Gene

KWMTBOMO04790  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009901

Annotation

PREDICTED:_zinc_finger_CCHC_domain-containing_protein_4_[Bombyx_mori]

Location

Bomo_Chr8(+):15010557-15017387      View in EpiBrowser

Full name

rRNA N6-adenosine-methyltransferase ZCCHC4      

Alternative Name

Zinc finger CCHC domain-containing protein 4

Location in the cell

Nuclear   Reliability : 2.685

CDS

ATGAGGAACAAAAAAGACTGCACAGTACACATCAGCGAAGAAGACTGGTTGAAGGAGAACGTCAAGAAACGAAATGAAAAGTACTATAGCCTAATTCCAACGATCAATAAAAATCAAGCGTGGAATAACTTTGCGGAGGTTAGATCAAGGCCAGTATCTGACCGGGCCTACTGTAACACATGCCAAGAACTGTACATAGTGTCAAAAACAAAAAAACATGGTAAAGACCACAGAGTCATCACTCCACTTATGGATGAGCAGCTCAAACAACCTTCATCATGGTTGCCATTATTGGAGAATGATGCAGTTGAAGCACAGTACTTGTTCACAAAGAAATCTGCCGGCACTGTGCTGGGTATACTCAAAAACAATAGCATAAGAAATATCTTATGCATTGGAACTCCAACTGTTCATGAGGCAGCACAAGCCCACCCAGACTTTAACTCTATACTCCTGGACTACGACAAGAGATACCATGTGTTCCACCCCCCTGATAAATACATATGGTACAACATGTTCAATAATTACATGTTCAATGCTAATGATGATGAAAAATTACTAAAAAAGTTCTTTAAGAAGTCAAGAGATGGTGGTATTTGTGTTGTAGTGGACCCTCCTTTTGGAGGCCGTGTGGAACCACTGGCAAAGACACTAAGGGAGCTCACAGATATGTACAATAAAATATGTGAGAAAGACGATACCTTGCTACCTGTTTTATGGGCGTTTCCATACTTCTCTGAGCCCTACATTACAAATATGTTACCGGAAATTATAATGCATGATTATCAGGTTGAATATGAGAATCATAAGAAATTTCAAACTAAAACGAAAACTGGACGCAAATACGGATCACCAGTTCGTTTCTATACTAACCTACCTCTTATCACTATAGATTTATCGAATGATAAAAACTACAAGTTCTGTGACAAATGTAAATACTGGGTTTCAGTGACAAATAACCACTGTAATAAGTGCAAAGAGTGCACGAGTAAGAATGGAATGACATATAGACATTGCAATATTTGCAAACGGTGCGTGAAGCCTACGTTCTTCCATTGTCAGCAGTGTGAACGATGTTGCCAGGAAAAGGAACATGTTTGTGGTGTTGAAGTGACAAGTCAGTCTTGCTACAATTGCAATGAAAAGGGTCACAAGAAAACCCAGTGCCCACAGCTACAGGAAAAAGTAAAGAAGAGACGAAAGCAAGCATGA

Protein

MRNKKDCTVHISEEDWLKENVKKRNEKYYSLIPTINKNQAWNNFAEVRSRPVSDRAYCNTCQELYIVSKTKKHGKDHRVITPLMDEQLKQPSSWLPLLENDAVEAQYLFTKKSAGTVLGILKNNSIRNILCIGTPTVHEAAQAHPDFNSILLDYDKRYHVFHPPDKYIWYNMFNNYMFNANDDEKLLKKFFKKSRDGGICVVVDPPFGGRVEPLAKTLRELTDMYNKICEKDDTLLPVLWAFPYFSEPYITNMLPEIIMHDYQVEYENHKKFQTKTKTGRKYGSPVRFYTNLPLITIDLSNDKNYKFCDKCKYWVSVTNNHCNKCKECTSKNGMTYRHCNICKRCVKPTFFHCQQCERCCQEKEHVCGVEVTSQSCYNCNEKGHKKTQCPQLQEKVKKRRKQA

Description

rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).

