Gene

KWMTBOMO04751

Pre Gene Modal

BGIBMGA009859

Annotation

PREDICTED:_phosphopantothenoylcysteine_decarboxylase_[Papilio_polytes]

Location

Bomo_Chr8(-):14106754-14108219      View in EpiBrowser

Full name

Phosphopantothenoylcysteine decarboxylase      

Alternative Name

CoaC

Location in the cell

Cytoplasmic   Reliability : 2.151

CDS

ATGGATGAAAATACTACATTTAATGTTTTAGTAGGTGTTACTGGAAGTGTTGCAGCTATAAAGATACCGAATTTAATAAAATCCGTGTTGGAGTTACGAAGCGAGACTCGATATAATTTTAAGGTACGACTAATAGTAACAGAACATGCAAAGCACTTCTTTGAGTGGACTGAAATGCCCTTGGATGTACTAAGATATGATGACTCTTCAGAATGGGTAACATGGAAAGGAAGAGGAGATCCAGTATTACATATAGAACTTGGAAAATGGGCTGACATAATGGTTATAGCACCAATGGATGCTAATACATTAGCAAAAGTGGCATTGGGCATGTGTGATAATTTAGTCACATGTACAGTAAGAGCATGGAACTTCTCCAAACCTCTGCTATTTTGTCCAGCTATGAATACTAGAATGTGGGACCATCCAATCACAGCCACTCACATTTCTACACTACGAGCCTGGGGTTTTATTCAAATACCACCCATAACTAAAACTTTGATGTGCGGTGACACCGGTGTAGGTGCCATGGCAGAAGTAGAGGCAATTGTTGAAAAAATCAAATTAATAGCTGATATGAAAATGAATAGAACACAATAA

Protein

MDENTTFNVLVGVTGSVAAIKIPNLIKSVLELRSETRYNFKVRLIVTEHAKHFFEWTEMPLDVLRYDDSSEWVTWKGRGDPVLHIELGKWADIMVIAPMDANTLAKVALGMCDNLVTCTVRAWNFSKPLLFCPAMNTRMWDHPITATHISTLRAWGFIQIPPITKTLMCGDTGVGAMAEVEAIVEKIKLIADMKMNRTQ

Description

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine (By similarity).

Catalytic Activity

H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D-pantetheine 4'-phosphate

Cofactor

FMN

Subunit

Homotrimer.

Similarity

Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.

Keywords

Coenzyme A biosynthesis   Complete proteome   Decarboxylase   Flavoprotein   FMN   Lyase   Reference proteome  

Feature

chain  Phosphopantothenoylcysteine decarboxylase

Uniprot

H9JK08   A0A0N0PAJ4   A0A2H1WRW2   A0A194PSJ4   A0A2A4JEQ2   A0A212FCL2   + More
A0A182KBI3   A0A2J7QP62   A0A2M4AWQ4   A0A0L0CQP0   Q7PZN2   A0A182XFQ3   A0A182FVS7   A0A2M3ZCL9   A0A182UQE4   A0A182HHS1   A0A2M3ZJK1   U5ESC8   A0A2M4C078   A0A1I8NPL5   A0A182KLL6   A0A067QIV1   A0A182W255   A0A2M3ZCS2   A0A084W4E2   A0A023EIV9   A0A034WTA2   A0A1I8MJB3   D2CFX2   A0A0K8USB0   A0A0K8TKK5   A0A182MV92   W8BHG4   W5JPY6   Q1HQE9   A0A182N9P8   A0A182RMQ5   A0A0L7L7Q6   J3JV50   A0A1Y1KW16   A0A1W4WXV5   U4TS01   A0A182R154   B0XL28   A0A1S4ETD4   A0A182J918   A0A3B3Z9U4   A0A0M3QUP7   A0A1Q3F7Z7   I3KE39   A0A250XW22   U3K8G5   A0A1B6FE18   A0A3B3Z9A2   A0A3P9D6X9   A0A1A9W118   A0A3Q4MXS0   H9GP06   A0A1Q3FIK7   A0A091RTN1   A0A1Q3FI41   A0A1Q3FJC3   A0A091KDT5   A0A3P8Q5B4   A0A3P9D7J4   A0A091LNL9   G1MTN7   A0A1A9XZK9   A0A091TWZ1   D3TRH5   A0A3L8RUI6   V5G7P2   A0A1B0G7E8   H0Z086   A0A091NJ21   A0A3Q4MXQ3   G3U899   E3TGC7   A0A0A0AM39   Q6PBQ5   Q1LWK2   K7FZ56   B4JW85   A0A091MGQ1   B0S701   B4P8F9   A0A093JBD5   A0A3P8PME1   A0A1U8BLH5   Q8BZB2   A0A3B4H8R4   I3MDG5   E1BUI2   A0A091P7J7   V9L0R4   A0A1B6JRG1   A0A2R7WHC0   A0A3Q1CJ39   A0A2Y9QQ67   A0A093EFJ3  

