Gene

KWMTBOMO04821  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009830

Annotation

eukaryotic_translation_initiation_factor_6_[Bombyx_mori]

Location

Bomo_Chr8(-):15870509-15871371      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 6      

Location in the cell

Cytoplasmic   Reliability : 1.716

CDS

ATGGCGGTTCGCGTTCAATTTGAAAATAATAATGAAGTGGGAGTGTTCAGTAAATTAACAAACACATACTGCCTTGTCGCGATTGGAGGTTCGGAGAATTTTTACAGCGTGTTCGAAGCTGAATTAGCGGAGACCATCCCAGTGATACATGCGAGTGTTGGAGGCTGCCGAATCATCGGTAGAATGACCGTAGGGAACAAGAACGGTCTCTTAGTTCCATCTTCGACCACGGACACAGAATTACAACACATTAGAAACAGTCTGCCGGAGAACGTGAAATTACAACGCGTGGAGGAACGGCTTAGTGCCCTCGGTAACGTCATAGCCTGTAACGACTATGTAGCACTTGTACATCCTGACTTAGACAAAGACACAGAAGAAATATTAGCCGACACATTAAACGTGGAAGTATTCAGACAAACAATAGCGGGAAACGTACTTGTTGGTTCTTACACTGCATTGAGCAACCGAGGAGGGCTGGTACACCCGAAGACAAATATACAGGACCAGGATGAACTCTCTTCGCTACTCCAAGTGCCCTTAGTTGCCGGAACAGTTAACAGAGGCAGTGATGTCGTAGCTGCTGGAATGGTGGTCAACGATTGGTGTGCATTCTGCGGACTGGACACAACGTCAACTGAGATTTCTGTTATTGAGAGTGTTTTCAAATTAAATGATGCTAAACCGACTGCAATCACATCTACAATGAGAGCATCGCTCATTGACAGTATGTCATAA

Protein

MAVRVQFENNNEVGVFSKLTNTYCLVAIGGSENFYSVFEAELAETIPVIHASVGGCRIIGRMTVGNKNGLLVPSSTTDTELQHIRNSLPENVKLQRVEERLSALGNVIACNDYVALVHPDLDKDTEEILADTLNVEVFRQTIAGNVLVGSYTALSNRGGLVHPKTNIQDQDELSSLLQVPLVAGTVNRGSDVVAAGMVVNDWCAFCGLDTTSTEISVIESVFKLNDAKPTAITSTMRASLIDSMS

Description

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.

Subunit

Monomer. Associates with the 60S ribosomal subunit.

Similarity

Belongs to the eIF-6 family.

Keywords

Cytoplasm   Initiation factor   Nucleus   Protein biosynthesis   Ribosome biogenesis  

Feature

chain  Eukaryotic translation initiation factor 6

Uniprot

Q1HQ59   A0A0L7LH40   A0S6A4   A0A212FEJ5   A0A1E1WBJ3   A0A2W1BHC2   + More
A0A2A4JS04   A0A194PSS3   A0A3S2NZ78   A0A194RD87   S4P457   A0A088A2P5   E0VVM1   A0A0V0G988   A0A2A3EH32   A0A1S4EIA4   A0A067QMJ9   K7IPC1   A0A0P4W221   R4G4M6   A0A224XV59   A0A023F9D2   E2BSI5   R4WJE1   A0A2R7W8G1   A0A023GGS0   A0A158NE26   A0A1B6DEM1   G3MMH3   A0A1B6G0I8   A0A1B6IX34   A0A023FXX0   A0A1E1XIB0   A0A131XI39   A0A224Z9Z6   A0A131Z3M0   L7M4J9   A0A023FGL5   A0A0C9S1Z6   A0A0K8TRQ2   A0A1B6K9R5   F4W519   A0A0A9YU28   A0A2P6LBR9   A0A195BQL5   A0A195F545   A0A151XED4   A0A151IF09   A0A0L7RB36   A0A087U4V8   A0A195D9U9   A0A2R5LF86   A0A131XUQ6   A0A026WZX9   A0A1Z5LHA1   H2LCJ9   A0A3P8WUI6   A0A3B5BCR8   E2AQP0   A0A3B4DSN8   A0A1Y1L5Y5   I5APZ0   A0A3Q3LQP7   A0A3B3BAX9   A0A0Q9XAB8   A0A0P8Y1K9   A0A3Q2PSI8   A0A1L8EDA3   A0A3P9JY68   E9J331   B4K0F6   A0A3Q0RLG6   A0A1A8EY25   A0A0M3QUM4   A0A1A7ZLU5   A0A3Q1J9L5   A0A3P8U4V6   A0A1I8MIU5   A0A1A8JQ36   A0A1A8CW35   A0A3B4XE96   A0A3B4V057   A0A1L8ES41   A0A2U9BEW4   A0A3B3QPR3   A0A3Q1CBD9   A0A293N4Q0   A0A3B1JW97   A0A1A8SIU3   A0A1A8MN39   A0A1A7X9K4   V5HK20   A0A3S2N4J7   Q6GR45   H2YS09   B4LIY3   A0A1I8PD35   A0A2I4BSR8   C1BL53   W5MM18  

Pubmed

19121390    26227816    22118469    28756777    26354079    23622113    + More
20566863    24845553    20075255    27129103    25474469    20798317    23691247    21347285    22216098    28503490    28049606    28797301    26830274    25576852    26131772    26369729    21719571    25401762    26823975    24508170    30249741    28528879    17554307    24487278    28004739    15632085    17994087    29451363    21282665    25315136    27762356    29240929    25329095    25765539    16425228   

EMBL

BABH01026740    DQ443193    ABF51282.1    JTDY01001166    KOB74674.1    DQ289585    + More
ODYU01006120    ABB92838.1    SOQ47692.1    AGBW02008930    OWR52161.1    GDQN01006739    JAT84315.1    KZ150126    PZC73105.1    NWSH01000742    PCG74468.1    KQ459595    KPI95809.1    RSAL01000018    RVE52872.1    KQ460367    KPJ15434.1    GAIX01006144    JAA86416.1    AAZO01005657    DS235812    EEB17427.1    GECL01001473    JAP04651.1    KZ288252    PBC31030.1    KK853149    KDR10668.1    GDKW01000929    JAI55666.1    GAHY01000641    JAA76869.1    GFTR01004044    JAW12382.1    GBBI01000722    JAC17990.1    GL450240    EFN81318.1    AK417640    BAN20855.1    KK854459    PTY16017.1    GBBM01002266    JAC33152.1    ADTU01012616    ADTU01012617    GEDC01013253    JAS24045.1    JO843074    AEO34691.1    GECZ01013811    JAS55958.1    GECU01016210    JAS91496.1    GBBL01001752    JAC25568.1    GFAC01000362    JAT98826.1    GEFH01002773    JAP65808.1    GFPF01012737    MAA23883.1    GEDV01002650    JAP85907.1    GACK01005783    JAA59251.1    GBBK01003456    JAC21026.1    GBZX01001801    JAG90939.1    GDAI01000561    JAI17042.1    GEBQ01031791    GEBQ01014878    JAT08186.1    JAT25099.1    GL887596    EGI70715.1    GBHO01008503    GBRD01010348    GDHC01018468    JAG35101.1    JAG55476.1    JAQ00161.1    MWRG01000475    PRD36025.1    KQ976424    KYM88256.1    KQ981820    KYN35194.1    KQ982254    KYQ58731.1    KQ977830    KYM99407.1    KQ414617    KOC68132.1    KK118176    KFM72397.1    KQ981082    KYN09658.1    GGLE01004067    MBY08193.1    GEFM01006495    JAP69301.1    KK107054    QOIP01000004    EZA61595.1    RLU23485.1    GFJQ02000432    JAW06538.1    GL441804    EFN64229.1    GEZM01066587    JAV67780.1    CM000071    EIM53025.1    CH933808    KRG05440.1    CH902619    KPU75685.1    GFDG01002167    JAV16632.1    GL768055    EFZ12818.1    CH916444    EDV95481.1    HAEB01004227    HAEC01013355    SBQ50754.1    CP012524    ALC40883.1    HADY01005327    HAEJ01006632    SBP43812.1    HAED01018135    HAEE01002203    SBR22223.1    HADZ01020071    HAEA01003468    SBP84012.1    CM004482    OCT62164.1    CP026248    AWP02349.1    GFWV01022662    MAA47389.1    HAEH01004523    HAEI01015673    SBS18142.1    HAEF01016685    HAEG01005974    SBR57844.1    HADW01013392    HADX01003783    SBP14792.1    GANP01006539    JAB77929.1    CM012441    RVE73357.1    AY383654    BC071088    CH940648    EDW60433.1    BT075332    ACO09756.1    AHAT01024190   

Proteomes

UP000005204    UP000037510    UP000007151    UP000218220    UP000053268    UP000283053    + More
UP000053240    UP000005203    UP000009046    UP000242457    UP000079169    UP000027135    UP000002358    UP000008237    UP000005205    UP000007755    UP000078540    UP000078541    UP000075809    UP000078542    UP000053825    UP000054359    UP000078492    UP000053097    UP000279307    UP000001038    UP000265120    UP000261400    UP000000311    UP000261440    UP000001819    UP000261640    UP000261560    UP000009192    UP000007801    UP000265000    UP000265180    UP000001070    UP000261340    UP000092553    UP000265040    UP000265080    UP000095301    UP000261360    UP000261420    UP000186698    UP000246464    UP000261540    UP000257160    UP000018467    UP000007875    UP000008792    UP000095300    UP000192220    UP000018468   

PRIDE

Q1HQ59    G3MMH3    L7M4J9    V5HK20   

Pfam

PF01912   eIF-6

Interpro

IPR002769   eIF6       

CDD

cd00527  IF6

ProteinModelPortal

Q1HQ59   A0A0L7LH40   A0S6A4   A0A212FEJ5   A0A1E1WBJ3   A0A2W1BHC2   + More
A0A2A4JS04   A0A194PSS3   A0A3S2NZ78   A0A194RD87   S4P457   A0A088A2P5   E0VVM1   A0A0V0G988   A0A2A3EH32   A0A1S4EIA4   A0A067QMJ9   K7IPC1   A0A0P4W221   R4G4M6   A0A224XV59   A0A023F9D2   E2BSI5   R4WJE1   A0A2R7W8G1   A0A023GGS0   A0A158NE26   A0A1B6DEM1   G3MMH3   A0A1B6G0I8   A0A1B6IX34   A0A023FXX0   A0A1E1XIB0   A0A131XI39   A0A224Z9Z6   A0A131Z3M0   L7M4J9   A0A023FGL5   A0A0C9S1Z6   A0A0K8TRQ2   A0A1B6K9R5   F4W519   A0A0A9YU28   A0A2P6LBR9   A0A195BQL5   A0A195F545   A0A151XED4   A0A151IF09   A0A0L7RB36   A0A087U4V8   A0A195D9U9   A0A2R5LF86   A0A131XUQ6   A0A026WZX9   A0A1Z5LHA1   H2LCJ9   A0A3P8WUI6   A0A3B5BCR8   E2AQP0   A0A3B4DSN8   A0A1Y1L5Y5   I5APZ0   A0A3Q3LQP7   A0A3B3BAX9   A0A0Q9XAB8   A0A0P8Y1K9   A0A3Q2PSI8   A0A1L8EDA3   A0A3P9JY68   E9J331   B4K0F6   A0A3Q0RLG6   A0A1A8EY25   A0A0M3QUM4   A0A1A7ZLU5   A0A3Q1J9L5   A0A3P8U4V6   A0A1I8MIU5   A0A1A8JQ36   A0A1A8CW35   A0A3B4XE96   A0A3B4V057   A0A1L8ES41   A0A2U9BEW4   A0A3B3QPR3   A0A3Q1CBD9   A0A293N4Q0   A0A3B1JW97   A0A1A8SIU3   A0A1A8MN39   A0A1A7X9K4   V5HK20   A0A3S2N4J7   Q6GR45   H2YS09   B4LIY3   A0A1I8PD35   A0A2I4BSR8   C1BL53   W5MM18  

PDB

5T62     E-value=3.20737e-101,     Score=938

KEGG

733105    K03264 translation initiation factor 6 | (RefSeq) eukaryotic translation initiation factor 6

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0042273   GO:0043023   GO:0042256   GO:0003743   GO:0005737   GO:0005730   GO:0043022   GO:1902626   GO:0000054   GO:0005829   GO:0030687   GO:0016020   GO:0007264   GO:0008083   GO:0006003   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR10784  

Subcellular location

Cytoplasm   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.
Nucleus   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.
Nucleolus   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.

Length:

245

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.33643

Exp number, first 60 AAs:

0.321

Total prob of N-in:

0.11876

outside

1  -  245

 

 

Pi

13.278972

Theta

12.867727

Tajima's D

0.130474

CLR

0

CSRT

0.408879556022199

Interpretation

Uncertain