Gene

KWMTBOMO04867

Pre Gene Modal

BGIBMGA008025

Annotation

PREDICTED:_set1/Ash2_histone_methyltransferase_complex_subunit_ASH2_[Papilio_xuthus]

Location

Bomo_Chr9(-):590038-603535      View in EpiBrowser

Full name

Set1/Ash2 histone methyltransferase complex subunit ASH2      

Alternative Name

Absent, small, or homeotic discs protein 2

Location in the cell

Mitochondrial   Reliability : 1.905

CDS

ATGGATAAAAATAAAGGAAATAAAACTTCTGCTGAATCTCAAGGGACATGCTACTGCGGTAAAGATCGTAATCTGAACATAGCTGAGTTATTATGTGCATCATGCAATAGATGGTTTCACGAATCCTGTATCGGTTATCAACTTGGCAAGCTGGTACCTTTCATGACAAATTATCTCTTTATTTGTAAGAACTGCTCTCCTACTGGTTTGGAAACATTCAAAAAAAATCAAGCACCATTCCCGCAAATGTGTCTAACTGCAATTGCTAATCTTCAACAAGATAGTGTGAAAAATGGTAGCAATAGACGTCTGTTCAGCAAAGACCGAGAGATCATACCATACATTGACCAGTATTGGGAAGCTATGACCACAATGCCCAGAAGGGTGACCCAGTCGTGGTATGCTACAGTACAGAGAGCTCTAATCAAGGATATCCAGGTTTTGTTCACATATGAAGAAGACTCGTCTGATGGTCCCATGTTTGGGCTCTGCAACGCAGAACTGACAATTATTAAACCTAACTACGAAGCCATGATCAAGCATGGTCAGCTCAAAGTCACAGATATGGGTATAGCTACAATTCCACTAGCCGGCAACGTGAAGGGCAGGCAAGGTAAGCGCAGGCCTGCGGTCGGCAGCGCGGCCGAGACCGGGGCTCCCATCGGCAAGAAAGGCCGTAACGCCGATGTCACCGCTCTGAAACTGCCCTCGCACGGCTACCCCACCGAGCATCCCTTCAACAAAGACGGTTACAGATACATCTTGGCGGAACCAGACCCGCACGCGCCCTTCAGACAGGAGTTCGACGAGAGCAACGAGTGGAGCGGCAAGCCGATCCCGGGCTGGCTGTACCGGCCGCTGTGCCCGGGCGGCGTGCTGCTGGCGCTGCACGACCGCGCGCCGCAGCTGCGCGTGGCCGAGGACCGGCTGGCCGTCACGGGCGACCGCGGCTACTGCACGGTGCGCGCCACGCACGGCGTGTCGCGCGGCAGCTGGTACTGGGAGGCGTGCGTGGAGGAGCTGCCGGAGGGCGCGGGGGTGCGCGCGGGGTGGGGCCGCCGCGTGGCCAACCTGCAGGCGCCGCTCGGGTACGACAAGTTCGGCTACTCGTGGCGGAGTCGCAAGGGGACCAGGTTCCACGAGTCCCGAGGCAAGCACTACAGCGGTGCGTACGGCGAGGGCGACACGCTGGGCTTCCTCATCGTGCTGCCGGACTGCGCCTCCACCAAGTTCACGCCCAACACCTACAAGGACCGGCCTCTAGTCAAATTCAAGAGCCACCTGTACTACGAGGACAAGGACAACATCCAGGAGTGCCTCAACAACCTGAAGCAGCTCCCCGGCAGCAAGATCATATTCTTCAAGAACGGCGAGTGCCAGGGCGAGGCCTTCAGTGACATCTACCGCGGCTGCTACTACCCCGCCGTCTCGCTGCACCGCACCGCCACCCTCAGCGTCAACTTCGGGCCCAGCTTCAAGTACCAGCCCTCCACGCACTACCCCTACAGACCTATGTCAGAAAAAGCGGAAGAAGCAATATGCGAACAAACGATGGCCGACATGCTGTATCTGACCGAGAACGAGGGCAAGCTGCGCCTGGACAACTTCAACATTTGA

