Gene

KWMTBOMO04710  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009941

Annotation

Ubiquitin_carboxyl-terminal_hydrolase_5_[Papilio_xuthus]

Location

Bomo_Chr8(+):13064220-13085098      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase       + More
Ubiquitinyl hydrolase 1      

Location in the cell

Cytoplasmic   Reliability : 3.17

CDS

ATGGCATCGTTAAGCTTATTAACGTCTCATTTGTCTAAAATTAAATTGCCAGGACCGCATCAGCTTGTGTACAAAGACGAATGTGTATATTCTTTTGACAACCCGGAATCCGAGACGGGTCTCTATGTGTCCCTGGTGTCATTCTTGGGATTCGGGCGCAATTACGTTGAACAGTATTTCCAGAAAACCGGAAACGCCGTCTTCTTACATATCAGAAGAGAGAAACAACCAATCCCTGAACCAGAGCAAACAGGCGATGGTCCCGAGAAGAAGATCACCAGGCTCGCCATAGGAGTTGAGGGAGGCTTTGATCCTGAATGTGGAAAACCTAAATTTACATACACTGATCATTACAGTGTGGTGGTGCTACCAGGATTTCACACATTCCCATGGCCTGATCCTAATTTACCAGAACCTGTAAAGAAATCAGTTCAAGCTGTTATCGATGCAGAATCACCATTCAAAATCGCAGAATTGGCAGCATTACAAGGCACCTGGGATGGTGAAAAACGTGAAGTTTCTGTACACTCTGTTAACCTCAAGCAGCTGGACAATGGTATCCGTATACCTCCATCTGGATGGAAATGTGAGAAGTGTGACCTGACTAATAACCTCTGGTTGAACCTGACTGATGGGTCCATACTTTGCGGACGTCGCTTCTTCGATGGCACCGGAGGGAATGATCATGCTGTAGAACACTACAGAGAGACAGGCTATCCACTCGCTGTCAAGCTGGGAACCATTACCGCTGAAGGAAAAGGAGATGTTTTTTCGTACGCTGAAGATGATATGGTGGAAGACCCATTTCTCGCTGATCACCTCAAACACTTTGGGATTAATGTACAGCAGCTGCAGAAGACAGATAAATCTATGGTGGAATTAGAGCTCGAGCTGAACCAGCGTTCGGGAGAATGGAATACCTTGCAAGAATCTGGAAGTGATCTAAGACCACTGCACGGGCCCGCTCTCACTGGACTCAACAACTTGGGAAACTCTTGTTACATCAACAGCGTCGTACAGGTGATGTTCCGAATGCCCGACTTCGTGCGTCGCTACGTGGAGGGGGCTCCGGAGATATTCGCCACCTTCCCCGAAGATCCGGTCAACGATTTTAATGTTCAAACCGCAAAGCTGGGCGTGGGTCTGCTGTCGGGCCGGTACTCGACCCCGGACCCCGAGGGGGGCCAGCTGGGGGTGAGCCCGCACATGTACCGGCAGCTCGTCGGGAAGCACCACCCGGAGTTCGCCACCAAGCGGCAGCAGGACGCGCACGAGTTCTACTTGCATCTCTTGACGCTCCTACAGCGAAACAGCCGCCACAAGCCGAACCCTGCGGACTGCTTGAAGTTCGCAGTGGAGGAGCGCATCAAGTGCTCGGAGTCGAACTGCGTGAGGTACACCACGAGAGCCGAACATCATCTGCCGCTGCCCGTGCCCCTCTCCGCTGCTACCAACGTGGAGCAGGTCCAGCAGTACGAGGCCAGACGGGCCCAGGCCGAAGCCAGTGGTCAGAGATTAGACCCGGCCCTGGTGGTGAGGCCACACATTCCGTTTAAAGCTTGCTTGGAGAGTTTCATGAGGGAGGAGACAATTGAGCAGTTCTTCAGTAGTGCCTTAAACAAGAAAGTCACCGCACATAAAATAACTCGACTAGCGACGTTTCCTGACTACCTCCTGATACAACTTAAAAAGTTTACTATCAAAGAAGATTGGACCCCTGCAAAACTTGACGTGGCTGTCGACATGCCTTGGGAGGTGGATCTAAGCAGCCTCCGTGGACGAGGGTTGCAGCCTGACGAGAAGCAGCTGCCCGAGGCATCCCCTGACACCCCAGCTCCTACATACGATGAAGTATTACTGTCACAACTGCTCGACATGGGGTTCCCGGTGGAAGCGTGCAAGAAATCTTTGTACTACACCAACAACTCTGGTATCGAAGCCGCATCCAACTGGCTCATGGAACACATGACCGATTGGGACTTTGAACATAAGTTTGAACCGCCTGGGACTAAGCCTTCGGATGCGGCCGTGGGTGCCAACGTTGATGAAGCAAGCGTGGAGCAGATAATGAGTATGGGATTCACTCGGGCTCAGGTAGTCCGCGCGCTTGGGGCCACGGGCGGTGACGTCACACGAGCGCTTGACTGGATCTTCAGTCGCGCTGATCAACTCGACCTGGATGAACCCACCCCGGGACCTGACAGGACACTTGGATGTAGGGACGGACCAGAAAAATACAAACTGATAGCATTTATATCCCATATGGGCACTTCTACAATGGTTGGTCATTATGTGTGTCACATACTCCATGAAGGAAGATGGGTCATATTCAACGACAATAAGGTTGCTCTCTCAGAGAATCCGCCCAAAGATCTTGGTTATTTATATTTATATGAGAGGCTATGA

