Gene

KWMTBOMO04808

Pre Gene Modal

BGIBMGA009912

Annotation

PREDICTED:_protein-S-isoprenylcysteine_O-methyltransferase_[Papilio_machaon]

Location

Bomo_Chr8(+):15599262-15602090      View in EpiBrowser

Full name

Protein-S-isoprenylcysteine O-methyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 4.966

CDS

ATGAAAAACATATGCCCCGCCGGAAAACAAGCGATAATATGGTTTATGCTAACCGTTTGTATATTTTTCATATCATTCTTTTCTGGAAGCCTTTTAGGATTCACATCTGAGATCTGGGCACTTACTTATTGGGGTCCCTCATTATATTTCTGTTTGTTGAATTTTATTTTAAGATATGCCTATAAAGGATTTTTATATGAGGTGTCAATACGAGCAGCATTCCTCGGAGCAGTATTCACAATAGGCCTCTATTTATCGACATTTGAAGATGGCATTAAGGTTTTCGGTCTCTACACCATGGTGCTGTCGATGTTCCATTTTTCTGAGTTCATGAGTGTAGCCCTAACAAACCCTAGGACATTAACAATTGATTCATATATATTGAATCACAGTGTGCAGTATGGAGTTGCAGCGGTCACTAGTTGGATTGAATGGGCCATTGAATATTATTTCTTTCCGGGGATGAAGACTTATTTCTGGTTGTCAAGCATAGGTGTAATAATGTGTATAGGAGGAGAAATATTAAGAAAATCAGCTATGTTCACAGCCAAAACTAACTTCAACCACACAGTACAATTCGTAAAGAGAGTGGATCATCGGCTAGTTACGCACGGGGTGTACTCTCTCTGTAGACATCCAAGCTATGTAGGATGGTTCTATTGGTCAGTCGGTACTCAGTTTATCCTCCTGAATCCTTTTTGCCTGATCATCTACACGCTAGCCTCGTGGATGTTCTTTAGGGAAAGAGTTTATGCTGAGGAATTGACACTATTGACATTCTTTGGTCCCGCCTATGAAGTCTACCAAAGCAAAGTCAGTACAGGCCTTCCGTTCATCCAGGGTTATGTACCAGAGAACACAGGACAATTTGTCAAAGAAGACCATTGGAGTTACTGA

Protein

MKNICPAGKQAIIWFMLTVCIFFISFFSGSLLGFTSEIWALTYWGPSLYFCLLNFILRYAYKGFLYEVSIRAAFLGAVFTIGLYLSTFEDGIKVFGLYTMVLSMFHFSEFMSVALTNPRTLTIDSYILNHSVQYGVAAVTSWIEWAIEYYFFPGMKTYFWLSSIGVIMCIGGEILRKSAMFTAKTNFNHTVQFVKRVDHRLVTHGVYSLCRHPSYVGWFYWSVGTQFILLNPFCLIIYTLASWMFFRERVYAEELTLLTFFGPAYEVYQSKVSTGLPFIQGYVPENTGQFVKEDHWSY

Catalytic Activity

[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine

Cofactor

Zn(2+)

Similarity

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Uniprot

H9JK61   A0A2H1WV57   A0A3S2LWB9   A0A194RCV9   A0A194PR43   A0A2A4K7M7   + More
A0A212FHF2   A0A1E1W8E9   A0A1W4WHL0   A0A067R9D3   A0A0L0BUD4   A0A0L7QSP4   A0A1B6EU79   A0A1B6EVX0   A0A026X1E4   A0A1B6J5S1   A0A1I8PFP1   B3NCY3   B4L0J4   A0A1B6KK98   A0A1I8MQ03   B4PHB2   B4HGN4   A0A1L8DTQ6   E9IR42   B3MAU2   A0A3B0JS31   B4QIY4   A0A069DRE1   A0A224XJ06   Q2M0C1   B4GRU3   A0A1W4VJJ0   A0A195E430   Q9VU37   A0A0A1XI35   A0A154PRU5   A0A2A3EED2   A0A0K8WG38   E2AWE2   A0A195C132   F4WJM6   A0A0V0G8H3   B4LBH3   A0A3R7MGL4   A0A195FWB1   K1PPT4   A0A195AUC0   U5EKS2   A0A158NNC1   A0A1J1HXB0   A0A1A9ZKP5   D3TNL2   B4MM66   A0A1A9UFT9   E2BPW0   A0A1A9XGE7   A0A1B3PDH5   A0A232EXP3   A0A2P2I3B3   A0A1B0AWF9   B4K006   A0A182JF20   A0A0P4WHV6   A0A182FRK2   A0A210PXN4   A0A310S4W4   V3ZGY2   A0A023F474   A0A182YBD6   A0A1S4FUR4   A0A182P9K3   A0A084VXV7   A0A1Q3F6H3   A0A0K8TSQ5   T1HDA1   A0A131XYF9   W5J3Q6   A0A336KG15   Q16NH8   U4TVP3   U3FCE4   A0A2M4AXT5   A0A182UMX8   A0A182X9L2   A0A182L8T7   A0A182HKJ5   Q7PXA7   A0A0B8RX18   A0A0M4EER0   A0A1S3JQC1   A0A182Q4P4   A0A1A9WSN9   A0A182NQK0   A0A0L8HV91   A0A098LXW4   E0VRB9   Q6INK2   A0A182GTA5  

EC Number

2.1.1.100

Pubmed

19121390    26354079    22118469    24845553    26108605    24508170    + More
30249741    17994087    25315136    17550304    21282665    22936249    26334808    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25830018    20798317    21719571    22992520    21347285    20353571    28648823    28812685    23254933    25474469    25244985    24438588    26369729    29652888    20920257    23761445    17510324    23537049    23915248    20966253    12364791    14747013    17210077    25476704    20566863    26483478   

EMBL

BABH01026710    BABH01026711    BABH01026712    ODYU01011250    SOQ56872.1    RSAL01000151    + More
RVE45756.1    KQ460367    KPJ15457.1    KQ459595    KPI95782.1    NWSH01000074    PCG79938.1    AGBW02008504    OWR53154.1    GDQN01007788    JAT83266.1    KK852804    KDR16214.1    JRES01001310    KNC23685.1    KQ414756    KOC61662.1    GECZ01028224    JAS41545.1    GECZ01027644    JAS42125.1    KK107031    QOIP01000008    EZA62100.1    RLU19318.1    GECU01013199    JAS94507.1    CH954178    EDV51639.1    CH933809    EDW19163.1    GEBQ01028111    JAT11866.1    CM000159    EDW94373.2    CH480815    EDW41342.1    GFDF01004266    JAV09818.1    GL765043    EFZ16968.1    CH902618    EDV39176.1    OUUW01000002    SPP76166.1    CM000363    CM002912    EDX10315.1    KMY99349.1    GBGD01002429    JAC86460.1    GFTR01003950    JAW12476.1    CH379069    EAL31013.1    CH479188    EDW40478.1    KQ979685    KYN19841.1    AE014296    AY070700    AY071003    AAF49854.1    AAL48171.1    AGB94486.1    GBXI01003651    JAD10641.1    KQ435090    KZC14593.1    KZ288266    PBC30143.1    GDHF01002509    JAI49805.1    GL443286    EFN62242.1    KQ978457    KYM93878.1    GL888186    EGI65518.1    GECL01001665    JAP04459.1    CH940647    EDW70783.1    QCYY01001711    ROT75935.1    KQ981208    KYN44711.1    JH818211    EKC18440.1    KQ976738    KYM75833.1    GANO01001698    JAB58173.1    ADTU01021232    CVRI01000021    CRK91988.1    CCAG010012835    EZ423014    ADD19290.1    CH963847    EDW73075.1    GL449658    EFN82311.1    KU659973    AOG17771.1    NNAY01001723    OXU23123.1    IACF01002889    LAB68524.1    JXJN01004688    CH916383    EDV98688.1    GDRN01050903    JAI66435.1    NEDP02005415    OWF41250.1    KQ773953    OAD52337.1    KB202408    ESO90488.1    GBBI01002903    JAC15809.1    ATLV01018208    KE525224    KFB42801.1    GFDL01011898    JAV23147.1    GDAI01000447    JAI17156.1    ACPB03001054    GEFM01004531    GEGO01002690    JAP71265.1    JAR92714.1    ADMH02002105    ETN59002.1    UFQS01000320    UFQT01000320    SSX02852.1    SSX23220.1    CH477823    EAT35916.1    KB631628    ERL84837.1    GAEP01000772    JAB54049.1    GGFK01012295    MBW45616.1    APCN01000834    AAAB01008987    EAA01195.3    GBSH01002548    JAG66478.1    CP012525    ALC44308.1    AXCN02001518    KQ417224    KOF93138.1    GBSI01001193    JAC95303.1    DS235465    EEB15925.1    BC072278    AAH72278.1    JXUM01086651    JXUM01086652    KQ563582    KXJ73635.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000192223    UP000027135    UP000037069    UP000053825    UP000053097    UP000279307    UP000095300    UP000008711    UP000009192    UP000095301    UP000002282    UP000001292    UP000007801    UP000268350    UP000000304    UP000001819    UP000008744    UP000192221    UP000078492    UP000000803    UP000076502    UP000242457    UP000000311    UP000078542    UP000007755    UP000008792    UP000283509    UP000078541    UP000005408    UP000078540    UP000005205    UP000183832    UP000092445    UP000092444    UP000007798    UP000078200    UP000008237    UP000092443    UP000215335    UP000092460    UP000001070    UP000075880    UP000069272    UP000242188    UP000030746    UP000076408    UP000075885    UP000030765    UP000015103    UP000000673    UP000008820    UP000030742    UP000075903    UP000076407    UP000075882    UP000075840    UP000007062    UP000092553    UP000085678    UP000075886    UP000091820    UP000075884    UP000053454    UP000009046    UP000069940    UP000249989   

