Gene

KWMTBOMO04881  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008053

Annotation

PREDICTED:_sphingosine-1-phosphate_lyase_[Bombyx_mori]

Location

Bomo_Chr9(+):782876-794891      View in EpiBrowser

Full name

Sphingosine-1-phosphate lyase      

Alternative Name

Sphingosine-1-phosphate aldolase

Location in the cell

Mitochondrial   Reliability : 1.346 Peroxisomal   Reliability : 1.523

CDS

ATGAGTGAGAGACCACAGCCCTTAAGGGCTATAAACAAGTTTTTTGATGGAAAGGAGCCATGGCAAATTGTATCAATGACAGCTTCTTCTTTATTAGCCATAGTTTGGGTTCACAGTTTATACAATGCAAGAGAAAGTGTGACAGTCCGCCTTCGAAAACAGTTTTTCAGGTGGCTACGTCAAGTTCCAATGGTAAGGAAGAAGATAGAACAAAAAATGGCCGAGATAAAGAAAGATTTCCATACAGATGTAGAAAAGAGACTCGCAGGAGTCACAATTAGAAGAGAATTGCCTGAACAAGGTTTGGATCCTGAACAGATATCGCAAGAAGTCAGAGATCATCTGAATTTAGGGGCTTATGATTGGAAGAATGGTGCAGTATCTGGTGCAGTCTACCACTTGTGTGAAGACATCAGTCGTGTGGCTTGCGAGGCTTATACCTTGACTGCCTACACCAATCCACTGCACTCAGATGTCTTCCCAGGAATTAACAAAATGGAGGCGGAGATTGTGCAGATGGCTATTAACTTATTCAATGGTGATGAGGAGTGTTGTGGGACAGTAACTACAGGTGGCACAGAATCCATAATAATGGCGTGCAAGGCCTTCAGGGACCTCGCCTACAGCAAAGGCATAAGCAACCCACAGATAATCGTGCCATCAACTGCCCATTCTGCTTTCGACAAGGCGGCTCAGTACTTAGGCCTGTTTGTTGTGACCATACCGGTGGACCCGGTGACGCTATGTGTCGATGTCGATAAGGTCAGCGATGCTATTGGAAGACGAACGTGCTTGATCGTGGGGTCGGCTCCGAACTACCCGTACGGCACGATGGACGACATCGGCGCGTTGTCTGCGCTGGCGGCGCGCGCGGGGGTGCCGCTGCACGTGGACGCGTGCCTGGGCGGGCTGGTGGCGGGCTTCATGCCGGCCGCCGGACACCCCGTGCCGCCCTTCGACTTCCGCCTGCCCGGAGTCGCCAGCATCTCCGCCGACACGCACAAGTACGGGTACGCCCCGAAGGGCACGTCGGTGATCCTGTACCGGCGTGCGGAGTACCGGCACTGCCAGTACACCGTCACCACGGAGTGGCCGGGCGGCGTGTACGGCTCGCCCACCGTCAACGGCAGCCGAGCCGGCGGGCTGATCGCGGCGTGCTGGGCCACCATGATGTTCGTGGGCAGACAGAGATACATTCAGATGACGAAGGAGGTGGTGGACACGGCGAGATACATCGAAAATGAATTACGCAAGATAGACGGCATCTTCATATTCGGCAAGCCCGCCACCACCGTCATCGCGTTCGGCTCCCAGCGGTTCGACATCTTCCAGCTGGCCGACCTGCTGCACAAGCGCGGCTGGGCGCTCAACGCGCTGCAGTTCCCGTCCGGGGTGCACCTGTGCGTGACGCACGCGCACACGTGCGACGGCGTGGCGGCGCGCTTCGTGGCGGACGTGGCGGCCGCCGCGCGCACCTGCCTCACCGACGCCGCGGCGCCAGTGCACGGCAAGATGGCGATATACGGCGTGGCGCAGGAGATATCGGACCGCAGCCTCGTGTCCGACATCACGAAGCACTTCATAGACTCCATGTACTACCTGCCCAAGGGCGACCCGCAGTAG

Protein

MSERPQPLRAINKFFDGKEPWQIVSMTASSLLAIVWVHSLYNARESVTVRLRKQFFRWLRQVPMVRKKIEQKMAEIKKDFHTDVEKRLAGVTIRRELPEQGLDPEQISQEVRDHLNLGAYDWKNGAVSGAVYHLCEDISRVACEAYTLTAYTNPLHSDVFPGINKMEAEIVQMAINLFNGDEECCGTVTTGGTESIIMACKAFRDLAYSKGISNPQIIVPSTAHSAFDKAAQYLGLFVVTIPVDPVTLCVDVDKVSDAIGRRTCLIVGSAPNYPYGTMDDIGALSALAARAGVPLHVDACLGGLVAGFMPAAGHPVPPFDFRLPGVASISADTHKYGYAPKGTSVILYRRAEYRHCQYTVTTEWPGGVYGSPTVNGSRAGGLIAACWATMMFVGRQRYIQMTKEVVDTARYIENELRKIDGIFIFGKPATTVIAFGSQRFDIFQLADLLHKRGWALNALQFPSGVHLCVTHAHTCDGVAARFVADVAAAARTCLTDAAAPVHGKMAIYGVAQEISDRSLVSDITKHFIDSMYYLPKGDPQ

Description

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development.

Catalytic Activity

sphinganine 1-phosphate = hexadecanal + phosphoethanolamine

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the group II decarboxylase family.
Belongs to the CRISP family.
Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Lipid metabolism   Lyase   Membrane   Pyridoxal phosphate   Reference proteome   Signal-anchor   Sphingolipid metabolism   Transmembrane   Transmembrane helix  

Feature

chain  Sphingosine-1-phosphate lyase

Uniprot

A0A2W1BTK8   A0A194QEK6   A0A194QKC2   A0A2H1VXE7   D6W8W6   A0A146L8Z5   + More
A0A1S4F3W7   A0A069DVF1   Q17G38   V5G2K7   A0A182GG03   A0A224XMN8   A0A195CRL9   A0A023F8H5   A0A034W6K0   X2D8H1   A0A0K8VL60   A0A0K8VUA2   A0A0A1X605   B3MD62   T1I8Q6   A0A1I8N556   A0A0P4VQY5   R4G5W3   A0A1W4W7L3   A0A1L8EHM1   U5EV11   A0A2M4CYU3   A0A087Z7V1   Q9V7Y2   A0A1L8EHT5   F4WLC4   B4HMH6   B4QIK3   T1P9B9   B4P8H4   A0A195FYI1   A0A2M3Z547   A0A2M4BJF9   A0A2M4BJH6   A0A2M4AIQ9   A0A2M4AHP3   A0A2A3E436   A0A158NZF1   A0A1L8EAP5   B0XFI0   A0A088AET0   A0A182FPV8   A0A1Q3FCN8   A0A1L8EAZ3   W8AGS9   A0A1B0B4E6   A0A0M4EIM4   A0A1A9YMW8   A0A067R790   A0A1Y1NA95   B3NP20   A0A1A9UGZ6   A0A2P8XBA2   A0A1L8E2I0   A0A151X3N5   J9JT04   A0A1I8P6T2   A0A1A9ZI41   A0A1W4VDG6   A0A1L8E2Z6   A0A182JU78   B4N5T0   Q290S2   A0A084VLC4   A0A182RZK1   B4J547   D3TNM0   A0A182Y3T6   A0A182VZM6   A0A1A9WWT6   A0A3B0J331   K7IMX0   B4LKG7   A0A182IPS7   A0A182Q4E5   A0A182M8F7   B4KQG4   A0A2H8TKP9   A0A182T279   A0A0M8ZT55   E2BL08   A0A182PSI3   Q7PY31   A0A182HLP2   A0A182WST9   A0A182VKI3   A0A2S2P5E8   A0A182LA33   A0A1B6H4D6   A0A182UED7   A0A154P1Y3   A0A182NRT2   J3JXX2  

EC Number

4.1.2.27

Pubmed

28756777    26354079    18362917    19820115    26823975    26334808    + More
17510324    26483478    25474469    25348373    25830018    17994087    18057021    25315136    27129103    20920257    12702658    10731132    12537572    12537569    28165339    21719571    22936249    17550304    21347285    24495485    24845553    28004739    29403074    15632085    23185243    24438588    20353571    25244985    20075255    20798317    12364791    14747013    17210077    20966253    22516182   

EMBL

KZ149969    PZC76110.1    KQ459185    KPJ03380.1    KQ461198    KPJ05982.1    + More
ODYU01004706    SOQ44874.1    KQ971312    EEZ98407.1    GDHC01014420    JAQ04209.1    GBGD01001098    JAC87791.1    CH477266    EAT45547.1    GALX01004216    JAB64250.1    JXUM01060987    KQ562129    KXJ76631.1    GFTR01007023    JAW09403.1    KQ977349    KYN03388.1    GBBI01001090    JAC17622.1    GAKP01009017    GAKP01009015    JAC49937.1    KC763805    AHJ81369.1    GDHF01012687    JAI39627.1    GDHF01009876    JAI42438.1    GBXI01014119    GBXI01007548    JAD00173.1    JAD06744.1    CH902619    EDV37395.1    KPU76786.1    ACPB03003517    GDKW01001757    JAI54838.1    GAHY01000170    JAA77340.1    GFDG01000645    JAV18154.1    GANO01002086    JAB57785.1    GGFL01006322    MBW70500.1    GGFL01006321    MBW70499.1    AJ297394    AE013599    AY052075    GFDG01000646    JAV18153.1    GL888207    EGI65087.1    CH480816    EDW48244.1    CM000362    CM002911    EDX07450.1    KMY94463.1    KA644503    AFP59132.1    CM000158    EDW92191.1    KQ981169    KYN45362.1    GGFM01002874    MBW23625.1    GGFJ01004068    MBW53209.1    GGFJ01004069    MBW53210.1    GGFK01007358    MBW40679.1    GGFK01006973    MBW40294.1    KZ288426    PBC25919.1    ADTU01004559    GFDG01003008    JAV15791.1    DS232930    EDS26818.1    GFDL01009787    JAV25258.1    GFDG01003007    JAV15792.1    GAMC01018970    JAB87585.1    JXJN01008282    CP012524    ALC40980.1    KK852898    KDR14164.1    GEZM01012147    GEZM01012146    JAV93146.1    CH954179    EDV55659.1    KQS62379.1    PYGN01004758    PSN29272.1    GFDF01001131    JAV12953.1    KQ982558    KYQ55001.1    ABLF02016317    GFDF01001132    JAV12952.1    CH964154    EDW79719.1    CM000071    EAL25290.1    KRT02047.1    ATLV01014444    KE524972    KFB38768.1    CH916367    EDW00673.1    EZ423022    ADD19298.1    OUUW01000001    SPP73603.1    CH940648    EDW60688.1    KRF79545.1    AXCN02001148    AXCM01000026    CH933808    EDW10304.1    GFXV01002427    MBW14232.1    KQ435890    KOX69456.1    GL448858    EFN83629.1    AAAB01008987    EAA00871.5    APCN01000909    GGMR01012016    MBY24635.1    GECZ01000210    JAS69559.1    KQ434803    KZC05959.1    BT128094    AEE63055.1   

Proteomes

UP000053268    UP000053240    UP000007266    UP000008820    UP000069940    UP000249989    + More
UP000078542    UP000007801    UP000015103    UP000095301    UP000192223    UP000000803    UP000007755    UP000001292    UP000000304    UP000002282    UP000078541    UP000242457    UP000005205    UP000002320    UP000005203    UP000069272    UP000092460    UP000092553    UP000092443    UP000027135    UP000008711    UP000078200    UP000245037    UP000075809    UP000007819    UP000095300    UP000092445    UP000192221    UP000075881    UP000007798    UP000001819    UP000030765    UP000075900    UP000001070    UP000076408    UP000075920    UP000091820    UP000268350    UP000002358    UP000008792    UP000075880    UP000075886    UP000075883    UP000009192    UP000075901    UP000053105    UP000008237    UP000075885    UP000007062    UP000075840    UP000076407    UP000075903    UP000075882    UP000075902    UP000076502    UP000075884   

