Gene
KWMTBOMO04767
Pre Gene Modal
BGIBMGA009852
Annotation
PREDICTED:_AN1-type_zinc_finger_protein_1-like_[Amyelois_transitella]
Full name
AN1-type zinc finger protein 1
Alternative Name
Zinc finger AN1-type-containing protein 1
Location in the cell
Nuclear Reliability : 3.02
Sequence
CDS
ATGGAATTTCCAACGCTTGGTGAAAATTGCCAATATCCTGGCTGCAACCAAACAGACTTCTTGCCATTACAGTGCAAATGTGCAAAAGTTTTTTGCAGAGAACATTTCAACACTCACTGCCTGTCCGGAGAATGTGAATTAGCACCGCAACCTAAAGAAGTTAATTTAAAGAAAGACGACCAAATTTTCAAATGCTCCGAAAAAAGTTGCAATAAAGGAAACATTCATGAGATGACTTGTTCTAAATGTAATAAACATTTTTGTGTAGAACATAGGTTTCACCCTTCATGTCCAGAAATAGATGATGAGACTCTGGCTGCAAAAATAGAACAATTTGAAGCACCAAAAAGACAATTTAGGGAAGCAAACAAACATTTACAAGGAATGATAACAGAAAACATACGTAAAGCACTACAATCGTCAGCAAAAGTGAAAACGGCATCGAAAATTCACTTGATGAGAATAAAACAGAAAGCCTCCGGCCCGAAAAGCATTCCACCATCTGACCGAGTATACTTCGCCATTAGGAAACCCATCAACATGGACGCCAAACCGCTAAAAATATTACAAGACGAGGACCATCTAATTAAACTAGGAACTTTAGTATTAGAACCAGACTTAAAAGATACAGTCCCAGTTTTTATTAGCACTAAATGGAGCTTAGGTCGGGCTATTGATTGTATTTGTGAGACATGTAATATAAGAAATGATAACAATAAAATAGGAAATATAAAGTTAAGACTGTTCAGGCAACTAGATGGCTATTGTATAAGCCCCACAGCGATGGATGTTGAAATTAATGAGTTGGTAAACAAAGAAATATTGTTGGAAGGTGACCAATTGCTCATTGAATATATCGATAGTAATTCTTTAGCCAGTTTAGATGAGAATGCTCATGTTTTTTTAGTTGTGTAA
Protein
MEFPTLGENCQYPGCNQTDFLPLQCKCAKVFCREHFNTHCLSGECELAPQPKEVNLKKDDQIFKCSEKSCNKGNIHEMTCSKCNKHFCVEHRFHPSCPEIDDETLAAKIEQFEAPKRQFREANKHLQGMITENIRKALQSSAKVKTASKIHLMRIKQKASGPKSIPPSDRVYFAIRKPINMDAKPLKILQDEDHLIKLGTLVLEPDLKDTVPVFISTKWSLGRAIDCICETCNIRNDNNKIGNIKLRLFRQLDGYCISPTAMDVEINELVNKEILLEGDQLLIEYIDSNSLASLDENAHVFLVV
Summary
Description
Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).
Subunit
Associates with the 26S proteasome; this association occurs upon exposure to arsenite and is reduced in the presence of ATP (PubMed:29804830). Interacts (via AN1-type 1 and 2 zinc fingers) with PSMD1; this interaction is increased upon arsenite treatment and occurs in an ATP-independent manner (PubMed:29804830). Interacts with PSMC4 (PubMed:29804830). Interacts with PSMA1 (PubMed:29804830). Interacts (via its ubiquitin-like region) with VCP; this interaction occurs in an arsenite-dependent manner and is necessary for the recruitment of the ubiquitin-selective ATPase VCP to stress granules (SGs) (PubMed:29804830).
Keywords
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
Reference proteome
Repeat
Zinc
Zinc-finger
Feature
chain AN1-type zinc finger protein 1
splice variant In isoform 2.
splice variant In isoform 2.
