Gene

KWMTBOMO04871  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008023

Annotation

PREDICTED:_uncharacterized_protein_LOC101735409_[Bombyx_mori]

Location

Bomo_Chr9(-):638887-646605      View in EpiBrowser

Full name

Kynurenine 3-monooxygenase      

Alternative Name

Kynurenine 3-hydroxylase

Location in the cell

Cytoplasmic   Reliability : 3.327

CDS

ATGCACCATCTGTCATCTGTCAGTAATGACTGCAAGCAATGCCCTAGAGTGCTGGCCGAGATAGAGCATATCGACGACGACGCTGACGCTGCAGGAATCAACTTTGTGAAGATCGACGACAGACAAATGGCCAAAGAGCACGGCGTGTTCGCGCTGCCGGCCGTCCTGTTCTTCAAGCTGGGCTCCAAGGATCCTGTTATATACGCCGGTGACCTATACGACGAGCAGCAACTGTTGAGTTGGTTGCTGACCCAAAAAAATCCAGCCGGAGACGTGATCGAGGCTCTCGAAGGCCAAGAGCTACTCGATTTGATACAAGAGTCAACATCATTGGCGGTTTACTTCTATCTGGAACTTCCAGACGGTCCTGACTGCGAGCAGTGCGCCGGCATCTTGGAGGAGCTGGAGAACATCGATGACGACTGCGACAGACACGGCATTAAGTTCGTTAAGACCCAAGATTATTCCATAGCCGAGTCATACGGCGTAACAGATTTTCCAGTATTGGTCTACTTCGAAAACAACATACCTAATGTGTACGAAGGATCTCTGACTGAGGAAGAGGAAGTTTTACAATGGCTGATTACACAGAAGACTGAAGATCGTATTGAACTTATTACTAGGGTGATGCTGGAAAAAATGGTTGAAGAAACGCAATATCTGGCCGTATACTTTTACAAAATTAATTGCCACATATGTGAACACATACTCGAAGGTTTGGAGAGCATTGATGATGAATGTGACGTGTACGGGATACATATGGTCAAGATCCAAGATCCGCAACTAGCCAAGCGATACTCCATAAAAACTTTCCCTGCTATGGTCTATTTCAGGAACGGCAATCCGTTGCTGTTTGAAGGTGATCTACAGAACGAAGAGTCTATTTTGGAGTGGCTCATCGATGACGACAATCGGGAACTAGCTGATGAAATTGAGTCCGTCAATGATCGCATGCTGGAGAGGCTGCTGTACGAGTCACACTTGCTCGCTGTGTTCTTCTATGACGATGAAGATTGTCCCGAATGTCACGAGATCCTAGAGGCTCTGGAGCAGATAGACGGCGAGGTGGACCAGTACGGCATCGACTTCGTGAAGATCGCCAGCCCGGAGGCCGCGGCCGCCCACAACATCATCAACATACCCTCGCTCGTGTACTTCAGGAAGCAGGTGCCGATGCTGTACGACGGCGATCTGCACCAGGTCGACAAGGTCCTGCAGTGGCTCACTTCCCAGGACGTCTTCGAGATTAAGAACGAAATCGAAGAAGTCAACAGGAAAATGTTAGACAAACTCTTAGAGGAGAACGAGTTCTTGGCGGTTTATTTCTATGAGAAGTCAACAGAAAGTCGCGCGGTTCTAGACAAGCTGGAGAACATTGACAGCGAAACTGATAACTTGGACATAACCTTCGTTAAAATGCAAGACCCGAGATACGCTCGGAAGTGGGGGGTGACTAAACTGCCAGCCATAGTCTACTTCAGGAAGAGATTCCCCAGCATCTACCGAGGTGACCTCATGTCAGAGGAGGAGGTCCTGGAATGGCTGCGGAAGAACAGGTTCCGTCAGCCCGAGCTGAACATATTCATGTACGCGCTGCTGGCGCTCTCCGTGGCCTTCATCATGTACACCGCCTTCCTGCTGCAATGCTTCAAGGCGACGCCTCCAGCTCAAACACAGCACCCGAAACAAGCGTGA

