Gene

KWMTBOMO04706

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr8(+):12907304-12908948      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 1.702

CDS

ATGGTCAGGAACGACAGGCTCTCTGCCCGTGGTGGTGGTACCGTCATTTACTATAGAAGAGCCCTGCATTGCGTCCCGCTCGATCCTCCCGCGCTCGCTAATATCGAAGCAGCAGTGTGCCGAATCTCACTGACGGGACACGCGCCGATCGTTATCGCGTCCGTTTATCTTCCACCGGATAAGATCGTTCTAAGCAGTGATATCGAGGCGCTGCTCGGTATGGGGAGCTCTGTCATTCTGGCGGGCGACCTAAATTGTAAACACATCAGGTGGAACTCACACACCACAACCCCGAATGGCAGGCGGCTTGACGCGTTAGTCGATGATCTCGCCTTCGATATCGTCGCTCCGCTAACCCCGACTCACTACCCGCTAAATATCGCGCATCGCCCGGATATACTCGACATAGCGTTATTAAAAAACGTAACTCTGCGCTTACACTCGATCGAAGTAGTTTCAGAGTTAGATTCAGACCACCGTCCCGTCGTTATGAAGCTCGGTCGCGCTCCCGATTCCGTTCCCGTCACGAGGACTGTGGTGGATTGGCACACGCTGGGCATCAGCCTGGCTGAATCTGATCCACCATCGCTTCCGTTTAGTCCGGACTCTATCCCGTCTCCTCAGGATACCGCTGAAGCCATAGACATCGTAACGTCACACATCACCTCGACATTAGATAGGTCATCGAAGCAAGTTGTAGCGGAGGACTTCCTTCACCGCTTCAAATTGCCCGACGATATTAGGGAACTCCTTAGAGCTAAGAACGCCTCGATCCGTGTGTACGATAGGTATCCTACCGCGGAAAATCGTATTCGAATGCGTGCCCTACAACGCGACGTAAAGTCTCGCATCACCGAAGTCCGAGATGCCAGATGGTCTGATTTCTTAGAAGGACTCGCGCCCTCTCAAAGGTCTTACTACCGCTTAGCTCGTACTCTCAAATCGGATACGGTAGTAACTATGCCCCCCCTCGTAGGCCCCTCAGGCCGACTCGCGGCGTTCGATGATGACGAAAAAGCAGAGCTGCTGGCCGATACATTGCAAACCCAGTGCACGCCCAGCACTCAATCCGTGGACCCTGTTCATGTAGAATTAGTAGACAGTGAGGTAGAATGCAGAGCCTCCTTGCCACCCTCTGATGCGTTACCACCCGTCACCCCGATGGAAGTTAAAGACTTGATCAAAGACCTACGTCCTCGCAAGGCTCCCGGTTCCGACGGTATATCCAACCGCGTTATTAAACTTCTACCCGTCCAACTCATCGTGATGTTGGCATCTATTTTCAATGCCGCTATGGCGAACTGTATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGCATACATAAACCCGGTGCACCGGCTCACGGAGCACATTCTTGTGGGGCTTAA

Protein

MVRNDRLSARGGGTVIYYRRALHCVPLDPPALANIEAAVCRISLTGHAPIVIASVYLPPDKIVLSSDIEALLGMGSSVILAGDLNCKHIRWNSHTTTPNGRRLDALVDDLAFDIVAPLTPTHYPLNIAHRPDILDIALLKNVTLRLHSIEVVSELDSDHRPVVMKLGRAPDSVPVTRTVVDWHTLGISLAESDPPSLPFSPDSIPSPQDTAEAIDIVTSHITSTLDRSSKQVVAEDFLHRFKLPDDIRELLRAKNASIRVYDRYPTAENRIRMRALQRDVKSRITEVRDARWSDFLEGLAPSQRSYYRLARTLKSDTVVTMPPLVGPSGRLAAFDDDEKAELLADTLQTQCTPSTQSVDPVHVELVDSEVECRASLPPSDALPPVTPMEVKDLIKDLRPRKAPGSDGISNRVIKLLPVQLIVMLASIFNAAMANCIFPAVWKEADVIGIHKPGAPAHGAHSCGA

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q93137   Q9BPQ0   Q9XXW0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   K7IN67   X1WQI9   A0A023EYS8   A0A1B6MIM7   A0A2S2QEE0   J9LC21   V5GNJ2   X1X0M4   A0A139WA11   A0A2S2PPK8   A0A087THU2   A0A2S2NJB5   X1WNI2   A0A087U3K8   A0A2S2PEZ9   A0A1Y1K0C8   A0A224XB44   A0A087T3W0   A0A2S2PJ52   A0A087UCW3   A0A224X6Q4   X1WVL6   A0A224XI99   V5GNF3   A0A1B6C2V8   A0A2S2QDN9   A0A224X6S1   A0A2M4CV52   A0A2M4CV42   X1WZH0   X1WXR6   J9MAC6   A0A224X6U5   X1WKS2   A0A2M4AQK3   A0A2S2PA10   A0A2M4AQV0   J9KPF1   A0A224X6T4   A0A2S2Q383   A0A087UB64   A0A2S2NCK2   J9JZG6   J9M522   A0A224X6W2   A0A2S2N6Q7   J9JS95   J9KKL6   A0A0J7K503   J9MAR0   X1WK15   A0A224X7Z3   A0A2S2P6H1   A0A2S2R2E8   U4UGQ8   A0A1Y1KFT3   A0A224XJI0   A0A2J7PP17   A0A023F1L2   A0A1Y1KFR3   A0A2S2P6S3   X1WLB2   A0A1Y1MT28   J9LFC9   A0A3S2NJ07   A0A2S2PJG2   A0A224X746   A0A0V0G5B6   A0A232ENU1   A0A023EZE6   A0A2S2Q2R8   A0A2S2NPT6   P21328   J9KLB1   A0A0J7MTN6   A0A224X724   A0A2G3AQH2   J9LK81   U4U0U7   J9LNE5   U4UJ93   A0A2M4BD66   A0A0P4VK54   J9LVT4   A0A2J7RE85   A0A2M4BDA5   A0A2M4BD62   A0A2J7QR37   A0A224XHW8   A0A2J7QY69   A0A2J7PBY3   A0A2J7RB85  

EC Number

2.7.7.49

Pubmed

10333566    26354079    10380107    28004739    18362917    19820115    + More
20075255    25474469    23537049    28648823    2463954    3040362    1714378    29089032    27129103   

EMBL

U07847    AAA17752.1    AB055391    BAB21761.1    AB018558    BAA76304.1    + More
KQ459265    KPJ02064.1    AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ973342    KXZ75569.1    ABLF02022418    GBBI01004395    JAC14317.1    GEBQ01004157    JAT35820.1    GGMS01006359    MBY75562.1    ABLF02036316    ABLF02036319    ABLF02048663    ABLF02066977    GALX01005299    JAB63167.1    ABLF02065839    KQ971729    KYB24751.1    GGMR01018716    MBY31335.1    KK115285    KFM64681.1    GGMR01004661    MBY17280.1    ABLF02008153    ABLF02008462    ABLF02008464    KK118005    KFM71947.1    GGMR01015412    MBY28031.1    GEZM01099921    GEZM01099920    GEZM01099918    GEZM01099906    JAV53125.1    GFTR01008262    JAW08164.1    KK113281    KFM59799.1    GGMR01016297    MBY28916.1    KK119261    KFM75202.1    GFTR01008279    JAW08147.1    ABLF02042385    GFTR01008256    JAW08170.1    GALX01005359    JAB63107.1    GEDC01029594    JAS07704.1    GGMS01006655    MBY75858.1    GFTR01008271    JAW08155.1    GGFL01004957    MBW69135.1    GGFL01005012    MBW69190.1    ABLF02034467    ABLF02008605    ABLF02008608    ABLF02008609    ABLF02008610    ABLF02017023    ABLF02007779    ABLF02007782    ABLF02050375    GFTR01008251    JAW08175.1    ABLF02005245    ABLF02013477    ABLF02047385    ABLF02066435    GGFK01009732    MBW43053.1    GGMR01013409    MBY26028.1    GGFK01009846    MBW43167.1    ABLF02041767    GFTR01008261    JAW08165.1    GGMS01002992    MBY72195.1    KK119069    KFM74603.1    GGMR01002322    MBY14941.1    ABLF02037436    ABLF02024246    GFTR01008260    JAW08166.1    GGMR01000226    MBY12845.1    ABLF02028535    ABLF02028545    ABLF02015631    ABLF02021986    ABLF02021987    ABLF02021991    LBMM01014024    KMQ85369.1    ABLF02037715    ABLF02012584    ABLF02013765    ABLF02024884    GFTR01007929    JAW08497.1    GGMR01012189    MBY24808.1    GGMS01014910    MBY84113.1    KB632143    ERL89075.1    GEZM01084970    JAV60359.1    GFTR01008257    JAW08169.1    NEVH01023280    PNF18085.1    GBBI01003811    JAC14901.1    GEZM01084969    JAV60363.1    GGMR01012443    MBY25062.1    ABLF02042518    ABLF02057746    GEZM01021881    JAV88842.1    ABLF02023911    RSAL01000708    RVE41206.1    GGMR01016905    MBY29524.1    GFTR01008151    JAW08275.1    GECL01003538    JAP02586.1    NNAY01003095    OXU19992.1    GBBI01004571    JAC14141.1    GGMS01002786    MBY71989.1    GGMR01006581    MBY19200.1    M22874    M38643    ABLF02040174    ABLF02040183    ABLF02055266    LBMM01018163    KMQ83860.1    GFTR01008169    JAW08257.1    MCIT02004487    PHT96476.1    ABLF02023551    ABLF02023561    KB631961    ERL87484.1    ABLF02001804    ABLF02035179    ABLF02062794    KB632327    ERL92508.1    GGFJ01001844    MBW50985.1    GDKW01003730    JAI52865.1    ABLF02003241    ABLF02003242    ABLF02025904    NEVH01005277    PNF39135.1    GGFJ01001842    MBW50983.1    GGFJ01001843    MBW50984.1    NEVH01011985    PNF31054.1    GFTR01008254    JAW08172.1    NEVH01009134    PNF33528.1    NEVH01027074    PNF13841.1    NEVH01005923    PNF38085.1   

Proteomes

UP000053268    UP000007266    UP000002358    UP000007819    UP000054359    UP000036403    + More
UP000030742    UP000235965    UP000283053    UP000215335    UP000224522   

PRIDE

Q93137    Q9BPQ0    Q9XXW0    P21328   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF07727   RVT_2
PF03372   Exo_endo_phos
PF03564   DUF1759
PF18701   DUF5641
PF00665   rve
PF05380   Peptidase_A17
PF17921   Integrase_H2C2
PF05585   DUF1758
PF14291   DUF4371

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       
IPR041588   Integrase_H2C2       
IPR036397   RNaseH_sf       
IPR005312   DUF1759       
IPR040676   DUF5641       
IPR008737   Peptidase_asp_put       
IPR008042   Retrotrans_Pao       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       
IPR025398   DUF4371       

SUPFAM

SSF56219   SSF56219        + More
SSF53098   SSF53098       

Gene 3D

3.60.10.10     3.30.420.10    

ProteinModelPortal

Q93137   Q9BPQ0   Q9XXW0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   K7IN67   X1WQI9   A0A023EYS8   A0A1B6MIM7   A0A2S2QEE0   J9LC21   V5GNJ2   X1X0M4   A0A139WA11   A0A2S2PPK8   A0A087THU2   A0A2S2NJB5   X1WNI2   A0A087U3K8   A0A2S2PEZ9   A0A1Y1K0C8   A0A224XB44   A0A087T3W0   A0A2S2PJ52   A0A087UCW3   A0A224X6Q4   X1WVL6   A0A224XI99   V5GNF3   A0A1B6C2V8   A0A2S2QDN9   A0A224X6S1   A0A2M4CV52   A0A2M4CV42   X1WZH0   X1WXR6   J9MAC6   A0A224X6U5   X1WKS2   A0A2M4AQK3   A0A2S2PA10   A0A2M4AQV0   J9KPF1   A0A224X6T4   A0A2S2Q383   A0A087UB64   A0A2S2NCK2   J9JZG6   J9M522   A0A224X6W2   A0A2S2N6Q7   J9JS95   J9KKL6   A0A0J7K503   J9MAR0   X1WK15   A0A224X7Z3   A0A2S2P6H1   A0A2S2R2E8   U4UGQ8   A0A1Y1KFT3   A0A224XJI0   A0A2J7PP17   A0A023F1L2   A0A1Y1KFR3   A0A2S2P6S3   X1WLB2   A0A1Y1MT28   J9LFC9   A0A3S2NJ07   A0A2S2PJG2   A0A224X746   A0A0V0G5B6   A0A232ENU1   A0A023EZE6   A0A2S2Q2R8   A0A2S2NPT6   P21328   J9KLB1   A0A0J7MTN6   A0A224X724   A0A2G3AQH2   J9LK81   U4U0U7   J9LNE5   U4UJ93   A0A2M4BD66   A0A0P4VK54   J9LVT4   A0A2J7RE85   A0A2M4BDA5   A0A2M4BD62   A0A2J7QR37   A0A224XHW8   A0A2J7QY69   A0A2J7PBY3   A0A2J7RB85  

KEGG

105842617    no KO assigned | (RefSeq) uncharacterized LOC105842617

GO

GO:0003964   GO:0004519   GO:0016021   GO:0003676   GO:0015074  

Length:

464

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

12.76643

Exp number, first 60 AAs:

0.0905

Total prob of N-in:

0.06732

outside

1  -  464

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

221.974912

CSRT

0

Interpretation

Uncertain