PRIDE

H9JK61    Q9VU37   

Pfam

PF04140   ICMT

Interpro

IPR007269   ICMT_MeTrfase        + More
IPR025770   PPMT_MeTrfase       

ProteinModelPortal

H9JK61   A0A2H1WV57   A0A3S2LWB9   A0A194RCV9   A0A194PR43   A0A2A4K7M7   + More
A0A212FHF2   A0A1E1W8E9   A0A1W4WHL0   A0A067R9D3   A0A0L0BUD4   A0A0L7QSP4   A0A1B6EU79   A0A1B6EVX0   A0A026X1E4   A0A1B6J5S1   A0A1I8PFP1   B3NCY3   B4L0J4   A0A1B6KK98   A0A1I8MQ03   B4PHB2   B4HGN4   A0A1L8DTQ6   E9IR42   B3MAU2   A0A3B0JS31   B4QIY4   A0A069DRE1   A0A224XJ06   Q2M0C1   B4GRU3   A0A1W4VJJ0   A0A195E430   Q9VU37   A0A0A1XI35   A0A154PRU5   A0A2A3EED2   A0A0K8WG38   E2AWE2   A0A195C132   F4WJM6   A0A0V0G8H3   B4LBH3   A0A3R7MGL4   A0A195FWB1   K1PPT4   A0A195AUC0   U5EKS2   A0A158NNC1   A0A1J1HXB0   A0A1A9ZKP5   D3TNL2   B4MM66   A0A1A9UFT9   E2BPW0   A0A1A9XGE7   A0A1B3PDH5   A0A232EXP3   A0A2P2I3B3   A0A1B0AWF9   B4K006   A0A182JF20   A0A0P4WHV6   A0A182FRK2   A0A210PXN4   A0A310S4W4   V3ZGY2   A0A023F474   A0A182YBD6   A0A1S4FUR4   A0A182P9K3   A0A084VXV7   A0A1Q3F6H3   A0A0K8TSQ5   T1HDA1   A0A131XYF9   W5J3Q6   A0A336KG15   Q16NH8   U4TVP3   U3FCE4   A0A2M4AXT5   A0A182UMX8   A0A182X9L2   A0A182L8T7   A0A182HKJ5   Q7PXA7   A0A0B8RX18   A0A0M4EER0   A0A1S3JQC1   A0A182Q4P4   A0A1A9WSN9   A0A182NQK0   A0A0L8HV91   A0A098LXW4   E0VRB9   Q6INK2   A0A182GTA5  

PDB

5V7P     E-value=9.36871e-62,     Score=599

KEGG

101739673    K00587 protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100] | (RefSeq) protein-S-isoprenyl

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0004671   GO:0016021   GO:0005789   GO:0006481   GO:0005783   GO:0006000   GO:0006003   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

Subcellular location

Endoplasmic reticulum membrane  

Length:

298

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

140.9543

Exp number, first 60 AAs:

42.83703

Total prob of N-in:

0.97829

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  34

outside

35  -  37

TMhelix

38  -  57

inside

58  -  63

TMhelix

64  -  86

outside

87  -  95

TMhelix

96  -  118

inside

119  -  124

TMhelix

125  -  147

outside

148  -  156

TMhelix

157  -  175

inside

176  -  217

TMhelix

218  -  240

outside

241  -  298

 

 

Pi

26.153712

Theta

25.531187

Tajima's D

0.134316

CLR

0.557037

CSRT

0.410729463526824

Interpretation

Uncertain