3   A0A182HJC0   A0A182VQQ6   A0A0Q9WS09   A0A182VL05   B4JG93   A0A182K733   A0A182N587   A0A1B6GCI6   A0A182MKQ4   Q961H1   A0A182RTT0   W8B3K0   A0A3F2Z047   A0A182ITX1   A0A1W4UWS4   A0A0Q9WUU5   E1JJ62   A0A1S3D1F0   A0A0R1E8U3   E0W309   A0A182GX67   A0A2C9NGQ7   A0A0Q9X4R0   A0A182FSJ0   A0A0Q9XB01   A0A1W4UX28   A0A1W4UJA6   A0A0R1E405   A0A182PE66   A0A182Q4L5   A0A0Q9X0P7   A0A1J1IJA5   I5AP40   A0A0Q9XAR9  

PDB

5ZQM     E-value=3.63052e-107,     Score=994

KEGG

101736610    K07767 katanin p60 ATPase-containing subunit A1 [EC:5.6.1.1] | (RefSeq) katanin p60 ATPase-containin

GO

GO:0000922   GO:0016853   GO:0005737   GO:0005813   GO:0051013   GO:0008017   GO:0051301   GO:0005524   GO:0007049   GO:0005874   GO:0008568   GO:0016322   GO:0050775   GO:0008352   GO:0005875   GO:0007017   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

Subcellular location

Cytoplasm   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Cytoskeleton   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Microtubule organizing center   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Centrosome   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Spindle pole   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Spindle   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.

Length:

537

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10163

Exp number, first 60 AAs:

0.09688

Total prob of N-in:

0.00791

outside

1  -  537

 

 

Pi

201.965495

Theta

162.797953

Tajima's D

0.724359

CLR

0.000001

CSRT

0.577321133943303

Interpretation

Uncertain