Silkworm Genome Informatics Database

Gene

KWMTBOMO04858

Pre Gene Modal

BGIBMGA008045

Annotation

PREDICTED:_acid_sphingomyelinase-like_phosphodiesterase_3a_isoform_X2_[Papilio_xuthus]

Location

Bomo_Chr9(+):297486-328051 View in EpiBrowser

Full name

Sphingomyelinase phosphodiesterase       + More
Acid sphingomyelinase-like phosphodiesterase 3b
Acid sphingomyelinase-like phosphodiesterase

Location in the cell

PlasmaMembrane Reliability : 2.224

CDS

ATGCTGACCCTAAAAGATTTTTCTACTGATCTGTACTTTATAGTGCAAATGGCTGATATGACACTCTCCTGCTCTGTGTCACAAGGACAATATGAAATAAATTGTCGGAGATTAGCCGATCGTGGTAGTTCAAGATATCTCAGGGCTCTGGGGAAATATGGGGACTACGCCTGTGACAGCTCTTTGGAGCTCATCGAATCCGCTGCAAAGTACATGAGAACCCGGCACTCGGATAACGTAGAATTCGTATTGTGGACAGGGGACATAGTCACTTCCCACTACACGCTAAGCGAAGACGACCGTCTGAACGCTATCCGTAACATGACGTTCCTATTGAGTAGGACCTTCAGTTCTCACTTCGTGTTTCCTGTTCTCGGGGACTTGGACCCCAAGCCATCCGAAACTGTCACTACTCTATGGATGCAATGGCTACCTTTGGAAGCTTTAGAGACCTTCGCTAATGGTGGGTACTACACGATTGAGCAGAAACAGAACAAGCTGAGGCTTGTGATCCTGAACACGAACTTGTTCGGGATTCGTGAGCACAATACCCCAGAGTCAAGTCTGCAGTGGGAATGGCTCAGCTCCGTGTTCAACAAGGCGGACAAGGCTAACGAAATGATATACATCATAGGCCACACGGCGCCCGGGACGGAATATCGCCATGGGCACGAGATGGCGGTCGGCGCCGTGGAGAAATACATCAGGATGGTCCGTCAACACGCTCGCCGGATTGCCGGACAGTTCTTCGGGCACCTTCACACTGACACCTTCAGGATCTTCTATGACAATGAGCGTCCAGTATCTTGGGCACTGCTGGCGCCGTCAGTAACACCTCATCGGTACCCTAATGATGCCTCAAACCCTGGCCTGAGGCTGTATAAATTTGACACCCACAATGGAAAGGTATTAGATTACACCCAGTACTACTTAGATCTGAAAACAGCGAACCGCAATATAGAGTCTGCTCAGTGGACGGTAGAGTACAACGTGACTCTGTATTACGGACTCCACGATATCACAGCCACTTCTCTACATAACCTTGCCGATAGGATACGAACGGGAACCACTCACGATAATTCTGTTCTTAAGAGGTATCTGAGGGCGTACAAAGTAAAATTTGAGGAGTCAGAAAACTGCGACAGCGCGTGTGCTCACCAGCATTACTGCTCGATCACCTGCCTCGACCTTCCCGCCTACCAGCAGTGCCTAGACTCTGCCAGCAGTGCCCTGGCTACTGCGGCAGATTCTGCCGCCATCGAAACTTTCCCGCTCAAAGCCGCCATTGCACTGACCATTTTCGCCGCTGGAGTCTCGTTTTGA

Protein

MLTLKDFSTDLYFIVQMADMTLSCSVSQGQYEINCRRLADRGSSRYLRALGKYGDYACDSSLELIESAAKYMRTRHSDNVEFVLWTGDIVTSHYTLSEDDRLNAIRNMTFLLSRTFSSHFVFPVLGDLDPKPSETVTTLWMQWLPLEALETFANGGYYTIEQKQNKLRLVILNTNLFGIREHNTPESSLQWEWLSSVFNKADKANEMIYIIGHTAPGTEYRHGHEMAVGAVEKYIRMVRQHARRIAGQFFGHLHTDTFRIFYDNERPVSWALLAPSVTPHRYPNDASNPGLRLYKFDTHNGKVLDYTQYYLDLKTANRNIESAQWTVEYNVTLYYGLHDITATSLHNLADRIRTGTTHDNSVLKRYLRAYKVKFEESENCDSACAHQHYCSITCLDLPAYQQCLDSASSALATAADSAAIETFPLKAAIALTIFAAGVSF

Description

Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).

Cofactor

Zn(2+)

Subunit

Interacts with TLR4, TLR7, TLR8 and TLR9.

Similarity

Belongs to the acid sphingomyelinase family.

Keywords

Alternative splicing Cell membrane Complete proteome Disulfide bond Glycoprotein Glycosidase GPI-anchor Hydrolase Immunity Inflammatory response Innate immunity Lipid degradation Lipid metabolism Lipoprotein Membrane Metal-binding Polymorphism Reference proteome Secreted Signal Zinc

Feature

chain  Acid sphingomyelinase-like phosphodiesterase 3b
splice variant  In isoform 2.
sequence variant  In dbSNP:rs34560878.

Uniprot

H9JEU8 A0A2W1BKX4 A0A2H1W9F8 A0A3S2N4T6 A0A194QR38 A0A194QCX4 + More
A0A212EIY4 A0A2A4JBL4 A0A2H1VY23 A0A194QIT8 A0A212ES85 A0A139WAW8 A0A067RJ29 A0A0N1IQ10 A0A1W4X5I9 A0A2S2QMJ5 E0VZL8 A0A154PQH5 Q172E7 A0A2H8U085 A0A195F186 A0A195E6T8 A0A151IQE7 F4X6F8 A0A3B0JZE6 E2AMG6 A0A195B2Q9 A0A151XBZ8 B4J2N4 A0A026VYW8 B4PDW7 B4N490 A0A2A3EAU8 A0A088AER8 B3MA63 B4LG96 B4HAE2 Q2LZA0 A0A0Q9WI47 A0A158NGE5 A0A0M4F0F5 A0A1B6FNW2 A0A0M9A977 A0A336LRH4 A0A0C9QK20 A0A1D2NBQ4 A0A2P8XVA8 A0A0P4Y4T5 A0A0N8A3F6 A0A0P6DYQ7 A0A0P6HED9 T1HWJ8 A0A0P5DS43 A0A0P6C7J9 A0A0P5JPY0 H2YX51 Q92485 A0A2R9AWT9 J9NYQ3 A0A340XCA0 A0A383Z5Z0 A0A2J8JP43 B4DW34 A0A1U7U7J5 A0A3Q2NN50 S7PQU8 F7C9L5 G3RG15 K9IL01 A0A3Q7TVF7 L8IID3 G1QCT9 A6QQN6 A0A2B4RQL5 A0A3N0Y311 A0A3Q3G0E0 K7GCP6 A0A3Q2EAZ6 A0A0N7ZAS1 H2N8B7 A0A2Y9SVS0 A0A1U8DZB1 I3M4A5 G1T3N0 W5M6L3 H0XDL1

EC Number

3.1.4.-

Pubmed

19121390 28756777 26354079 22118469 18362917 19820115 + More
24845553 20566863 17510324 21719571 20798317 17994087 24508170 30249741 17550304 18057021 15632085 23185243 21347285 27289101 29403074 14702039 16710414 15489334 26095358 22722832 16341006 16136131 20431018 22398555 22751099 21993624 19393038 17381049

EMBL

BABH01023327 KZ150019 PZC74931.1 ODYU01007162 SOQ49700.1 RSAL01000531 + More
RVE41444.1 KQ461198 KPJ05996.1 KQ459185 KPJ03393.1 AGBW02014553 OWR41446.1 NWSH01002108 PCG69156.1 ODYU01005151 SOQ45727.1 KQ458714 KPJ05473.1 AGBW02012853 OWR44329.1 KQ971380 KYB25011.1 KK852603 KDR20460.1 KQ459930 KPJ19294.1 GGMS01009708 MBY78911.1 DS235853 EEB18824.1 KQ435040 KZC14166.1 CH477439 EAT40899.1 GFXV01008180 MBW19985.1 KQ981864 KYN34228.1 KQ979568 KYN20910.1 KQ976780 KYN08356.1 GL888818 EGI57918.1 OUUW01000012 SPP87455.1 GL440813 EFN65390.1 KQ976662 KYM78577.1 KQ982314 KYQ57884.1 CH916366 EDV96025.1 KK107681 QOIP01000006 EZA48054.1 RLU22212.1 CM000159 EDW93963.2 CH964095 EDW78964.2 KZ288301 PBC28838.1 CH902618 EDV39077.2 KPU77861.1 CH940647 EDW69404.2 CH479240 EDW37540.1 CH379069 EAL29608.3 KRT08182.1 KRF84365.1 KRF84366.1 KRF84367.1 ADTU01014853 ADTU01014854 ADTU01014855 CP012525 ALC44232.1 GECZ01023204 GECZ01017909 JAS46565.1 JAS51860.1 KQ435710 KOX79790.1 UFQS01000091 UFQT01000091 SSW99169.1 SSX19551.1 GBYB01000952 JAG70719.1 LJIJ01000099 ODN02678.1 PYGN01001292 PSN35949.1 GDIP01233722 JAI89679.1 GDIP01186289 LRGB01000966 JAJ37113.1 KZS14351.1 GDIQ01072105 JAN22632.1 GDIQ01021143 JAN73594.1 ACPB03013302 ACPB03013303 GDIP01158300 JAJ65102.1 GDIP01007721 JAM95994.1 GDIQ01195648 JAK56077.1 Y08134 AK316500 AL512288 CH471059 BC014444 AJFE02099117 AJFE02099118 AJFE02099119 AAEX03000411 AACZ04072219 NBAG03000438 PNI24533.1 AK301349 BAG62896.1 KE163683 EPQ13238.1 AAMC01091905 AAMC01091906 CABD030001953 CABD030001954 GABZ01005998 JAA47527.1 JH881135 ELR56305.1 AAPE02033945 AAPE02033946 BC149924 AAI49925.1 LSMT01000400 PFX18637.1 RJVU01053528 ROL33021.1 AGCU01165217 AGCU01165218 GDRN01094955 GDRN01094951 JAI59632.1 ABGA01202045 ABGA01202046 ABGA01202047 ABGA01202048 ABGA01202049 ABGA01365269 ABGA01365270 AGTP01007884 AGTP01007885 AGTP01007886 AAGW02062808 AHAT01009518 AAQR03155980