EC Number

4.1.1.36

Pubmed

19121390    26354079    22118469    26108605    12364791    14747013    + More
17210077    20966253    24845553    24438588    24945155    25348373    25315136    18362917    19820115    26369729    24495485    20920257    23761445    17204158    17510324    26227816    22516182    28004739    23537049    25463417    25186727    28087693    21881562    20838655    20353571    30282656    20360741    20634964    23594743    17381049    17994087    17550304    16141072    15489334    21183079    15592404    24402279   

EMBL

BABH01026591    KQ461192    KPJ07024.1    ODYU01010573    SOQ55778.1    KQ459595    + More
KPI95729.1    NWSH01001682    PCG70431.1    AGBW02009174    OWR51472.1    NEVH01012097    PNF30376.1    GGFK01011864    MBW45185.1    JRES01000049    KNC34561.1    AAAB01008986    EAA00226.3    GGFM01005500    MBW26251.1    APCN01002437    GGFM01007950    MBW28701.1    GANO01003307    JAB56564.1    GGFJ01009562    MBW58703.1    KK853297    KDR08781.1    GGFM01005517    MBW26268.1    ATLV01020327    KE525298    KFB45086.1    GAPW01004702    JAC08896.1    GAKP01001078    JAC57874.1    DS497670    EFA13040.1    GDHF01022732    JAI29582.1    GDAI01002711    JAI14892.1    AXCM01001643    GAMC01008373    JAB98182.1    ADMH02000674    ETN65373.1    DQ440495    CH477658    ABF18528.1    EAT37680.1    EAT37682.1    JTDY01002456    KOB71374.1    BT127116    AEE62078.1    GEZM01074077    JAV64681.1    KB630779    KB631357    ERL83860.1    ERL84259.1    AXCN02001803    DS234212    EDS33257.1    CP012524    ALC41039.1    GFDL01011344    JAV23701.1    AERX01005343    GFFV01004389    JAV35556.1    AGTO01001423    GECZ01021310    JAS48459.1    AAWZ02029030    GFDL01007732    JAV27313.1    KK931024    KFQ45116.1    GFDL01007804    JAV27241.1    GFDL01007443    JAV27602.1    KK739494    KFP38267.1    KK504214    KFP60766.1    KK467948    KFQ82954.1    EZ424027    ADD20303.1    QUSF01000201    RLV87459.1    GALX01002311    JAB66155.1    CCAG010021563    ABQF01049836    KL384642    KFP89486.1    GU589413    ADO29363.1    KL872122    KGL94648.1    BX571883    BC059622    AAH59622.1    BX548060    AGCU01107710    AGCU01107711    AGCU01107712    CH916375    EDV98223.1    KK827306    KFP73756.1    CAQ13581.1    CM000158    EDW91199.1    KK572421    KFW08294.1    AK036042    BC052928    BC089351    AGTP01003568    AADN05000047    KK668637    KFQ03123.1    JW871888    AFP04406.1    GECU01005915    JAT01792.1    KK854807    PTY18909.1    KK367153    KFV41713.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000075881    + More
UP000235965    UP000037069    UP000007062    UP000076407    UP000069272    UP000075903    UP000075840    UP000095300    UP000075882    UP000027135    UP000075920    UP000030765    UP000095301    UP000007266    UP000075883    UP000000673    UP000008820    UP000075884    UP000075900    UP000037510    UP000192223    UP000030742    UP000075886    UP000002320    UP000079169    UP000075880    UP000261520    UP000092553    UP000005207    UP000016665    UP000265160    UP000091820    UP000261580    UP000001646    UP000265100    UP000001645    UP000092443    UP000276834    UP000092444    UP000007754    UP000007646    UP000221080    UP000053858    UP000000437    UP000007267    UP000001070    UP000002282    UP000189706    UP000000589    UP000261460    UP000005215    UP000000539    UP000257160    UP000248480   

