Gene

KWMTBOMO04678  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005287

Annotation

tyramine_beta_hydroxylase_precursor_[Bombyx_mori]

Location

Bomo_Chr8(-):12019635-12024648      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 2.036

CDS

ATGTCGAATTGGTTTTTTGTGTTTTTTCTGTCTGTTTATACATTTATTTATACGTTTTCTGTGAACGTAAGCCCAGGTCATCGTTTCGCTGAAAGTGAATCAGTGTTGGATCCAAGCGGCGAGTTTTTATTAAAGTGGCGTGTTGATTATGCCGTTCGAAAGATTAAATTTACTTTGACTGTTTCTGAAAAAGCGCCGGCCTTCAATTGGTTTGCATTAGGCTTCTCCGATCGGGGCCAACTGAATAATTCGGATGTTTGTCTGTTTTGGACAGATTATAAAGCTCGTGATCATTTCGAGGATATGCACACAAACGGACAGGGGAATTTGATACGTGATCAAAAACAAAACTGTGAAGGGTTTTATTTGAATACAAATAGCCAAAGCATAATCTTTGATCGTTTATTTGATACTTGCGATGATGATGATTACGTGATTGAGGACGGCACAGTCCATGTGGTGTGGGCTCACGGAATAGACAAACTGTTCTCATCAAAGGGCTTGTGCCTTACTTGCACCGTACCTCAGAGGCACGGCTTTGTTAGAGTAAGGCTACTAACACCTCCCGGCTTGCAAAAAGCGAATGGTTACCAATTACGAATAACAAACAAAGATCTAAAAGTACCGGGAGACGACACGACGTACTGGTGCAAAGTCGTTAGGCTGCCCGAATTCGTCACGTCAAAAGTTCATCATATAGTTCAGTTCGAATCGACAATAACTCCCGGTAACGAAGGCCTAGTTCATCACATGGAAGTCTTCTATTGCGACGAAGATCCCCACAAGGAAATGCCGGCATACGAGGGAAATTGTTTTGCCGCAGAGAGACCGGCTATTACGAAAAGTTGTTCTAAGGTAAAAGCGGCATGGGCAATGGGCGCTCCCCCTTTTACCTACCCAAAAGAAGCGGGCCTCCCACTCGGTGGCCCGAAAGCCAACAAATACGTCATGCTAGAAGTCCACTACAACAATCCAGAATTAAGGAAAGATTGGGTCGACAGTTCGGGTATTGTTCTCTATATAACTGGAAGGAAGCGTACGTACGATGCCGCCATTATGGAATTGGGCTTAGAATACACCGACAAAATGGCTATACCTGGTGAACAAAAAGCATTTCCGTTAACTGGTTACTGTATCCCTCAGTGTACTGGAGTGGGCCTACCGGATGAAGGCATTACAGTTTTTGGAAGTCAACTTCACACGCATTTAACTGGTGCCGCGGTGTGGACCAGACACTCGAGACAGGGTGTAGAGCTTCCCGTATTAAACAAAGACATGCATTATTCTACGCATTTTCAGGAAATTAGAATACTGCATCGGCCCGTTAAAGTGCTACCAGGCGACTTCTTGGAAACCACCTGCATTTACAATACGGAAGATAAGTTAAACGCGACGATCGGCGGCCACGCTATAACGGACGAAATGTGCGTTAATTACATACATTACTATCCGGCGACCGAACTCGAGGTTTGCAAGAGCGCCGTGTCGAACGAAGCACTCGAGAAATATTTCGATTTCGAAAAACGATGGGACGATATACCGATTTCGTCGAAGGCGACGCCACGTGATAATTATTTAGCGATCCAACCGTGGACTAGATTAAGAGCCGACACACTACATACGCTGTACGTCGAGTCCCCAATATCAATGCAATGCAACAAATCCGATGGGAGTCGTTTTCAAGGTGATTGGGAAGGAATTCCGATACCGAAAATAAAACTGCCGCTTTCCGAAGAAATTCGAATCTGTCCTAAAATTAACTATTTAGTCGAGACCTAA