Protein

MHHLSSVSNDCKQCPRVLAEIEHIDDDADAAGINFVKIDDRQMAKEHGVFALPAVLFFKLGSKDPVIYAGDLYDEQQLLSWLLTQKNPAGDVIEALEGQELLDLIQESTSLAVYFYLELPDGPDCEQCAGILEELENIDDDCDRHGIKFVKTQDYSIAESYGVTDFPVLVYFENNIPNVYEGSLTEEEEVLQWLITQKTEDRIELITRVMLEKMVEETQYLAVYFYKINCHICEHILEGLESIDDECDVYGIHMVKIQDPQLAKRYSIKTFPAMVYFRNGNPLLFEGDLQNEESILEWLIDDDNRELADEIESVNDRMLERLLYESHLLAVFFYDDEDCPECHEILEALEQIDGEVDQYGIDFVKIASPEAAAAHNIINIPSLVYFRKQVPMLYDGDLHQVDKVLQWLTSQDVFEIKNEIEEVNRKMLDKLLEENEFLAVYFYEKSTESRAVLDKLENIDSETDNLDITFVKMQDPRYARKWGVTKLPAIVYFRKRFPSIYRGDLMSEEEVLEWLRKNRFRQPELNIFMYALLALSVAFIMYTAFLLQCFKATPPAQTQHPKQA

Description

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Catalytic Activity

H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)

Cofactor

FAD

Similarity

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Uniprot

A0A2W1BR63   A0A194QEL2   A0A2A4ITE2   A0A194QKC7   A0A212EJR9   A0A2H1W476   + More
A0A3S2LCA2   H9JES6   K7IYV6   A0A088AN82   A0A026X3Q6   A0A0L7RGX5   F4WXX7   A0A195B1Q4   E2BE86   A0A1L8DTU9   A0A1L8DTZ5   E2AH19   A0A195FV70   A0A3L8DY73   A0A195CIJ3   A0A182JI66   A0A139WMQ6   A0A1Y1L4X3   Q7Q5G3   A0A067R7B8   A0A0M4E6M5   Q16RV7   A0A0Q9X1D6   A0A0J9R6T3   A0A1I8M379   A0A0J9TUH8   Q9V9A9   A0A0J9R7Y1   T1PDM0   A0A1I8M373   E1JGY5   A0A0J9R7X6   Q0E9N3   A0A1W4VFE3   A0A1W4VEJ2   A0A2J7PVK7   A0A2J7PVM0   A0A1Y1KXN7   A0A3B0JPC9   B4GC84   B4QDC0   A0A023EWC9   A0A1I8P3Y4   A0A1I8P428   A0A182LKY6   A0A182X900   A0A034VVF4   A0A2J7PVN9   A0A182UEC6   A0A034VUQ8   A0A034VUR2   A0A182UQN0   A0A0A1WLE2   B0XCN5   A0A151WUI2   A0A1B0DF10   A0A1W4W2X2   B0XLF6   A0A0J9R6I3   Q0E9N2   A0A1W4V279   A0A0A9YDH4   A0A1W4VEI9   A0A182PB84   A0A1W4WET8   A0A146M1J4   E0VU05   N6U1F2   A0A2S2QPU4   A0A182FF95   A0A2S2PLL5   A0A084VAX6   A0A182GP34   A0A1B0EXM3   A0A1J1IBB7   B4P107   A0A2S2N975   A0A1S4G7U5   A0A0P5TIE3   A0A0N8E2H2   A0A0P4YH92   A0A0N8CQG6   A0A0P5KYF6   A0A0P5ZHF9   A0A0P5EXE7   A0A0P5SS90   A0A0P5QUZ3   A0A0P6JK16   A0A0P5VWF6   A0A0P4ZT75   A0A0P5XAV2   A0A0N8D3Y4   A0A0N7ZJF2   A0A0P4XUL6  

EC Number

1.14.13.9

Pubmed

28756777    26354079    22118469    19121390    20075255    24508170    + More
21719571    20798317    30249741    18362917    19820115    28004739    12364791    14747013    17210077    24845553    17510324    17994087    18057021    22936249    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24945155    20966253    25348373    25830018    25401762    26823975    20566863    23537049    24438588    26483478    17550304   

