Silkworm Genome Informatics Database

Gene

KWMTBOMO04744 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009877

Annotation

PREDICTED:_SWI/SNF-related_matrix-associated_actin-dependent_regulator_of_chromatin_subfamily_A_containing_DEAD/H_box_1_homolog_[Bombyx_mori]

Location

Bomo_Chr8(+):13924110-13938021 View in EpiBrowser

Full name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog

Alternative Name

Enhancer trap locus homolog 1

Location in the cell

Nuclear Reliability : 3.671

CDS

ATGTCTGAAAGTAACAGCCCTAGTGTGTTAAGTTATCTAAGACAATACAGGTTTCAGAGAAAACCAAATGAATCCTCAGGCTCCGGTAACCAAGTTACAATTAAGGCTTCTACATCGAGTTCTCAACCACAAATAATAAGGATGCCAGCTCCAAACCACACTGGCCAACGTCAAAACAATCCTGTTGTGGTCTACAAGAGGATCAGGTTACCAGATTCCGATTCTGACGATCCAGCATCGCCAGCAAAGAAAGCAGCCCTCCAAGTTGAACTTACTCCAGCTATCAAAGAGAGACGCTTTAGGAACATGCTAGAAATGTTTCCAGACATTTCACCATTGCTTGTCAAAAACAAATTAGTCAAACATGGCTGGAATGAAGAGCGTTCAAGAGATGAACTCCTGAAATACGACCCTGAGAGTAATGACAAAGGATCCTCATCCACCTTCTTCAGTGCACCATCTCATTCAAAAACTAATGGTAACATGACCATGGTGAGAGTGACTAGTGGTCCCAATAGATTTAATGTTGTTGTGAGGAAGCCAGTGGTGTCAAAGGGCGGCAGAGCCAGAAGAGGCAGCAGTGGTAGCGAAGATGATGACTATGGTGTTAGAAAAGGAAAAGATGATTTAGTTTATGACAGTGATGACTCTGACAATGAAGTGACAGACGATTTAATAGGTGACAAAAAGAAGGTATTCGAGTTCCTAAACACAAGTAATATGAATGAACTATCATTGTTGAGTGGATGCTCACAAAAGAAAGCAGAGGCTATAATGGCACTGAGACCATTCAAAGGATGGTTGGATATGGTAGAAAAATTTAATAGTAACAAAATGCTGAGCACGGATCTCTTAAACTCCACTCAAGAGCTACTAACAACCAGGAATAACATTCAACGGCTTATGAAGAAGTGTGTTGGTCTGGCGCAGCAGCTCGAGGCGGCTGTAGCTGCTGGCGCTGGACGTCTCAAACAACCCTCGATTTTAGATCCTAGTTTAAAGCTAGCCCCATACCAGTTGGTGGGACTAAACTGGCTAGCAGTACTCCATAAGCAGGGCGTATCCGGGATCCTGGCAGATGAGATGGGACTTGGCAAGACAGTTCAAGTGATAGCCTTTCTTGCGCATTTGAAAGAGACAGGCCAAGCCAAGGGAACTCATTTGATTGTTGTTCCGGCTTCTACTTTAGACAACTGGAGCAGCGAGCTGTCCCGCTGGTGCCCGTCGCTGCGCGTGAGCAAGTACTACGGGCACCCGGACGAGCGGCGGCAGCTGAGGATCGAGTACGCGCGCGGGCTGCAGGACGTCGACGTCGTGCTCACCACTTACACCATGGTGAACAGCTGCCCCGAAGAGCGGAAGATGTTCAGGATAACTCCGATGCATTACGTCATCTACGACGAAGCGCACATGCTCAAGAACATGTCCACGCAGCGATACGATAATCTCCTTAAAATTAAGTCTAAACACCGTCTCCTGCTGACCGGGACTCCGCTGCAGAACAACCTGATCGAGCTGATGTCGCTGCTGTGCTTCGTGATGCCGCACATGTTCTCCGGGAAGACCGACGACCTGAAGAGCTTGTTCCAGAAGAATACCAAATCGAAGACAAAGAAGACGGACGGCGCGAAAGAGGACGACGAGCCGGCCTTCGAGCAGAGCCAGATAACGCAGGCGAAGCGGATAATGAAGCCGTTCGTGCTGCGGCGGCTGAAGCGGGACGTGCTGCAGGACCTGCCCGACAAGACCAACCACACGCAGCTGTGCGCCATGTCCGCCGCGCAGGGACGCCTCTACAAGGAGCTCATCAGCGGGTTCGCCGACAAGGACGGAGCGATCCACGCCACGACAGAGCAGAGCGGCATGGCCATGATGATGGACATGCGGAAGCTGTCGAACCACCCGCTCCTGCTGCGCTACCACTACCAGGAGGCGCAGTTGAAGAAGATAGCGGCGCGTCTCGTCAAGGAGCCGAGCTATAAAGAGAAGAACGAACACTACGCCTTCCAAGATCTCCTGTGTCTGTCCGACTTCCAGATACACCAGTTGGCTTTGCAGTATTGCAAACAGCACACGATACCGGAGTCGCTGATCCTGGACTCTGGAAAGTTCCAAAAGCTGGACGAGATGCTGCCGAAGCTGAAGGCGGGCGGCCACCGGGTGCTCATCTTCAGTCAGTTCACGATGATGCTGGACATCCTCGAGCCCTACCTCACCATCAGGAGGTATCAGTATCTGCGCCTGGACGGTAGCACCGCCGTTACGGAGAGACAAGACCTAATAGACCAGTACAACAACGAGAACATATTCGTGTTCCTGCTGTCGACGAAGGCGGGCGGGCTCGGCATCAACCTCACCGCGGCCGACACCGTCATCATCCACGACATCGACTTCAACCCATACAACGACAAGCAGGCGGAAGACAGGTGTCATAGACTGGGCCAGACCCGGCCGGTGACAATATACCGGCTGATCAGCGCCGGAACCATCGAGGAGGGAATATATCAGGTCGCGCAGGAGAAACTTAATCTAGAGAAACACGTCACCGGAGAAGATGAGAACGAACCGACGGAGCAGAAGAACGTCGTCCGGCTGCTGTCCGCCGCGCTGGGCCTCACCTCGCCCAACAAATGA

Protein

MSESNSPSVLSYLRQYRFQRKPNESSGSGNQVTIKASTSSSQPQIIRMPAPNHTGQRQNNPVVVYKRIRLPDSDSDDPASPAKKAALQVELTPAIKERRFRNMLEMFPDISPLLVKNKLVKHGWNEERSRDELLKYDPESNDKGSSSTFFSAPSHSKTNGNMTMVRVTSGPNRFNVVVRKPVVSKGGRARRGSSGSEDDDYGVRKGKDDLVYDSDDSDNEVTDDLIGDKKKVFEFLNTSNMNELSLLSGCSQKKAEAIMALRPFKGWLDMVEKFNSNKMLSTDLLNSTQELLTTRNNIQRLMKKCVGLAQQLEAAVAAGAGRLKQPSILDPSLKLAPYQLVGLNWLAVLHKQGVSGILADEMGLGKTVQVIAFLAHLKETGQAKGTHLIVVPASTLDNWSSELSRWCPSLRVSKYYGHPDERRQLRIEYARGLQDVDVVLTTYTMVNSCPEERKMFRITPMHYVIYDEAHMLKNMSTQRYDNLLKIKSKHRLLLTGTPLQNNLIELMSLLCFVMPHMFSGKTDDLKSLFQKNTKSKTKKTDGAKEDDEPAFEQSQITQAKRIMKPFVLRRLKRDVLQDLPDKTNHTQLCAMSAAQGRLYKELISGFADKDGAIHATTEQSGMAMMMDMRKLSNHPLLLRYHYQEAQLKKIAARLVKEPSYKEKNEHYAFQDLLCLSDFQIHQLALQYCKQHTIPESLILDSGKFQKLDEMLPKLKAGGHRVLIFSQFTMMLDILEPYLTIRRYQYLRLDGSTAVTERQDLIDQYNNENIFVFLLSTKAGGLGINLTAADTVIIHDIDFNPYNDKQAEDRCHRLGQTRPVTIYRLISAGTIEEGIYQVAQEKLNLEKHVTGEDENEPTEQKNVVRLLSAALGLTSPNK

Description

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Similarity

Belongs to the SNF2/RAD54 helicase family.

Keywords

ATP-binding Chromatin regulator Complete proteome DNA damage DNA repair DNA-binding Helicase Hydrolase Nucleotide-binding Nucleus Phosphoprotein Reference proteome

Feature

chain SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog

Uniprot

H9JK26 A0A212EZ75 A0A194PQJ3 A0A2H1X2M2 D6WXY6 A0A2J7Q7V2 + More
A0A1W4WYT4 A0A1W4X9N0 N6TFR2 A0A232FAA8 A0A1Y1NLJ0 A0A1Y1NKG0 A0A1Y1NGS1 K7IVI4 A0A0C9PPN0 A0A088AIY4 A0A0L7R8L3 A0A1B0CDQ2 A0A0M3QT62 A0A1I8MUS3 A0A1A9XJD6 B4LRC9 A0A1B0BLR0 A0A034WKS8 A0A1S4FH11 B4KJE3 B4JE36 A0A1Q3F1P8 A0A026WLD3 A0A1Q3F1N2 A0A2A3E4P0 E2BM94 A0A1B0FG91 A0A0K8VUJ6 A0A0K8WI08 A0A0L0CH67 A0A1B0A4U1 A0A0A1WS72 A0A0C9R8N9 A0A195D3L0 Q171Q1 A0A023EVC2 A0A1A9W5A9 A0A1I8Q1B1 W8BQK7 A0A1A9V2B8 A0A0N0U312 A0A1B6HJ59 F4WBW6 A0A0J7KZ47 A0A195DI21 A0A158NQP3 B4MZD3 B0W717 B3MPA4 A0A151XB40 E0VIU3 A0A1W4VXP7 Q9VL72 B4Q892 A0A182H8G0 B3N8J6 B4NYN6 A0A195FT54 A0A195BEC5 W5JCN7 A0A182F179 A0A3B0KP81 A0A084VSU5 Q29ND9 B4G7V9 A0A182Y6B1 A0A182Q7M2 A0A182W8S2 A0A182JM75 A0A182PJL1 A0A182MBE9 A0A182RWR8 A0A336N1R0 A0A1J1I0G1 A0A336MDF4 A0A182UGS7 A0A182VLV7 A0A1S4H3I0 A0A182NP32 A0A182HRA3 A0A182JVJ0 A0A182XGX4 A0A182KZ33 A0A1B6LLW3 Q7Q145 A0A069DX25 A0A023F1N9 A0A224XIJ3 A0A146M6I0 A0A2R7VR46

EC Number

3.6.4.12

Pubmed

19121390 22118469 26354079 18362917 19820115 23537049 + More
28648823 28004739 20075255 25315136 17994087 25348373 24508170 30249741 20798317 26108605 25830018 17510324 24945155 24495485 21719571 21347285 20566863 10731132 12537572 12537569 18327897 22936249 26483478 17550304 20920257 23761445 24438588 15632085 25244985 12364791 20966253 26334808 25474469 26823975

EMBL

BABH01026580 BABH01026581 AGBW02011376 OWR46761.1 KQ459595 KPI95721.1 + More
ODYU01012924 SOQ59466.1 KQ971362 EFA08918.1 NEVH01017010 PNF24659.1 APGK01040126 KB740975 KB632267 ENN76568.1 ERL91013.1 NNAY01000576 OXU27595.1 GEZM01002866 JAV97106.1 GEZM01002867 JAV97105.1 GEZM01002868 JAV97104.1 GBYB01003158 JAG72925.1 KQ414632 KOC67168.1 AJWK01008126 CP012523 ALC38329.1 CH940649 EDW64599.1 JXJN01016540 GAKP01004564 JAC54388.1 CH933807 EDW12518.1 CH916368 EDW03556.1 GFDL01013588 JAV21457.1 KK107154 QOIP01000001 EZA56862.1 RLU27492.1 GFDL01013580 JAV21465.1 KZ288372 PBC26723.1 GL449158 EFN83220.1 CCAG010000709 GDHF01009760 JAI42554.1 GDHF01001546 JAI50768.1 JRES01000384 KNC31758.1 GBXI01012595 JAD01697.1 GBYB01003156 JAG72923.1 KQ976885 KYN07495.1 CH477448 EAT40730.1 GAPW01000193 JAC13405.1 GAMC01007462 JAB99093.1 KQ435922 KOX68578.1 GECU01032987 JAS74719.1 GL888066 EGI68394.1 LBMM01001728 KMQ95837.1 KQ980824 KYN12543.1 ADTU01023456 ADTU01023457 CH963913 EDW77406.1 DS231851 EDS37291.1 CH902620 EDV32223.1 KQ982335 KYQ57567.1 DS235206 EEB13299.1 AE014134 AY060597 CM000361 CM002910 EDX04414.1 KMY89355.1 JXUM01118343 KQ566174 KXJ70348.1 CH954177 EDV58419.1 CM000157 EDW88700.2 KQ981280 KYN43482.1 KQ976511 KYM82547.1 ADMH02001782 ETN61103.1 OUUW01000010 SPP85648.1 ATLV01016141 KE525057 KFB41039.1 CH379060 EAL33403.2 CH479180 EDW28457.1 AXCN02001965 AXCM01005992 UFQT01003167 SSX34677.1 CVRI01000038 CRK93824.1 UFQS01000822 UFQT01000822 SSX07038.1 SSX27381.1 AAAB01008980 APCN01001661 GEBQ01015428 JAT24549.1 EAA13923.4 GBGD01000632 JAC88257.1 GBBI01003786 JAC14926.1 GFTR01008024 JAW08402.1 GDHC01003580 JAQ15049.1 KK854037 PTY09983.1

Proteomes

UP000005204 UP000007151 UP000053268 UP000007266 UP000235965 UP000192223 + More
UP000019118 UP000030742 UP000215335 UP000002358 UP000005203 UP000053825 UP000092461 UP000092553 UP000095301 UP000092443 UP000008792 UP000092460 UP000009192 UP000001070 UP000053097 UP000279307 UP000242457 UP000008237 UP000092444 UP000037069 UP000092445 UP000078542 UP000008820 UP000091820 UP000095300 UP000078200 UP000053105 UP000007755 UP000036403 UP000078492 UP000005205 UP000007798 UP000002320 UP000007801 UP000075809 UP000009046 UP000192221 UP000000803 UP000000304 UP000069940 UP000249989 UP000008711 UP000002282 UP000078541 UP000078540 UP000000673 UP000069272 UP000268350 UP000030765 UP000001819 UP000008744 UP000076408 UP000075886 UP000075920 UP000075880 UP000075885 UP000075883 UP000075900 UP000183832 UP000075902 UP000075903 UP000075884 UP000075840 UP000075881 UP000076407 UP000075882 UP000007062

PRIDE

H9JK26 Q9VL72

Pfam

PF00271   Helicase_C        + More
PF00176   SNF2_N
PF07529   HSA
PF02854   MIF4G

Interpro

IPR014001   Helicase_ATP-bd        + More
IPR001650   Helicase_C
IPR038718   SNF2-like_sf
IPR027417   P-loop_NTPase
IPR000330   SNF2_N
IPR009060   UBA-like_sf
IPR003892   CUE
IPR014012   HSA_dom
IPR017877   Myb-like_dom
IPR010994   RuvA_2-like
IPR016024   ARM-type_fold
IPR003890   MIF4G-like_typ-3
IPR016021   MIF4-like_sf

SUPFAM

SSF52540   SSF52540        + More
SSF46934   SSF46934
SSF47781   SSF47781
SSF48371   SSF48371

Gene 3D

3.40.50.10810 1.25.40.180

CDD

cd00079 HELICc

ProteinModelPortal

H9JK26 A0A212EZ75 A0A194PQJ3 A0A2H1X2M2 D6WXY6 A0A2J7Q7V2 + More
A0A1W4WYT4 A0A1W4X9N0 N6TFR2 A0A232FAA8 A0A1Y1NLJ0 A0A1Y1NKG0 A0A1Y1NGS1 K7IVI4 A0A0C9PPN0 A0A088AIY4 A0A0L7R8L3 A0A1B0CDQ2 A0A0M3QT62 A0A1I8MUS3 A0A1A9XJD6 B4LRC9 A0A1B0BLR0 A0A034WKS8 A0A1S4FH11 B4KJE3 B4JE36 A0A1Q3F1P8 A0A026WLD3 A0A1Q3F1N2 A0A2A3E4P0 E2BM94 A0A1B0FG91 A0A0K8VUJ6 A0A0K8WI08 A0A0L0CH67 A0A1B0A4U1 A0A0A1WS72 A0A0C9R8N9 A0A195D3L0 Q171Q1 A0A023EVC2 A0A1A9W5A9 A0A1I8Q1B1 W8BQK7 A0A1A9V2B8 A0A0N0U312 A0A1B6HJ59 F4WBW6 A0A0J7KZ47 A0A195DI21 A0A158NQP3 B4MZD3 B0W717 B3MPA4 A0A151XB40 E0VIU3 A0A1W4VXP7 Q9VL72 B4Q892 A0A182H8G0 B3N8J6 B4NYN6 A0A195FT54 A0A195BEC5 W5JCN7 A0A182F179 A0A3B0KP81 A0A084VSU5 Q29ND9 B4G7V9 A0A182Y6B1 A0A182Q7M2 A0A182W8S2 A0A182JM75 A0A182PJL1 A0A182MBE9 A0A182RWR8 A0A336N1R0 A0A1J1I0G1 A0A336MDF4 A0A182UGS7 A0A182VLV7 A0A1S4H3I0 A0A182NP32 A0A182HRA3 A0A182JVJ0 A0A182XGX4 A0A182KZ33 A0A1B6LLW3 Q7Q145 A0A069DX25 A0A023F1N9 A0A224XIJ3 A0A146M6I0 A0A2R7VR46

PDB

5HZR E-value=2.85305e-87, Score=824

KEGG

101735864 K14439 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containi

GO

GO:0005524 GO:0004386 GO:0003682 GO:0008094 GO:0005634 GO:0043044 GO:0003677 GO:0045089 GO:0050829 GO:0006325 GO:0006281 GO:0003723 GO:0005622 GO:0005840 GO:0006412 GO:0006511 GO:0016020 GO:0035023 GO:0005515 GO:0016742 GO:0003824

Subcellular location

Nucleus

Length:

877

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20461

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00003

outside

1 - 877

Pi

228.953045

Theta

183.33958

Tajima's D

0.929611

CLR

0.000348

CSRT

0.635218239088046

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics