Gene

KWMTBOMO04737  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009874

Annotation

carboxyl/cholinesterase_7_precursor_[Bombyx_mori]

Location

Bomo_Chr8(+):13842360-13856624      View in EpiBrowser

Full name

Carboxylic ester hydrolase       + More
Venom carboxylesterase-6      

Location in the cell

Extracellular   Reliability : 1.023 Lysosomal   Reliability : 1.021

CDS

ATGCTCTTATTCGCGTCATATTACGGTGACCATCAATTAGGAGATGATCAAAGCCCAATCCACTTCTTAGAACCCCAACAGCTGAAGCCTTGGACTGGAGTTTGGGATGCCACGAGGACTCTTTCCTCGTGTCTACAGTACGATCCATTCGTCGGAACTATAACTGGTAGTGAGAATTGTCTGTTCGTGAATGTGTACACACCCAAGCTGACTCCAACGGCCTCTCTTCCTGTTATGGTTTTCATCCATGGCGGGGCCTTCATGTACGGTGAAGGGGGATTTTACGATGCCGGAAATCTGATGGACAGGGATATGGTGGTCGTCACGTTGAATTATAGATTGGGACCTCTAGGTTTCCTTAGCACAGGCGACGAGGTAGCGCCAGGCAACAACGGCTTGAAAGACCAGTCCTTCGCCCTCCACTGGGTCAAGAACAACATACAGATGTTTGGCGGGAACCCAGACAGCGTGACCCTCACTGGATGCTCCGCAGGCGGCGCCAGCGTCCACTATCACTACCTTTCACCGCTTTCTAGAGGAACATTCCACCGCGGTATCGCCTTTAGTGGATCAGCCTTCGCCTCGTGGACGCACTCAGTGAAACCGGCTCAAAAAGCCAAGACTCTAGCCAGTATAGTAGGCTGTCCTACGGGTACCAGCAAGGAGATCATTGATTGCCTAAAGTATAGGCCAGCTGAAGTTATTGTTAGGGCGCAGATTGAAATGTTTGATTGGAAGGTCCACATGTTCACACCATTCACTCCTACTACGGAAGCTCCAGGGGTAAGAGAGCCCTTCCTATCGCAATATCCATACCACGCCGCTATTGCCGGAGCCATGGCGAAATTACCTCTCATTACTTCGGTTACAAGCGAAGAAGGACTCTATCCTGCTGCAGTATACCAAACGGAGCCCGGAATGTTAAACGAACTTGAAGCTCATTGGGAACAATTGGCGAGCAACATATTTGAGTACAACGACACTCTCCCATTGAACCTCAGAGCGGATGTGGCTGCGAAGATCAAAGAGCATTACCTCGGAGGGAAACCAGTCAGTCAGGAAACATACCCGCAACTTGTACAGGCCTTAGGTGACCGCTTGTTTGTGGTGGACGTAGGCAGAATGGCACAAATTCACGCCCTCAAAACCGGCCAACCTACTTACGTATACCGATATTCGTTCAGAGGAGAGTTTAGTTTATCGAATTTAATGGCGAGGAACGAAAATAATTACGGTGTATGCCACGCTGACGACGTCCTAAGAATATTCAAATACCCAAACTTGAGTAAGATTTCCGCAGAAGACACCAGTATTATAGAATCTCTGATCGATTTGGTGTACAGCTACGCAGCGACCGGGTAA

Protein

MLLFASYYGDHQLGDDQSPIHFLEPQQLKPWTGVWDATRTLSSCLQYDPFVGTITGSENCLFVNVYTPKLTPTASLPVMVFIHGGAFMYGEGGFYDAGNLMDRDMVVVTLNYRLGPLGFLSTGDEVAPGNNGLKDQSFALHWVKNNIQMFGGNPDSVTLTGCSAGGASVHYHYLSPLSRGTFHRGIAFSGSAFASWTHSVKPAQKAKTLASIVGCPTGTSKEIIDCLKYRPAEVIVRAQIEMFDWKVHMFTPFTPTTEAPGVREPFLSQYPYHAAIAGAMAKLPLITSVTSEEGLYPAAVYQTEPGMLNELEAHWEQLASNIFEYNDTLPLNLRADVAAKIKEHYLGGKPVSQETYPQLVQALGDRLFVVDVGRMAQIHALKTGQPTYVYRYSFRGEFSLSNLMARNENNYGVCHADDVLRIFKYPNLSKISAEDTSIIESLIDLVYSYAATG

Catalytic Activity

a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)

Similarity

Belongs to the type-B carboxylesterase/lipase family.

Keywords

Allergen   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Reference proteome   Secreted   Serine esterase   Signal  

Feature

chain  Carboxylic ester hydrolase

Uniprot

H9JK23   E1CGA6   U5KK05   A0A291P0T2   A0A076FR89   A0A291P0Y0   + More
E5KG13   D3GDM4   A0A2U3T8K3   E5KG17   A0A0F7QIE8   A0A0H4SZ14   A0A0B4RY06   A0A0K0XRP9   A0A3S2TTX4   A0A194PQI9   A0A0N0PEV4   A0A1U9X1X5   A0A0C5C1L1   S4PYG7   A0A1L8D6K7   Q3KVM1   Q2TIL4   A0A2H1W8L8   A0A1U9X1Z1   A0A3S2P8Q6   A0A2Z4HPU1   A0A2Z4HPS2   A0A1B6DY64   A0A1B6F6E1   A0A1B6DQ93   A0A1B6DUM7   W8EA95   A0A195C0B2   T1T2X3   A0A1B6J7A4   A0A0C9PIH0   A0A0C9PV54   A0A2J7QJE6   A0A0C5KC25   A0A0K1YWF8   A0A067QFP9   K7IVN6   A0A2J7QJG9   E2AJL8   A0A1B6GMS2   A0A1B6F5U3   A0A1B6HU31   A0A0J7KJE1   K7IVN5   A0A1B6EW62   A0A026X3B8   A0A3L8DLC7   A0A151IVJ7   E2AJL7   E2A4N5   A0A0K1YWD2   A0A154PFR2   A0A154PFL4   A0A195BSF6   E2A4N6   A0A195FZA7   E2BFU2   A0A232ER59   D7ELD3   A0A173DWC2   F4X7W6   A0A151WFZ9   A0A139WD60   J9K2J7   A0A1B6IWH5   A0A1B6E0H5   E2AJL9   A0A310SQJ6   A0A089GRW2   A0A1B6FLE1   A0A348G5Z5   A0A0C5CGY0   E2AI90   Q76LA5   A0A1Y1NET1   A0A2P8XXF2   Q59HJ3   A0A2A3EIC1   A0A1B6M3H1   A0A158NUH4   A0A088AQ41   E2BFU1   E9IIB7   A0A0A7ENJ5   B2D0J5   A0A0A0WDA2   E2BFT9   A0A2S2Q259   A0A3Q9JNY2   A0A0L7QZ65   J9JKD6   A0A151WG00   A0A0L7QZ14  

EC Number

3.1.1.-
3.1.1.1

Pubmed

19121390    21071843    24053512    28986331    24817326    24955877    + More
25803580    26198868    26354079    23622113    16172410    24845553    20075255    20798317    24508170    30249741    28648823    18362917    19820115    21719571    14745104    18308604    28004739    29403074    21347285    21282665    17073008    30090072   

EMBL

BABH01026570    BABH01026571    BABH01026572    BABH01026573    AB543062    BAJ11979.1    + More
JX866742    AGS49146.1    MF687558    ATJ44484.1    KF960785    AII21987.1    MF687627    ATJ44553.1    HQ116556    ADR64697.1    FJ652456    ACV60240.1    KX015855    ARM65384.1    HQ116560    ADR64701.1    LC017764    BAR64778.1    KP677290    AKP92858.1    KJ023200    AIY69028.1    KP938887    AKS40368.1    RSAL01000001    RVE55140.1    KQ459595    KPI95716.1    KQ459784    KPJ19952.1    KY021867    AQY62756.1    KP001151    AJN91196.1    GAIX01003318    JAA89242.1    GEYN01000051    JAV02078.1    AY866480    AAX58711.1    AY866481    AAX58712.1    ODYU01007027    SOQ49410.1    KY021881    AQY62770.1    RVE55139.1    MF163426    MF163428    AWW17128.1    MF163427    AWW17129.1    GEDC01010899    GEDC01006682    JAS26399.1    JAS30616.1    GECZ01024025    GECZ01012469    JAS45744.1    JAS57300.1    GEDC01009443    JAS27855.1    GEDC01007926    JAS29372.1    KF849387    AHJ81350.1    KQ978501    KYM93601.1    KC422259    AGT57960.1    GECU01012653    JAS95053.1    GBYB01000728    JAG70495.1    GBYB01005263    JAG75030.1    NEVH01013556    PNF28713.1    KP114653    AJP62565.1    KP859363    AKZ17673.1    KK853575    KDR06604.1    PNF28712.1    GL440027    EFN66413.1    GECZ01006034    JAS63735.1    GECZ01024140    GECZ01023038    JAS45629.1    JAS46731.1    GECU01029520    JAS78186.1    LBMM01006747    KMQ90359.1    GECZ01027590    JAS42179.1    KK107039    EZA61889.1    QOIP01000006    RLU21207.1    KQ980900    KYN11701.1    EFN66412.1    GL436710    EFN71637.1    KP859359    AKZ17669.1    KQ434893    KZC10652.1    KZC10653.1    KQ976417    KYM89950.1    EFN71638.1    KQ981193    KYN45134.1    GL448039    EFN85480.1    NNAY01002653    OXU20859.1    DS497833    EFA11999.1    KR905662    ANG60750.1    GL888900    EGI57452.1    KQ983203    KYQ46763.1    KQ971361    KYB25880.1    ABLF02021811    GECU01016412    JAS91294.1    GEDC01005884    JAS31414.1    EFN66414.1    KQ760221    OAD61356.1    KM025026    AIP87046.1    GECZ01018764    JAS51005.1    FX985533    BBF97868.1    KP001152    AJN91197.1    GL439688    EFN66849.1    AY647436    AB083009    AAU81605.1    BAC54130.1    GEZM01007534    JAV95105.1    PYGN01001205    PSN36676.1    AB208650    BAD91554.1    KZ288232    PBC31467.1    GEBQ01009537    JAT30440.1    ADTU01026415    ADTU01026416    EFN85479.1    GL763459    EFZ19670.1    KM220528    AIY68319.1    EU564833    KM507200    AIW82257.1    EFN85477.1    GGMS01002576    MBY71779.1    MH561906    AZS52837.1    KQ414685    KOC63846.1    ABLF02021810    KYQ46764.1    KOC63849.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000078542    UP000235965    + More
UP000027135    UP000002358    UP000000311    UP000036403    UP000053097    UP000279307    UP000078492    UP000076502    UP000078540    UP000078541    UP000008237    UP000215335    UP000007266    UP000007755    UP000075809    UP000007819    UP000005203    UP000245037    UP000242457    UP000005205    UP000053825   

PRIDE

H9JK23    E1CGA6    Q76LA5   

Pfam

PF00135   COesterase        + More
PF00027   cNMP_binding

Interpro

IPR029058   AB_hydrolase        + More
IPR019826   Carboxylesterase_B_AS       
IPR002018   CarbesteraseB       
IPR019819   Carboxylesterase_B_CS       
IPR002168   Lipase_GDXG_HIS_AS       
IPR000595   cNMP-bd_dom       
IPR018490   cNMP-bd-like       
IPR014710   RmlC-like_jellyroll       

SUPFAM

SSF53474   SSF53474        + More
SSF51206   SSF51206       

Gene 3D

3.40.50.1820     2.60.120.10    

CDD

cd00038  CAP_ED

ProteinModelPortal

H9JK23   E1CGA6   U5KK05   A0A291P0T2   A0A076FR89   A0A291P0Y0   + More
E5KG13   D3GDM4   A0A2U3T8K3   E5KG17   A0A0F7QIE8   A0A0H4SZ14   A0A0B4RY06   A0A0K0XRP9   A0A3S2TTX4   A0A194PQI9   A0A0N0PEV4   A0A1U9X1X5   A0A0C5C1L1   S4PYG7   A0A1L8D6K7   Q3KVM1   Q2TIL4   A0A2H1W8L8   A0A1U9X1Z1   A0A3S2P8Q6   A0A2Z4HPU1   A0A2Z4HPS2   A0A1B6DY64   A0A1B6F6E1   A0A1B6DQ93   A0A1B6DUM7   W8EA95   A0A195C0B2   T1T2X3   A0A1B6J7A4   A0A0C9PIH0   A0A0C9PV54   A0A2J7QJE6   A0A0C5KC25   A0A0K1YWF8   A0A067QFP9   K7IVN6   A0A2J7QJG9   E2AJL8   A0A1B6GMS2   A0A1B6F5U3   A0A1B6HU31   A0A0J7KJE1   K7IVN5   A0A1B6EW62   A0A026X3B8   A0A3L8DLC7   A0A151IVJ7   E2AJL7   E2A4N5   A0A0K1YWD2   A0A154PFR2   A0A154PFL4   A0A195BSF6   E2A4N6   A0A195FZA7   E2BFU2   A0A232ER59   D7ELD3   A0A173DWC2   F4X7W6   A0A151WFZ9   A0A139WD60   J9K2J7   A0A1B6IWH5   A0A1B6E0H5   E2AJL9   A0A310SQJ6   A0A089GRW2   A0A1B6FLE1   A0A348G5Z5   A0A0C5CGY0   E2AI90   Q76LA5   A0A1Y1NET1   A0A2P8XXF2   Q59HJ3   A0A2A3EIC1   A0A1B6M3H1   A0A158NUH4   A0A088AQ41   E2BFU1   E9IIB7   A0A0A7ENJ5   B2D0J5   A0A0A0WDA2   E2BFT9   A0A2S2Q259   A0A3Q9JNY2   A0A0L7QZ65   J9JKD6   A0A151WG00   A0A0L7QZ14  

PDB

5THM     E-value=2.71749e-63,     Score=614

KEGG

100500761    K01044 carboxylesterase 1 [EC:3.1.1.1] | (RefSeq) cce-7, Bmcce-7; carboxyl/cholinesterase 7

PATHWAY

00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)

GO

GO:0016787   GO:0016021   GO:0052689   GO:0005615   GO:0080030   GO:0005576  

Subcellular location

Secreted  

Length:

453

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.52734

Exp number, first 60 AAs:

0.0156

Total prob of N-in:

0.01335

outside

1  -  453

 

 

Pi

266.074514

Theta

179.356497

Tajima's D

1.987466

CLR

0.059265

CSRT

0.876356182190891

Interpretation

Uncertain