EMBL

KZ149969    PZC76105.1    KQ459185    KPJ03385.1    NWSH01007220    PCG63035.1    + More
KQ461198    KPJ05987.1    AGBW02014406    OWR41726.1    ODYU01006240    SOQ47899.1    RSAL01000048    RVE50479.1    BABH01023357    BABH01023358    BABH01023359    BABH01023360    BABH01023361    KK107013    EZA62912.1    KQ414596    KOC69941.1    GL888434    EGI60913.1    KQ976681    KYM78212.1    GL447768    EFN85931.1    GFDF01004277    JAV09807.1    GFDF01004207    JAV09877.1    GL439460    EFN67266.1    KQ981276    KYN43764.1    QOIP01000003    RLU24899.1    KQ977696    KYN00550.1    KQ971312    KYB29136.1    GEZM01071025    GEZM01071024    GEZM01071022    GEZM01071021    GEZM01071015    GEZM01071014    GEZM01071012    JAV66127.1    AAAB01008960    EAA11892.2    KK852827    KDR15395.1    CP012524    ALC42178.1    CH477696    EAT37127.1    CH963894    KRF98564.1    KRF98565.1    KRF98567.1    CM002911    KMY91798.1    KMY91795.1    AF216973    AE013599    AAF34746.1    AAN16126.1    KMY91789.1    KA646882    AFP61511.1    ACZ94346.1    KMY91784.1    ABI31025.2    NEVH01020956    PNF20361.1    PNF20371.1    GEZM01071026    GEZM01071023    GEZM01071020    GEZM01071019    GEZM01071018    GEZM01071017    GEZM01071016    GEZM01071013    JAV66132.1    OUUW01000001    SPP73028.1    CH479181    EDW31402.1    CM000362    EDX05907.1    GAPW01000053    JAC13545.1    GAKP01013137    JAC45815.1    PNF20370.1    GAKP01013125    GAKP01013121    JAC45827.1    GAKP01013131    GAKP01013120    JAC45832.1    GBXI01014610    JAC99681.1    DS232707    EDS44931.1    KQ982748    KYQ51295.1    AJVK01058476    DS234457    EDS34063.1    KMY91787.1    ABI31026.3    GBHO01014458    GBHO01014456    GBRD01003454    JAG29146.1    JAG29148.1    JAG62367.1    GDHC01004946    JAQ13683.1    DS235777    EEB16861.1    APGK01053421    APGK01053422    APGK01053423    APGK01053424    KB741223    ENN72382.1    GGMS01010544    MBY79747.1    GGMR01017721    MBY30340.1    ATLV01004734    ATLV01004735    ATLV01004736    ATLV01004737    ATLV01004738    ATLV01004739    ATLV01004740    KE524237    KFB35120.1    JXUM01014797    JXUM01014798    JXUM01014799    KQ560413    KXJ82542.1    AJWK01034186    CVRI01000043    CRK96270.1    CM000157    EDW89081.2    GGMR01001165    MBY13784.1    GDIP01125817    JAL77897.1    GDIQ01068292    JAN26445.1    GDIP01228660    JAI94741.1    GDIP01108919    JAL94795.1    GDIQ01182452    JAK69273.1    GDIP01045285    JAM58430.1    GDIQ01265617    JAJ86107.1    GDIP01141364    JAL62350.1    GDIQ01129525    JAL22201.1    GDIQ01004918    JAN89819.1    GDIP01108918    JAL94796.1    GDIP01209908    JAJ13494.1    GDIP01076371    JAM27344.1    GDIP01071175    JAM32540.1    GDIP01252160    GDIP01239521    GDIP01230262    GDIP01222615    GDIP01186762    GDIP01186761    GDIP01167061    GDIP01163062    GDIP01146768    GDIP01124681    GDIP01095329    GDIP01088073    GDIP01087073    GDIP01074885    GDIP01056078    GDIP01048337    GDIP01034884    JAI83880.1    GDIP01236506    JAI86895.1   

Proteomes

UP000053268    UP000218220    UP000053240    UP000007151    UP000283053    UP000005204    + More
UP000002358    UP000005203    UP000053097    UP000053825    UP000007755    UP000078540    UP000008237    UP000000311    UP000078541    UP000279307    UP000078542    UP000075880    UP000007266    UP000007062    UP000027135    UP000092553    UP000008820    UP000007798    UP000095301    UP000000803    UP000192221    UP000235965    UP000268350    UP000008744    UP000000304    UP000095300    UP000075882    UP000076407    UP000075902    UP000075903    UP000002320    UP000075809    UP000092462    UP000192223    UP000075885    UP000009046    UP000019118    UP000069272    UP000030765    UP000069940    UP000249989    UP000092461    UP000183832    UP000002282   

PRIDE

H9JES6    Q9V9A9    E1JGY5    Q0E9N3    Q0E9N2   

Pfam

PF00085   Thioredoxin        + More
PF01494   FAD_binding_3

Interpro

IPR013766   Thioredoxin_domain        + More
IPR036249   Thioredoxin-like_sf       
IPR000048   IQ_motif_EF-hand-BS       
IPR027545   Kynurenine_monooxygenase       
IPR036188   FAD/NAD-bd_sf       
IPR002938   FAD-bd       

SUPFAM

SSF52833   SSF52833        + More
SSF51905   SSF51905       

Gene 3D

3.50.50.60    

ProteinModelPortal

A0A2W1BR63   A0A194QEL2   A0A2A4ITE2   A0A194QKC7   A0A212EJR9   A0A2H1W476   + More
A0A3S2LCA2   H9JES6   K7IYV6   A0A088AN82   A0A026X3Q6   A0A0L7RGX5   F4WXX7   A0A195B1Q4   E2BE86   A0A1L8DTU9   A0A1L8DTZ5   E2AH19   A0A195FV70   A0A3L8DY73   A0A195CIJ3   A0A182JI66   A0A139WMQ6   A0A1Y1L4X3   Q7Q5G3   A0A067R7B8   A0A0M4E6M5   Q16RV7   A0A0Q9X1D6   A0A0J9R6T3   A0A1I8M379   A0A0J9TUH8   Q9V9A9   A0A0J9R7Y1   T1PDM0   A0A1I8M373   E1JGY5   A0A0J9R7X6   Q0E9N3   A0A1W4VFE3   A0A1W4VEJ2   A0A2J7PVK7   A0A2J7PVM0   A0A1Y1KXN7   A0A3B0JPC9   B4GC84   B4QDC0   A0A023EWC9   A0A1I8P3Y4   A0A1I8P428   A0A182LKY6   A0A182X900   A0A034VVF4   A0A2J7PVN9   A0A182UEC6   A0A034VUQ8   A0A034VUR2   A0A182UQN0   A0A0A1WLE2   B0XCN5   A0A151WUI2   A0A1B0DF10   A0A1W4W2X2   B0XLF6   A0A0J9R6I3   Q0E9N2   A0A1W4V279   A0A0A9YDH4   A0A1W4VEI9   A0A182PB84   A0A1W4WET8   A0A146M1J4   E0VU05   N6U1F2   A0A2S2QPU4   A0A182FF95   A0A2S2PLL5   A0A084VAX6   A0A182GP34   A0A1B0EXM3   A0A1J1IBB7   B4P107   A0A2S2N975   A0A1S4G7U5   A0A0P5TIE3   A0A0N8E2H2   A0A0P4YH92   A0A0N8CQG6   A0A0P5KYF6   A0A0P5ZHF9   A0A0P5EXE7   A0A0P5SS90   A0A0P5QUZ3   A0A0P6JK16   A0A0P5VWF6   A0A0P4ZT75   A0A0P5XAV2   A0A0N8D3Y4   A0A0N7ZJF2   A0A0P4XUL6  

PDB

6ESX     E-value=0.000192526,     Score=108

KEGG

101735409    no KO assigned | (RefSeq) uncharacterized LOC101735409

GO

GO:0016021   GO:0005623   GO:0045454   GO:0016853   GO:0071949   GO:0019805   GO:0031966   GO:0034354   GO:0043420   GO:0006569   GO:0004502   GO:0008270   GO:0005524   GO:0005886   GO:0007166   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

Subcellular location

Mitochondrion  
Membrane  

Length:

564

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.45193

Exp number, first 60 AAs:

0.02453

Total prob of N-in:

0.03747

outside

1  -  524

TMhelix

525  -  547

inside

548  -  564

 

 

Pi

232.238187

Theta

174.452729

Tajima's D

0.896891

CLR

0.935211

CSRT

0.630018499075046

Interpretation

Uncertain