Pre Gene Modal
BGIBMGA008038
Annotation
peptidoglycan_recognition_protein_precursor_[Bombyx_mori]
Full name
Peptidoglycan-recognition protein
+ More
Peptidoglycan recognition protein
Peptidoglycan-recognition protein SA
Peptidoglycan recognition protein
Peptidoglycan-recognition protein SA
Alternative Name
Protein semmelweis
Location in the cell
Extracellular Reliability : 2.131
Sequence
CDS
ATGAGGGTCGCGAGAGTGTGGGCCGCATGCCGCGTGCTGACGTGCTGGCACGCGCCGCTCCTCGACATGGCCCGCCTCCACTCGGCAGTTGTACTCGCGCTCGCTCTCAGCTCGCTTCTCACAGAAATAGCAGCCGATTGCGACGTCGTCAGTAAAAAGCAATGGGACGGTTTGATCCCGGTGCACGTGTCGTACCTGGCGCGGCCCGTGAGCCTCGTCATCGTCCAGCACACAGTCACACCCTTCTGCAGGACGGACGCTGGCTGCGAGGAGCTCGTGCGGAATATCCAGACCAACCACATGGAGGCCTTGCAATACTGGGACATCGGACCCTCGTTCCTGGTGGGAGGTAACGGCAAGGTGTACGAGGGCTCCGGCTGGCTGCACGTCGGCGCGCACACCTACGGGTACAACTCGAGGTCCATCGGAGTCGCATTCATCGGCAACTTCAACACGGACGAGCCGAGCGGCGCGATGCTGGAGGCGCTGCGGTCGCTGCTGCGCTGCGGCGTGGAGCGCGGCCACCTCGCGGGGGACTACCGCGTCGTGGCGCACCGACAGCTCATTGCCTCTGAGAGCCCCGGCCGGAAGCTCTACAACCAGATACGACGCTGGCCTGAGTGGCTGGAGAACGTGGACTCCATCAAGAACGCGTAA
Protein
MRVARVWAACRVLTCWHAPLLDMARLHSAVVLALALSSLLTEIAADCDVVSKKQWDGLIPVHVSYLARPVSLVIVQHTVTPFCRTDAGCEELVRNIQTNHMEALQYWDIGPSFLVGGNGKVYEGSGWLHVGAHTYGYNSRSIGVAFIGNFNTDEPSGAMLEALRSLLRCGVERGHLAGDYRVVAHRQLIASESPGRKLYNQIRRWPEWLENVDSIKNA
Summary
Description
Binds specifically to peptidoglycan and triggers the propenoloxidase cascade which is an important insect defense mechanism.
Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).
Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).
Catalytic Activity
H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl
Biophysicochemical Properties
21.4 uM for GlcNAc-MurNAc(anhydro)-L-Ala-gamma-D-Glu-meso-DAP-D-Ala
Subunit
Monomer.
Similarity
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Keywords
Complete proteome
Direct protein sequencing
Disulfide bond
Immunity
Innate immunity
Reference proteome
Signal
3D-structure
Hydrolase
Protease
Secreted
Feature
chain Peptidoglycan-recognition protein
Uniprot
H9JEU1
Q9XTN0
A0A2W1BLP2
W8JAI9
A0A2A4IX89
A0A194QM25
+ More
I4DNW9 O76537 Q0Q026 B2CZ95 A0A194QFH8 A0A2I6B3J1 B7SFX0 D2CNK4 A0A212FB31 A0A125S9Y2 Q0KKW5 E5D600 Q0Q025 Q86D95 Q86RS6 A0A346RAC4 A0JCK5 O97369 A0A1W4XAW5 A0A2W1BT81 A0A194QJS3 A0A2H1WXQ3 A0A194QKT5 E2BUB1 A0A346RAC5 A0A194QR53 A0A0U3SX80 A0A1Y1M729 A0A154PIJ2 D7ELY4 H8YU85 A0A212ESF3 A0A1A9W1I3 B4JXA3 A0A1B0G8B0 A0A1A9VBQ1 A0A195FQQ2 A0A0M3QYU6 N6T3G6 U5EYY5 U4UEM8 A0A067R4L8 A0A0F6S9Z9 A0A1A9Z640 A0A2P8YB58 A0A1A9XXQ5 A0A0C9QKJ8 B4R346 A0A088AJM6 B4MAP1 B3NUC2 A0A195C4A0 B3MY97 A0A1I8NR01 X2JEI8 Q9VYX7 A0A158NJR8 B4PY99 A0A195ELR0 E2A975 A0A195B5L9 F4WCD8 A0A232EPL5 A0A1W4UNB6 A0A151XJR7 B4KMX7 E9J784 K7J8A5 A0A0S2GL43 Q29IN1 B4H2R6 A0A0L0BNN8 B4L734 A0A0L0BNT7 D9J147 A0A1W4XFA2 A0A0L0BNW2 Q28Y58 Q8WSZ1 A0A182YQ46 M1HIP9 A0A026WT18 A0A0L0CNU3 H9JEP0 A0A3B0KUJ9 A0A1J0M178 A0A1I8Q988 A0A3B0J0B1 W6EL05 B4J8L9
I4DNW9 O76537 Q0Q026 B2CZ95 A0A194QFH8 A0A2I6B3J1 B7SFX0 D2CNK4 A0A212FB31 A0A125S9Y2 Q0KKW5 E5D600 Q0Q025 Q86D95 Q86RS6 A0A346RAC4 A0JCK5 O97369 A0A1W4XAW5 A0A2W1BT81 A0A194QJS3 A0A2H1WXQ3 A0A194QKT5 E2BUB1 A0A346RAC5 A0A194QR53 A0A0U3SX80 A0A1Y1M729 A0A154PIJ2 D7ELY4 H8YU85 A0A212ESF3 A0A1A9W1I3 B4JXA3 A0A1B0G8B0 A0A1A9VBQ1 A0A195FQQ2 A0A0M3QYU6 N6T3G6 U5EYY5 U4UEM8 A0A067R4L8 A0A0F6S9Z9 A0A1A9Z640 A0A2P8YB58 A0A1A9XXQ5 A0A0C9QKJ8 B4R346 A0A088AJM6 B4MAP1 B3NUC2 A0A195C4A0 B3MY97 A0A1I8NR01 X2JEI8 Q9VYX7 A0A158NJR8 B4PY99 A0A195ELR0 E2A975 A0A195B5L9 F4WCD8 A0A232EPL5 A0A1W4UNB6 A0A151XJR7 B4KMX7 E9J784 K7J8A5 A0A0S2GL43 Q29IN1 B4H2R6 A0A0L0BNN8 B4L734 A0A0L0BNT7 D9J147 A0A1W4XFA2 A0A0L0BNW2 Q28Y58 Q8WSZ1 A0A182YQ46 M1HIP9 A0A026WT18 A0A0L0CNU3 H9JEP0 A0A3B0KUJ9 A0A1J0M178 A0A1I8Q988 A0A3B0J0B1 W6EL05 B4J8L9
EC Number
3.4.17.13
Pubmed
19121390
10207004
8662762
28756777
26354079
22651552
+ More
9707603 16857061 22118469 17434328 12225919 16640722 29910977 9755476 20798317 26694822 28004739 18362917 19820115 17994087 23537049 24845553 29403074 29396863 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 11106397 14738318 12537569 11742401 12032070 14684822 14722090 15448690 16399077 15223330 15361936 21347285 17550304 21719571 28648823 21282665 20075255 26549814 15632085 26108605 20542901 25244985 24508170 25797797
9707603 16857061 22118469 17434328 12225919 16640722 29910977 9755476 20798317 26694822 28004739 18362917 19820115 17994087 23537049 24845553 29403074 29396863 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 11106397 14738318 12537569 11742401 12032070 14684822 14722090 15448690 16399077 15223330 15361936 21347285 17550304 21719571 28648823 21282665 20075255 26549814 15632085 26108605 20542901 25244985 24508170 25797797
EMBL
BABH01023291
AB016605
AB016249
KZ149974
PZC75969.1
KF954940
+ More
AHK59818.1 NWSH01005638 PCG64086.1 KQ461198 KPJ06010.1 AK403178 BAM19609.1 AF076481 DQ666505 ABG72708.1 EU557313 ACB45568.1 KQ459144 KPJ03700.1 MG570190 AUI41055.1 EU289210 ABZ81267.1 EU399240 ACB32179.1 AGBW02009391 OWR50928.1 KT725231 AME17978.1 AB232695 BAF03522.1 GU182905 ADR51143.1 DQ666506 ABG72709.1 AF413068 AAO21509.1 AF413061 AAO21502.1 MH200914 AXS59124.1 AB282643 BAF36823.1 AF035445 AAD02029.1 PZC75970.1 KPJ03701.1 ODYU01011865 SOQ57853.1 KPJ06009.1 GL450619 EFN80739.1 MH200915 AXS59125.1 KPJ06011.1 KU218682 ALX00062.1 GEZM01038634 JAV81582.1 KQ434924 KZC11632.1 DS497945 EFA12467.1 JF915527 AFD54029.1 AGBW02012798 OWR44425.1 CH916376 EDV95379.1 CCAG010000228 KQ981305 KYN42798.1 CP012528 ALC48229.1 APGK01053980 KB741240 ENN72103.1 GANO01001737 JAB58134.1 KB632257 ERL90793.1 KK852704 KDR18042.1 KP261086 AKE92867.1 PYGN01000736 PSN41492.1 GBYB01004084 JAG73851.1 CM000366 EDX17648.1 CH940655 EDW66300.1 CH954180 EDV46037.2 KQ978292 KYM95445.1 CH902632 EDV32591.1 AE014298 AHN59598.1 AF207540 AF207541 AJ556551 AJ556552 AJ556553 AJ556554 AJ556555 AJ556556 AJ556557 AJ556558 AJ556559 AJ556560 AJ556561 AY075293 ADTU01001951 CM000162 EDX01961.1 KQ978739 KYN28814.1 GL437711 EFN70060.1 KQ976582 KYM79781.1 GL888070 EGI68118.1 NNAY01002929 OXU20278.1 KQ982052 KYQ60662.1 CH933808 EDW09899.1 GL768424 EFZ11322.1 KT390717 ALN97024.1 CH379063 EAL32622.2 CH479204 EDW30633.1 JRES01001589 KNC21662.1 CH933812 EDW06180.1 KNC21676.1 HM243543 ADI87391.1 KNC21658.1 CM000071 EAL26107.2 AF441723 AAL32058.1 KC161204 AGE46001.1 KK107119 EZA58826.1 JRES01000125 KNC33995.1 BABH01023631 OUUW01000021 SPP89506.1 KX342009 APD13821.1 OUUW01000001 SPP74324.1 KF906541 AHJ11178.1 CH916367 EDW01286.1
AHK59818.1 NWSH01005638 PCG64086.1 KQ461198 KPJ06010.1 AK403178 BAM19609.1 AF076481 DQ666505 ABG72708.1 EU557313 ACB45568.1 KQ459144 KPJ03700.1 MG570190 AUI41055.1 EU289210 ABZ81267.1 EU399240 ACB32179.1 AGBW02009391 OWR50928.1 KT725231 AME17978.1 AB232695 BAF03522.1 GU182905 ADR51143.1 DQ666506 ABG72709.1 AF413068 AAO21509.1 AF413061 AAO21502.1 MH200914 AXS59124.1 AB282643 BAF36823.1 AF035445 AAD02029.1 PZC75970.1 KPJ03701.1 ODYU01011865 SOQ57853.1 KPJ06009.1 GL450619 EFN80739.1 MH200915 AXS59125.1 KPJ06011.1 KU218682 ALX00062.1 GEZM01038634 JAV81582.1 KQ434924 KZC11632.1 DS497945 EFA12467.1 JF915527 AFD54029.1 AGBW02012798 OWR44425.1 CH916376 EDV95379.1 CCAG010000228 KQ981305 KYN42798.1 CP012528 ALC48229.1 APGK01053980 KB741240 ENN72103.1 GANO01001737 JAB58134.1 KB632257 ERL90793.1 KK852704 KDR18042.1 KP261086 AKE92867.1 PYGN01000736 PSN41492.1 GBYB01004084 JAG73851.1 CM000366 EDX17648.1 CH940655 EDW66300.1 CH954180 EDV46037.2 KQ978292 KYM95445.1 CH902632 EDV32591.1 AE014298 AHN59598.1 AF207540 AF207541 AJ556551 AJ556552 AJ556553 AJ556554 AJ556555 AJ556556 AJ556557 AJ556558 AJ556559 AJ556560 AJ556561 AY075293 ADTU01001951 CM000162 EDX01961.1 KQ978739 KYN28814.1 GL437711 EFN70060.1 KQ976582 KYM79781.1 GL888070 EGI68118.1 NNAY01002929 OXU20278.1 KQ982052 KYQ60662.1 CH933808 EDW09899.1 GL768424 EFZ11322.1 KT390717 ALN97024.1 CH379063 EAL32622.2 CH479204 EDW30633.1 JRES01001589 KNC21662.1 CH933812 EDW06180.1 KNC21676.1 HM243543 ADI87391.1 KNC21658.1 CM000071 EAL26107.2 AF441723 AAL32058.1 KC161204 AGE46001.1 KK107119 EZA58826.1 JRES01000125 KNC33995.1 BABH01023631 OUUW01000021 SPP89506.1 KX342009 APD13821.1 OUUW01000001 SPP74324.1 KF906541 AHJ11178.1 CH916367 EDW01286.1
Proteomes
UP000005204
UP000218220
UP000053240
UP000053268
UP000007151
UP000192223
+ More
UP000008237 UP000076502 UP000007266 UP000091820 UP000001070 UP000092444 UP000078200 UP000078541 UP000092553 UP000019118 UP000030742 UP000027135 UP000092445 UP000245037 UP000092443 UP000000304 UP000005203 UP000008792 UP000008711 UP000078542 UP000007801 UP000095300 UP000000803 UP000005205 UP000002282 UP000078492 UP000000311 UP000078540 UP000007755 UP000215335 UP000192221 UP000075809 UP000009192 UP000002358 UP000001819 UP000008744 UP000037069 UP000076408 UP000053097 UP000268350
UP000008237 UP000076502 UP000007266 UP000091820 UP000001070 UP000092444 UP000078200 UP000078541 UP000092553 UP000019118 UP000030742 UP000027135 UP000092445 UP000245037 UP000092443 UP000000304 UP000005203 UP000008792 UP000008711 UP000078542 UP000007801 UP000095300 UP000000803 UP000005205 UP000002282 UP000078492 UP000000311 UP000078540 UP000007755 UP000215335 UP000192221 UP000075809 UP000009192 UP000002358 UP000001819 UP000008744 UP000037069 UP000076408 UP000053097 UP000268350
Pfam
PF01510 Amidase_2
Interpro
SUPFAM
SSF55846
SSF55846
Gene 3D
CDD
ProteinModelPortal
H9JEU1
Q9XTN0
A0A2W1BLP2
W8JAI9
A0A2A4IX89
A0A194QM25
+ More
I4DNW9 O76537 Q0Q026 B2CZ95 A0A194QFH8 A0A2I6B3J1 B7SFX0 D2CNK4 A0A212FB31 A0A125S9Y2 Q0KKW5 E5D600 Q0Q025 Q86D95 Q86RS6 A0A346RAC4 A0JCK5 O97369 A0A1W4XAW5 A0A2W1BT81 A0A194QJS3 A0A2H1WXQ3 A0A194QKT5 E2BUB1 A0A346RAC5 A0A194QR53 A0A0U3SX80 A0A1Y1M729 A0A154PIJ2 D7ELY4 H8YU85 A0A212ESF3 A0A1A9W1I3 B4JXA3 A0A1B0G8B0 A0A1A9VBQ1 A0A195FQQ2 A0A0M3QYU6 N6T3G6 U5EYY5 U4UEM8 A0A067R4L8 A0A0F6S9Z9 A0A1A9Z640 A0A2P8YB58 A0A1A9XXQ5 A0A0C9QKJ8 B4R346 A0A088AJM6 B4MAP1 B3NUC2 A0A195C4A0 B3MY97 A0A1I8NR01 X2JEI8 Q9VYX7 A0A158NJR8 B4PY99 A0A195ELR0 E2A975 A0A195B5L9 F4WCD8 A0A232EPL5 A0A1W4UNB6 A0A151XJR7 B4KMX7 E9J784 K7J8A5 A0A0S2GL43 Q29IN1 B4H2R6 A0A0L0BNN8 B4L734 A0A0L0BNT7 D9J147 A0A1W4XFA2 A0A0L0BNW2 Q28Y58 Q8WSZ1 A0A182YQ46 M1HIP9 A0A026WT18 A0A0L0CNU3 H9JEP0 A0A3B0KUJ9 A0A1J0M178 A0A1I8Q988 A0A3B0J0B1 W6EL05 B4J8L9
I4DNW9 O76537 Q0Q026 B2CZ95 A0A194QFH8 A0A2I6B3J1 B7SFX0 D2CNK4 A0A212FB31 A0A125S9Y2 Q0KKW5 E5D600 Q0Q025 Q86D95 Q86RS6 A0A346RAC4 A0JCK5 O97369 A0A1W4XAW5 A0A2W1BT81 A0A194QJS3 A0A2H1WXQ3 A0A194QKT5 E2BUB1 A0A346RAC5 A0A194QR53 A0A0U3SX80 A0A1Y1M729 A0A154PIJ2 D7ELY4 H8YU85 A0A212ESF3 A0A1A9W1I3 B4JXA3 A0A1B0G8B0 A0A1A9VBQ1 A0A195FQQ2 A0A0M3QYU6 N6T3G6 U5EYY5 U4UEM8 A0A067R4L8 A0A0F6S9Z9 A0A1A9Z640 A0A2P8YB58 A0A1A9XXQ5 A0A0C9QKJ8 B4R346 A0A088AJM6 B4MAP1 B3NUC2 A0A195C4A0 B3MY97 A0A1I8NR01 X2JEI8 Q9VYX7 A0A158NJR8 B4PY99 A0A195ELR0 E2A975 A0A195B5L9 F4WCD8 A0A232EPL5 A0A1W4UNB6 A0A151XJR7 B4KMX7 E9J784 K7J8A5 A0A0S2GL43 Q29IN1 B4H2R6 A0A0L0BNN8 B4L734 A0A0L0BNT7 D9J147 A0A1W4XFA2 A0A0L0BNW2 Q28Y58 Q8WSZ1 A0A182YQ46 M1HIP9 A0A026WT18 A0A0L0CNU3 H9JEP0 A0A3B0KUJ9 A0A1J0M178 A0A1I8Q988 A0A3B0J0B1 W6EL05 B4J8L9
PDB
6CKH
E-value=1.22405e-62,
Score=605
Ontologies
GO
PANTHER
Topology
Subcellular location
Secreted
SignalP
Position: 1 - 45,
Likelihood: 0.747258
Length:
218
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.49915
Exp number, first 60 AAs:
1.39749
Total prob of N-in:
0.30047
outside
1 - 218
Population Genetic Test Statistics
Pi
184.940188
Theta
149.285835
Tajima's D
0.750762
CLR
0.289526
CSRT
0.586270686465677
Interpretation
Uncertain
