Gene

KWMTBOMO04731

Pre Gene Modal

BGIBMGA009872

Annotation

Membrane-bound_alkaline_phosphatase_[Papilio_xuthus]

Location

Bomo_Chr8(+):13562181-13594983      View in EpiBrowser

Full name

Alkaline phosphatase       + More
Membrane-bound alkaline phosphatase      

Location in the cell

Cytoplasmic   Reliability : 1.36

CDS

ATGGCGCGACAATGGATCGCAGTGCTGGCTTTCGCCGTTGTCCTCGTCCTGACTGACGCAGAAGATGCAGCGACCACGCCGAAACCCAAGAAGGTTCTGGAAACCGTCATGAATCCAGCCTACATACCGGCTGAAGAAAAACACGGTTCCTATTGGAAGAAGTCTGCTGCATCAACACTAAAATCTAAACTAAAAGAGAAGACCAACAAAAATAAGGCCAGAAACGGAATTCTTTTTATTGGCGATGGAATGTCGTTGGCCACTGTCATGGCAGCCCGGACTTATGCCGGCCAACTGGATCGAGGGCTGGGAGAAGAGAATATTCTCGAATTCGAGAAATTCCCGGTGACCGGATTGGCTAGGACATACTGCTTAGACGCCCAAGTGCCGGATTCAGCGTGCACCGCCACCTCATACCTGACCGGAGTGAAGACTAAATACGGAGTAATAGGCTTAGATGGGAACGTGACCCGAGGATCATGTCACTCCCAACTCCACAAAGGAAACTGGGCGCCGTCTATTGGACAATGGGCCATTGAAAACGGATTAGACGTTGGTTTGGTTACAACAACTAGAGTGACGCACGCCTCACCCGCCGGCATGTATGCTCACGTTTCCGAGAGAAATTGGGAGTCGGACGTTGATGTACCAGCGGAGTGCCTGACCCTTGGCTGCCGGGATATCGCGTACCAGCTCGTCATGGACAACCCAGGGAGACAGTTCAAGGTCATCTTGGGCGGCGGCAGACGAGAATTCCTCCCGAACGTCACTGGCTTTGGTAACAACACCGGGAAACGGGTTGATGGAGTGGATCTAACCGAGCTGTGGCACGTGGATAAGCTCCAGAAGAATGTGAGCCATCAGTACGTGACAGACAGACTGGAGCTCTTGAAGGTATACAATTCTGATGATTTACCCGAATACCTCCTGGGATTGTTCAACACTGACCACATGGCGTACCATTTGAAGGCAGAAGACGAGCCGACTTTGGAAGAGATGGTGGAAGTGGCCATCAAAATGCTCAGCAGGAACCCGAAGGGATATTTCCTGTTCGTTGAAGGTGGAAGAATAGACCACGCGCATCACGACAGCCTCGCGTATTTGGCGTTAGACGAGACCGTCGAATACGCTAAAGCCGTAAGAAAAGCCAGATCGCTGACCGACGAATCTGAGACCCTTATTGTCGTGAGCTCCGACCACGCCCACACCATGACCGTGGCCGGCTACCCGTCCAGAGGCAACGACATCCTGGGCGTGGTGGACACGACGAACGGTGGCGACGGAAGACCTTACACTACGATCAGCTACGCAAATGGAAAAGCCGCTTCCATTGACACGGACGGGCTCAGAGTCGACGTTACGAAGGAAAAAGGATTTACGGAGCGTAGCTTGGATTACGCGTACCCAAGTCTCGTGCCTCTGGACTCGGAGACCCACGGCGGCGAGGACGTGGCGGTGTTCGCGCTGGGACCCTGGCAGCACCTGTTCACCGCCAGCTACGATCAGTCCGTGGTGCCTCACTTAATGGCGTACGCGATGTGCCTCACGGACGACCAGCATCAGAACTGCCACCAGCCCGAGAGGCTCACGGAAGCCGCCTCGAGCGCGGTGTCAGTCTATCCATACCAACTATTATTAGCCCAAGCTGTGATATCAATTATTAGTTGTCTCTTATAG

Protein

MARQWIAVLAFAVVLVLTDAEDAATTPKPKKVLETVMNPAYIPAEEKHGSYWKKSAASTLKSKLKEKTNKNKARNGILFIGDGMSLATVMAARTYAGQLDRGLGEENILEFEKFPVTGLARTYCLDAQVPDSACTATSYLTGVKTKYGVIGLDGNVTRGSCHSQLHKGNWAPSIGQWAIENGLDVGLVTTTRVTHASPAGMYAHVSERNWESDVDVPAECLTLGCRDIAYQLVMDNPGRQFKVILGGGRREFLPNVTGFGNNTGKRVDGVDLTELWHVDKLQKNVSHQYVTDRLELLKVYNSDDLPEYLLGLFNTDHMAYHLKAEDEPTLEEMVEVAIKMLSRNPKGYFLFVEGGRIDHAHHDSLAYLALDETVEYAKAVRKARSLTDESETLIVVSSDHAHTMTVAGYPSRGNDILGVVDTTNGGDGRPYTTISYANGKAASIDTDGLRVDVTKEKGFTERSLDYAYPSLVPLDSETHGGEDVAVFALGPWQHLFTASYDQSVVPHLMAYAMCLTDDQHQNCHQPERLTEAASSAVSVYPYQLLLAQAVISIISCLL

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate

Cofactor

Mg(2+)
Zn(2+)

Similarity

Belongs to the alkaline phosphatase family.