Uniprot
H9JK01
A0A2H1WJX1
A0A2A4JIP1
A0A1E1W5H2
S4PY24
A0A3S2M970
+ More
A0A212F6E1 A0A0N0PAJ8 A0A0L7LKG0 A0A0T6B6H6 V5G857 A0A1Y1JRJ9 A0A310S9R7 K7JCE7 A0A0N0U7C4 A0A2P8YVV6 N6TUI7 A0A195EDQ2 A0A2J7RD63 A0A1B6GBC9 A0A0L7QYQ3 A0A1B6JCC7 A0A067QVD4 F4W9W9 A0A026W9C0 A0A2A3EQZ0 E2A4Q7 A0A154P1T5 A0A195EYJ9 A0A158NZJ6 A0A151IKA9 E9IFQ0 A0A088AF80 J9JR59 A0A195BQA1 E2BKZ2 A0A2S2PYF2 E0VUR2 A0A1S3D4F5 A0A0A9XVP2 A0A151WKH4 A0A1B6KLT1 A0A0V0GAN3 A0A232EDF1 U4UPW5 R4G8P8 A0A1D2N292 A0A0P5YG25 A0A164U4S3 A0A3S0ZDD6 F1R230 A0A3B4DLL5 Q6DGC0 A0A3B1KCB3 A0A0P4ZMQ2 G1KP60 C1BYA1 A0A0P5GBQ2 A0A0B7AA40 A0A3P8ZJ52 W5N1W7 A0A224XWA2 V9LAD6 A0A3Q3MPP2 F6YXA0 H2PQN9 E3TFS6 A0A2J8V9Q6 A0A1W5AH23 A0A1S3ICH2 A0A1S3HCK3 A0A0P5G9D3 A0A2K6TL91 A0A1L8FZB9 H0X1B5 A0A384BXL4 A0A3Q7USQ2 A0A0P5GAY6 G1TDW5 A0A2K5HTB3 A0A1A8B849 A0A250YDZ3 Q8TCF1 A0A1A8E1M0 A0A2D4G9Q9 A0A1D5PDC2 A0A2C9KIF4 H2QWC7 A0A1S3Q8A6 A0A0D9RLB6 A0A2D4IL74 A0A0E9WV06 G3RTV9 A0A2I4DA23 A0A2R9BZC9 V5I0M0 A0A2K6AYK2 A0A2K5VJ76 A0A096NH22
A0A212F6E1 A0A0N0PAJ8 A0A0L7LKG0 A0A0T6B6H6 V5G857 A0A1Y1JRJ9 A0A310S9R7 K7JCE7 A0A0N0U7C4 A0A2P8YVV6 N6TUI7 A0A195EDQ2 A0A2J7RD63 A0A1B6GBC9 A0A0L7QYQ3 A0A1B6JCC7 A0A067QVD4 F4W9W9 A0A026W9C0 A0A2A3EQZ0 E2A4Q7 A0A154P1T5 A0A195EYJ9 A0A158NZJ6 A0A151IKA9 E9IFQ0 A0A088AF80 J9JR59 A0A195BQA1 E2BKZ2 A0A2S2PYF2 E0VUR2 A0A1S3D4F5 A0A0A9XVP2 A0A151WKH4 A0A1B6KLT1 A0A0V0GAN3 A0A232EDF1 U4UPW5 R4G8P8 A0A1D2N292 A0A0P5YG25 A0A164U4S3 A0A3S0ZDD6 F1R230 A0A3B4DLL5 Q6DGC0 A0A3B1KCB3 A0A0P4ZMQ2 G1KP60 C1BYA1 A0A0P5GBQ2 A0A0B7AA40 A0A3P8ZJ52 W5N1W7 A0A224XWA2 V9LAD6 A0A3Q3MPP2 F6YXA0 H2PQN9 E3TFS6 A0A2J8V9Q6 A0A1W5AH23 A0A1S3ICH2 A0A1S3HCK3 A0A0P5G9D3 A0A2K6TL91 A0A1L8FZB9 H0X1B5 A0A384BXL4 A0A3Q7USQ2 A0A0P5GAY6 G1TDW5 A0A2K5HTB3 A0A1A8B849 A0A250YDZ3 Q8TCF1 A0A1A8E1M0 A0A2D4G9Q9 A0A1D5PDC2 A0A2C9KIF4 H2QWC7 A0A1S3Q8A6 A0A0D9RLB6 A0A2D4IL74 A0A0E9WV06 G3RTV9 A0A2I4DA23 A0A2R9BZC9 V5I0M0 A0A2K6AYK2 A0A2K5VJ76 A0A096NH22
Pubmed
19121390
23622113
22118469
26354079
26227816
28004739
+ More
20075255 29403074 23537049 24845553 21719571 24508170 30249741 20798317 21347285 21282665 20566863 25401762 26823975 28648823 27289101 23594743 25329095 20433749 25069045 24402279 20431018 20634964 27762356 24813606 21993624 28087693 14702039 16421571 15489334 17974005 21269460 29804830 15592404 15562597 16136131 25613341 22398555 22722832 25765539
20075255 29403074 23537049 24845553 21719571 24508170 30249741 20798317 21347285 21282665 20566863 25401762 26823975 28648823 27289101 23594743 25329095 20433749 25069045 24402279 20431018 20634964 27762356 24813606 21993624 28087693 14702039 16421571 15489334 17974005 21269460 29804830 15592404 15562597 16136131 25613341 22398555 22722832 25765539
EMBL
BABH01026621
BABH01026622
ODYU01009094
SOQ53266.1
NWSH01001389
PCG71444.1
+ More
GDQN01008943 JAT82111.1 GAIX01004033 JAA88527.1 RSAL01000005 RVE54377.1 AGBW02010040 OWR49310.1 KQ461192 KPJ07034.1 JTDY01000855 KOB75661.1 LJIG01009505 KRT82946.1 GALX01002161 JAB66305.1 GEZM01103074 JAV51573.1 KQ767877 OAD53281.1 AAZX01003377 KQ435706 KOX80274.1 PYGN01000332 PSN48371.1 APGK01054147 APGK01054148 KB741247 ENN72041.1 KQ979039 KYN23333.1 NEVH01005296 PNF38774.1 GECZ01010021 JAS59748.1 KQ414688 KOC63708.1 GECU01030910 GECU01016593 GECU01010854 JAS76796.1 JAS91113.1 JAS96852.1 KK852976 KDR13050.1 GL888033 EGI69105.1 KK107321 QOIP01000002 EZA52697.1 RLU25394.1 KZ288199 PBC33636.1 GL436716 EFN71591.1 KQ434803 KZC05909.1 KQ981909 KYN33206.1 ADTU01000887 KQ977234 KYN04704.1 GL762889 EFZ20587.1 ABLF02031352 KQ976423 KYM88751.1 GL448858 EFN83646.1 GGMS01001191 MBY70394.1 DS235787 EEB17118.1 GBHO01020153 GBHO01020152 GBRD01017311 GDHC01012774 GDHC01000888 JAG23451.1 JAG23452.1 JAG48516.1 JAQ05855.1 JAQ17741.1 KQ983012 KYQ48372.1 GEBQ01027587 JAT12390.1 GECL01001123 JAP05001.1 NNAY01006739 OXU16364.1 KI209939 ERL96114.1 ACPB03007651 GAHY01000597 JAA76913.1 LJIJ01000286 ODM99360.1 GDIP01059768 JAM43947.1 LRGB01001581 KZS11061.1 RQTK01000669 RUS76349.1 CR753886 BC076430 AAH76430.1 GDIP01223648 JAI99753.1 BT079580 ACO14004.1 GDIQ01264885 JAJ86839.1 HACG01029975 HACG01029976 CEK76840.1 CEK76841.1 AHAT01031775 GFTR01004137 JAW12289.1 JW876598 AFP09115.1 AAMC01060263 ABGA01194787 ABGA01194788 GU589210 ADO29162.1 NDHI03003426 PNJ54263.1 GDIQ01249460 JAK02265.1 CM004476 OCT76938.1 AAQR03011381 AAQR03011382 AAQR03011383 GDIQ01251010 JAK00715.1 AAGW02012051 AAGW02012052 HADY01024190 HAEJ01010007 SBP62675.1 GFFW01002916 JAV41872.1 AK024069 