PRIDE

Q9V7Y2   

Pfam

PF00282   Pyridoxal_deC        + More
PF00188   CAP

Interpro

IPR015422   PyrdxlP-dep_Trfase_dom1        + More
IPR015424   PyrdxlP-dep_Trfase       
IPR002129   PyrdxlP-dep_de-COase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR002413   V5_allergen-like       
IPR014044   CAP_domain       
IPR035940   CAP_sf       

SUPFAM

SSF53383   SSF53383        + More
SSF55797   SSF55797       

Gene 3D

3.40.640.10     3.90.1150.10     3.40.33.10    

ProteinModelPortal

A0A2W1BTK8   A0A194QEK6   A0A194QKC2   A0A2H1VXE7   D6W8W6   A0A146L8Z5   + More
A0A1S4F3W7   A0A069DVF1   Q17G38   V5G2K7   A0A182GG03   A0A224XMN8   A0A195CRL9   A0A023F8H5   A0A034W6K0   X2D8H1   A0A0K8VL60   A0A0K8VUA2   A0A0A1X605   B3MD62   T1I8Q6   A0A1I8N556   A0A0P4VQY5   R4G5W3   A0A1W4W7L3   A0A1L8EHM1   U5EV11   A0A2M4CYU3   A0A087Z7V1   Q9V7Y2   A0A1L8EHT5   F4WLC4   B4HMH6   B4QIK3   T1P9B9   B4P8H4   A0A195FYI1   A0A2M3Z547   A0A2M4BJF9   A0A2M4BJH6   A0A2M4AIQ9   A0A2M4AHP3   A0A2A3E436   A0A158NZF1   A0A1L8EAP5   B0XFI0   A0A088AET0   A0A182FPV8   A0A1Q3FCN8   A0A1L8EAZ3   W8AGS9   A0A1B0B4E6   A0A0M4EIM4   A0A1A9YMW8   A0A067R790   A0A1Y1NA95   B3NP20   A0A1A9UGZ6   A0A2P8XBA2   A0A1L8E2I0   A0A151X3N5   J9JT04   A0A1I8P6T2   A0A1A9ZI41   A0A1W4VDG6   A0A1L8E2Z6   A0A182JU78   B4N5T0   Q290S2   A0A084VLC4   A0A182RZK1   B4J547   D3TNM0   A0A182Y3T6   A0A182VZM6   A0A1A9WWT6   A0A3B0J331   K7IMX0   B4LKG7   A0A182IPS7   A0A182Q4E5   A0A182M8F7   B4KQG4   A0A2H8TKP9   A0A182T279   A0A0M8ZT55   E2BL08   A0A182PSI3   Q7PY31   A0A182HLP2   A0A182WST9   A0A182VKI3   A0A2S2P5E8   A0A182LA33   A0A1B6H4D6   A0A182UED7   A0A154P1Y3   A0A182NRT2   J3JXX2  

PDB

4Q6R     E-value=7.97794e-121,     Score=1111

KEGG

101743812    K01634 sphinganine-1-phosphate aldolase [EC:4.1.2.27] | (RefSeq) sphingosine-1-phosphate lyase

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016831   GO:0030170   GO:0019752   GO:0001667   GO:0006665   GO:0005783   GO:0008117   GO:0030149   GO:0016021   GO:0007527   GO:0005789   GO:0007275   GO:0003824   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742  

Subcellular location

Endoplasmic reticulum membrane  

Length:

540

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.95812999999998

Exp number, first 60 AAs:

6.48741

Total prob of N-in:

0.24922

outside

1  -  540

 

 

Pi

187.228813

Theta

155.45265

Tajima's D

0.45979

CLR

0.354445

CSRT

0.509374531273436

Interpretation

Uncertain