Gene

KWMTBOMO04857

Pre Gene Modal

BGIBMGA008032

Annotation

PREDICTED:_uncharacterized_protein_LOC101742377_[Bombyx_mori]

Location

Bomo_Chr9(-):264857-273205      View in EpiBrowser

Full name

Juvenile hormone acid O-methyltransferase      

Alternative Name

Juvenile hormone acid methyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.138 Nuclear   Reliability : 2.322

CDS

ATGAACGATGACGCTGAACTGTATCGGAACAGTAGCAGTATGCAAAGGCGAGACGCTTTGAATTCGTTAACTGAATATTTACCTAAATTTAAATGGAAGGAAAGTAAAGAAAAGATTTTAGACATCGGTTGTGCTGACGGAAGTGTCACAAATATCATTAGCTCATGCTGTCCCACGGACTTTGAACTTTTTGAAGCGTGCGACGTGAACGTTAAATCTGTTAAATATGCTACGGAGCATTACGGAACCAGTAAGATGAGGTTCAGAGTCATGGATATAGAGAGTGACCTACCGAAGGAAATGAAAGGAAAGTTTGATCACGTCTTCTCATTTTACACGCTGCATTGGATCGAGAATCAAGAGAAAGCCTTTCAAAACATTTACGATCTCACGGCAGATGACGGTGAGTGCTTCCTAACCTTGCTGGCTCAAATGCCTGTCTTCAACTTATTTGATGCTCTCAAACACACTGAAAAATGGCGACATTGGCTCAGATACATCAAAAACTTTATCTCCCCATACTATGAGACTTCGGATCCAGATGTGGTGATAGAGTTACTACTTAAGAGAGTGGGTTTTCGTTACGTGGACGTGCGCTGTCGACAAAAGAAATTTGAATTTTACGACTTAAAATCATTTCGGAATCTACTAGAGGCGGTGAGTCCCTTCAAAGTAGGACAAGAGTTGCAGGAAGAATTAATCGATGACGTCATGGAAGTCGCAAAAGAAATGAGAATTATAGACACACAAAACAGCACAGCCAAACTTATATATAACCTAGTTGTTATACATTGTCGAAAATAA

Protein

MNDDAELYRNSSSMQRRDALNSLTEYLPKFKWKESKEKILDIGCADGSVTNIISSCCPTDFELFEACDVNVKSVKYATEHYGTSKMRFRVMDIESDLPKEMKGKFDHVFSFYTLHWIENQEKAFQNIYDLTADDGECFLTLLAQMPVFNLFDALKHTEKWRHWLRYIKNFISPYYETSDPDVVIELLLKRVGFRYVDVRCRQKKFEFYDLKSFRNLLEAVSPFKVGQELQEELIDDVMEVAKEMRIIDTQNSTAKLIYNLVVIHCRK

Description

O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:14530389). Also able to methylate farnesoate to methyl farnesoate (PubMed:14530389).
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:18549957). Also able to methylate farnesoate to methyl farnesoate (PubMed:18549957).

Catalytic Activity

(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine

Biophysicochemical Properties

3.32 uM for juvenile hormone III acid
0.18 uM for farnesoate

Similarity

Belongs to the methyltransferase superfamily.

Keywords

Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Juvenile hormone acid O-methyltransferase

Uniprot

H9JWV0   H9JLJ1   Q767F1   A0A194PH70   A0A194R0H9   A0A1P1ENW6   + More
A5LFV6   A0A173GZJ8   D2Y4U6   A0A2H1VCR6   A0A212F9H0   A5LFV5   Q1KN64   A0A2A4K0R4   A0A0R5ZNF1   A0A2H1VCN4   A0A2A4JYY3   A0A3S2M9U8   Q9U4Z8   A0A1W5ZM45   A0A0L7L836   A0A024BT15   A0A2J7RC57   A0A146IWP0   A0A1L2BNI6   A0A3S5X9D4   A0A0A1WN75   A0A2R4N6F4   B4MZR7   A0A034W1Z2   A0A1W4VSL6   A0A1W4VJN5   B3MUK9   T1GFV4   B4I231   A0A1I8MHL4   A0A3B0K301   B4G7P2   A0A0J9TPF7   Q29LS0   B4P880   A0A1A9Z807   Q9VJK8   B4KKK5   A0A1I8MHF6   B4LVM0   A0A1A9VCC9   A0A0L0C8K2   A0A0M3QU49   A0A0K8U8D4   A0A1A9XET3   A0A1B0BCZ1   A0A0K8TS48   A0A1B0G4E2   B3NNG6   R4IKD3   Q206L4   B4JZ63   E7EAU2   A0A0A7ERV5   A0A084VUE9   A0A075W3Z0   A0A182KF39   A0A182ILY4   A0A182PFZ1   A0A182M749   B2DCQ0   A0A1I8MED4   A0A1I8MGC1   A0A182T4X4   A0A1B0D0M7   A0A1B3PDM2   A0A1I8PV71   A0A182HNS9   Q7Q9F0   A0A146J3Z5   A0A346D9Y3   A0A1B3PD94   A0A0P5UJX1   C6KTH2   A0A0P6GX36   A0A0P4ZT02   A0A1J0I2X3   A0A182YBZ0   A0A2M4BW66   A0A182WMH0   A0A0P6AGH7   A0A0K8W5Y7   T1IRK8   A0A2P1AAW4   A0A2M4BWC8   W8BZU3   A0A2M4BVZ2   A0A182RP42   A0A1I8NU96   A0A2C9DK13   A0A182X8H7  

EC Number

2.1.1.325

Pubmed

19121390    14530389    26354079    22118469    18839418    10620045    + More
28382786    26227816    25830018    17994087    25348373    25315136    22936249    15632085    17550304    18549957    10731132    12537572    12537569    26108605    26369729    23499946    17510324    21195178    25101838    24438588    18435763    18362917    19820115    12364791    14747013    17210077    26894583    21292972    25721056    25244985    29136191    24495485    28536442   

EMBL

BABH01018740    BABH01005671    AB113578    JN851817    KQ459603    KPI92751.1    + More
KQ460883    KPJ11207.1    BABH01005674    AB127945    BAF63630.1    KX289532    ANI21405.1    GU323798    ADA83703.1    ODYU01001839    SOQ38586.1    AGBW02009587    OWR50378.1    AB127944    BAF63629.1    DQ465408    ABE98256.1    NWSH01000345    PCG77232.1    KM926339    AJR27469.1    SOQ38587.1    PCG77231.1    RSAL01000003    RVE54742.1    AF117590    AAF16712.1    KY421777    ARI71313.1    JTDY01002391    KOB71509.1    KJ188030    AHZ20738.1    NEVH01005887    PNF38426.1    LC049616    BAU78328.1    KU159280    ALT10380.1    KT869353    ALO17567.1    GBXI01014449    JAC99842.1    MG269999    AVX28147.1    CH963920    EDW77852.1    GAKP01009356    JAC49596.1    CH902624    EDV33538.1    CAQQ02017873    CAQQ02017874    CAQQ02017875    CAQQ02017876    CAQQ02017877    CAQQ02017878    CH480820    EDW54588.1    OUUW01000004    SPP79391.1    CH479180    EDW29313.1    CM002910    KMY90515.1    CH379060    EAL33975.2    CM000158    EDW90127.1    AB113579    AE014134    AY075194    CH933807    EDW11655.1    CH940649    EDW64414.1    JRES01000751    KNC28768.1    CP012523    ALC40009.1    GDHF01029498    JAI22816.1    JXJN01012210    GDAI01000627    JAI16976.1    CCAG010005611    CH954179    EDV56617.1    JX291120    AFQ01089.1    DQ409061    CH477383    ABD65474.1    EAT42177.1    CH916379    EDV94172.1    HQ634702    ADV17350.1    KJ200310    AIY69118.1    ATLV01016737    KE525103    KFB41593.1    KM212828    AIG94926.1    AXCM01012846    AB360763    KQ971338    BAG30999.1    EFA02917.1    AJVK01009988    KU660028    AOG17826.1    APCN01002761    AAAB01008900    EAA09331.1    LC055463    BAU79434.1    MH176615    AXM43874.1    KU659901    AOG17700.1    GDIP01111856    JAL91858.1    AB222845    GL732523    BAH86593.1    EFX90188.1    GDIQ01027709    JAN67028.1    GDIP01208327    JAJ15075.1    KT947473    APC62652.1    GGFJ01008101    MBW57242.1    GDIP01031053    JAM72662.1    GDHF01005837    JAI46477.1    JH431370    MF197905    QKKF02019844    AVI10246.1    RZF39563.1    GGFJ01008100    MBW57241.1    GAMC01001658    JAC04898.1    GGFJ01008104    MBW57245.1    KX880373    ARE68679.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000218220    UP000283053    + More
UP000037510    UP000235965    UP000007798    UP000192221    UP000007801    UP000015102    UP000001292    UP000095301    UP000268350    UP000008744    UP000001819    UP000002282    UP000092445    UP000000803    UP000009192    UP000008792    UP000078200    UP000037069    UP000092553    UP000092443    UP000092460    UP000092444    UP000008711    UP000008820    UP000001070    UP000030765    UP000079169    UP000075881    UP000075880    UP000075885    UP000075883    UP000007266    UP000075901    UP000092462    UP000095300    UP000075840    UP000007062    UP000000305    UP000076408    UP000075920    UP000291343    UP000075900    UP000076407   

PRIDE

H9JWV0    H9JLJ1    Q767F1    Q9VJK8   

Pfam

PF13847   Methyltransf_31        + More
PF13649   Methyltransf_25
PF08241   Methyltransf_11
PF08242   Methyltransf_12
PF00071   Ras

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR025714   Methyltranfer_dom       
IPR041698   Methyltransf_25       
IPR013216   Methyltransf_11       
IPR013217   Methyltransf_12       
IPR037872   Rab3       
IPR005225   Small_GTP-bd_dom       
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       

SUPFAM

SSF53335   SSF53335        + More
SSF52540   SSF52540       

CDD

cd01865  Rab3

ProteinModelPortal

H9JWV0   H9JLJ1   Q767F1   A0A194PH70   A0A194R0H9   A0A1P1ENW6   + More
A5LFV6   A0A173GZJ8   D2Y4U6   A0A2H1VCR6   A0A212F9H0   A5LFV5   Q1KN64   A0A2A4K0R4   A0A0R5ZNF1   A0A2H1VCN4   A0A2A4JYY3   A0A3S2M9U8   Q9U4Z8   A0A1W5ZM45   A0A0L7L836   A0A024BT15   A0A2J7RC57   A0A146IWP0   A0A1L2BNI6   A0A3S5X9D4   A0A0A1WN75   A0A2R4N6F4   B4MZR7   A0A034W1Z2   A0A1W4VSL6   A0A1W4VJN5   B3MUK9   T1GFV4   B4I231   A0A1I8MHL4   A0A3B0K301   B4G7P2   A0A0J9TPF7   Q29LS0   B4P880   A0A1A9Z807   Q9VJK8   B4KKK5   A0A1I8MHF6   B4LVM0   A0A1A9VCC9   A0A0L0C8K2   A0A0M3QU49   A0A0K8U8D4   A0A1A9XET3   A0A1B0BCZ1   A0A0K8TS48   A0A1B0G4E2   B3NNG6   R4IKD3   Q206L4   B4JZ63   E7EAU2   A0A0A7ERV5   A0A084VUE9   A0A075W3Z0   A0A182KF39   A0A182ILY4   A0A182PFZ1   A0A182M749   B2DCQ0   A0A1I8MED4   A0A1I8MGC1   A0A182T4X4   A0A1B0D0M7   A0A1B3PDM2   A0A1I8PV71   A0A182HNS9   Q7Q9F0   A0A146J3Z5   A0A346D9Y3   A0A1B3PD94   A0A0P5UJX1   C6KTH2   A0A0P6GX36   A0A0P4ZT02   A0A1J0I2X3   A0A182YBZ0   A0A2M4BW66   A0A182WMH0   A0A0P6AGH7   A0A0K8W5Y7   T1IRK8   A0A2P1AAW4   A0A2M4BWC8   W8BZU3   A0A2M4BVZ2   A0A182RP42   A0A1I8NU96   A0A2C9DK13   A0A182X8H7  

PDB

3MGG     E-value=0.0140845,     Score=88

KEGG

101742377    K10718 juvenile hormone-III synthase [EC:2.1.1.325] | (RefSeq) uncharacterized LOC101742377

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006718   GO:0035049   GO:0032259   GO:0019010   GO:0008168   GO:0016740   GO:0008049   GO:0003924   GO:0005525   GO:0016021  

Length:

267

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00676

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.11661

outside

1  -  267

 

 

Pi

187.977487

Theta

183.178035

Tajima's D

0.746918

CLR

0.00473

CSRT

0.587170641467927

Interpretation

Uncertain