Catalytic Activity

adenosine in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in 28S rRNA + S-adenosyl-L-homocysteine

Similarity

Belongs to the ZCCHC4 family.

Keywords

Acyltransferase   Cytoplasm   Metal-binding   Methyltransferase   Nucleus   Transferase   Zinc   Zinc-finger   Alternative splicing   Complete proteome   Polymorphism   Reference proteome  

Feature

chain  rRNA N6-adenosine-methyltransferase ZCCHC4
splice variant  In isoform 2.
sequence variant  In dbSNP:rs3752873.

Uniprot

H9JK50   A0A3S2NLS0   A0A2H1WK67   S4PE96   A0A212EV91   A0A0N1IER7   + More
A0A2H1VGT0   I4DJK4   A0A2A4JPF2   A0A194PSM7   A0A0L7KVM9   A0A0T6B1S7   A0A1W4WEU9   A0A067R591   A0A1Y1N8Q9   U4UM18   N6U834   A0A158NUZ1   A0A195FGK8   A0A195BDU3   A0A151WEA6   A0A195E412   E2BYM8   A0A0J7KPU6   E9IAJ7   A0A1Y1N7L4   G1TAN1   F4X497   A0A0C9RSH4   W8C4Y5   A0A1J1ILY9   K7IR31   A0A1L8HKY1   Q6DCD7   A0A0N0BBN2   G3VPG8   F6R8E8   H2QPA8   A0A3L8DKV5   E0VTV6   L8IGM4   A0A1S3AHN1   A0A2Y9JQI7   A0A1U7TC60   A0A0P6J2Z9   H0VJ96   A0A2U3ZI96   A0A026X433   L5LEC1   G1TPA6   A0A061IN71   D6WX24   Q9H5U6-3   A0A061IR12   A0A232EYE5   M3X3T0   F6Q4X7   A0A091CVE8   D3ZV31   I3LVM9   A0A2R9AF87   Q17CV8   Q9H5U6   A0A2D4J3M2   A0A2Y9JL44   G7P5C7   Q66IH9   A0A2K6FNK1   A0A3Q7Q9X0   A0A3Q7QCM9   I3NDY3   A0A2K6B4C8   A0A2K5TQX3   A0A2K5Y9L5   A0A3Q7WBA8   A0A2K6SKF1   A0A1S3EJW4   A0A2K5L8Z7   A0A2K5EL95   A0A2Y9G842   A0A2U3W4A1   G3T906   A0A2K5SJG1   A0A1U7QLS8   A0A2J8RG23   A0A2R8MCR2   H2PD18   F7H362   A0A096NZK3   A0A384BPM6   A0A2K6N949   A0A2U3YLQ6   A0A2U3YLQ3   A0A2K6L9R8   A0A2K5JZW9   A0A1B8Y7M9   G5B022   A0A1S3HUV5   E9G0B4   E1BGQ2  

EC Number

2.1.1.-

Pubmed

19121390    23622113    22118469    26354079    22651552    26227816    + More
24845553    28004739    23537049    21347285    20798317    21282665    21993624    21719571    24495485    20075255    27762356    21709235    17495919    16136131    30249741    20566863    22751099    24508170    23929341    18362917    19820115    14702039    15489334    15225602    30531910    28648823    17975172    17431167    22002653    15057822    30723633    22722832    17510324    25243066    25362486    20431018    21993625    21292972    19393038   

EMBL

BABH01026667    RSAL01000285    RVE42969.1    ODYU01009206    SOQ53471.1    GAIX01004622    + More
JAA87938.1    AGBW02012233    OWR45381.1    KQ461192    KPJ07057.1    ODYU01002484    SOQ40027.1    AK401472    BAM18094.1    NWSH01000843    PCG73881.1    KQ459595    KPI95764.1    JTDY01005143    KOB67332.1    LJIG01016298    KRT81021.1    KK868975    KDR17377.1    GEZM01010734    JAV93868.1    KB632408    ERL95119.1    APGK01036052    KB740932    ENN77830.1    ADTU01000445    KQ981606    KYN39528.1    KQ976509    KYM82728.1    KQ983238    KYQ46203.1    KQ979685    KYN19821.1    GL451499    EFN79182.1    LBMM01004558    KMQ92296.1    GL762022    EFZ22416.1    GEZM01010732    JAV93871.1    AAGW02010250    GL888633    EGI58693.1    GBYB01010391    JAG80158.1    GAMC01005199    JAC01357.1    CVRI01000054    CRL00580.1    CM004467    OCT96757.1    BC078110    KQ436054    KOX67472.1    AEFK01218613    AEFK01218614    AEFK01218615    AEFK01218616    AEFK01218617    AACZ04033722    AACZ04033723    GABE01001435    NBAG03000222    JAA43304.1    PNI75945.1    QOIP01000007    RLU20468.1    DS235774    EEB16812.1    JH881270    ELR55431.1    GEBF01005951    JAN97681.1    AAKN02041610    AAKN02041611    AAKN02041612    KK107019    EZA62776.1    KB112772    ELK24689.1    KE663546    ERE91305.1    KQ971361    EFA08055.2    AY629351    CH471069    AK299211    AK026677    BC016914    BC157834    BC171821    ERE91303.1    NNAY01001695    OXU23198.1    AANG04001605    JSUE03033075    JSUE03033076    CM001257    EHH25788.1    KN124309    KFO21680.1    AEMK02000064    DQIR01115217    DQIR01154251    DQIR01162413    DQIR01171309    HDA70693.1    AJFE02094147    AJFE02094148    CH477304    EAT44163.1    IACK01148495    LAA91063.1    CM001280    EHH53594.1    BC081342    AGTP01011338    AGTP01011339    AQIA01054026    AQIA01054027    AQIA01054028    NDHI03003700    PNJ07462.1    ABGA01251046    ABGA01251047    ABGA01251048    ABGA01251049    ABGA01251050    ABGA01251051    ABGA01251052    ABGA01251053    ABGA01251054    ABGA01251055    PNJ07460.1    GAMT01008686    GAMS01011019    GAMR01009161    GAMR01009160    GAMQ01004451    GAMQ01004450    GAMQ01004449    JAB03175.1    JAB12117.1    JAB24771.1    JAB37400.1    AHZZ02026382    KV460394    OCA18966.1    JH167715    EHB02634.1    GL732528    EFX87433.1    DAAA02017163    DAAA02017164   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000218220    UP000053268    + More
UP000037510    UP000192223    UP000027135    UP000030742    UP000019118    UP000005205    UP000078541    UP000078540    UP000075809    UP000078492    UP000008237    UP000036403    UP000001811    UP000007755    UP000183832    UP000002358    UP000186698    UP000053105    UP000007648    UP000002280    UP000002277    UP000279307    UP000009046    UP000079721    UP000248482    UP000189704    UP000005447    UP000245340    UP000053097    UP000030759    UP000007266    UP000005640    UP000215335    UP000011712    UP000006718    UP000028990    UP000002494    UP000008227    UP000240080    UP000008820    UP000009130    UP000008143    UP000233160    UP000286641    UP000005215    UP000233120    UP000233100    UP000233140    UP000286642    UP000233220    UP000081671    UP000233060    UP000233020    UP000248481    UP000007646    UP000233040    UP000189706    UP000008225    UP000001595    UP000028761    UP000261680    UP000233200    UP000245341    UP000233180    UP000233080    UP000006813    UP000085678    UP000000305    UP000009136   

PRIDE

H9JK50    Q9H5U6    D3ZV31    I3LVM9    Q66IH9    E1BGQ2    + More

Pfam

PF00098   zf-CCHC        + More
PF10237   N6-adenineMlase
PF06839   zf-GRF
PF00184   Hormone_5

Interpro

IPR001878   Znf_CCHC        + More
IPR039846   ZCCHC4       
IPR037275   Znf_CTCHY_sf       
IPR041370   Mlase_EEF1AKMT1/ZCCHC4       
IPR017921   Znf_CTCHY       
IPR002052   DNA_methylase_N6_adenine_CS       
IPR036875   Znf_CCHC_sf       
IPR010666   Znf_GRF       
IPR036387   Neurhyp_horm_dom_sf       
IPR022423   Neurohypophysial_hormone_CS       
IPR000981   Neurhyp_horm       

SUPFAM

SSF161245   SSF161245        + More
SSF57756   SSF57756       
SSF49606   SSF49606       

Gene 3D

2.60.9.10    

ProteinModelPortal

H9JK50   A0A3S2NLS0   A0A2H1WK67   S4PE96   A0A212EV91   A0A0N1IER7   + More
A0A2H1VGT0   I4DJK4   A0A2A4JPF2   A0A194PSM7   A0A0L7KVM9   A0A0T6B1S7   A0A1W4WEU9   A0A067R591   A0A1Y1N8Q9   U4UM18   N6U834   A0A158NUZ1   A0A195FGK8   A0A195BDU3   A0A151WEA6   A0A195E412   E2BYM8   A0A0J7KPU6   E9IAJ7   A0A1Y1N7L4   G1TAN1   F4X497   A0A0C9RSH4   W8C4Y5   A0A1J1ILY9   K7IR31   A0A1L8HKY1   Q6DCD7   A0A0N0BBN2   G3VPG8   F6R8E8   H2QPA8   A0A3L8DKV5   E0VTV6   L8IGM4   A0A1S3AHN1   A0A2Y9JQI7   A0A1U7TC60   A0A0P6J2Z9   H0VJ96   A0A2U3ZI96   A0A026X433   L5LEC1   G1TPA6   A0A061IN71   D6WX24   Q9H5U6-3   A0A061IR12   A0A232EYE5   M3X3T0   F6Q4X7   A0A091CVE8   D3ZV31   I3LVM9   A0A2R9AF87   Q17CV8   Q9H5U6   A0A2D4J3M2   A0A2Y9JL44   G7P5C7   Q66IH9   A0A2K6FNK1   A0A3Q7Q9X0   A0A3Q7QCM9   I3NDY3   A0A2K6B4C8   A0A2K5TQX3   A0A2K5Y9L5   A0A3Q7WBA8   A0A2K6SKF1   A0A1S3EJW4   A0A2K5L8Z7   A0A2K5EL95   A0A2Y9G842   A0A2U3W4A1   G3T906   A0A2K5SJG1   A0A1U7QLS8   A0A2J8RG23   A0A2R8MCR2   H2PD18   F7H362   A0A096NZK3   A0A384BPM6   A0A2K6N949   A0A2U3YLQ6   A0A2U3YLQ3   A0A2K6L9R8   A0A2K5JZW9   A0A1B8Y7M9   G5B022   A0A1S3HUV5   E9G0B4   E1BGQ2  

KEGG

101738695    no KO assigned | (RefSeq) zinc finger CCHC domain-containing protein 4

GO

GO:0008270   GO:0003676   GO:0008168   GO:0008988   GO:0031167   GO:0016746   GO:0045727   GO:0005730   GO:0005737   GO:0005185   GO:0005576   GO:0005524   GO:0006000   GO:0006003   GO:0006032   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR13493  

Subcellular location

Cytoplasm   Accumulates in the nucleolus, where ribosome biogenesis takes place.   With evidence from 1 publications.
Nucleus   Accumulates in the nucleolus, where ribosome biogenesis takes place.   With evidence from 1 publications.
Nucleolus   Accumulates in the nucleolus, where ribosome biogenesis takes place.   With evidence from 1 publications.

Length:

403

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05532

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.24853

outside

1  -  403

 

 

Pi

21.002762

Theta

15.072767

Tajima's D

-1.163421

CLR

0.673435

CSRT

0.106744662766862

Interpretation

Uncertain