Gene

KWMTBOMO04707

Pre Gene Modal

BGIBMGA009937

Annotation

PREDICTED:_ankyrin_repeat_and_zinc_finger_domain-containing_protein_1-like_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr8(-):12939104-12949143      View in EpiBrowser

Full name

Ankyrin repeat and zinc finger domain-containing protein 1      

Location in the cell

Nuclear   Reliability : 4.406

CDS

ATGGCGCTGAAGCCCGAGGCAGTAAAAACTAAAATCGTGAAAGTCTATGAGATCGACGAATTTCAAAAACTCCTAAAAGGTGTTCATGTGGCAGCATGTATGATAACAGAATCACATAATGTCATTGATGAACAGAGTGTCTTGCGTCGCCTTAATGCTTTAACCTTAAATGGTGCTTCTGATGGTAATTGTTGTTCGTGTTGCGGAGTGGGTCCATTCGAGACCCGTGCGCAGCAAACGGCTCATTATAAGCATCACTGGCACACTTTTAACTTGAAGAGGAAACTATTTGGAAAATCTCCATTATCCATTGGCCAGTATAATTCTCGGAAAGATGAATCAAGCAGTGAGTCTGAGGAAGAAGTGGAGGACAGTAAGAGACCTCCGAGTGACCTATTTGCTGCAGCAACAAGACATTGCAAGGCGTTCTTCACTAATCATTATGGGCAGGTCTTCTGTATTTATAGATGTATCCTACATCATAAGAAGGAAGAATTATCAACGGATGGTGATGGCAGTGCCTGGGTAGAACGTGTGGAGCAGCTATTGATCCCAGGCTATCAAAGATGGGCAGTCCTGATGGTCTCGGGTGGCAGATTTGCTGGGGCAGTTTTCAGTGGTGGCACTATAGTTCTACACAAGACATTTCATTCATATGTCACAAGGAGAGGGCAAGGTCAAGCCCAGGCTACAAGAGATGCTCATCATGGACACGCGAGGTCTGCCGGTGCTAGCCTTAGAAGATATAATCAGGCGCAGTTTCTAGAGCATATCCAAGATATTATAAGTCAATGGACAGAAGACTTCAAAGGTTGTTCTCTAATATTATATCGGGCTGTAGGATCTTTAAATCAAGCTGCTATATTTGGAAAGAACTCCCCTATAAAGAAAGATGATCCAAGACTTAGAGTGCTACCTTTCCCTACTAGAAAACCTACATTTAAAGAAGTTCAGCGGGTTCATTCTACACTTGCTAGTCTAGAGGTTTACGATTCGTTGGAGTTGTTCCAAAAAGCACTGATAACATCGACAGCTAAACCAGCAAATAAAGCTACACTGGATCTTGGTAATGAAAATATTAAGAAAACAGCAAAGAAAAGTCCTAGTAAAACTATTGATAGAGCAAAATCAAGAGAACGCACTCCTAGAGAGCTACCAACCCAGTTGATGTCGAGCGAAGACGAAGGTCCCTGCTTCATAGACTCTGAGACACCTGTAGGTTGGATCAAAACACTATCGGAACAAAAAACCAGTGGGATTATTATTAATTCTAAAAAAGTTGTCCTAAACGATTGTGCTATTCAAGATAGGTCAACACCTAGTCCCTGCGAGAGCGAGAAGGAAGATTTAAAGCAGGAAGTAAAAGAGAAATATGAAACTGATAGGAGGAAAAAGATAAAAGATCCCGCTGTTCTTAACAAGCCCAGTCAAAAGATTCCTAATCCTATTAAGAAGATGTGGAAAATGATAATAGGAAATGAATTGAAATCACTGGAGACGATATTCGAAGGCTGGGAGGAAGAGAATCTGGCGGAGGCTTGTAACACTCGCGATCCTAGCGATGGCAACACTGCGCTACACAAAGCCGCCATTGCTGCGAAACCAGATATGGTCACTGAGATCCTGACTGCCGGTGGAGATCCGTGCATCAGGAACAATCAGCTGCAGACCCCGTACGCGGCCTCGCCACACCAGGAGACACGCCTCGCCTTCAGAATGTTCCAGGCTCAGTTTCCAGACAAATACAATTACGCTAAGTCGCACATTCCCGGCCCGGTGACCCCCGAGACTCTGGAACAAGAGAAAGAGAGGAAGCTACAACAGAAACGAGCTAAGAGGCAACGAGACAAGGAGAAGCAATTGGAGAAGATTAAAACCAACAAGTTCCTTCAGATGACCGATACCGAAAAGGCGAAGTCATCGGAGAAGCGTTGTTTTCTTTGTGGCTCAAATCTCCCGAAGAAACCGTTCGAGTACGAAGTGTACAGATTCTGCGCAGTGCAATGTCTCCAGAACCACAGAAACATTCGACCTCTAAACATGAGCGCGTGA