Protein

MDKNKGNKTSAESQGTCYCGKDRNLNIAELLCASCNRWFHESCIGYQLGKLVPFMTNYLFICKNCSPTGLETFKKNQAPFPQMCLTAIANLQQDSVKNGSNRRLFSKDREIIPYIDQYWEAMTTMPRRVTQSWYATVQRALIKDIQVLFTYEEDSSDGPMFGLCNAELTIIKPNYEAMIKHGQLKVTDMGIATIPLAGNVKGRQGKRRPAVGSAAETGAPIGKKGRNADVTALKLPSHGYPTEHPFNKDGYRYILAEPDPHAPFRQEFDESNEWSGKPIPGWLYRPLCPGGVLLALHDRAPQLRVAEDRLAVTGDRGYCTVRATHGVSRGSWYWEACVEELPEGAGVRAGWGRRVANLQAPLGYDKFGYSWRSRKGTRFHESRGKHYSGAYGEGDTLGFLIVLPDCASTKFTPNTYKDRPLVKFKSHLYYEDKDNIQECLNNLKQLPGSKIIFFKNGECQGEAFSDIYRGCYYPAVSLHRTATLSVNFGPSFKYQPSTHYPYRPMSEKAEEAICEQTMADMLYLTENEGKLRLDNFNI

Description

Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of transcriptionally active chromatin through down-regulation of histone H1 hyperphosphorylation.

Subunit

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6. Interacts with hcf, sktl and trr.

Keywords

Alternative splicing   Chromosome   Complete proteome   Developmental protein   DNA-binding   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation   Zinc   Zinc-finger  

Feature

chain  Set1/Ash2 histone methyltransferase complex subunit ASH2
splice variant  In isoform B.

Uniprot

H9JES8   A0A2H1W9Q6   A0A194QCW9   A0A212EJS5   A0A1Y1MNB3   D6X3Q8   + More
E9J271   A0A151I3D9   A0A151IW66   E2ABY2   A0A026X3K3   A0A151WIR0   F4WMV2   A0A195FV15   A0A2J7QW12   A0A0N0BGY4   A0A067R8L5   A0A1B6ERW4   A0A0C9RK78   A0A0C9RK43   A0A088A739   A0A2A3E6E0   A0A0L0C6Q0   A0A1B6LI47   A0A154PC03   A0A347ZJ80   E2BJ62   A0A1I8NTC6   A0A0T6BDA4   A0A1I8MIX7   A0A034WBC1   W8AVH1   A0A0K8UQH0   A0A0K8WCL8   A0A034WGI3   K7IWY2   A0A232FH95   A0A146KS09   A0A0A9W5I5   A0A023F522   A0A1Q3F413   T1IC53   A0A1A9XMX5   U5EVF7   A0A1W4VQ12   A0A182R054   Q94545   A0A182H8T1   A0A182HC27   B4PVR5   A0A182K860   A0A182F8E5   A0A182YEV3   B4HH49   A0A182UW56   A0A182TYK0   A0A182WVF3   Q5TT37   A0A182I932   A0A182W2Z6   W5JKQ7   A0A182KXX9   A0A182PU00   B3P708   B4GPG0   B5DXS8   A0A2M4BK60   A0A182NCL0   A0A182R8D4   A0A3B0K8F0   Q0IFZ7   B4K509   B4LW29   A0A1B0A8U9   A0A1A9UQ50   I3RSF7   B4N8U0   B4JEJ8   A0A0L7QYX7   B3M048   B0WEX2   A0A0P6G913   A0A0P6ADR8   A0A1B0ET16   A0A336M6A2   A0A084WR33   A0A0P6JWD4   A0A1S3D0C8   A0A0M5JC78   A0A182MP34   A0A182J148   A0A069DVC9   A0A0P6H0J6   A0A2H8THW3   A0A0P6B7C5   E9G3M1   A0A1D2N0E0   E0W163   A0A226EVX8   A0A336LH73  

Pubmed

19121390    26354079    22118469    28004739    18362917    19820115    + More
21282665    20798317    24508170    30249741    21719571    24845553    26108605    25315136    25348373    24495485    20075255    28648823    26823975    25401762    25474469    8889525    10731132    12537572    12537569    8555105    12068954    12626737    15371308    15280236    17466076    21694722    21875999    21310711    23197473    26483478    17994087    17550304    25244985    12364791    14747013    17210077    20920257    23761445    20966253    15632085    17510324    22328714    24438588    26334808    21292972    27289101    20566863   

EMBL

BABH01023354    BABH01023355    ODYU01007214    SOQ49798.1    KQ459185    KPJ03388.1    + More
AGBW02014406    OWR41724.1    GEZM01028888    JAV86210.1    KQ971377    EEZ97384.2    GL767820    EFZ13081.1    KQ976482    KYM83725.1    KQ980882    KYN11937.1    GL438386    EFN69077.1    KK107019    QOIP01000007    EZA62643.1    RLU20024.1    KQ983089    KYQ47625.1    GL888223    EGI64422.1    KQ981261    KYN44132.1    NEVH01009768    PNF32764.1    KQ435762    KOX75454.1    KK852667    KDR18916.1    GECZ01029097    GECZ01012982    JAS40672.1    JAS56787.1    GBYB01007241    GBYB01008471    GBYB01008472    JAG77008.1    JAG78238.1    JAG78239.1    GBYB01008580    JAG78347.1    KZ288353    PBC27280.1    JRES01000835    KNC27911.1    GEBQ01016703    JAT23274.1    KQ434869    KZC09415.1    FX985648    BBA84386.1    GL448558    EFN84212.1    LJIG01001626    KRT85314.1    GAKP01006086    GAKP01006076    JAC52866.1    GAMC01017872    JAB88683.1    GDHF01023581    JAI28733.1    GDHF01003714    JAI48600.1    GAKP01006079    GAKP01006069    JAC52883.1    AAZX01004124    NNAY01000194    OXU30104.1    GDHC01019368    JAP99260.1    GBHO01039902    JAG03702.1    GBBI01002573    JAC16139.1    GFDL01012750    JAV22295.1    ACPB03004429    GANO01003425    JAB56446.1    AXCN02001184    U73809    AE014297    AY051803    BT011328    BT120264    AAC47328.2    AAK93227.1    AAO41602.1    AAR96120.1    JXUM01119205    KQ566265    KXJ70267.1    JXUM01126286    JXUM01126287    JXUM01126288    CM000160    EDW98914.2    CH480815    EDW43525.1    AAAB01008888    EAL40623.3    APCN01003167    ADMH02001252    ETN63480.1    CH954182    EDV53828.1    CH479186    EDW39043.1    CM000070    EDY67519.1    GGFJ01004200    MBW53341.1    OUUW01000005    SPP81301.1    CH477281    EAT44927.1    CH933806    EDW13980.2    CH940650    EDW66534.1    JQ611724    AFK29242.1    CH964232    EDW81541.1    CH916369    EDV93129.1    KQ414686    KOC63766.1    CH902617    EDV42005.1    DS231912    EDS25830.1    GDIQ01039557    JAN55180.1    GDIP01044059    LRGB01001574    JAM59656.1    KZS11620.1    AJWK01005374    AJWK01005375    UFQT01000615    SSX25786.1    ATLV01025911    KE525402    KFB52677.1    GDIQ01006018    JAN88719.1    CP012526    ALC45918.1    AXCM01000016    GBGD01001118    JAC87771.1    GDIQ01036575    JAN58162.1    GFXV01001487    MBW13292.1    GDIP01019377    JAM84338.1    GL732531    EFX85961.1    LJIJ01000336    ODM98671.1    DS235866    EEB19369.1    LNIX01000001    OXA61679.1    UFQS01004023    UFQT01004023    SSX16107.1    SSX35436.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000007266    UP000078540    UP000078492    + More
UP000000311    UP000053097    UP000279307    UP000075809    UP000007755    UP000078541    UP000235965    UP000053105    UP000027135    UP000005203    UP000242457    UP000037069    UP000076502    UP000008237    UP000095300    UP000095301    UP000002358    UP000215335    UP000015103    UP000092443    UP000192221    UP000075886    UP000000803    UP000069940    UP000249989    UP000002282    UP000075881    UP000069272    UP000076408    UP000001292    UP000075903    UP000075902    UP000076407    UP000007062    UP000075840    UP000075920    UP000000673    UP000075882    UP000075885    UP000008711    UP000008744    UP000001819    UP000075884    UP000075900    UP000268350    UP000008820    UP000009192    UP000008792    UP000092445    UP000078200    UP000007798    UP000001070    UP000053825    UP000007801    UP000002320    UP000076858    UP000092461    UP000030765    UP000079169    UP000092553    UP000075883    UP000075880    UP000000305    UP000094527    UP000009046    UP000198287   

