Silkworm Genome Informatics Database

Gene

KWMTBOMO04815

Pre Gene Modal

BGIBMGA009917

Annotation

putative_histone_deacetylase_7A_[Danaus_plexippus]

Location

Bomo_Chr8(+):15724262-15799475 View in EpiBrowser

Full name

Histone deacetylase

Location in the cell

Nuclear Reliability : 2.599

CDS

ATGGCCCACGAGGGCCCAGCAAGGACGGAGGGCTCGCCCCACCACACGCCCTCGCCGCCCCACCTCCCTCACCTCCCAGTCACCGACTCCGGCTTCCATCATCAGATAATGCAGAATCACAGTCCAAGAAAGAATCATATCGTGGAGAGAGCCAAACAAACGTTAGAAAACTCTTTCCTGCAGCAATTGAAGAAGCAGCAACAGCTCCAACAGGAGATTCTACTGCAGCATTTCCAGCAGCAGAGGCAACAGTTGGCAAGAGAACACGAGAACCAGATGAGGGAACATTTGAAGTTATGGGAGCAACAGAAGAAAGCAATGGAGGAGGCAGCGTTGCGCGAGGCCCGAGAGGCGCGGGAGGCTCGGGAGGCCCGGGAGAGGCACGAGCGCGACCGCGTCGAGCTGATGCGGAAGAAGGATATACACGAACACAGCGCCAACGCGTCTACCCAAGTTAAACAGAAATTACAGGAGTTTATAAAAAAGAAACAGGCCAACGCCAATGGCACCGTGACGACTGCCTCCTACCGCAACTGGGGCATAGTGAAGTCTTCATCAGGGGAGTCGATAACGTCGACGGGGGCGACAGCGACGCACCCTTACCGGCTCACGGCGCCGCTGCCACTCAACCTCAACGCGCCCCCTCCGCAACCCTCCCCCGCAGACTACCCCCTGCGCAAGACCGCGTCGGAGCCCAACATGCTGAAGCAGCGGCTGAAAGCGCGCGTCATCGAACGCCGGGCCTCGCCCCTCGCGCGCCGCCCCCTCCGGACCCGGCACAAACACCGCAACTGCGAAGGTGGGTCCCCCCGCGGCTCGCCCCCCGGTGGCTGCGCCGCGGCTCCCATCCGCGAGGAGGAGGAGAACGGCTCCCGCGCCGCAGAGTTCTTGTTTTCGTCTCCGTCACTGCCCAACATCTCTCTGGGACGACCTCACGTGGGTCCCCGCCTGCACCCGCCCCCCGCGGCGCACACCCCGGCGCCCGTGGTGCTGCCCCCCGTGTCGGAGGCGGAGGCGCTGGTGGTGGGCGGGGCGGGGGGCCGGCCGGTGCAGCGCCTCGGTCGCACGCACTCCGCGCCGCTGCCCCTGGGCGACCCGGCCCTGCAGCCGCCCCCCGTGCACCACTACCTCAGAGATCAGATCCGGAAAACTGTGTTGACCCGCGCACATGACGCGGCGGTGCAGCTGCGGGAGGAGGAGGGCGAGGTCATCGACCTGACGTCGAAGCGTAACGATCCTCCCGCCCCCGTCGAGCCGGCCCCCCTCACCCGCGCCCTCTCGTCGCCCCTGGTGGGGGCCAGGGTGCCCGCCACGGGACTCGCCTACGACCCGCTCATGCTCAAGCATGGGTGTGCGTGCGGACAGCACGCCCCCACGCACCCGGAGCACGGCGGCCGCCTGCAGTCCGTGTGGGCGCGCCTGTGCGAGACCGGCCTGGCCGCCCGCACCGAGCGCACGCGGCCCAGGAAGGCCACGCTCGACGAACTGCAGAGCGTGCACACGGAGGCGCACGTGCAGGTGTTCGCGGGGCGGGGGCGCGACGGCGCGGGCGTGGGGGCGGGGGGCGGCGCGGGGGGCGCGGTGCGGCAGCTGGTGCGGCTGGCGTGCGGCGGGCTGGGCGTGGACTCGGACACGGCGTGGTCGGACCTGCACACGGCGCCCGCCGCGCGCCTCGCCGCCGGAGCCCTGCTGGACCTGGCGCTGCGCACCGCGCGCGGACACCTCCGGAACGGGTTCGCGGTGGTGCGGCCCCCCGGTCACCACGCGGAGCCCAACCAGGCGATGGGCTTCTGTTTCTTCAACAACGTGGCCATCGCCGCCCGCGTGCTGCACACCAGGCTGGGGCTGCAGAGGATACTCATCGTCGACTGGGACGTGCATCACGGCAACGGCACCCAGCAGATATTCTACGAGGATCCTCACGTGCTGTACATGAGCATCCACCGGCACGACGACGGGAACTTCTTCCCTGGAACGGGAGCGGCCACCGAGTGCGGCGCCGGCCCGGGGCTCGGCTACAACGTGAACGTGCCCTGGAGCTGCGGCACCGACCCGCCCCTGGGGGACGCGGAGTACCTGGCCGCCTTCCGCTCCGTCATCATGCCCATCGCCAAGGAGTACGACCCCGAGATAGTGCTCGTGTCGTGCGGGTTCGACGCCGCGGCCGGGCACCCGGCGCCGCTCGGCGGGTACAGCGTGTCCGCCGCCTGCTTCGCGCACATGACCAGGGACCTCATGCAGCTCGCCAACGGCAAGGTGGTGATGTCGCTGGAGGGCGGCTACGACCTGGCGGCCATGTGCGACTGCGCGCAGGAGGTGGTCCGCGCGCTGCTGGGGGACCGCCCCCCCGCGCCCCCCTACGCCGAGCTGTGCCGCGCCCCCCACCCCCGCGCCCAGCACGCGCTCGCCGCCACGATTGCCGTGCAGGCGCAGCACTGGCCCACCATCAAGCGGTACAGCAGCCTGGTGGGCATGTCTGCGTTAGAGGCCGCGCCCTCGGTGGCGGCGGCCCGGCTCGGAGCCCTGCAGAGCGAACGGGACGCCGCCGACACCGCAGCCGCCATGGCGACGCTGTCAATGCACCAGCACAACCGGCCCGTGTCCACGTCTGCAGAAAGTTCAAGGTCGGTTTCGGAGGAGCCCATGGAGCAGGACGAAGCGAAAGATGACTATTTGTGTGACAACAAGGAATAA