Protein

MALKPEAVKTKIVKVYEIDEFQKLLKGVHVAACMITESHNVIDEQSVLRRLNALTLNGASDGNCCSCCGVGPFETRAQQTAHYKHHWHTFNLKRKLFGKSPLSIGQYNSRKDESSSESEEEVEDSKRPPSDLFAAATRHCKAFFTNHYGQVFCIYRCILHHKKEELSTDGDGSAWVERVEQLLIPGYQRWAVLMVSGGRFAGAVFSGGTIVLHKTFHSYVTRRGQGQAQATRDAHHGHARSAGASLRRYNQAQFLEHIQDIISQWTEDFKGCSLILYRAVGSLNQAAIFGKNSPIKKDDPRLRVLPFPTRKPTFKEVQRVHSTLASLEVYDSLELFQKALITSTAKPANKATLDLGNENIKKTAKKSPSKTIDRAKSRERTPRELPTQLMSSEDEGPCFIDSETPVGWIKTLSEQKTSGIIINSKKVVLNDCAIQDRSTPSPCESEKEDLKQEVKEKYETDRRKKIKDPAVLNKPSQKIPNPIKKMWKMIIGNELKSLETIFEGWEEENLAEACNTRDPSDGNTALHKAAIAAKPDMVTEILTAGGDPCIRNNQLQTPYAASPHQETRLAFRMFQAQFPDKYNYAKSHIPGPVTPETLEQEKERKLQQKRAKRQRDKEKQLEKIKTNKFLQMTDTEKAKSSEKRCFLCGSNLPKKPFEYEVYRFCAVQCLQNHRNIRPLNMSA

Description

Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).

Subunit

Interacts (via VIM motif) with VCP.

Similarity

Belongs to the ANKZF1/VMS1 family.

Keywords

ANK repeat   Coiled coil   Complete proteome   Cytoplasm   Metal-binding   Phosphoprotein   Reference proteome   Repeat   Zinc   Zinc-finger  

Feature

chain  Ankyrin repeat and zinc finger domain-containing protein 1

Uniprot

H9JK86   A0A3S2P2V4   A0A194PRW1   A0A2A4JGB5   A0A0N1PJC0   A0A212EX95   + More
A0A2H1VA90   A0A195EGX9   A0A224XL02   A0A069DZF8   A0A0A9VX70   A0A2J7RI97   A0A1Y1NCG2   A0A088A054   A0A2A3E523   A0A154P3C1   A0A2A3E4A7   A0A0L7R757   N6TMS3   A0A195F7K7   A0A1S4EN03   A0A151I4F0   A0A158NI24   A0A195CKK8   J9JXP6   A0A026W8N7   A0A151WJS7   E2C8J3   E2APC5   A0A0C9QF49   A0A0A9W064   A0A0N0BDV2   A0A1S3IMI7   A0A1S3ILJ1   A0A0J7L5I0   A0A2S2R626   H2THP4   A0A2U9C979   E7F4D7   A0A3S2PCV0   A0A1Y1NAM8   I3JR47   A0A2S2P475   A0A3P9GZQ1   A0A3P9BKM8   A0A3Q2UW42   A0A3P8Q0C5   A0A2R2MR32   A0A3B4EU68   A0A1D2M511   A0A0N7ZA02   A0A3Q2V4B2   F7A9G2   A0A226EWR2   G5AKK1   A0A0P4VQR9   A0A0N8ETG3   A0A2I3RLX9   A0A2R9AQV1   A0A2I2YQS1   F6WVX7   A0A1W2W4B3   G3HWF2   A0A2J8TUH4   Q66H85  

Pubmed

19121390    26354079    22118469    26334808    25401762    26823975    + More
28004739    23537049    21347285    24508170    30249741    20798317    21551351    23594743    25186727    17554307    27289101    20431018    21993625    16136131    22722832    12481130    15114417    21804562    15489334   

EMBL

BABH01039520    RSAL01000041    RVE50938.1    KQ459595    KPI95693.1    NWSH01001561    + More
PCG70859.1    KQ459784    KPJ19926.1    AGBW02011805    OWR46109.1    ODYU01001469    SOQ37706.1    KQ978957    KYN27142.1    GFTR01007717    JAW08709.1    GBGD01000715    JAC88174.1    GBHO01042797    GBRD01013116    GDHC01019157    JAG00807.1    JAG52710.1    JAP99471.1    NEVH01003502    PNF40559.1    GEZM01009457    GEZM01009456    JAV94580.1    KZ288379    PBC26594.1    KQ434809    KZC06435.1    PBC26593.1    KQ414643    KOC66669.1    APGK01058603    KB741291    KB632343    ENN70520.1    ERL93018.1    KQ981763    KYN36049.1    KQ976456    KYM84879.1    ADTU01016189    KQ977622    KYN01265.1    ABLF02003796    KK107341    QOIP01000012    EZA52420.1    RLU16320.1    KQ983039    KYQ48057.1    GL453666    EFN75723.1    GL441504    EFN64724.1    GBYB01002004    JAG71771.1    GBHO01042798    JAG00806.1    KQ435848    KOX70984.1    LBMM01000688    KMQ97754.1    GGMS01015609    MBY84812.1    CP026256    AWP13018.1    CR752651    CM012457    RVE58082.1    GEZM01009458    GEZM01009455    JAV94578.1    AERX01017599    GGMR01011644    MBY24263.1    LJIJ01004272    ODM88001.1    GDRN01107043    JAI57480.1    AAMC01028606    AAMC01028607    LNIX01000001    OXA61504.1    JH165659    EHA97561.1    GDRN01107050    JAI57479.1    GEBF01004459    JAN99173.1    AACZ04056567    AJFE02063776    EAAA01000312    JH000831    EGW11868.1    NDHI03003483    PNJ36662.1    BC081973   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000053240    UP000007151    + More
UP000078492    UP000235965    UP000005203    UP000242457    UP000076502    UP000053825    UP000019118    UP000030742    UP000078541    UP000079169    UP000078540    UP000005205    UP000078542    UP000007819    UP000053097    UP000279307    UP000075809    UP000008237    UP000000311    UP000053105    UP000085678    UP000036403    UP000005226    UP000246464    UP000000437    UP000005207    UP000265200    UP000265160    UP000264840    UP000265100    UP000261460    UP000094527    UP000008143    UP000198287    UP000006813    UP000002277    UP000240080    UP000001519    UP000008144    UP000001075    UP000002494   

PRIDE

H9JK86    G3HWF2    Q66H85   

Pfam

PF18716   VATC        + More
PF18826   bVLRF1
PF15062   ARL6IP6
PF00023   Ank
PF13606   Ank_3
PF12796   Ank_2

Interpro

IPR020683   Ankyrin_rpt-contain_dom        + More
IPR036770   Ankyrin_rpt-contain_sf       
IPR041540   VATC       
IPR041175   VLRF1/Vms1       
IPR002110   Ankyrin_rpt       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR003604   Matrin/U1-like-C_Znf_C2H2       
IPR029383   ARL6IP6       

SUPFAM

SSF48403   SSF48403        + More
SSF57667   SSF57667       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9JK86   A0A3S2P2V4   A0A194PRW1   A0A2A4JGB5   A0A0N1PJC0   A0A212EX95   + More
A0A2H1VA90   A0A195EGX9   A0A224XL02   A0A069DZF8   A0A0A9VX70   A0A2J7RI97   A0A1Y1NCG2   A0A088A054   A0A2A3E523   A0A154P3C1   A0A2A3E4A7   A0A0L7R757   N6TMS3   A0A195F7K7   A0A1S4EN03   A0A151I4F0   A0A158NI24   A0A195CKK8   J9JXP6   A0A026W8N7   A0A151WJS7   E2C8J3   E2APC5   A0A0C9QF49   A0A0A9W064   A0A0N0BDV2   A0A1S3IMI7   A0A1S3ILJ1   A0A0J7L5I0   A0A2S2R626   H2THP4   A0A2U9C979   E7F4D7   A0A3S2PCV0   A0A1Y1NAM8   I3JR47   A0A2S2P475   A0A3P9GZQ1   A0A3P9BKM8   A0A3Q2UW42   A0A3P8Q0C5   A0A2R2MR32   A0A3B4EU68   A0A1D2M511   A0A0N7ZA02   A0A3Q2V4B2   F7A9G2   A0A226EWR2   G5AKK1   A0A0P4VQR9   A0A0N8ETG3   A0A2I3RLX9   A0A2R9AQV1   A0A2I2YQS1   F6WVX7   A0A1W2W4B3   G3HWF2   A0A2J8TUH4   Q66H85  

PDB

5WHG     E-value=2.74504e-15,     Score=202

KEGG

101735746    no KO assigned | (RefSeq) ankyrin repeat and zinc finger domain-containing protein 1-like

GO

GO:0016021   GO:0008270   GO:0003676   GO:0072671   GO:0030433   GO:0036266   GO:0071630   GO:0005737   GO:0070301   GO:0046872   GO:0005515   GO:0006950   GO:0004888   GO:0007166   GO:0016020   GO:0035023   GO:0016742   GO:0003824  

Subcellular location

Cytoplasm   Translocates to the mitochondria upon exposure to hydrogen peroxide.   With evidence from 1 publications.

Length:

683

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.63517

Exp number, first 60 AAs:

0.0008

Total prob of N-in:

0.02552

outside

1  -  683

 

 

Pi

246.67667

Theta

180.132644

Tajima's D

1.124163

CLR

0.13387

CSRT

0.692165391730413

Interpretation

Uncertain