Keywords

Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Magnesium   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Zinc  

Feature

chain  Alkaline phosphatase
propeptide  Removed in mature form

Uniprot

H9JK21   A0A194PQI4   A0A2H1V6P7   A0A212FHB6   A0A0N1IIK6   A0A0U1ZF85   + More
W8DT07   M4M265   A0A0L7LK11   C6L8N9   B2ZZW4   B2ZZW8   Q7KXT0   H9JXN7   B2ZZX2   O96056   A5A747   C3U1V9   G3GBT4   A0A3S2PC92   A0A2W1BHB3   C3U1W1   A0A2H5CLJ8   A0A2H1WA01   B4Z1D7   A0A2J7PHL4   C3U1W0   B4X983   I6MML5   A0A212F875   A0A1B0RHM8   A0A2H5CLG8   A0A1B0RHM5   C3U1W2   A0A194R254   I0E1Y2   A0A2A4J355   B4Z1D6   A0A194R1W7   A0A194Q2C7   A0A2W1BMI5   A0A3G1LC34   A0A067QRJ2   E0VEB3   A0A194Q2F4   A0A0U2IR33   I6PI83   A0A2A4J4Q0   A0A2H1VP42   A0A0U1ZJ21   M4M3L4   A0A0U2WZB7   U5EGZ8   R4I4E9   A0A0U2WPZ0   G1JT78   B2ZZW3   A0A1W4X350   B2ZZX0   B2ZZW7   A0A067QT98   A5A746   P29523   A0A212F895   C0JBW1   C6L8N8   H9JH21   B2ZZX1   H9JH27   I6PF06   A0A2L1IQA2   W5JCJ1   B2ZZW5   A0A0U1ZEC3   A0A2H1VQS9   A0A194R7D1   A0A0U1ZEU5   A0A109P4P6   J9JZX4   A0A2H1W0P4   A0A1B0CIG9   A0A0M4F783   A0A2H8TJT6   A0A1B6CV61   R4I4D0   A0A1B6MFZ1   A0A1B6MN90   A0A194R2N2   A0A182JCN5   B3M052   Q16WV8   B4LW25   A0A3F2YW16   B3NZR8   A0A0P6JST2   A0A1S4FLA4   A0A2J7PHK8   Q9VHD0  

EC Number

3.1.3.1

Pubmed

19121390    26354079    22118469    25875245    26227816    14508679    + More
10196735    21840855    28756777    20170658    24845553    20566863    26637593    1756175    29415259    20920257    23761445    17994087    17510324    26999592    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356   

EMBL

BABH01026539    BABH01026540    KQ459595    KPI95711.1    ODYU01000769    SOQ36062.1    + More
AGBW02008519    OWR53113.1    KQ459784    KPJ19948.1    KM048198    AJW76725.1    KC841472    AHF20243.2    JQ747496    AGG36453.1    JTDY01000813    KOB75782.1    AB516293    BAH95822.1    AB379672    BAG41969.1    AB379674    BAG41973.1    AB055428    AB379673    BAB62746.2    BAG41971.1    BABH01044837    AB379677    BAG41977.1    AB013386    BAA34926.1    AB270698    BAF62125.1    FJ416470    ACP39712.1    JF825967    AEG79734.1    RSAL01000106    RVE47295.1    KZ150047    PZC74489.1    FJ416472    ACP39714.1    KY912922    AUH25163.1    ODYU01007279    SOQ49911.1    EU729323    ACF40807.1    NEVH01025135    PNF15822.1    FJ416471    ACP39713.1    EF531619    ABR88230.1    HQ110096    AEL23233.1    AGBW02009775    OWR49944.1    KM360183    AKH49599.1    KY912924    AUH25165.1    KM360191    AKH49607.1    FJ416473    ACP39715.1    KQ460870    KPJ11777.1    JQ365182    AFH96950.1    NWSH01003359    PCG66485.1    EU729322    ACF40806.1    KPJ11778.1    KQ459562    KPI99722.1    PZC74487.1    KY922835    AUF74484.1    KK853042    KDR12134.1    DS235088    EEB11719.1    KPI99721.1    KT276304    ALS30431.1    JF979062    AFI81420.1    PCG66484.1    ODYU01003612    SOQ42593.1    KM048197    AJW76724.1    JQ747498    AGG36455.1    KT276303    ALS30430.1    GANO01003229    JAB56642.1    JN687588    AFJ04289.1    KT276297    ALS30424.1    JN392445    AEM43806.1    BAG41968.1    AB379676    BAG41975.1    BAG41972.1    KDR12135.1    BAF62124.1    D90454    OWR49943.1    FJ175380    ACN29682.1    AB516292    BAH95821.1    BABH01037520    BAG41976.1    BABH01037533    BABH01037534    JF979061    AFI81421.1    MF741672    AVD96955.1    ADMH02001562    ETN62062.1    BAG41970.1    KM048195    AJW76722.1    SOQ42594.1    KPJ11776.1    KM048196    AJW76723.1    KP420013    ALK86921.1    ABLF02034222    ABLF02034224    ODYU01005624    SOQ46661.1    AJWK01013324    CP012526    ALC47682.1    GFXV01002612    MBW14417.1    GEDC01019991    JAS17307.1    JN687589    AFJ04290.1    GEBQ01005162    JAT34815.1    GEBQ01002563    JAT37414.1    KPJ11779.1    CH902617    EDV42009.2    CH477553    EAT39089.1    CH940650    EDW66530.1    CH954181    EDV49778.1    GDUN01000056    JAN95863.1    PNF15827.1    AE014297    AY058670    AAF54384.4    AAL13899.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000037510    UP000283053    + More
UP000235965    UP000218220    UP000027135    UP000009046    UP000192223    UP000000673    UP000007819    UP000092461    UP000092553    UP000075880    UP000007801    UP000008820    UP000008792    UP000075884    UP000008711    UP000000803   

PRIDE

H9JK21    C6L8N9    B2ZZW4    B2ZZW8    Q7KXT0    H9JXN7    + More
B2ZZX2    O96056    A5A747    B2ZZW3    B2ZZX0    B2ZZW7    A5A746    P29523    C6L8N8    H9JH21    B2ZZX1    H9JH27    B2ZZW5    Q9VHD0   

Pfam

PF00245   Alk_phosphatase

Interpro

IPR018299   Alkaline_phosphatase_AS        + More
IPR001952   Alkaline_phosphatase       
IPR017850   Alkaline_phosphatase_core_sf       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16012  ALP

ProteinModelPortal

H9JK21   A0A194PQI4   A0A2H1V6P7   A0A212FHB6   A0A0N1IIK6   A0A0U1ZF85   + More
W8DT07   M4M265   A0A0L7LK11   C6L8N9   B2ZZW4   B2ZZW8   Q7KXT0   H9JXN7   B2ZZX2   O96056   A5A747   C3U1V9   G3GBT4   A0A3S2PC92   A0A2W1BHB3   C3U1W1   A0A2H5CLJ8   A0A2H1WA01   B4Z1D7   A0A2J7PHL4   C3U1W0   B4X983   I6MML5   A0A212F875   A0A1B0RHM8   A0A2H5CLG8   A0A1B0RHM5   C3U1W2   A0A194R254   I0E1Y2   A0A2A4J355   B4Z1D6   A0A194R1W7   A0A194Q2C7   A0A2W1BMI5   A0A3G1LC34   A0A067QRJ2   E0VEB3   A0A194Q2F4   A0A0U2IR33   I6PI83   A0A2A4J4Q0   A0A2H1VP42   A0A0U1ZJ21   M4M3L4   A0A0U2WZB7   U5EGZ8   R4I4E9   A0A0U2WPZ0   G1JT78   B2ZZW3   A0A1W4X350   B2ZZX0   B2ZZW7   A0A067QT98   A5A746   P29523   A0A212F895   C0JBW1   C6L8N8   H9JH21   B2ZZX1   H9JH27   I6PF06   A0A2L1IQA2   W5JCJ1   B2ZZW5   A0A0U1ZEC3   A0A2H1VQS9   A0A194R7D1   A0A0U1ZEU5   A0A109P4P6   J9JZX4   A0A2H1W0P4   A0A1B0CIG9   A0A0M4F783   A0A2H8TJT6   A0A1B6CV61   R4I4D0   A0A1B6MFZ1   A0A1B6MN90   A0A194R2N2   A0A182JCN5   B3M052   Q16WV8   B4LW25   A0A3F2YW16   B3NZR8   A0A0P6JST2   A0A1S4FLA4   A0A2J7PHK8   Q9VHD0  

PDB

1EW2     E-value=1.96033e-97,     Score=910

KEGG

101747022    K01077 alkaline phosphatase [EC:3.1.3.1] | (RefSeq) membrane-bound alkaline phosphatase-like

PATHWAY

00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004035   GO:0016791   GO:0016021   GO:0005886   GO:0031225   GO:0046872   GO:0001666   GO:0035094   GO:0016311   GO:0009986   GO:0003824   GO:0008152   GO:0006412   GO:0006511   GO:0016020   GO:0035023   GO:0005515   GO:0016742  

PANTHER

PTHR11596  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.998066

 

 

Length:

558

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.43320999999998

Exp number, first 60 AAs:

2.13921

Total prob of N-in:

0.39682

outside

1  -  558

 

 

Pi

162.093577

Theta

139.136945

Tajima's D

0.811329

CLR

0.085932

CSRT

0.606619669016549

Interpretation

Uncertain