Protein

MSNWFFVFFLSVYTFIYTFSVNVSPGHRFAESESVLDPSGEFLLKWRVDYAVRKIKFTLTVSEKAPAFNWFALGFSDRGQLNNSDVCLFWTDYKARDHFEDMHTNGQGNLIRDQKQNCEGFYLNTNSQSIIFDRLFDTCDDDDYVIEDGTVHVVWAHGIDKLFSSKGLCLTCTVPQRHGFVRVRLLTPPGLQKANGYQLRITNKDLKVPGDDTTYWCKVVRLPEFVTSKVHHIVQFESTITPGNEGLVHHMEVFYCDEDPHKEMPAYEGNCFAAERPAITKSCSKVKAAWAMGAPPFTYPKEAGLPLGGPKANKYVMLEVHYNNPELRKDWVDSSGIVLYITGRKRTYDAAIMELGLEYTDKMAIPGEQKAFPLTGYCIPQCTGVGLPDEGITVFGSQLHTHLTGAAVWTRHSRQGVELPVLNKDMHYSTHFQEIRILHRPVKVLPGDFLETTCIYNTEDKLNATIGGHAITDEMCVNYIHYYPATELEVCKSAVSNEALEKYFDFEKRWDDIPISSKATPRDNYLAIQPWTRLRADTLHTLYVESPISMQCNKSDGSRFQGDWEGIPIPKIKLPLSEEIRICPKINYLVET

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

Uniprot

F1T2L6   A0A2A4IVW4   A0A194PQE1   A0A0G3VI00   A0A194QUD3   A0A212EIM8   + More
A0A0L7LUG0   A0A1B6KW36   A0A1B6EFZ9   A0A1B6CBY6   I7C6J7   I7BWB2   I7D3M3   I7CTE1   A0A2J7PJ22   A0A067QTZ3   A0A2H8TGU2   A0A0P6H9G9   A0A1W4WN56   A0A0P6GQ74   A0A0P5LMW4   A0A0P5H9I3   A0A0P5LRQ0   A0A0P5MBJ7   W8VKK1   A0A0P5M143   A0A0P5P5B5   A0A0P6FVD3   A0A0P5H0D0   A0A0P5QZD0   A0A0P6EIS1   A0A0P5L6R5   A0A0P5NUR4   A0A0P5NQ72   A0A0P5LG82   A0A0P6EVL1   A0A0P5MNP2   A0A0P5MER8   A0A0P5M937   A0A0P5PMI4   A0A0P5PSW4   A0A0P5R021   A0A0N8DWZ2   A0A0P5MT95   A0A0P6HCP7   E0VHU4   A0A0P6ACI3   A0A0P5HAF7   A0A0P5MGX2   A0A0P5KR28   A0A0P6EZ15   A0A0P5EWS2   A0A164VW34   A0A0P6F255   A0A0P5IQN1   A0A0P5F328   D6WEK9   A0A2P8YLP8   A0A2S2N8E7   X2KVP5   J9K380   A0A0P5JYZ3   A0A0P5BG39   A0A0P6FB14   A0A0P5YSU2   A0A0P5DFR6   A0A0P5IC69   E9HK72   A0A0P5LGM6   A0A2A3EII7   A0A0P6EWW9   A0A087TQF1   W8VTH9   K7J3J6   E2B3J5   A0A0L7R8A1   A0A195FM60   A0A0P5MYZ9   A0A154PNF6   A0A151J6J3   A0A2L2YJK8   A0A195BW72   A0A158NEC4   A0A151WVS2   A0A195CCB6   A0A0C9R1Y8   A0A0P5JW18   L7LXT4   A0A232FDF1   A0A0M8ZPV4   E1ZZB1   F4WJ90   E9J1G9   T1K603   A0A1B6I325   A0A139WM35   Q147S1   A0A0P4YDU6  

Pubmed

26354079    22118469    26227816    24845553    20566863    29403074    + More
24646461    21292972    20075255    20798317    26561354    21347285    25576852    28648823    21719571    21282665    18362917    19820115    16809468   

EMBL

AB621950    BAK09201.1    NWSH01005952    PCG63809.1    KQ459595    KPI95666.1    + More
KP657630    AKL78855.1    KQ461154    KPJ08590.1    AGBW02014614    OWR41334.1    JTDY01000066    KOB79082.1    GEBQ01024543    JAT15434.1    GEDC01000504    JAS36794.1    GEDC01026310    JAS10988.1    JQ316454    AFO63077.1    JQ316456    AFO63079.1    JQ316457    AFO63080.1    JQ316453    JQ316455    AFO63076.1    AFO63078.1    NEVH01024952    PNF16319.1    KK853274    KDR09110.1    GFXV01001510    MBW13315.1    GDIQ01023602    JAN71135.1    GDIQ01097519    GDIQ01095784    GDIQ01031867    JAN62870.1    GDIQ01178047    JAK73678.1    GDIQ01236230    JAK15495.1    GDIQ01176392    JAK75333.1    GDIQ01160609    JAK91116.1    AB897808    BAO52001.1    GDIQ01162070    JAK89655.1    GDIQ01154421    JAK97304.1    GDIQ01060043    JAN34694.1    GDIQ01235080    JAK16645.1    GDIQ01127815    JAL23911.1    GDIQ01062186    JAN32551.1    GDIQ01179489    JAK72236.1    GDIQ01137464    JAL14262.1    GDIQ01141812    JAL09914.1    GDIQ01180900    GDIQ01067901    JAK70825.1    GDIQ01174142    GDIQ01057408    JAN37329.1    GDIQ01156905    JAK94820.1    GDIQ01160608    JAK91117.1    GDIQ01158906    JAK92819.1    GDIQ01131760    GDIQ01130468    JAL19966.1    GDIQ01144857    GDIQ01082337    GDIQ01042848    JAL06869.1    GDIQ01107474    JAL44252.1    GDIQ01083732    JAN11005.1    GDIQ01151526    JAL00200.1    GDIQ01030623    JAN64114.1    DS235171    EEB12867.1    GDIP01032747    JAM70968.1    GDIQ01229285    JAK22440.1    GDIQ01179490    JAK72235.1    GDIQ01180901    JAK70824.1    GDIQ01063606    JAN31131.1    GDIQ01266766    JAJ84958.1    LRGB01001361    KZS12718.1    GDIQ01066408    JAN28329.1    GDIQ01235079    JAK16646.1    GDIQ01266465    GDIQ01144856    GDIQ01143364    JAJ85259.1    AB728502    BAM21526.1    PYGN01000508    PSN45176.1    GGMR01000593    MBY13212.1    KJ152557    AHN85840.1    ABLF02010960    GDIQ01197245    JAK54480.1    GDIP01185115    JAJ38287.1    GDIQ01051407    JAN43330.1    GDIP01054041    JAM49674.1    GDIP01156935    JAJ66467.1    GDIQ01219742    JAK31983.1    GL732667    EFX67831.1    GDIQ01169869    JAK81856.1    KZ288232    PBC31518.1    GDIQ01069507    JAN25230.1    KK116287    KFM67340.1    AB897810    BAO52003.1    GL445346    EFN89747.1    KQ414632    KOC67112.1    KQ981490    KYN41069.1    GDIQ01149313    JAL02413.1    KQ434998    KZC13267.1    KQ979851    KYN18841.1    IAAA01020797    LAA08302.1    KQ976401    KYM92530.1    ADTU01013248    KQ982696    KYQ51984.1    KQ978023    KYM97876.1    GBYB01002015    JAG71782.1    GDIQ01198644    JAK53081.1    GACK01008627    JAA56407.1    NNAY01000390    OXU28715.1    KQ435922    KOX68655.1    GL435311    EFN73526.1    GL888182    EGI65668.1    GL767671    EFZ13313.1    CAEY01001591    GECU01026383    JAS81323.1    KQ971318    KYB28963.1    BK005823    DAA05780.1    GDIP01232479    JAI90922.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    UP000235965    + More
UP000027135    UP000192223    UP000009046    UP000076858    UP000245037    UP000007819    UP000000305    UP000242457    UP000054359    UP000002358    UP000008237    UP000053825    UP000078541    UP000076502    UP000078492    UP000078540    UP000005205    UP000075809    UP000078542    UP000215335    UP000053105    UP000000311    UP000007755    UP000015104    UP000007266    UP000005203   

PRIDE

F1T2L6    L7LXT4   

Pfam

PF03351   DOMON        + More
PF01082   Cu2_monooxygen
PF03712   Cu2_monoox_C
PF00313   CSD
PF00069   Pkinase

Interpro

IPR000323   Cu2_ascorb_mOase_N        + More
IPR020611   Cu2_ascorb_mOase_CS-1       
IPR024548   Cu2_monoox_C       
IPR008977   PHM/PNGase_F_dom_sf       
IPR028460   Tbh/DBH       
IPR036939   Cu2_ascorb_mOase_N_sf       
IPR014784   Cu2_ascorb_mOase-like_C       
IPR005018   DOMON_domain       
IPR035979   RBD_domain_sf       
IPR010280   U5_MeTrfase_fam       
IPR029063   SAM-dependent_MTases       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR002059   CSP_DNA-bd       
IPR012340   NA-bd_OB-fold       
IPR011129   CSD       
IPR014783   Cu2_ascorb_mOase_CS-2       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF49742   SSF49742        + More
SSF54928   SSF54928       
SSF53335   SSF53335       
SSF50249   SSF50249       
SSF56112   SSF56112       

Gene 3D

2.60.120.230     2.60.120.310     3.30.70.330    

CDD

cd04458  CSP_CDS

ProteinModelPortal

F1T2L6   A0A2A4IVW4   A0A194PQE1   A0A0G3VI00   A0A194QUD3   A0A212EIM8   + More
A0A0L7LUG0   A0A1B6KW36   A0A1B6EFZ9   A0A1B6CBY6   I7C6J7   I7BWB2   I7D3M3   I7CTE1   A0A2J7PJ22   A0A067QTZ3   A0A2H8TGU2   A0A0P6H9G9   A0A1W4WN56   A0A0P6GQ74   A0A0P5LMW4   A0A0P5H9I3   A0A0P5LRQ0   A0A0P5MBJ7   W8VKK1   A0A0P5M143   A0A0P5P5B5   A0A0P6FVD3   A0A0P5H0D0   A0A0P5QZD0   A0A0P6EIS1   A0A0P5L6R5   A0A0P5NUR4   A0A0P5NQ72   A0A0P5LG82   A0A0P6EVL1   A0A0P5MNP2   A0A0P5MER8   A0A0P5M937   A0A0P5PMI4   A0A0P5PSW4   A0A0P5R021   A0A0N8DWZ2   A0A0P5MT95   A0A0P6HCP7   E0VHU4   A0A0P6ACI3   A0A0P5HAF7   A0A0P5MGX2   A0A0P5KR28   A0A0P6EZ15   A0A0P5EWS2   A0A164VW34   A0A0P6F255   A0A0P5IQN1   A0A0P5F328   D6WEK9   A0A2P8YLP8   A0A2S2N8E7   X2KVP5   J9K380   A0A0P5JYZ3   A0A0P5BG39   A0A0P6FB14   A0A0P5YSU2   A0A0P5DFR6   A0A0P5IC69   E9HK72   A0A0P5LGM6   A0A2A3EII7   A0A0P6EWW9   A0A087TQF1   W8VTH9   K7J3J6   E2B3J5   A0A0L7R8A1   A0A195FM60   A0A0P5MYZ9   A0A154PNF6   A0A151J6J3   A0A2L2YJK8   A0A195BW72   A0A158NEC4   A0A151WVS2   A0A195CCB6   A0A0C9R1Y8   A0A0P5JW18   L7LXT4   A0A232FDF1   A0A0M8ZPV4   E1ZZB1   F4WJ90   E9J1G9   T1K603   A0A1B6I325   A0A139WM35   Q147S1   A0A0P4YDU6  

PDB

4ZEL     E-value=2.82846e-119,     Score=1098

KEGG

100862766    K00503 dopamine beta-monooxygenase [EC:1.14.17.1] | (RefSeq) Tbh; tyramine beta hydroxylase

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016715   GO:0005507   GO:0004500   GO:0006396   GO:0003676   GO:0008173   GO:0016021   GO:0030667   GO:0042421   GO:0006589   GO:0005615   GO:0042420   GO:0005737   GO:0004672   GO:0005524   GO:0003824   GO:0004497   GO:0009058   GO:0005089   GO:0035023   GO:0005515   GO:0016742   GO:0055114  

SignalP

Position:   1 - 20,         Likelihood:  0.621979

 

 

Length:

592

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

15.36485

Exp number, first 60 AAs:

15.34309

Total prob of N-in:

0.74281

POSSIBLE N-term signal

sequence

outside

1  -  592

 

 

Pi

311.379368

Theta

195.692829

Tajima's D

2.364925

CLR

0.204443

CSRT

0.931753412329384

Interpretation

Uncertain