Proteomes

UP000005204 UP000283053 UP000053240 UP000053268 UP000007151 UP000218220 + More
UP000007266 UP000027135 UP000192223 UP000009046 UP000076502 UP000008820 UP000078541 UP000078492 UP000078542 UP000007755 UP000268350 UP000000311 UP000078540 UP000075809 UP000001070 UP000053097 UP000279307 UP000002282 UP000007798 UP000242457 UP000005203 UP000007801 UP000008792 UP000008744 UP000001819 UP000005205 UP000092553 UP000053105 UP000094527 UP000245037 UP000076858 UP000015103 UP000007875 UP000005640 UP000240080 UP000002254 UP000265300 UP000261681 UP000002277 UP000189704 UP000265000 UP000008143 UP000001519 UP000286640 UP000001074 UP000009136 UP000225706 UP000264800 UP000007267 UP000265020 UP000001595 UP000248484 UP000189705 UP000005215 UP000001811 UP000018468 UP000005225

PRIDE

H9JEU8 Q92485 J9NYQ3 B4DW34

Pfam

PF00149 Metallophos

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR029052   Metallo-depent_PP-like
IPR042283   GpdQ_catalytic
IPR042281   GpdQ_beta-strand
IPR041805   ASMase/PPN1_MPP
IPR017064   ASM-like_Pdiesterase_prd

Gene 3D

3.60.21.10 3.30.750.180 3.60.21.40

CDD

cd00842 MPP_ASMase

ProteinModelPortal

H9JEU8 A0A2W1BKX4 A0A2H1W9F8 A0A3S2N4T6 A0A194QR38 A0A194QCX4 + More
A0A212EIY4 A0A2A4JBL4 A0A2H1VY23 A0A194QIT8 A0A212ES85 A0A139WAW8 A0A067RJ29 A0A0N1IQ10 A0A1W4X5I9 A0A2S2QMJ5 E0VZL8 A0A154PQH5 Q172E7 A0A2H8U085 A0A195F186 A0A195E6T8 A0A151IQE7 F4X6F8 A0A3B0JZE6 E2AMG6 A0A195B2Q9 A0A151XBZ8 B4J2N4 A0A026VYW8 B4PDW7 B4N490 A0A2A3EAU8 A0A088AER8 B3MA63 B4LG96 B4HAE2 Q2LZA0 A0A0Q9WI47 A0A158NGE5 A0A0M4F0F5 A0A1B6FNW2 A0A0M9A977 A0A336LRH4 A0A0C9QK20 A0A1D2NBQ4 A0A2P8XVA8 A0A0P4Y4T5 A0A0N8A3F6 A0A0P6DYQ7 A0A0P6HED9 T1HWJ8 A0A0P5DS43 A0A0P6C7J9 A0A0P5JPY0 H2YX51 Q92485 A0A2R9AWT9 J9NYQ3 A0A340XCA0 A0A383Z5Z0 A0A2J8JP43 B4DW34 A0A1U7U7J5 A0A3Q2NN50 S7PQU8 F7C9L5 G3RG15 K9IL01 A0A3Q7TVF7 L8IID3 G1QCT9 A6QQN6 A0A2B4RQL5 A0A3N0Y311 A0A3Q3G0E0 K7GCP6 A0A3Q2EAZ6 A0A0N7ZAS1 H2N8B7 A0A2Y9SVS0 A0A1U8DZB1 I3M4A5 G1T3N0 W5M6L3 H0XDL1

PDB

5EBE E-value=7.91003e-49, Score=490

KEGG

101742527 K01128 sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-] | (RefSeq) acid sphingomyelinase-lik

GO

GO:0016787 GO:0016021 GO:0005615 GO:0008081 GO:0006685 GO:0004767 GO:0046872 GO:0045087 GO:0050728 GO:0016798 GO:0034122 GO:0031225 GO:0070062 GO:0006954 GO:0046466 GO:0005886 GO:0008270 GO:0009143 GO:0016226 GO:0007156 GO:0005524 GO:0007166 GO:0006032 GO:0005515 GO:0016742 GO:0003824

Subcellular location

Secreted
Cell membrane

Length:

440

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.19457

Exp number, first 60 AAs:

0.01306

Total prob of N-in:

0.00417

outside

1 - 440

Pi

244.208074

Theta

182.255796

Tajima's D

0.533582

CLR

0.403522

CSRT

0.533523323833808

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics