Gene

KWMTBOMO04757  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009857

Annotation

PREDICTED:_myosin-IB_isoform_X1_[Papilio_xuthus]

Location

Bomo_Chr8(-):14228116-14297743      View in EpiBrowser

Full name

Unconventional myosin IC      

Alternative Name

Brush border myosin IB
Myosin-IB
Unconventional myosin 1C

Location in the cell

Nuclear   Reliability : 2.688

CDS

ATGGAGCACTCCCTGCAGCATCGCGAGCGGGTCGGAGTCCAAGACTTCGTTTTGCTGGAGGACTACCGATCCGAAGCGGCCTTCATTGACAATTTGAAGAAACGTTTCCATGAAAACATTATTTATACTTACATCGGTAATGTACTGATCTCGGTGAATCCGTACAAGAATCTACCGATTTACACTGAAGAGAAAACCAAACTTTACTTCAAGAAAGCATTCTTTGAGGCACCGCCGCACGTTTTCGCGATCGCCGACAACGCTTATCGGTCTTTGGTTTACGAGCACAGAGAGCAATGTATTTTGATCTCAGGCGAATCCGGCTCGGGCAAAACGGAAGCGTCGAAGAAAGTTCTGGAATACATAGCCGCCAGAACGAACCACCTCCGGAACGTGGAAAACGTGAAAGATAAGCTGTTACAAAGCAACCCGCTGCTCGAAGCGTTCGGTAACGCGAAGACGCACCGCAACGACAATTCCAGTCGCTTCGGCAAATACATGGACATCCAGTTCAACTACGAAGGCGGGCCCGAAGGTGGTCACATCCTGAACTATCTGCTGGAAAAGTCCAGGGTCGTCAGTCAGATGCATGGCGAGAGGAACTTCCACATATTCTATCAGCTACTAGCTAGCAGCGATCAGTCACTGATGACTCATTTGAAGCTTCAAGGAAGACCTGAAGCTTATAAGTACACTTCCGATTCGACCTCGCACATGAGTCAGAGAGCGAACGACCAGGAACAGTTCCGTGTCGTACAAGAGGCCATGAAGGTCATAGAAATCGGCGAGAGTGAACAGCGGGAGATCTTTGAGATCGTGGCCAGCGTCCTGCACCTCGGCAACGTGAAGTTCGTCCAGAATGACAAGGGCTATGCCGAGATCCTGTCCCACGACGCCAACAGTGGGAATGCTGCTGATCTCCTAAAAGTGAACGCGACGGCATTACGCGAGGCCCTGACCAATAGGACGATAGAGGCCCGCGGCGACGTCGTCAGCACACCCCTGGACGTGGAACAGGCTCAATACGCTAGAGACGCTCTGGCTAAAGCTATATACGACAAGCACTTCAGCTGGCTGGTCTCCAGGCTAAACTCGTCGCTTGCGCCCATCGAGAAGGACGCTAAATCTTCTGTTATAGGAATCTTGGATATCTACGGCTTTGAGATATTCCCTAAGAACAGCTTCGAGCAGTTCTGCATAAACTTCTGTAACGAGAAGCTCCAGCAGCTGTTCATCCAGCTCACGCTGCGGCAGGAGCAGGAGGAGTACCTGCGGGAAGGCATCGAGTGGGAGCCGGTCGAGTACTTCAACAATATCATCATTTGCGACCTTATCGAAGCCAGGCATAAGGGTATAATATCAATACTGGACGACGAGTGCCTTCGTCCCGGGGACGCGACAGACGCGAGTTTCCTCGACAAGCTGAACCAGCATCTGGACGGCCACCAGCACTACAAGTCCCACCGCAAATCCGACACCAAGACCCAGAAGCTGATGGGCCGTGATGAGTTCTGCCTGGTCCACTACGCCGGCGAAGTGACTTACAACGTGAACACCTTCTTGGAGAAGAACAACGATCTCCTCTTCCGCGACATCCAGAGCCTGATGGCGTCCAGCGACAACACCATCGTCGGCTGCTGCTTCAAGGACTACAACTTGAGGAGCAAGAAACGTCCGGAGACCGCCATCACTCAGTTCAAGAATTCTCTGAACGACCTCATCAAGATCCTCAGCAGCAAGGAGCCCTCGTACATCCGCTGCATCAAGCCCAACGACTTCAAGGCGCCGATGCAATTCGACGACAAGCTGGTCTCCCACCAGGTGAAGTATCTCGGTCTGATGGAGAACCTCAGGGTGCGGCGCGCCGGCTTCGCTTACAGGAGGACTTACGAAGCGTTCTTGGAAAGGTACAAGTGCCTGAGCGCGGAGACGTGGCCCAACTACCGCGGCGCCGCGCGGGACGGCGTGCAGCGGCTGGTGGAGGCCCTCCAGTACGAGAAAGAGGAATACAGGATGGGGAATACGAAAATCTTCGTTCGATTCCCGAAGACGCTCTTCGCAACGGAAGACGCCTTCCAGATAAAGAAGAACGACATAGCCACCATCATCCAGAGCAGGTGGCGAGGTTACTACCTCAGGAAGAGGTACCTCCGAATGCGGAACGCGGCCATCGTCATCCAGAAGTGGGTGAGGAGGTTCCTGGCCCAAAGACTCAGGGAGAGGAGGAGGAAAGCCGCTGACGTCATCAGAGCTTTTATTAAAGGCTTCATCACTCGCAACGGTCCGGAGACGCCAGAAAACCGGCGATTCCTCGGCGTCGCCAAGGTGCACTGGCTGAAGCGTCTCTCGGCGCAGCTCCCAACCAAGCTGCTGGACCTGTCGTGGCCGCCGTGCCCCTCCACCTGCCGAGAGGCCTCCGAGGAGCTCCATCGCCTGCACCGGGCCCACCTCGCCAGGAAGTACAGGCTGGCCTTGTCTCCTGACGATAAGAAGCAGTTTGAGCTGAAGGTCTTGGCCGAAAAAATATTTAAGGGTAAAAAGAACAGCTACCTCAGCAGCGTCGGGGAGAGGTTCGTGAACGACCGCATGAGTCCCGAGCACAGGACCTTGAGGGACACCTTCATGGCGTCGCCGGCCTGGCCGAGCGGCGAGGAACTCATCTACTCGTGCGAGGCGGTGAAGTACGACCGGCGCGGCTACAAGGCCCGCGCGCGCGGCCTGCTGGCGTCCCGCGCGGCGCTGTACGTGCTGGACGCGGGCGGGCGCCGCACGTTCCGGCTCAAGCACCGGCTGCCGCTGGACCGCCTCACCGTCGTCGTCACCAACGAGTCCGACTCGCTGCTGCTGGTCAAGGTGCCGCGCGACCTCAAGAAGGACAAGGGAGATCTGATCATATCCGTGACGCATCTCATCGAGGCCCTGACCATCGTGACGGACTACACCAAGAAGCCGGAGCTCATTGAGATAGTCGACACCAGGACCATCGCGCACTCCCTGGTCAACGGCAAGCAGGGGGGTACCATCGAGGTGACGAAGGGCACCCAGCCCGCCATACAACGCGCCAAGAGCGGGAACCTGCTCGTGGTTGCGACTCCTTAG

Protein

MEHSLQHRERVGVQDFVLLEDYRSEAAFIDNLKKRFHENIIYTYIGNVLISVNPYKNLPIYTEEKTKLYFKKAFFEAPPHVFAIADNAYRSLVYEHREQCILISGESGSGKTEASKKVLEYIAARTNHLRNVENVKDKLLQSNPLLEAFGNAKTHRNDNSSRFGKYMDIQFNYEGGPEGGHILNYLLEKSRVVSQMHGERNFHIFYQLLASSDQSLMTHLKLQGRPEAYKYTSDSTSHMSQRANDQEQFRVVQEAMKVIEIGESEQREIFEIVASVLHLGNVKFVQNDKGYAEILSHDANSGNAADLLKVNATALREALTNRTIEARGDVVSTPLDVEQAQYARDALAKAIYDKHFSWLVSRLNSSLAPIEKDAKSSVIGILDIYGFEIFPKNSFEQFCINFCNEKLQQLFIQLTLRQEQEEYLREGIEWEPVEYFNNIIICDLIEARHKGIISILDDECLRPGDATDASFLDKLNQHLDGHQHYKSHRKSDTKTQKLMGRDEFCLVHYAGEVTYNVNTFLEKNNDLLFRDIQSLMASSDNTIVGCCFKDYNLRSKKRPETAITQFKNSLNDLIKILSSKEPSYIRCIKPNDFKAPMQFDDKLVSHQVKYLGLMENLRVRRAGFAYRRTYEAFLERYKCLSAETWPNYRGAARDGVQRLVEALQYEKEEYRMGNTKIFVRFPKTLFATEDAFQIKKNDIATIIQSRWRGYYLRKRYLRMRNAAIVIQKWVRRFLAQRLRERRRKAADVIRAFIKGFITRNGPETPENRRFLGVAKVHWLKRLSAQLPTKLLDLSWPPCPSTCREASEELHRLHRAHLARKYRLALSPDDKKQFELKVLAEKIFKGKKNSYLSSVGERFVNDRMSPEHRTLRDTFMASPAWPSGEELIYSCEAVKYDRRGYKARARGLLASRAALYVLDAGGRRTFRLKHRLPLDRLTVVVTNESDSLLLVKVPRDLKKDKGDLIISVTHLIEALTIVTDYTKKPELIEIVDTRTIAHSLVNGKQGGTIEVTKGTQPAIQRAKSGNLLVVATP

Description

Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Functions as antagonist for Myo31DF, an unconventional myosin with an essential role in the establishment of body left-right asymmetry (PubMed:16598258, PubMed:18521948, PubMed:22491943, PubMed:25659376, PubMed:30467170).

Subunit

Binds F-actin.

Miscellaneous

Overexpression in larval epidermis causes sinistral twisting of the whole larval body. Ectopic expression in tracheal precursor cells causes sinistral spiraling of tracheal branches, giving rise to a spiraling ribbon shape instead of the normal smooth tube. Ectopic expression in epithelial cells causes increased elongation and a clear shift of the membrane orientation toward one side, so that the membrane is no longer perpendicular to the anterior-posterior axis (PubMed:30467170). Overexpression causes reversal of the normal left-right laterality of the embryonic midgut and hindgut (PubMed:16598258, PubMed:18521948). Overexpression causes loss of the normal dextral rotation of the male genitalia, and leads to sinistral rotation in some cases (PubMed:22491943).

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Keywords

Actin-binding   Alternative splicing   ATP-binding   Calmodulin-binding   Cell membrane   Complete proteome   Cytoplasm   Lipid-binding   Membrane   Motor protein   Myosin   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Unconventional myosin IC
splice variant  In isoform B.

Uniprot

A0A194PRZ8   A0A0N1INH8   A0A1E1WK14   A0A1E1W8K0   A0A2A4JZ64   A0A3S2MAG9   + More
H9JK06   A0A0L7L631   A0A348G646   A0A151J6J8   E2B7F9   A0A0C9QXW7   A0A026VZT4   A0A195CCQ9   A0A088AVI4   A0A158NEW1   A0A151WVP6   A0A195BVC0   A0A310ST08   A0A1L8E5X6   A0A182FKP9   A0A2J7QFE4   A0A2J7QFE9   F4WJ87   A0A2M4AA58   U5EW26   A0A0Q9XL00   B4L0P1   A0A2M4A9P6   W5JML8   A0A182QYK2   A0A1Q3FLX3   A0A1Q3FLL4   A0A1A9V471   A0A182YL50   A0A1A9YEG4   A0A1B0B7X8   A0A1Q3FLT0   A0A1Q3FLT2   A0A1Q3FM21   A0A0M3QVU1   B4IXH1   A0A0Q9WHM7   A0A182H660   B4LG69   A0A182KAK6   A0A1S4FUJ9   Q16NP7   B0X747   A0A0M8ZS21   A0A182TTN5   A0A182VJX7   A0A182L4J8   A0A1A9ZS32   A0A182IYV6   A0A182WED5   A0A0P8ZU70   A0A084VBX9   B3M521   A0A1A9WLI6   A0A3B0KL26   A0A182PEJ1   Q29EW2   A0A0R3P5Y2   B4N3T9   A0A1L8EGC1   T1P833   B4PD73   A0A0R1DZQ6   A0A1I8N9X0   A0A1I8N9W3   A0A2A3EPN8   H8F4R0   A0A0L0CIE1   Q23979   Q23979-2   Q23979-3   A0A0Q5UH73   B3NB94   A0A0Q5U5L1   A0A0A1WZ38   A0A0A1WHX9   A0A034W3K4   A0A034W101   A0A0J9RLM0   W8B7N0   A0A0J9RLH4   A0A0K8V3T3   A0A0K8UZK9   A0A0J9RN04   A0A1W4W7N5   B4HVR8   A0A1W4VV78   A0A1W4W748   A0A1I8P1M8   A0A182R4F7   A0A182HH34   A0A023FBM3   A0A1B6CDD8   A0A1Y1JZT2  

Pubmed

26354079    19121390    26227816    20798317    24508170    21347285    + More
21719571    17994087    18057021    20920257    23761445    25244985    26483478    17510324    20966253    24438588    15632085    23185243    17550304    25315136    26108605    8201616    10731132    12537572    12537569    8216259    7589814    17372656    16598258    18521948    22491943    25659376    30467170    25830018    25348373    22936249    24495485    25474469    28004739   

EMBL

KQ459595    KPI95733.1    KQ461192    KPJ07027.1    GDQN01003710    JAT87344.1    + More
GDQN01010062    GDQN01009104    GDQN01007779    JAT80992.1    JAT81950.1    JAT83275.1    NWSH01000384    PCG76793.1    RSAL01000001    RVE55153.1    BABH01026599    BABH01026600    JTDY01002788    KOB70729.1    FX985586    BBF97919.1    KQ979851    KYN18844.1    GL446181    EFN88334.1    GBYB01005532    JAG75299.1    KK107522    EZA49318.1    KQ978023    KYM97873.1    ADTU01013250    KQ982696    KYQ51980.1    KQ976401    KYM92527.1    KQ759817    OAD62770.1    GFDF01000172    JAV13912.1    NEVH01015298    PNF27310.1    PNF27312.1    GL888182    EGI65665.1    GGFK01004356    MBW37677.1    GANO01001623    JAB58248.1    CH933809    KRG05987.1    KRG05988.1    EDW18118.1    GGFK01004141    MBW37462.1    ADMH02000614    ETN65622.1    AXCN02001655    GFDL01006559    JAV28486.1    GFDL01006669    JAV28376.1    JXJN01009740    GFDL01006514    JAV28531.1    GFDL01006567    JAV28478.1    GFDL01006509    JAV28536.1    CP012525    ALC42993.1    CH916366    EDV96408.1    CH940647    KRF84347.1    KRF84348.1    JXUM01026809    JXUM01026810    KQ560768    KXJ80961.1    EDW69377.2    CH477814    EAT35966.1    DS232438    EDS41741.1    KQ435922    KOX68473.1    CH902618    KPU78069.1    KPU78070.1    ATLV01009818    KE524548    KFB35473.1    EDV39500.2    OUUW01000012    SPP87269.1    CH379070    EAL29947.3    KRT08507.1    KRT08508.1    CH964095    EDW79294.1    GFDG01001150    JAV17649.1    KA644801    AFP59430.1    CM000159    EDW92821.2    KRK00729.1    KRK00730.1    KZ288198    PBC33660.1    BT133300    AFD10747.1    JRES01000356    KNC31972.1    U07596    AE014296    AY069044    L13070    AJ000879    CH954178    KQS43058.1    EDV50147.2    KQS43059.1    KQS43060.1    GBXI01013699    GBXI01010609    JAD00593.1    JAD03683.1    GBXI01015820    JAC98471.1    GAKP01010599    JAC48353.1    GAKP01010593    JAC48359.1    CM002912    KMY96796.1    GAMC01020721    GAMC01020720    JAB85834.1    KMY96793.1    GDHF01018788    GDHF01014275    JAI33526.1    JAI38039.1    GDHF01020202    JAI32112.1    KMY96794.1    KMY96795.1    CH480817    EDW50033.1    APCN01002381    GBBI01000313    JAC18399.1    GEDC01025847    JAS11451.1    GEZM01099418    GEZM01099415    GEZM01099412    GEZM01099410    GEZM01099409    JAV53330.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000283053    UP000005204    UP000037510    + More
UP000078492    UP000008237    UP000053097    UP000078542    UP000005203    UP000005205    UP000075809    UP000078540    UP000069272    UP000235965    UP000007755    UP000009192    UP000000673    UP000075886    UP000078200    UP000076408    UP000092443    UP000092460    UP000092553    UP000001070    UP000008792    UP000069940    UP000249989    UP000075881    UP000008820    UP000002320    UP000053105    UP000075902    UP000075903    UP000075882    UP000092445    UP000075880    UP000075920    UP000007801    UP000030765    UP000091820    UP000268350    UP000075885    UP000001819    UP000007798    UP000002282    UP000095301    UP000242457    UP000037069    UP000000803    UP000008711    UP000192221    UP000001292    UP000095300    UP000075900    UP000075840   

PRIDE

H9JK06    H8F4R0    Q23979   

Pfam

PF06017   Myosin_TH1        + More
PF00612   IQ
PF00063   Myosin_head

Interpro

IPR000048   IQ_motif_EF-hand-BS        + More
IPR036072   MYSc_Myo1       
IPR010926   Myosin_TH1       
IPR036961   Kinesin_motor_dom_sf       
IPR001609   Myosin_head_motor_dom       
IPR027417   P-loop_NTPase       

SUPFAM

SSF52540   SSF52540       

Gene 3D

3.40.850.10    

CDD

cd01378  MYSc_Myo1

ProteinModelPortal

A0A194PRZ8   A0A0N1INH8   A0A1E1WK14   A0A1E1W8K0   A0A2A4JZ64   A0A3S2MAG9   + More
H9JK06   A0A0L7L631   A0A348G646   A0A151J6J8   E2B7F9   A0A0C9QXW7   A0A026VZT4   A0A195CCQ9   A0A088AVI4   A0A158NEW1   A0A151WVP6   A0A195BVC0   A0A310ST08   A0A1L8E5X6   A0A182FKP9   A0A2J7QFE4   A0A2J7QFE9   F4WJ87   A0A2M4AA58   U5EW26   A0A0Q9XL00   B4L0P1   A0A2M4A9P6   W5JML8   A0A182QYK2   A0A1Q3FLX3   A0A1Q3FLL4   A0A1A9V471   A0A182YL50   A0A1A9YEG4   A0A1B0B7X8   A0A1Q3FLT0   A0A1Q3FLT2   A0A1Q3FM21   A0A0M3QVU1   B4IXH1   A0A0Q9WHM7   A0A182H660   B4LG69   A0A182KAK6   A0A1S4FUJ9   Q16NP7   B0X747   A0A0M8ZS21   A0A182TTN5   A0A182VJX7   A0A182L4J8   A0A1A9ZS32   A0A182IYV6   A0A182WED5   A0A0P8ZU70   A0A084VBX9   B3M521   A0A1A9WLI6   A0A3B0KL26   A0A182PEJ1   Q29EW2   A0A0R3P5Y2   B4N3T9   A0A1L8EGC1   T1P833   B4PD73   A0A0R1DZQ6   A0A1I8N9X0   A0A1I8N9W3   A0A2A3EPN8   H8F4R0   A0A0L0CIE1   Q23979   Q23979-2   Q23979-3   A0A0Q5UH73   B3NB94   A0A0Q5U5L1   A0A0A1WZ38   A0A0A1WHX9   A0A034W3K4   A0A034W101   A0A0J9RLM0   W8B7N0   A0A0J9RLH4   A0A0K8V3T3   A0A0K8UZK9   A0A0J9RN04   A0A1W4W7N5   B4HVR8   A0A1W4VV78   A0A1W4W748   A0A1I8P1M8   A0A182R4F7   A0A182HH34   A0A023FBM3   A0A1B6CDD8   A0A1Y1JZT2  

PDB

4BYF     E-value=0,     Score=2224

KEGG

101736752    K10356 myosin I | (RefSeq) myosin-IB

GO

GO:0016459   GO:0005524   GO:0003779   GO:0003774   GO:0042623   GO:0005938   GO:0005516   GO:0042742   GO:0005546   GO:0005903   GO:0032528   GO:0005886   GO:0007498   GO:0007368   GO:0048803   GO:0005515   GO:0030036   GO:0016020   GO:0035023   GO:0016742   GO:0003824  

Subcellular location

Cytoplasm   Protein shifts from the basolateral to apical domain in enterocytes and follicle cells (PubMed:7589814). Colocalizes with the actin cytoskeleton (PubMed:22491943, PubMed:25659376).   With evidence from 7 publications.
Cell cortex   Protein shifts from the basolateral to apical domain in enterocytes and follicle cells (PubMed:7589814). Colocalizes with the actin cytoskeleton (PubMed:22491943, PubMed:25659376).   With evidence from 7 publications.
Cell membrane   Protein shifts from the basolateral to apical domain in enterocytes and follicle cells (PubMed:7589814). Colocalizes with the actin cytoskeleton (PubMed:22491943, PubMed:25659376).   With evidence from 7 publications.

Length:

1032

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.825689999999999

Exp number, first 60 AAs:

0.76653

Total prob of N-in:

0.03733

outside

1  -  1032

 

 

Pi

242.716803

Theta

160.850652

Tajima's D

0.892276

CLR

0.437625

CSRT

0.630968451577421

Interpretation

Uncertain