Protein

MASLSLLTSHLSKIKLPGPHQLVYKDECVYSFDNPESETGLYVSLVSFLGFGRNYVEQYFQKTGNAVFLHIRREKQPIPEPEQTGDGPEKKITRLAIGVEGGFDPECGKPKFTYTDHYSVVVLPGFHTFPWPDPNLPEPVKKSVQAVIDAESPFKIAELAALQGTWDGEKREVSVHSVNLKQLDNGIRIPPSGWKCEKCDLTNNLWLNLTDGSILCGRRFFDGTGGNDHAVEHYRETGYPLAVKLGTITAEGKGDVFSYAEDDMVEDPFLADHLKHFGINVQQLQKTDKSMVELELELNQRSGEWNTLQESGSDLRPLHGPALTGLNNLGNSCYINSVVQVMFRMPDFVRRYVEGAPEIFATFPEDPVNDFNVQTAKLGVGLLSGRYSTPDPEGGQLGVSPHMYRQLVGKHHPEFATKRQQDAHEFYLHLLTLLQRNSRHKPNPADCLKFAVEERIKCSESNCVRYTTRAEHHLPLPVPLSAATNVEQVQQYEARRAQAEASGQRLDPALVVRPHIPFKACLESFMREETIEQFFSSALNKKVTAHKITRLATFPDYLLIQLKKFTIKEDWTPAKLDVAVDMPWEVDLSSLRGRGLQPDEKQLPEASPDTPAPTYDEVLLSQLLDMGFPVEACKKSLYYTNNSGIEAASNWLMEHMTDWDFEHKFEPPGTKPSDAAVGANVDEASVEQIMSMGFTRAQVVRALGATGGDVTRALDWIFSRADQLDLDEPTPGPDRTLGCRDGPEKYKLIAFISHMGTSTMVGHYVCHILHEGRWVIFNDNKVALSENPPKDLGYLYLYERL

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C19 family.

Uniprot

H9JK90   A0A2H1VSJ8   A0A194PQH0   A0A2J7R738   A0A067RRG2   A0A0L7R712   + More
A0A2A3E6B2   N6TK40   D6WG65   A0A088A052   A0A154P5H2   A0A310SBJ0   E2C8J6   A0A1Y1K1D3   A0A0C9QMW7   K7IQ82   E9IBI0   F4X108   A0A026W8P1   A0A195CKN4   A0A151WJN1   A0A232FG33   E2APC3   A0A195EG60   A0A1S3HXG5   A0A224XK41   A0A1W4WWK6   A0A0P4VUD1   A0A158NI21   A0A069DZJ8   A0A195F6G1   A0A151I4L0   A0A3L8D766   A0A182G657   A0A146L2B4   A0A0N0BJ93   A0A1S3K6I8   A0A1L8DT27   A0A0V0G595   A0A2J7R729   Q17M51   A0A1Q3F5R2   A0A1Q3F5X5   A0A210PTM4   B0WEJ5   B4KWS1   K1QEK7   A0A2T7PUE0   A0A0M4EYA4   A0A182PBN1   A0A131XRQ0   A0A147BUF6   A0A0L0CCA5   A0A182XD99   A0A1W4W1K5   A0A1I8M0R3   T1PFU5   A0A182JWG6   Q7Q039   A0A3B0J4P6   B4LGX5   A0A2R5LMB6   A0A182V5M6   A0A182HPZ0   B4QP23   A0A084WB42   A0A182NPG4   G3MGM4   B4PCV0   A0A1I8NZS3   Q29E26   A0A182RGL7   B4IZQ1   B3M7D9   Q9VZU7   B3NF32   B4N6C5   B4HTK4   A0A034W439   A0A0A1WS18   A0A182QI34   A0A182KST4   A0A0K8VMY8   A0A182M4Y9   A0A131Z4F3   A0A182JEL7   A0A182Y1W8   A0A182W997   T1J4C8   A0A224Z2Y8   E0VFY2   L7MHZ5   A0A131XDA5   A0A336MN68   A0A2M4BDN1   A0A1E1XF72   A0A1B0FM68   A0A1A9Y9M2   A0A1B0B9A1  

EC Number

3.4.19.12

Pubmed

19121390    26354079    24845553    23537049    18362917    19820115    + More
20798317    28004739    20075255    21282665    21719571    24508170    28648823    27129103    21347285    26334808    30249741    26483478    26823975    17510324    28812685    17994087    22992520    29652888    26108605    25315136    12364791    14747013    17210077    22936249    24438588    22216098    17550304    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18057021    25348373    25830018    20966253    26830274    25244985    28797301    20566863    25576852    28049606    28503490   

EMBL

BABH01039537    BABH01039538    BABH01039539    ODYU01004207    SOQ43831.1    KQ459595    + More
KPI95696.1    NEVH01006738    PNF36649.1    KK852470    KDR23210.1    KQ414643    KOC66672.1    KZ288379    PBC26591.1    APGK01021637    APGK01021638    KB740350    ENN80834.1    KQ971320    EFA00536.1    KQ434809    KZC06438.1    KQ764717    OAD54425.1    GL453666    EFN75726.1    GEZM01095909    JAV55269.1    GBYB01002002    GBYB01002005    JAG71769.1    JAG71772.1    GL762111    EFZ22125.1    GL888520    EGI59868.1    KK107341    EZA52425.1    KQ977622    KYN01268.1    KQ983039    KYQ48062.1    NNAY01000281    OXU29523.1    GL441504    EFN64722.1    KQ978957    KYN27146.1    GFTR01008047    JAW08379.1    GDKW01000449    JAI56146.1    ADTU01016186    GBGD01000515    JAC88374.1    KQ981763    KYN36053.1    KQ976456    KYM84876.1    QOIP01000012    RLU16315.1    JXUM01000628    KQ560109    KXJ84469.1    GDHC01015986    JAQ02643.1    KQ435719    KOX78854.1    GFDF01004472    JAV09612.1    GECL01002997    JAP03127.1    PNF36647.1    CH477208    EAT47794.1    GFDL01012141    JAV22904.1    GFDL01012083    JAV22962.1    NEDP02005506    OWF39838.1    DS231910    EDS45711.1    CH933809    EDW17518.1    JH818590    EKC19946.1    PZQS01000002    PVD36997.1    CP012525    ALC43107.1    GEFM01006489    JAP69307.1    GEGO01000945    JAR94459.1    JRES01000611    KNC29870.1    KA647010    AFP61639.1    AAAB01008986    EAA00302.3    OUUW01000002    SPP76515.1    CH940647    EDW68445.1    GGLE01006469    MBY10595.1    APCN01003284    CM000363    CM002912    EDX09018.1    KMY97260.1    ATLV01022312    KE525331    KFB47436.1    JO841025    AEO32642.1    CM000159    EDW93854.1    CH379070    EAL30237.1    CH916366    EDV95636.1    CH902618    EDV39837.1    AE014296    AY121697    AAF47720.1    AAM52024.1    AFH04260.1    API64953.1    CH954178    EDV50374.1    CH964154    EDW79914.1    CH480817    EDW50275.1    GAKP01009880    JAC49072.1    GBXI01013059    JAD01233.1    AXCN02001828    GDHF01012073    JAI40241.1    AXCM01000926    GEDV01002912    JAP85645.1    JH431842    GFPF01013070    MAA24216.1    DS235129    EEB12288.1    GACK01001208    JAA63826.1    GEFH01004034    JAP64547.1    UFQT01000827    SSX27428.1    GGFJ01001930    MBW51071.1    GFAC01001399    JAT97789.1    CCAG010023908    CCAG010023909    JXJN01010337   

Proteomes

UP000005204    UP000053268    UP000235965    UP000027135    UP000053825    UP000242457    + More
UP000019118    UP000007266    UP000005203    UP000076502    UP000008237    UP000002358    UP000007755    UP000053097    UP000078542    UP000075809    UP000215335    UP000000311    UP000078492    UP000085678    UP000192223    UP000005205    UP000078541    UP000078540    UP000279307    UP000069940    UP000249989    UP000053105    UP000008820    UP000242188    UP000002320    UP000009192    UP000005408    UP000245119    UP000092553    UP000075885    UP000037069    UP000076407    UP000192221    UP000095301    UP000075881    UP000007062    UP000268350    UP000008792    UP000075903    UP000075840    UP000000304    UP000030765    UP000075884    UP000002282    UP000095300    UP000001819    UP000075900    UP000001070    UP000007801    UP000000803    UP000008711    UP000007798    UP000001292    UP000075886    UP000075882    UP000075883    UP000075880    UP000076408    UP000075920    UP000009046    UP000092444    UP000092443    UP000092460   

PRIDE

H9JK90    G3MGM4    Q9VZU7    L7MHZ5   

Pfam

PF00627   UBA        + More
PF17807   zf-UBP_var
PF02148   zf-UBP
PF00443   UCH
PF00687   Ribosomal_L1
PF00621   RhoGEF
PF00435   Spectrin

Interpro

IPR009060   UBA-like_sf        + More
IPR028889   USP_dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR016652   Ubiquitinyl_hydrolase       
IPR001394   Peptidase_C19_UCH       
IPR001607   Znf_UBP       
IPR015940   UBA       
IPR018200   USP_CS       
IPR038765   Papain-like_cys_pep_sf       
IPR041432   UBP13_Znf-UBP_var       
IPR028364   Ribosomal_L1/biogenesis       
IPR023674   Ribosomal_L1-like       
IPR035899   DBL_dom_sf       
IPR028570   TRIO       
IPR018159   Spectrin/alpha-actinin       
IPR036865   CRAL-TRIO_dom_sf       
IPR001849   PH_domain       
IPR000219   DH-domain       
IPR001251   CRAL-TRIO_dom       
IPR011993   PH-like_dom_sf       
IPR002017   Spectrin_repeat       

SUPFAM

SSF46934   SSF46934        + More
SSF54001   SSF54001       
SSF56808   SSF56808       
SSF48065   SSF48065       

Gene 3D

3.30.40.10     1.20.900.10     2.30.29.30     3.40.525.10    

CDD

cd00170  SEC14
cd00160  RhoGEF

ProteinModelPortal

H9JK90   A0A2H1VSJ8   A0A194PQH0   A0A2J7R738   A0A067RRG2   A0A0L7R712   + More
A0A2A3E6B2   N6TK40   D6WG65   A0A088A052   A0A154P5H2   A0A310SBJ0   E2C8J6   A0A1Y1K1D3   A0A0C9QMW7   K7IQ82   E9IBI0   F4X108   A0A026W8P1   A0A195CKN4   A0A151WJN1   A0A232FG33   E2APC3   A0A195EG60   A0A1S3HXG5   A0A224XK41   A0A1W4WWK6   A0A0P4VUD1   A0A158NI21   A0A069DZJ8   A0A195F6G1   A0A151I4L0   A0A3L8D766   A0A182G657   A0A146L2B4   A0A0N0BJ93   A0A1S3K6I8   A0A1L8DT27   A0A0V0G595   A0A2J7R729   Q17M51   A0A1Q3F5R2   A0A1Q3F5X5   A0A210PTM4   B0WEJ5   B4KWS1   K1QEK7   A0A2T7PUE0   A0A0M4EYA4   A0A182PBN1   A0A131XRQ0   A0A147BUF6   A0A0L0CCA5   A0A182XD99   A0A1W4W1K5   A0A1I8M0R3   T1PFU5   A0A182JWG6   Q7Q039   A0A3B0J4P6   B4LGX5   A0A2R5LMB6   A0A182V5M6   A0A182HPZ0   B4QP23   A0A084WB42   A0A182NPG4   G3MGM4   B4PCV0   A0A1I8NZS3   Q29E26   A0A182RGL7   B4IZQ1   B3M7D9   Q9VZU7   B3NF32   B4N6C5   B4HTK4   A0A034W439   A0A0A1WS18   A0A182QI34   A0A182KST4   A0A0K8VMY8   A0A182M4Y9   A0A131Z4F3   A0A182JEL7   A0A182Y1W8   A0A182W997   T1J4C8   A0A224Z2Y8   E0VFY2   L7MHZ5   A0A131XDA5   A0A336MN68   A0A2M4BDN1   A0A1E1XF72   A0A1B0FM68   A0A1A9Y9M2   A0A1B0B9A1  

PDB

3IHP     E-value=0,     Score=2133

KEGG

101735878    K11836 ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-termi

GO

GO:0008270   GO:0006511   GO:0004843   GO:0016579   GO:0004197   GO:0043161   GO:0010995   GO:0001751   GO:0005623   GO:0090364   GO:0043066   GO:0046329   GO:1990380   GO:0036459   GO:0071108   GO:0010992   GO:0005737   GO:0005634   GO:0005089   GO:0035023   GO:0005515   GO:0016020   GO:0016742   GO:0003824  

PANTHER

PTHR22826:SF104  

Length:

801

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11516

Exp number, first 60 AAs:

0.00208

Total prob of N-in:

0.00012

outside

1  -  801

 

 

Pi

196.279022

Theta

161.259656

Tajima's D

0.474176

CLR

0.431613

CSRT

0.504124793760312

Interpretation

Uncertain