PRIDE

H9JK08    Q8BZB2   

Pfam

PF02441   Flavoprotein        + More
PF06747   CHCH

Interpro

IPR003382   Flavoprotein        + More
IPR036551   Flavin_trans-like       
IPR010625   CHCH       

SUPFAM

SSF52507   SSF52507       

Gene 3D

3.40.50.1950    

ProteinModelPortal

H9JK08   A0A0N0PAJ4   A0A2H1WRW2   A0A194PSJ4   A0A2A4JEQ2   A0A212FCL2   + More
A0A182KBI3   A0A2J7QP62   A0A2M4AWQ4   A0A0L0CQP0   Q7PZN2   A0A182XFQ3   A0A182FVS7   A0A2M3ZCL9   A0A182UQE4   A0A182HHS1   A0A2M3ZJK1   U5ESC8   A0A2M4C078   A0A1I8NPL5   A0A182KLL6   A0A067QIV1   A0A182W255   A0A2M3ZCS2   A0A084W4E2   A0A023EIV9   A0A034WTA2   A0A1I8MJB3   D2CFX2   A0A0K8USB0   A0A0K8TKK5   A0A182MV92   W8BHG4   W5JPY6   Q1HQE9   A0A182N9P8   A0A182RMQ5   A0A0L7L7Q6   J3JV50   A0A1Y1KW16   A0A1W4WXV5   U4TS01   A0A182R154   B0XL28   A0A1S4ETD4   A0A182J918   A0A3B3Z9U4   A0A0M3QUP7   A0A1Q3F7Z7   I3KE39   A0A250XW22   U3K8G5   A0A1B6FE18   A0A3B3Z9A2   A0A3P9D6X9   A0A1A9W118   A0A3Q4MXS0   H9GP06   A0A1Q3FIK7   A0A091RTN1   A0A1Q3FI41   A0A1Q3FJC3   A0A091KDT5   A0A3P8Q5B4   A0A3P9D7J4   A0A091LNL9   G1MTN7   A0A1A9XZK9   A0A091TWZ1   D3TRH5   A0A3L8RUI6   V5G7P2   A0A1B0G7E8   H0Z086   A0A091NJ21   A0A3Q4MXQ3   G3U899   E3TGC7   A0A0A0AM39   Q6PBQ5   Q1LWK2   K7FZ56   B4JW85   A0A091MGQ1   B0S701   B4P8F9   A0A093JBD5   A0A3P8PME1   A0A1U8BLH5   Q8BZB2   A0A3B4H8R4   I3MDG5   E1BUI2   A0A091P7J7   V9L0R4   A0A1B6JRG1   A0A2R7WHC0   A0A3Q1CJ39   A0A2Y9QQ67   A0A093EFJ3  

PDB

1QZU     E-value=4.54981e-58,     Score=565

KEGG

101736474    K01598 phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] | (RefSeq) phosphopantothenoylcystein

PATHWAY

00770    Pantothenate and CoA biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0003824   GO:0042802   GO:0004633   GO:0015937   GO:0016043   GO:0005488   GO:0017048   GO:0030036   GO:0016020   GO:0035023   GO:0005515   GO:0016742  

Length:

199

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.13101

Exp number, first 60 AAs:

4.04809

Total prob of N-in:

0.28927

outside

1  -  199

 

 

Pi

317.884719

Theta

232.292353

Tajima's D

1.16045

CLR

0

CSRT

0.702064896755162

Interpretation

Uncertain