PRIDE

H9JES8    Q94545   

Pfam

PF00622   SPRY

Interpro

IPR013320   ConA-like_dom_sf        + More
IPR001870   B30.2/SPRY       
IPR037353   ASH2       
IPR003877   SPRY_dom       
IPR011011   Znf_FYVE_PHD       
IPR001965   Znf_PHD       
IPR019786   Zinc_finger_PHD-type_CS       

SUPFAM

SSF57903   SSF57903        + More
SSF49899   SSF49899       

ProteinModelPortal

H9JES8   A0A2H1W9Q6   A0A194QCW9   A0A212EJS5   A0A1Y1MNB3   D6X3Q8   + More
E9J271   A0A151I3D9   A0A151IW66   E2ABY2   A0A026X3K3   A0A151WIR0   F4WMV2   A0A195FV15   A0A2J7QW12   A0A0N0BGY4   A0A067R8L5   A0A1B6ERW4   A0A0C9RK78   A0A0C9RK43   A0A088A739   A0A2A3E6E0   A0A0L0C6Q0   A0A1B6LI47   A0A154PC03   A0A347ZJ80   E2BJ62   A0A1I8NTC6   A0A0T6BDA4   A0A1I8MIX7   A0A034WBC1   W8AVH1   A0A0K8UQH0   A0A0K8WCL8   A0A034WGI3   K7IWY2   A0A232FH95   A0A146KS09   A0A0A9W5I5   A0A023F522   A0A1Q3F413   T1IC53   A0A1A9XMX5   U5EVF7   A0A1W4VQ12   A0A182R054   Q94545   A0A182H8T1   A0A182HC27   B4PVR5   A0A182K860   A0A182F8E5   A0A182YEV3   B4HH49   A0A182UW56   A0A182TYK0   A0A182WVF3   Q5TT37   A0A182I932   A0A182W2Z6   W5JKQ7   A0A182KXX9   A0A182PU00   B3P708   B4GPG0   B5DXS8   A0A2M4BK60   A0A182NCL0   A0A182R8D4   A0A3B0K8F0   Q0IFZ7   B4K509   B4LW29   A0A1B0A8U9   A0A1A9UQ50   I3RSF7   B4N8U0   B4JEJ8   A0A0L7QYX7   B3M048   B0WEX2   A0A0P6G913   A0A0P6ADR8   A0A1B0ET16   A0A336M6A2   A0A084WR33   A0A0P6JWD4   A0A1S3D0C8   A0A0M5JC78   A0A182MP34   A0A182J148   A0A069DVC9   A0A0P6H0J6   A0A2H8THW3   A0A0P6B7C5   E9G3M1   A0A1D2N0E0   E0W163   A0A226EVX8   A0A336LH73  

PDB

6E2H     E-value=3.07125e-59,     Score=580

KEGG

101746886    K14964 Set1/Ash2 histone methyltransferase complex subunit ASH2 | (RefSeq) set1/Ash2 histone methylt

GO

GO:0048188   GO:0051568   GO:0046872   GO:0008168   GO:0044212   GO:0006351   GO:0005634   GO:0044666   GO:0007420   GO:0007444   GO:0051571   GO:0044665   GO:0003677   GO:0007474   GO:0010628   GO:0035209   GO:0048813   GO:0006357   GO:0048096   GO:0033128   GO:0005703   GO:0019899   GO:0035075   GO:0005700   GO:0002168   GO:0007476   GO:0010629   GO:0005515   GO:0008270   GO:0016021   GO:0005524   GO:0005886   GO:0007166   GO:0006032   GO:0016742   GO:0003824  

PANTHER

PTHR10598  

Subcellular location

Nucleus   Accumulates on salivary gland polytene chromosomes.   With evidence from 8 publications.
Chromosome   Accumulates on salivary gland polytene chromosomes.   With evidence from 8 publications.

Length:

538

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0730700000000002

Exp number, first 60 AAs:

0.06051

Total prob of N-in:

0.01485

outside

1  -  538

 

 

Pi

326.042987

Theta

183.667858

Tajima's D

-1.163414

CLR

1133.186524

CSRT

0.109094545272736

Interpretation

Uncertain