CR457323 AK225195 AC132219 BC022251 BC056877 AL833030 HADZ01008076 HAEA01011383 SBQ39863.1 IACJ01109815 LAA56489.1 AADN05000031 AACZ04016161 GABC01010817 GABD01006941 GABE01011359 NBAG03000263 JAA00521.1 JAA26159.1 JAA33380.1 PNI56370.1 AQIB01087604 IACK01110064 IACK01110065 LAA84874.1 GBXM01014496 JAH94081.1 CABD030057890 CABD030057891 AJFE02110617 AJFE02110618 AJFE02110619 GANP01003730 JAB80738.1 AQIA01068354 AHZZ02033899
GDQN01008943 JAT82111.1 GAIX01004033 JAA88527.1 RSAL01000005 RVE54377.1 AGBW02010040 OWR49310.1 KQ461192 KPJ07034.1 JTDY01000855 KOB75661.1 LJIG01009505 KRT82946.1 GALX01002161 JAB66305.1 GEZM01103074 JAV51573.1 KQ767877 OAD53281.1 AAZX01003377 KQ435706 KOX80274.1 PYGN01000332 PSN48371.1 APGK01054147 APGK01054148 KB741247 ENN72041.1 KQ979039 KYN23333.1 NEVH01005296 PNF38774.1 GECZ01010021 JAS59748.1 KQ414688 KOC63708.1 GECU01030910 GECU01016593 GECU01010854 JAS76796.1 JAS91113.1 JAS96852.1 KK852976 KDR13050.1 GL888033 EGI69105.1 KK107321 QOIP01000002 EZA52697.1 RLU25394.1 KZ288199 PBC33636.1 GL436716 EFN71591.1 KQ434803 KZC05909.1 KQ981909 KYN33206.1 ADTU01000887 KQ977234 KYN04704.1 GL762889 EFZ20587.1 ABLF02031352 KQ976423 KYM88751.1 GL448858 EFN83646.1 GGMS01001191 MBY70394.1 DS235787 EEB17118.1 GBHO01020153 GBHO01020152 GBRD01017311 GDHC01012774 GDHC01000888 JAG23451.1 JAG23452.1 JAG48516.1 JAQ05855.1 JAQ17741.1 KQ983012 KYQ48372.1 GEBQ01027587 JAT12390.1 GECL01001123 JAP05001.1 NNAY01006739 OXU16364.1 KI209939 ERL96114.1 ACPB03007651 GAHY01000597 JAA76913.1 LJIJ01000286 ODM99360.1 GDIP01059768 JAM43947.1 LRGB01001581 KZS11061.1 RQTK01000669 RUS76349.1 CR753886 BC076430 AAH76430.1 GDIP01223648 JAI99753.1 BT079580 ACO14004.1 GDIQ01264885 JAJ86839.1 HACG01029975 HACG01029976 CEK76840.1 CEK76841.1 AHAT01031775 GFTR01004137 JAW12289.1 JW876598 AFP09115.1 AAMC01060263 ABGA01194787 ABGA01194788 GU589210 ADO29162.1 NDHI03003426 PNJ54263.1 GDIQ01249460 JAK02265.1 CM004476 OCT76938.1 AAQR03011381 AAQR03011382 AAQR03011383 GDIQ01251010 JAK00715.1 AAGW02012051 AAGW02012052 HADY01024190 HAEJ01010007 SBP62675.1 GFFW01002916 JAV41872.1 AK024069 CR457323 AK225195 AC132219 BC022251 BC056877 AL833030 HADZ01008076 HAEA01011383 SBQ39863.1 IACJ01109815 LAA56489.1 AADN05000031 AACZ04016161 GABC01010817 GABD01006941 GABE01011359 NBAG03000263 JAA00521.1 JAA26159.1 JAA33380.1 PNI56370.1 AQIB01087604 IACK01110064 IACK01110065 LAA84874.1 GBXM01014496 JAH94081.1 CABD030057890 CABD030057891 AJFE02110617 AJFE02110618 AJFE02110619 GANP01003730 JAB80738.1 AQIA01068354 AHZZ02033899
Proteomes
UP000005204
UP000218220
UP000283053
UP000007151
UP000053240
UP000037510
+ More
UP000002358 UP000053105 UP000245037 UP000019118 UP000078492 UP000235965 UP000053825 UP000027135 UP000007755 UP000053097 UP000279307 UP000242457 UP000000311 UP000076502 UP000078541 UP000005205 UP000078542 UP000005203 UP000007819 UP000078540 UP000008237 UP000009046 UP000079169 UP000075809 UP000215335 UP000030742 UP000015103 UP000094527 UP000076858 UP000271974 UP000000437 UP000261440 UP000018467 UP000001646 UP000265140 UP000018468 UP000261660 UP000008143 UP000001595 UP000221080 UP000192224 UP000085678 UP000233220 UP000186698 UP000005225 UP000261680 UP000291021 UP000286642 UP000001811 UP000233080 UP000005640 UP000000539 UP000076420 UP000002277 UP000087266 UP000029965 UP000001519 UP000192220 UP000240080 UP000233120 UP000233100 UP000028761
UP000002358 UP000053105 UP000245037 UP000019118 UP000078492 UP000235965 UP000053825 UP000027135 UP000007755 UP000053097 UP000279307 UP000242457 UP000000311 UP000076502 UP000078541 UP000005205 UP000078542 UP000005203 UP000007819 UP000078540 UP000008237 UP000009046 UP000079169 UP000075809 UP000215335 UP000030742 UP000015103 UP000094527 UP000076858 UP000271974 UP000000437 UP000261440 UP000018467 UP000001646 UP000265140 UP000018468 UP000261660 UP000008143 UP000001595 UP000221080 UP000192224 UP000085678 UP000233220 UP000186698 UP000005225 UP000261680 UP000291021 UP000286642 UP000001811 UP000233080 UP000005640 UP000000539 UP000076420 UP000002277 UP000087266 UP000029965 UP000001519 UP000192220 UP000240080 UP000233120 UP000233100 UP000028761
SUPFAM
SSF118310
SSF118310
Gene 3D
ProteinModelPortal
H9JK01
A0A2H1WJX1
A0A2A4JIP1
A0A1E1W5H2
S4PY24
A0A3S2M970
+ More
A0A212F6E1 A0A0N0PAJ8 A0A0L7LKG0 A0A0T6B6H6 V5G857 A0A1Y1JRJ9 A0A310S9R7 K7JCE7 A0A0N0U7C4 A0A2P8YVV6 N6TUI7 A0A195EDQ2 A0A2J7RD63 A0A1B6GBC9 A0A0L7QYQ3 A0A1B6JCC7 A0A067QVD4 F4W9W9 A0A026W9C0 A0A2A3EQZ0 E2A4Q7 A0A154P1T5 A0A195EYJ9 A0A158NZJ6 A0A151IKA9 E9IFQ0 A0A088AF80 J9JR59 A0A195BQA1 E2BKZ2 A0A2S2PYF2 E0VUR2 A0A1S3D4F5 A0A0A9XVP2 A0A151WKH4 A0A1B6KLT1 A0A0V0GAN3 A0A232EDF1 U4UPW5 R4G8P8 A0A1D2N292 A0A0P5YG25 A0A164U4S3 A0A3S0ZDD6 F1R230 A0A3B4DLL5 Q6DGC0 A0A3B1KCB3 A0A0P4ZMQ2 G1KP60 C1BYA1 A0A0P5GBQ2 A0A0B7AA40 A0A3P8ZJ52 W5N1W7 A0A224XWA2 V9LAD6 A0A3Q3MPP2 F6YXA0 H2PQN9 E3TFS6 A0A2J8V9Q6 A0A1W5AH23 A0A1S3ICH2 A0A1S3HCK3 A0A0P5G9D3 A0A2K6TL91 A0A1L8FZB9 H0X1B5 A0A384BXL4 A0A3Q7USQ2 A0A0P5GAY6 G1TDW5 A0A2K5HTB3 A0A1A8B849 A0A250YDZ3 Q8TCF1 A0A1A8E1M0 A0A2D4G9Q9 A0A1D5PDC2 A0A2C9KIF4 H2QWC7 A0A1S3Q8A6 A0A0D9RLB6 A0A2D4IL74 A0A0E9WV06 G3RTV9 A0A2I4DA23 A0A2R9BZC9 V5I0M0 A0A2K6AYK2 A0A2K5VJ76 A0A096NH22
A0A212F6E1 A0A0N0PAJ8 A0A0L7LKG0 A0A0T6B6H6 V5G857 A0A1Y1JRJ9 A0A310S9R7 K7JCE7 A0A0N0U7C4 A0A2P8YVV6 N6TUI7 A0A195EDQ2 A0A2J7RD63 A0A1B6GBC9 A0A0L7QYQ3 A0A1B6JCC7 A0A067QVD4 F4W9W9 A0A026W9C0 A0A2A3EQZ0 E2A4Q7 A0A154P1T5 A0A195EYJ9 A0A158NZJ6 A0A151IKA9 E9IFQ0 A0A088AF80 J9JR59 A0A195BQA1 E2BKZ2 A0A2S2PYF2 E0VUR2 A0A1S3D4F5 A0A0A9XVP2 A0A151WKH4 A0A1B6KLT1 A0A0V0GAN3 A0A232EDF1 U4UPW5 R4G8P8 A0A1D2N292 A0A0P5YG25 A0A164U4S3 A0A3S0ZDD6 F1R230 A0A3B4DLL5 Q6DGC0 A0A3B1KCB3 A0A0P4ZMQ2 G1KP60 C1BYA1 A0A0P5GBQ2 A0A0B7AA40 A0A3P8ZJ52 W5N1W7 A0A224XWA2 V9LAD6 A0A3Q3MPP2 F6YXA0 H2PQN9 E3TFS6 A0A2J8V9Q6 A0A1W5AH23 A0A1S3ICH2 A0A1S3HCK3 A0A0P5G9D3 A0A2K6TL91 A0A1L8FZB9 H0X1B5 A0A384BXL4 A0A3Q7USQ2 A0A0P5GAY6 G1TDW5 A0A2K5HTB3 A0A1A8B849 A0A250YDZ3 Q8TCF1 A0A1A8E1M0 A0A2D4G9Q9 A0A1D5PDC2 A0A2C9KIF4 H2QWC7 A0A1S3Q8A6 A0A0D9RLB6 A0A2D4IL74 A0A0E9WV06 G3RTV9 A0A2I4DA23 A0A2R9BZC9 V5I0M0 A0A2K6AYK2 A0A2K5VJ76 A0A096NH22
PDB
1WYS
E-value=0.0452624,
Score=84
Ontologies
GO
PANTHER
Topology
Subcellular location
Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner (PubMed:29804830). Not localized in SGs in response to other heat- oxidative- or osmotic-induced stress treatments. Colocalizes with VCP in cytoplasmic speckles (PubMed:29804830). With evidence from 3 publications.
Length:
304
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00692
outside
1 - 304
Population Genetic Test Statistics
Pi
21.71642
Theta
22.803831
Tajima's D
-0.492079
CLR
1.740297
CSRT
0.23998800059997
Interpretation
Uncertain