Protein

MAHEGPARTEGSPHHTPSPPHLPHLPVTDSGFHHQIMQNHSPRKNHIVERAKQTLENSFLQQLKKQQQLQQEILLQHFQQQRQQLAREHENQMREHLKLWEQQKKAMEEAALREAREAREAREARERHERDRVELMRKKDIHEHSANASTQVKQKLQEFIKKKQANANGTVTTASYRNWGIVKSSSGESITSTGATATHPYRLTAPLPLNLNAPPPQPSPADYPLRKTASEPNMLKQRLKARVIERRASPLARRPLRTRHKHRNCEGGSPRGSPPGGCAAAPIREEEENGSRAAEFLFSSPSLPNISLGRPHVGPRLHPPPAAHTPAPVVLPPVSEAEALVVGGAGGRPVQRLGRTHSAPLPLGDPALQPPPVHHYLRDQIRKTVLTRAHDAAVQLREEEGEVIDLTSKRNDPPAPVEPAPLTRALSSPLVGARVPATGLAYDPLMLKHGCACGQHAPTHPEHGGRLQSVWARLCETGLAARTERTRPRKATLDELQSVHTEAHVQVFAGRGRDGAGVGAGGGAGGAVRQLVRLACGGLGVDSDTAWSDLHTAPAARLAAGALLDLALRTARGHLRNGFAVVRPPGHHAEPNQAMGFCFFNNVAIAARVLHTRLGLQRILIVDWDVHHGNGTQQIFYEDPHVLYMSIHRHDDGNFFPGTGAATECGAGPGLGYNVNVPWSCGTDPPLGDAEYLAAFRSVIMPIAKEYDPEIVLVSCGFDAAAGHPAPLGGYSVSAACFAHMTRDLMQLANGKVVMSLEGGYDLAAMCDCAQEVVRALLGDRPPAPPYAELCRAPHPRAQHALAATIAVQAQHWPTIKRYSSLVGMSALEAAPSVAAARLGALQSERDAADTAAAMATLSMHQHNRPVSTSAESSRSVSEEPMEQDEAKDDYLCDNKE

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic Activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Similarity

Belongs to the histone deacetylase family. HD type 2 subfamily.

Uniprot

A0A2H1WBE5 A0A212FEG2 A0A2J7R179 A0A2J7R178 A0A1L7N253 D6WLF8 + More
A0A1Y1NDK1 A0A1Y1N898 A0A146LH71 A0A146MCD2 A0A1L8DX56

EC Number

3.5.1.98

Pubmed

22118469 27956627 18362917 19820115 28004739 26823975 + More

EMBL

ODYU01007465 SOQ50266.1 AGBW02008930 OWR52155.1 NEVH01008208 PNF34591.1 + More
PNF34590.1 LC096259 BAW19563.1 KQ971343 EFA04105.2 GEZM01010939 JAV93697.1 GEZM01010938 JAV93698.1 GDHC01012323 JAQ06306.1 GDHC01002152 JAQ16477.1 GFDF01003090 JAV10994.1

Proteomes

UP000007151 UP000235965 UP000007266

Pfam

PF00850 Hist_deacetyl

Interpro

IPR017320   Histone_deAcase_II_euk        + More
IPR023801   His_deacetylse_dom
IPR037138   His_deacetylse_dom_sf
IPR000286   His_deacetylse
IPR023696   Ureohydrolase_dom_sf

SUPFAM

SSF52768 SSF52768

Gene 3D

3.40.800.20

ProteinModelPortal

A0A2H1WBE5 A0A212FEG2 A0A2J7R179 A0A2J7R178 A0A1L7N253 D6WLF8 + More
A0A1Y1NDK1 A0A1Y1N898 A0A146LH71 A0A146MCD2 A0A1L8DX56

PDB

5ZOP E-value=2.2373e-123, Score=1135

KEGG

105841244 no KO assigned | (RefSeq) histone deacetylase 5

GO

GO:0032041 GO:0000118 GO:0046872 GO:0004407 GO:0006325 GO:0016575

Subcellular location

Nucleus

Length:

897

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0169

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00003

outside

1 - 897

Pi

2.711671

Theta

23.881606

Tajima's D

-1.216707

CLR

1.632387

CSRT

0.101044947752612

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics