Gene

KWMTBOMO04873  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008023

Annotation

hypothetical_protein_RR46_06541_[Papilio_xuthus]

Location

Bomo_Chr9(-):650955-669915      View in EpiBrowser

Full name

Kynurenine 3-monooxygenase      

Alternative Name

Kynurenine 3-hydroxylase

Location in the cell

Cytoplasmic   Reliability : 1.793 Nuclear   Reliability : 1.393

CDS

ATGTTATGTTATCCGACAGACGCAAGGAGCTGTGTGACGTGCGACAAGGTGCTGGATGAGTTGGAGAAGATCGACGACGACACGGACACGTTCGGCGTGGACTTCGTCAAGATCAACGACAAGCGGCTCGCGAAGCAGTATGGCATCACGAAATTCCCCGCCCTCACGTACTTCCGTGAGAAGGAACCGATCATTTACGAAGGAGATCTCATGGACGAAGAAAGTGTCCTGGATTTCCTGACGAGCTTAGAAGCAATGGACCTTCCTGACCGGATAGAAGAGGTTAACCAAAAGATTCTGTCGAAAATTATCGAGGAGACAGACTATGTAGCAGTGCTTTTCTGTCCGGATCACAAAAGTTGCGGTCCCTCAAACAACAAGCCGGAGTGTAAGAAATGTGCGAAGGCTCTACAAGAGTTGGAGAACATTGACGACGAGGCCGACCAGCTCGGGATTGGTTTCGTGAAGATCCACGACGAGGAATTGGCCGAGGAGTACAGTCTTGGAGAACTGCCAAGACTGGTCTACTATAGGCATCAAATACCTATTATCTATGAAGGTGAATTGAGCAAGGAAGAGGACGTGCTGGAGTGGCTGATTGCCAACAAGTCTACCGGCGATGAGGAGGACGTCATCGAAGACGTAACAGCCAAGACCTTGAATACTCTGATTATCAACGTCGATCATCTTGTTGTACTCTTTTACGACCACGGCGACGAAGAATCAATGACTGTTCTGAATGAGTTGGAGAAGATAGACGATGACTGCGACCGTCACGGGATCCAGTTCGTCAAGATCGACGACCAGAAGGCGGCGCGAGCTTTCGGCATTGATGACCTACCCTCCATAGTCTACTTCGAGAAGCAAATACCAAATGTTTATGACGGAGACCTTGAAAACGAAGAAGAAATCTTAGAGTGGCTTGTAGACCAACTAGAGAAGGATGAAATTGAAGATGTCACCGATGAAATGCTGGACCGGCTCATCAAGGACGGGAAAACTGTCGCCGTGTTGTTTTATGACAACAACGATCGTAGGTCACAGAAAGTGCTCAACGAATTGGAAAATATCGATGACGAATGCGATCAGCTCGGCATTGCGTTTGTGAAAATTGACAACGACGAGGAAGCCAAAGAATACGGCATCGAAAAGATACCGACGCTTTTGTACTTTGAAAAGGGAATACCCACGTACTACGAAGGAAACCTTGAAGAAGAGGAAAAAGTATTAGAATGGTTGCAACATCAAGCCGAGAGTGACGAAATCGAAGACATCACCGACGAGATGCTGGACCTCATCATTGAGAAGATGCCGTACGTGGCCGTCTTGTTCTACGACAAGGACCAAAAGAAAAGCCAAAAGGTCCTGGTTGAGTTGGAGAACATTGATGATGAATGCGATCAAAATGACATCGCCTTCGTGAAAATAGATGACGACAAAGAGGCCAAAGAGTATGGCATTGAAACCATCCCTACCATGGTGTTCTTTGAAAAGGGTATCCCACATATTTATGAAGGTGATTTGATGAAGGAAGAAGAGCTTCTTGGATGGTTGCTGCATCAGAAACGGCACAGTGAAATCCCTGAAGTCACGGACGAAATGATGGACAAACTCATCGAAACAACTCCTTATTTGGCGGTTATTTTCTATGACAAAGACGACAAGCAAGACATCAGGATCCTCAATGAACTTGAGAACATCGACGATGAATTAGAGAAAGAAGGCATCGTTATTGTGCGTATGGACAACGATGCAGAAGCCAAAGAATACGGCATAGATCATCTGCCCACGCTGGTCTACTTCGAGGAGCATATCCCGGCGATATACGAAGGCGACCTCATGAACGAAGACGAAGTGCTGGAATGGCTGATCGAACAGAAGAACAGCGCGACCATCGAGGAAGTCACCGATGAGATATTAGTCGATCTTATTGAAGAGCACGAATATGTTGTCGTGTATTTCAGCGGTAACTGCGAGGAAGGCGAGGAATGCGACAACATCTTGGATGAACTGGAGAATATCGACGACGAGCTTGATGAGACCGGCATTATCTTCGTGACCACCGAGGACACCAGCTTAGCCAAGAAGTACGGCATCAAGACGTTCCCGACCCTCGTGTTCTTCAGGAACAAGGATCCGTTAGTCTACAAAGGTGACATCGAAGACGAAGATGAAGTATTGGCGTGGTTAACTGACGAGAACACATTGGAAATTCCTGGCAAAATTGAAGAGGTCAATTCTAAAATGCTTGAAAAGATTCTAGAAGAGAACGATCACGTCGTTGTATTCTTCTACAAAGAAGGTGACAAGAAGTCTCAAAAGATTCTAAGCGAATTGGAAAACATTGACGACGAGTGTGAAGAAAAAGACATCGACTTTGTCAAGACATCAGACAACGGCATCGACAAGGAATACGACCTCCCAGAATTACCAGCCTTGGCTTTCTACAGGCACAAGTTCAGGACCATCTACGAAGGAGACTTGATGCACGAAGAAGCTATCTTAAAGTGGGTTTTAGATCTGCACGATTCACAACCGGATATCATTGAAAACGTCGACAGGAAGACTCTTAAGAACCTAATCAATGATGTTGAACATTTGGCCGTTTTCTTCTACAGTGAAGATTGTGACACGTGCGACGACATCCTGGTGGAGCTGGAGACTATTGATGACGACACTGACAAGCACGGCATCCAATTCGTAAAGTCAAAGGATTCTAAGCTAGCTACCGATATAGGAATATTCAGTTTCCCGGCTTTGGTTTATTACGAAACTGGTGTTCCGATTATGTACGACGGTGACTTAAAGAACGAAAATAAGGTTCTCCAGTGGCTTGTAGATCAAAAAAGCGATCGCTGTTTCTACATTGGATTGGGGGCGAAACCGGCCGTCCCAAAAATGACTTACGAACCATACCAGTGCTGTCCCACTAAAGTTCAGAGCCCGACTAAAGTAGCCAAGGCCACGCCGACCAAGGTGCCACCCAAGAAACTGGAGAAACAAGAAAAGGGAAAACCCAAACAGCAGGAAAAGGAAAAAGAAAAGCCGTCTAAAGGGAAAAATAAGGCACTCGCCAAGCCCGACAAACCTTCTAAAGGGAAAAAAGCTGAAGATAATTATGAAAACTTTTTAGGAGATCTTTTGGACGAATCTGAGGTACTCGACTGGATGGTGAAACAAAAAGAAGATGAAAGCATTGAAGAAATAGACAGAGATGAATTGTTCAAATATATCGAAACGAAAGAGTTTTTAGCCGTTATATTTTATAAAGAAGACGACCCAGAAAGCCCAAGAGTTCTGAGGCACGTGGAGCTGATAGACGACGAAGCGGCTCAGTACGGTATCAAAATCGCAAAATGCAGCGACAAATTGATGGCCAAGAAATACGGCTTCCGCAATCCGCCGGGCATTACCTATTTCAGAAAAACTAAATACATTAATTACGATGGCGACATTGACGACGAAGAAGAGATATTGGACTGGCTGACGAATCCAGAAAACATGGAGCTGACTGATCACATCGAGAAAGTTAATAGGAAAATGTTTCAGAAGATAAGACAAACGTCGGATTACGTTGCTGTGTTCTTTTGTGAGTGTGCAACATTTTTTATTTATTTTTTAATTGCGTAG

Protein

MLCYPTDARSCVTCDKVLDELEKIDDDTDTFGVDFVKINDKRLAKQYGITKFPALTYFREKEPIIYEGDLMDEESVLDFLTSLEAMDLPDRIEEVNQKILSKIIEETDYVAVLFCPDHKSCGPSNNKPECKKCAKALQELENIDDEADQLGIGFVKIHDEELAEEYSLGELPRLVYYRHQIPIIYEGELSKEEDVLEWLIANKSTGDEEDVIEDVTAKTLNTLIINVDHLVVLFYDHGDEESMTVLNELEKIDDDCDRHGIQFVKIDDQKAARAFGIDDLPSIVYFEKQIPNVYDGDLENEEEILEWLVDQLEKDEIEDVTDEMLDRLIKDGKTVAVLFYDNNDRRSQKVLNELENIDDECDQLGIAFVKIDNDEEAKEYGIEKIPTLLYFEKGIPTYYEGNLEEEEKVLEWLQHQAESDEIEDITDEMLDLIIEKMPYVAVLFYDKDQKKSQKVLVELENIDDECDQNDIAFVKIDDDKEAKEYGIETIPTMVFFEKGIPHIYEGDLMKEEELLGWLLHQKRHSEIPEVTDEMMDKLIETTPYLAVIFYDKDDKQDIRILNELENIDDELEKEGIVIVRMDNDAEAKEYGIDHLPTLVYFEEHIPAIYEGDLMNEDEVLEWLIEQKNSATIEEVTDEILVDLIEEHEYVVVYFSGNCEEGEECDNILDELENIDDELDETGIIFVTTEDTSLAKKYGIKTFPTLVFFRNKDPLVYKGDIEDEDEVLAWLTDENTLEIPGKIEEVNSKMLEKILEENDHVVVFFYKEGDKKSQKILSELENIDDECEEKDIDFVKTSDNGIDKEYDLPELPALAFYRHKFRTIYEGDLMHEEAILKWVLDLHDSQPDIIENVDRKTLKNLINDVEHLAVFFYSEDCDTCDDILVELETIDDDTDKHGIQFVKSKDSKLATDIGIFSFPALVYYETGVPIMYDGDLKNENKVLQWLVDQKSDRCFYIGLGAKPAVPKMTYEPYQCCPTKVQSPTKVAKATPTKVPPKKLEKQEKGKPKQQEKEKEKPSKGKNKALAKPDKPSKGKKAEDNYENFLGDLLDESEVLDWMVKQKEDESIEEIDRDELFKYIETKEFLAVIFYKEDDPESPRVLRHVELIDDEAAQYGIKIAKCSDKLMAKKYGFRNPPGITYFRKTKYINYDGDIDDEEEILDWLTNPENMELTDHIEKVNRKMFQKIRQTSDYVAVFFCECATFFIYFLIA

Description

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Catalytic Activity

H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)

Cofactor

FAD

Similarity

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Uniprot

A0A194QEL2   A0A0L7LBA3   A0A195FV70   A0A195B1Q4   E2BE86   F4WXX7   + More
H9JES6   A0A067R7B8   A0A194QKC7   A0A2W1BR63   A0A2H1W476   A0A3S2LCA2   A0A0L7RGJ2   A0A212EJR9   A0A0C9RUC2   A0A3L8DY73   A0A026X3Q6   A0A151WTY0   A0A195CIJ3   A0A158NZ91   A0A0J9TUG9   K7IYV6   A0A1W4VFE8   A0A0Q9X0P2   A0A1B6EFX8   A0A1B6F054   A0A0J9TUG3   A0A0Q5WNY3   A0A1B6LBI4   A0A1B6DCF0   A0A0L0CE53   A0A232ERZ5   A0A1Y1L3H5   A0A1Y1KXP6   W8AVA6   W8AR81   B4P107   A0A1W4VE31   A0A1W4V1T0   B4HQB3   A0A0C9R9T6   B4J6K1   A0A139WMR8   A0A034VR99   A0A034VUQ8   A0A0M4E6M5   A0A139WM79   A0A1Y1L3G5   A0A0T6B0M2   E2AH21   A0A1Y1L4Y4   A0A2R7VRI3   A0A1Y1KXN3   A0A1Y1L045   A0A0J9TUH8   B3MIN9   Q9V9A9   A0A0J9R6U2   E1JGY6   A0A1I8P428   A0A1I8P422   A0A1I8P3Y7   A0A1W4VEI9   A0A1I8P433   B3NB27   A0A1W4VE25   B4LK14   A0A1W4V1S5   A0A1W4VFE3   B4MY49   A0A0Q9X1D6   A0A146M1J4   A0A0C9RFW1   A0A1I8M374   A0A1I8M384   A0A1I8M378   A0A1I8M379   A0A1W4WET8   A0A139WM70   A0A1Y1L171   A0A1W4W2X2   A0A034VRA7   A0A2J7PVL4   A0A1Y1L2F8   A0A034VUR2   A0A1A9UIW9   A0A1J1I7I3   A0A1J1IBB7   A0A0J9R6J4   A0A0J9R6I3   Q0E9N2   A0A1I8P3Y0   A0A0J9R6T3   A0A1I8P423   A0A1W4V279   U5EMW7   A0A1B0EXM3   A0A2H8TVP0   A0A1I8M376   A0A2J7PVK4  

EC Number

1.14.13.9

Pubmed

26354079    26227816    20798317    21719571    19121390    24845553    + More
28756777    22118469    30249741    24508170    21347285    22936249    20075255    17994087    26108605    28648823    28004739    24495485    17550304    18362917    19820115    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18057021    26823975    25315136   

EMBL

KQ459185    KPJ03385.1    JTDY01001873    KOB72664.1    KQ981276    KYN43764.1    + More
KQ976681    KYM78212.1    GL447768    EFN85931.1    GL888434    EGI60913.1    BABH01023357    BABH01023358    BABH01023359    BABH01023360    BABH01023361    KK852827    KDR15395.1    KQ461198    KPJ05987.1    KZ149969    PZC76105.1    ODYU01006240    SOQ47899.1    RSAL01000048    RVE50479.1    KQ414596    KOC69939.1    AGBW02014406    OWR41726.1    GBYB01011201    JAG80968.1    QOIP01000003    RLU24899.1    KK107013    EZA62912.1    KQ982748    KYQ51296.1    KQ977696    KYN00550.1    ADTU01004077    ADTU01004078    CM002911    KMY91790.1    CH963894    KRF98566.1    GEDC01011253    GEDC01000460    JAS26045.1    JAS36838.1    GECZ01026147    JAS43622.1    KMY91785.1    CH954177    KQS71010.1    GEBQ01018942    JAT21035.1    GEDC01013935    GEDC01004680    JAS23363.1    JAS32618.1    JRES01000505    KNC30530.1    NNAY01002528    OXU21133.1    GEZM01071025    GEZM01071017    JAV66136.1    GEZM01071018    JAV66134.1    GAMC01017987    JAB88568.1    GAMC01017988    JAB88567.1    CM000157    EDW89081.2    CH480816    EDW46652.1    GBYB01009697    JAG79464.1    CH916367    EDW02002.1    KQ971312    KYB29137.1    GAKP01013136    GAKP01013128    JAC45816.1    GAKP01013125    GAKP01013121    JAC45827.1    CP012524    ALC42178.1    KYB29139.1    GEZM01071026    GEZM01071022    JAV66126.1    LJIG01016421    KRT80653.1    GL439460    EFN67268.1    GEZM01071021    GEZM01071016    JAV66137.1    KK854011    PTY09280.1    GEZM01071024    GEZM01071023    JAV66122.1    GEZM01071019    GEZM01071014    JAV66141.1    KMY91795.1    CH902619    EDV38115.2    AF216973    AE013599    AAF34746.1    AAN16126.1    KMY91791.1    ACZ94345.1    EDV59792.2    CH940648    EDW61668.2    EDW77038.2    KRF98564.1    KRF98565.1    KRF98567.1    GDHC01004946    JAQ13683.1    GBYB01007240    JAG77007.1    KYB29138.1    GEZM01071015    GEZM01071013    JAV66140.1    GAKP01013126    JAC45826.1    NEVH01020956    PNF20369.1    GEZM01071020    GEZM01071012    JAV66145.1    GAKP01013131    GAKP01013120    JAC45832.1    CVRI01000043    CRK96271.1    CRK96270.1    KMY91797.1    KMY91787.1    ABI31026.3    KMY91798.1    GANO01004322    JAB55549.1    AJWK01034186    GFXV01005413    MBW17218.1    PNF20363.1   

Proteomes

UP000053268    UP000037510    UP000078541    UP000078540    UP000008237    UP000007755    + More
UP000005204    UP000027135    UP000053240    UP000283053    UP000053825    UP000007151    UP000279307    UP000053097    UP000075809    UP000078542    UP000005205    UP000002358    UP000192221    UP000007798    UP000008711    UP000037069    UP000215335    UP000002282    UP000001292    UP000001070    UP000007266    UP000092553    UP000000311    UP000007801    UP000000803    UP000095300    UP000008792    UP000095301    UP000192223    UP000235965    UP000078200    UP000183832    UP000092461   

PRIDE

H9JES6    Q9V9A9    E1JGY6    Q0E9N2   

Pfam

PF00085   Thioredoxin        + More
PF07449   HyaE
PF01494   FAD_binding_3

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR013766   Thioredoxin_domain       
IPR010893   NiFe-hyd_mat_HyaE       
IPR000048   IQ_motif_EF-hand-BS       
IPR027545   Kynurenine_monooxygenase       
IPR036188   FAD/NAD-bd_sf       
IPR002938   FAD-bd       

SUPFAM

SSF52833   SSF52833        + More
SSF51905   SSF51905       

Gene 3D

3.50.50.60    

ProteinModelPortal

A0A194QEL2   A0A0L7LBA3   A0A195FV70   A0A195B1Q4   E2BE86   F4WXX7   + More
H9JES6   A0A067R7B8   A0A194QKC7   A0A2W1BR63   A0A2H1W476   A0A3S2LCA2   A0A0L7RGJ2   A0A212EJR9   A0A0C9RUC2   A0A3L8DY73   A0A026X3Q6   A0A151WTY0   A0A195CIJ3   A0A158NZ91   A0A0J9TUG9   K7IYV6   A0A1W4VFE8   A0A0Q9X0P2   A0A1B6EFX8   A0A1B6F054   A0A0J9TUG3   A0A0Q5WNY3   A0A1B6LBI4   A0A1B6DCF0   A0A0L0CE53   A0A232ERZ5   A0A1Y1L3H5   A0A1Y1KXP6   W8AVA6   W8AR81   B4P107   A0A1W4VE31   A0A1W4V1T0   B4HQB3   A0A0C9R9T6   B4J6K1   A0A139WMR8   A0A034VR99   A0A034VUQ8   A0A0M4E6M5   A0A139WM79   A0A1Y1L3G5   A0A0T6B0M2   E2AH21   A0A1Y1L4Y4   A0A2R7VRI3   A0A1Y1KXN3   A0A1Y1L045   A0A0J9TUH8   B3MIN9   Q9V9A9   A0A0J9R6U2   E1JGY6   A0A1I8P428   A0A1I8P422   A0A1I8P3Y7   A0A1W4VEI9   A0A1I8P433   B3NB27   A0A1W4VE25   B4LK14   A0A1W4V1S5   A0A1W4VFE3   B4MY49   A0A0Q9X1D6   A0A146M1J4   A0A0C9RFW1   A0A1I8M374   A0A1I8M384   A0A1I8M378   A0A1I8M379   A0A1W4WET8   A0A139WM70   A0A1Y1L171   A0A1W4W2X2   A0A034VRA7   A0A2J7PVL4   A0A1Y1L2F8   A0A034VUR2   A0A1A9UIW9   A0A1J1I7I3   A0A1J1IBB7   A0A0J9R6J4   A0A0J9R6I3   Q0E9N2   A0A1I8P3Y0   A0A0J9R6T3   A0A1I8P423   A0A1W4V279   U5EMW7   A0A1B0EXM3   A0A2H8TVP0   A0A1I8M376   A0A2J7PVK4  

PDB

4EL1     E-value=2.78797e-06,     Score=127

KEGG

101735409    no KO assigned | (RefSeq) uncharacterized LOC101735409

GO

GO:0005623   GO:0016021   GO:0045454   GO:0016853   GO:0071949   GO:0019805   GO:0031966   GO:0034354   GO:0043420   GO:0006569   GO:0004502   GO:0008270   GO:0004190   GO:0006508   GO:0015074   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

Subcellular location

Mitochondrion  
Membrane  

Length:

1209

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

16.49972

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00002

outside

1  -  1190

TMhelix

1191  -  1208

inside

1209  -  1209

 

 

Pi

208.505855

Theta

191.863857

Tajima's D

0.621169

CLR

0.145395

CSRT

0.551722413879306

Interpretation

Uncertain